R H Hruban

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma--part 3: update on 5-year survival
    Taylor S Riall
    Departments of Surgery, The Sol Goldman Pancreas Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gastrointest Surg 9:1191-204; discussion 1204-6. 2005
  2. ncbi Surgical management of giant Brunner's gland hamartoma: case report and literature review
    Zoe A Stewart
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, Maryland, USA
    World J Surg Oncol 7:68. 2009
  3. ncbi Evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Amol K Narang
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Radiat Oncol 6:126. 2011
  4. ncbi Molecular classification of neoplasms of the pancreas
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 40:612-23. 2009
  5. ncbi Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
    R H Hruban
    Departments of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 25:579-86. 2001
  6. ncbi An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    Ralph H Hruban
    Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Weinberg 2242, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 28:977-87. 2004
  7. ncbi Familial pancreatic cancer: from genes to improved patient care
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Hospital, Weinberg Building 2242, 401 North Broadway, Baltimore, MD 21231, USA
    Expert Rev Gastroenterol Hepatol 1:81-8. 2007
  8. ncbi Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 66:95-106. 2006
  9. ncbi Precursors to pancreatic cancer
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Gastroenterol Clin North Am 36:831-49, vi. 2007
  10. ncbi Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs
    Ralph H Hruban
    Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 20:S61-70. 2007

Detail Information

Publications124 found, 100 shown here

  1. ncbi Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma--part 3: update on 5-year survival
    Taylor S Riall
    Departments of Surgery, The Sol Goldman Pancreas Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Gastrointest Surg 9:1191-204; discussion 1204-6. 2005
    ..002)...
  2. ncbi Surgical management of giant Brunner's gland hamartoma: case report and literature review
    Zoe A Stewart
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, Maryland, USA
    World J Surg Oncol 7:68. 2009
    ..We report here an unusual case of a giant BGH that was not amenable to endoscopic or surgical local resection thus requiring a pancreaticoduodenectomy for extirpation. The relevant literature is discussed...
  3. ncbi Evaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital-Mayo Clinic collaborative study
    Amol K Narang
    Department of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Radiat Oncol 6:126. 2011
    ..We combined the experience of two institutions to better delineate which patients may benefit from adjuvant chemoradiation...
  4. ncbi Molecular classification of neoplasms of the pancreas
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Hum Pathol 40:612-23. 2009
    ..This classification does not ignore previous histology-based classification systems but instead embraces them, creating an integrated histological-molecular classification...
  5. ncbi Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions
    R H Hruban
    Departments of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA
    Am J Surg Pathol 25:579-86. 2001
    ..The acceptance of a standard classification system will facilitate the study of pancreatic duct lesions, and will lead ultimately to a better understanding of their biologic importance...
  6. ncbi An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
    Ralph H Hruban
    Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Weinberg 2242, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 28:977-87. 2004
    ..We present a consensus classification of the precursor lesions in the pancreatic ducts, PanINs and IPMNs...
  7. ncbi Familial pancreatic cancer: from genes to improved patient care
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Hospital, Weinberg Building 2242, 401 North Broadway, Baltimore, MD 21231, USA
    Expert Rev Gastroenterol Hepatol 1:81-8. 2007
    ..This review focuses on the genetic basis for the familial aggregation of pancreatic cancer, with emphasis placed on the implications of the genetic alterations on clinical patient care...
  8. ncbi Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendations
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 66:95-106. 2006
    ....
  9. ncbi Precursors to pancreatic cancer
    Ralph H Hruban
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Gastroenterol Clin North Am 36:831-49, vi. 2007
    ..Pancreatic intraepithelial neoplasia is a microscopic lesion. This article focuses on the clinical significance of these three important precursor lesions, with emphasis on their clinical manifestations, detection, and treatment...
  10. ncbi Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs
    Ralph H Hruban
    Departments of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 20:S61-70. 2007
    ..Pancreatic intraepithelial neoplasia (PanIN) is the presumed precursor lesion to infiltrating ductal adenocarcinoma, and PanIN lesions can mimic infiltrating cancer...
  11. ncbi Discovery of new markers of cancer through serial analysis of gene expression: prostate stem cell antigen is overexpressed in pancreatic adenocarcinoma
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Cancer Res 61:4320-4. 2001
    ..PSCA is a novel tumor marker for pancreatic carcinoma that has potential diagnostic and therapeutic implications. These results establish the validity of analyses of SAGE databases to identify novel tumor markers...
  12. ncbi Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer 91:1332-41. 2001
    ..Biliary tract carcinomas are clinically heterogeneous. It is not known if molecular heterogeneity underlies the clinical differences...
  13. ncbi Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE)
    P Argani
    Department of Pathology, The Johns Hopkins Medical Institutions, 2242 Weinberg, 410 North Broadway, Baltimore, MD 21231 2410, USA
    Clin Cancer Res 7:3862-8. 2001
    ..In this study, we evaluate the potential utility of mesothelin as a tumor marker for pancreatic adenocarcinoma...
  14. ncbi The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma
    M Tascilar
    Department of Pathology, The Johns Hopkins University School of Medicine, 632 Ross Building, Baltimore, MD 21205, USA
    Clin Cancer Res 7:4115-21. 2001
    ..36 (95% confidence interval, 1.01-1.83; P = 0.04). CONCLUSION: Patients undergoing Whipple resection for pancreatic adenocarcinoma survive longer if their cancers express SMAD4...
  15. ncbi Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases
    A Maitra
    Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Surg Pathol 25:595-601. 2001
    ..In contrast to pulmonary small cell carcinomas, p16INK4a function appears to be abrogated more frequently in these carcinomas...
  16. ncbi Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms
    N Fukushima
    Department of Pathology, The Johns Hopkins Medical Institutions, 632 Ross Building, 720 Rutland Ave, Baltimore, MD 21205 2196, USA
    Br J Cancer 89:338-43. 2003
    ..These results indicate that loss of SOCS-1 gene is associated with transcriptional silencing and may have growth-promoting effects, and that its methylation is a useful marker of pancreatic cancer...
  17. ncbi STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
    N Sato
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Pathol 159:2017-22. 2001
    ..None of the 22 IPMNs showed hypermethylation of the STK11/LKB1 gene. These results suggest that the STK11/LKB1 gene is involved in the pathogenesis of some IPMNs...
  18. ncbi Detection of mitochondrial DNA mutations in pancreatic cancer offers a "mass"-ive advantage over detection of nuclear DNA mutations
    J B Jones
    Predoctoral Program in Human Genetics Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cancer Res 61:1299-304. 2001
    ..Nevertheless, the nearly ubiquitous prevalence and high copy number of mtDNA mutations suggest that they be considered of promising clinical utility in diagnostic applications...
  19. ncbi Frequent germline deletion polymorphism of chromosomal region 8p12-p21 identified as a recurrent homozygous deletion in human tumors
    B Ryu
    Department of Oncology, The Johns Hopkins Medical Institutes, Baltimore, Maryland 21231, USA
    Genomics 72:108-12. 2001
    ..This problem would be accentuated in studies of cell lines where a paired sample of constitutional DNA is often unavailable...
  20. ncbi Pancreatic intraepithelial neoplasia and infiltrating adenocarcinoma: analysis of progression and recurrence by DPC4 immunohistochemical labeling
    D M McCarthy
    Departments of Pathology, Surgery, and Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Hum Pathol 32:638-42. 2001
    ..Additionally, Dpc4 expression can be used to differentiate recurrent or persistent adenocarcinoma from a second primary adenocarcinoma...
  21. ncbi Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma
    T Ueki
    Department of Pathology, Johns Hopkins School of Medicine and the Johns Hopkins School of Public Health, Baltimore, Maryland 21205, USA
    Cancer Res 61:8540-6. 2001
    ..ppENK, MICP25, and 27 were variably methylated in normal gastric, duodenal, and colonic mucosae. These data indicate that aberrant methylation of ppENK and its transcriptional repression is a common event in pancreatic carcinogenesis...
  22. ncbi Adjuvant chemoradiotherapy after pancreatic resection for invasive carcinoma associated with intraductal papillary mucinous neoplasm of the pancreas
    Michael J Swartz
    Department of Radiation Oncology and Molecular Radiation Sciences, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 2410, USA
    Int J Radiat Oncol Biol Phys 76:839-44. 2010
    ..Intraductal papillary mucinous neoplasms are mucin-producing cystic neoplasms of the pancreas. One-third are associated with invasive carcinoma. We examined the benefit of adjuvant chemoradiotherapy (CRT) for this cohort...
  23. ncbi Gene expression profiling identifies markers of ampullary adenocarcinoma
    N Tjarda Van Heek
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Biol Ther 3:651-6. 2004
    ..001). Measurement of markers of ampullary cancer such as osteopontin may aid in the early detection and differential diagnosis of patients with periampullary lesions...
  24. ncbi Intraductal papillary mucinous neoplasms of the pancreas: an updated experience
    Taylor A Sohn
    Departments of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Ann Surg 239:788-97; discussion 797-9. 2004
    ..Based on the age at resection data, there appears to be a 5-year lag time from IPMN adenoma (63.2 years) to invasive cancer (68.1 years)...
  25. ncbi Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer
    Kieran Brune
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1067-76. 2006
    ..The multifocal nature of familial pancreatic neoplasia suggests that surveillance of these patients is warranted after partial pancreatectomy...
  26. ncbi CpG island methylation profile of pancreatic intraepithelial neoplasia
    Norihiro Sato
    Departments of Pathology, Oncology and Medicine, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 21:238-44. 2008
    ..001), Reprimo (P=0.01), and LHX1 (P=0.03). These results suggest that aberrant CpG island hypermethylation begins in early stages of PanINs, and its prevalence progressively increases during neoplastic progression...
  27. ncbi Complement deposition in early cardiac transplant biopsies is associated with ischemic injury and subsequent rejection episodes
    W M Baldwin
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205 2196, USA
    Transplantation 68:894-900. 1999
    ..In animal models, tissue ischemia has been shown to activate complement...
  28. ncbi Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p
    S C Abraham
    Division of Gastrointestinal Liver Pathology, The Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 159:1619-27. 2001
    ..In addition, pancreatoblastoma may represent an extracolonic manifestation of FAP...
  29. ncbi Immunohistochemical labeling for the Dpc4 gene product is a specific marker for adenocarcinoma in biopsy specimens of the pancreas and bile duct
    M Tascilar
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Clin Pathol 116:831-7. 2001
    ..Importantly, loss of Dpc4 expression has been reported in in situ carcinomas, suggesting that loss of expression should not be equated with invasive carcinoma...
  30. ncbi Genetics of the FANCA gene in familial pancreatic cancer
    C D Rogers
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205-2196, USA
    J Med Genet 41:e126. 2004
  31. ncbi Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers
    G H Su
    Departments of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Pathol 154:1835-40. 1999
    ..Our results demonstrate that germline and somatic genetic alterations of the STK11/LKB1 gene may play a causal role in carcinogenesis and that the same gene contributes to the development of both sporadic and familial forms of cancer...
  32. ncbi Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231-2410, USA
    Mod Pathol 18:752-61. 2005
    ....
  33. ncbi Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases
    Denis M McCarthy
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Mod Pathol 16:272-8. 2003
    ..Although ampullary and pancreatic adenocarcinomas share histologic and molecular features, ampullary carcinomas are less likely to show loss of Dpc4 expression or K-ras gene mutations...
  34. ncbi Genetic and epigenetic alterations of familial pancreatic cancers
    Kieran Brune
    Department of Pathology, Medicine, Oncology, Johns Hopkins Medical Institutions, The Sol Goldman Pancreatic Cancer Research Center, 1550 Orleans Street, CRB2, Room 342, Baltimore, MD 21231, USA
    Cancer Epidemiol Biomarkers Prev 17:3536-42. 2008
    ..The aim of this study was to compare the prevalence of common genetic and epigenetic alterations in sporadic and familial pancreatic ductal adenocarcinomas...
  35. ncbi Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection
    Chanjuan Shi
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 7:353-360. 2008
    ..LigAmp quantification of mutant KRAS2 in pancreatic juice differentiates pancreatic adenocarcinoma from chronic pancreatitis, and may be a useful early detection tool for pancreatic cancer...
  36. ncbi KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin
    Chanjuan Shi
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 212312, USA
    Mol Cancer Res 7:230-6. 2009
    ..Isolated AMD lesions are genetically distinct from those associated with PanINs, and the latter may represent retrograde extension of the neoplastic PanIN cells or less likely are precursors to PanIN...
  37. ncbi Preferential expression of MUC6 in oncocytic and pancreatobiliary types of intraductal papillary neoplasms highlights a pyloropancreatic pathway, distinct from the intestinal pathway, in pancreatic carcinogenesis
    Olca Basturk
    Departments of Pathology, New York University, NY, USA
    Am J Surg Pathol 34:364-70. 2010
    ....
  38. ncbi Hypermethylation of multiple genes in pancreatic adenocarcinoma
    T Ueki
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 60:1835-9. 2000
    ..Thus, we conclude that many pancreatic carcinomas hypermethylate a small percentage of genes, whereas a subset displays a CIMP+ phenotype...
  39. ncbi Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity
    T A Sohn
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-4606, USA
    Ann Surg 234:313-21; discussion 321-2. 2001
    ....
  40. ncbi Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
    M Goggins
    Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Res 58:5329-32. 1998
    ..Our results indicate that the TGF-beta type I and type II receptor genes are selective targets of genetic inactivation in pancreatic and biliary cancers...
  41. ncbi Homozygous deletion map at 18q21.1 in pancreatic cancer
    S A Hahn
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 56:490-4. 1996
    ....
  42. ncbi Synchronous autoimmune pancreatitis and infiltrating pancreatic ductal adenocarcinoma: case report and review of the literature
    Agnieszka K Witkiewicz
    Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Hum Pathol 39:1548-51. 2008
    ..This case highlights the importance of carefully evaluating patients with autoimmune pancreatitis to rule out an underlying neoplasm and the importance of following those who were treated nonsurgically until the disease fully resolves...
  43. ncbi Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression
    Steven R Hustinx
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:1254-61. 2004
    ..TAGmapper should prove to be a powerful tool for the discovery of novel tumor markers through assignment of uncharacterized SAGE tags...
  44. ncbi Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells
    Nijaguna B Prasad
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer Res 65:1619-26. 2005
    ..These data show frequent up-regulation of foregut markers in early PanIN lesions and suggest that PanIN development may involve Hedgehog-mediated conversion to a gastric epithelial differentiation program...
  45. ncbi Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas
    Seung Woo Park
    Department of Surgery, The Sol Goldman Center for Pancreatic Cancer Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Gastroenterology 134:2080-90. 2008
    ..To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of both normal and oncogenic KRAS-expressing pancreatic progenitor cells in living zebrafish embryos...
  46. ncbi Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms
    Steven R Hustinx
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Cancer Biol Ther 4:596-601. 2005
    ..4; 0.9-2.2, p = 0.14). Aberrant expression of 14-3-3sigma may contribute to the outcome of patients with pancreatic ductal adenocarcinoma...
  47. ncbi Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers
    Jens Koopmann
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Clin Cancer Res 10:2386-92. 2004
    ..In this study, we evaluated serum macrophage inhibitory cytokine-1 (MIC-1) as a marker of pancreatic cancer...
  48. ncbi ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma
    G H Su
    Department of Oncology, Pathology, and Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 98:3254-7. 2001
    ..Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene...
  49. ncbi Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer
    R H Hruban
    Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Dig Dis 19:76-84. 2001
    ....
  50. ncbi Predicting resectability of periampullary cancer with three-dimensional computed tomography
    Michael G House
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Gastrointest Surg 8:280-8. 2004
    ....
  51. ncbi Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract
    Susan C Abraham
    Department of Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 34:902-10. 2003
    ..Finally, the frequency of allelic loss on 18q suggests that a locus on 18q is involved in the molecular pathogenesis of biliary IPNs, but this locus is not DPC4...
  52. ncbi Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    Sian Jones
    Sol Goldman Pancreatic Cancer Research Center, Ludwig Center and Howard Hughes Medical Institute at the Johns Hopkins Kimmel Cancer Center, Baltimore, MD 21231, USA
    Science 321:1801-6. 2008
    ..Dysregulation of these core pathways and processes through mutation can explain the major features of pancreatic tumorigenesis...
  53. ncbi Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer
    Hiroyuki Matsubayashi
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Biol Ther 2:652-5. 2003
    ..Furthermore, the N34S polymorphism is rarely found in patients with severe idiopathic chronic pancreatitis...
  54. ncbi Identification of novel highly expressed genes in pancreatic ductal adenocarcinomas through a bioinformatics analysis of expressed sequence tags
    Dengfeng Cao
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 3:1081-9; discussion 1090-1. 2004
    ....
  55. ncbi Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas
    Norihiro Sato
    Departments of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205-2196, USA
    Am J Pathol 164:903-14. 2004
    ..0001). Our findings suggest that preoperative assessment of gene expression profiles may be able to differentiate invasive from noninvasive IPMNs...
  56. ncbi Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
    Christine A Iacobuzio-Donahue
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Pathol 162:1151-62. 2003
    ..The genes and expressed sequence tags presented in this study provide clues to the pathobiology of pancreatic cancer and implicate a large number of potentially new molecular markers for the detection and treatment of pancreatic cancer...
  57. ncbi Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms
    Fikret Sahin
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:686-91. 2003
    ..Immunohistochemical analysis for Stk11 expression may be a valid surrogate for genetic analysis of STK11 gene mutations in cancers...
  58. ncbi Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients
    K Ranh Voong
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Hospital, Baltimore, MD 21231 6681, USA
    Hum Pathol 41:113-22. 2010
    ..Treatment with adjuvant chemoradiation therapy is associated with improved survival. The proportion of squamous differentiation in resected pancreatic adenosquamous carcinoma specimens does not appear to impact overall survival...
  59. ncbi Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms: a study of 39 cases
    Gregory Seidel
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Surg Pathol 26:56-63. 2002
    ..Instead, other factors such as tumor location, perineural invasion, vascular invasion, and margin status after resection are far more important...
  60. ncbi Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma
    Noriyoshi Fukushima
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:1573-81. 2002
    ....
  61. ncbi MUC4 expression increases progressively in pancreatic intraepithelial neoplasia
    Michael J Swartz
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Clin Pathol 117:791-6. 2002
    ..Our data help establish the patterns of MUC4 expression in neoplastic precursors in the pancreas and add further support to the progression model for pancreatic adenocarcinoma...
  62. ncbi Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47
    Anirban Maitra
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Am J Clin Pathol 118:52-9. 2002
    ..Fascin and HSP47 are novel tumor markers with potential diagnostic and therapeutic implications for pancreatic carcinoma. These results establish the usefulness of global expression platforms to identify novel tumor markers...
  63. ncbi New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8
    Zarir E Karanjawala
    The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 2410, USA
    Am J Surg Pathol 32:188-96. 2008
    ..New markers to distinguish benign reactive glands from infiltrating ductal adenocarcinoma of the pancreas are needed...
  64. ncbi Standard vs. radical pancreaticoduodenectomy for periampullary adenocarcinoma: a prospective, randomized trial evaluating quality of life in pancreaticoduodenectomy survivors
    Tom C Nguyen
    Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-4606, USA
    J Gastrointest Surg 7:1-9; discussion 9-11. 2003
    ..These results imply that no negative long-term QOL measures are associated with radical pancreaticoduodenectomy (as performed in this study) for periampullary adenocarcinoma...
  65. ncbi Absence of germline BRCA1 mutations in familial pancreatic cancer patients
    Jennifer E Axilbund
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, Maryland, USA
    Cancer Biol Ther 8:131-5. 2009
    ....
  66. ncbi Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions
    Anil V Parwani
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21231-2410, USA
    Mod Pathol 16:299-308. 2003
    ..It is noteworthy that all of these alterations occur at the level of carcinoma in situ...
  67. ncbi Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis
    Jeffrey M Hardacre
    Department of Surgery, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, MD 21287-4688, USA
    Ann Surg 237:853-8; discussion 858-9. 2003
    ..Nevertheless, differentiation from pancreatic neoplasia remains difficult. Patients undergoing pancreaticoduodenectomy for LPSP have durable relief of symptoms and a subjectively improved quality of life...
  68. ncbi Age- and disease-related methylation of multiple genes in nonneoplastic duodenum and in duodenal juice
    Hiroyuki Matsubayashi
    Department of Pathology, Division of Biostatistics, Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Clin Cancer Res 11:573-83. 2005
    ..Patients who develop pancreatic cancer may have a greater propensity to methylate CpG islands than age-matched controls...
  69. ncbi Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas
    N Volkan Adsay
    Departments of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
    Am J Surg Pathol 28:839-48. 2004
    ....
  70. ncbi Clear cell endocrine pancreatic tumor mimicking renal cell carcinoma: a distinctive neoplasm of von Hippel-Lindau disease
    M P Hoang
    Department of Pathology, The University of Texas Southwestern Medical Center, Dallas 75390-9073, USA
    Am J Surg Pathol 25:602-9. 2001
    ..Von Hippel-Lindau disease should be strongly suspected in patients with renal cell carcinoma, clear cell EPT, and multifocal microcystic serous adenomas...
  71. ncbi Molecular pathology of pancreatic cancer
    R H Hruban
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Cancer J 7:251-8. 2001
    ..In this article, we review the genetic alterations identified in pancreatic cancer and provide examples of how this information can be applied to patient care...
  72. ncbi DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    S A Hahn
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 271:350-3. 1996
    ..1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers...
  73. ncbi Sclerosing mesenteritis involving the pancreas: a mimicker of pancreatic cancer
    Jennifer R Scudiere
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Am J Surg Pathol 34:447-53. 2010
    ..Distinguishing SM from pancreatic carcinoma is crucial to appropriate management, as patients with SM may benefit from immunosuppressive therapy...
  74. ncbi Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large single-institutional series
    Sushanth Reddy
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    J Am Coll Surg 208:950-7; discussion 957-9. 2009
    ..Solid-pseudopapillary neoplasms (SPNs) are rare pancreatic tumors with malignant potential. Clinicopathologic characteristics and outcomes of patients with SPN were reviewed...
  75. ncbi Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    Shinichi Yachida
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Nature 467:1114-7. 2010
    ..These data provide novel insights into the genetic features underlying pancreatic cancer progression and define a broad time window of opportunity for early detection to prevent deaths from metastatic disease...
  76. ncbi Molecular genetics of pancreatic intraepithelial neoplasia
    Georg Feldmann
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Ross Bldg 632, Johns Hopkins University School of Medicine, 720 Rutland Ave, Baltimore, MD 21205, USA
    J Hepatobiliary Pancreat Surg 14:224-32. 2007
    ..Recent evidence suggests that noninvasive precursor lesions, classified as pancreatic intraepithelial neoplasia (PanIN), can progress to invasive pancreatic cancer. This review will discuss the major genetic alterations in PanIN lesions...
  77. ncbi Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs
    Carmelle D Rogers
    Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Biol Ther 5:1383-9. 2006
    ..RNA analysis of pancreatic juice deserves further investigation to determine its utility as a tool for the evaluation of pancreatic lesions...
  78. ncbi Elevated cancer mortality in the relatives of patients with pancreatic cancer
    Li Wang
    1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21231, USA
    Cancer Epidemiol Biomarkers Prev 18:2829-34. 2009
    ..Our results show that relatives of pancreatic cancer patients are at higher risk of developing cancers at other sites and highlight the importance of complete family history in clinical risk assessment...
  79. ncbi Genome-wide allelotypes of familial pancreatic adenocarcinomas and familial and sporadic intraductal papillary mucinous neoplasms
    Tadayoshi Abe
    Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Clin Cancer Res 13:6019-25. 2007
    ..Identifying the genomic losses that occur in pancreatic neoplasms, particularly those that occur in familial and precursor neoplasms, may help localize the genes responsible for pancreatic cancer susceptibility...
  80. ncbi Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach
    Mads Grønborg
    Department of Biological Chemistry, McKusick Nathans Institute of Genetic Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Proteomics 5:157-71. 2006
    ..28 was obtained, confirming previously reported poor associations between RNA and protein expression studies...
  81. ncbi Outcomes of adjuvant chemoradiation after pancreaticoduodenectomy with mesenterico-portal vein resection for adenocarcinoma of the pancreas
    Boris Hristov
    Department of Radiation Oncology and Molecular Radiation Sciences, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, USA
    Int J Radiat Oncol Biol Phys 76:176-80. 2010
    ..The purpose of this study was to compare outcomes between pancreaticoduodenectomy (PD) with and without mesenterico-portal vein resection (VR) in patients receiving adjuvant CRT for pancreatic adenocarcinoma...
  82. ncbi Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy
    Steven R Hustinx
    Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Cancer Biol Ther 4:83-6. 2005
    ..Thus, pancreatic cancer is a promising cancer type in which to explore novel chemotherapeutic strategies to exploit the selective loss of MTAP function...
  83. ncbi Prognostic value of hMLH1 methylation and microsatellite instability in pancreatic endocrine neoplasms
    Michael G House
    Department of Surgery, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, MD 21287, USA
    Surgery 134:902-8; discussion 909. 2003
    ..017) at 5 years. CONCLUSION: As in hereditary nonpolyposis colorectal cancer in which MSI is associated with improved survival, methylation of hMLH1 leads to MSI in PENs and affords a favorable prognosis...
  84. ncbi LigAmp for sensitive detection of single-nucleotide differences
    Chanjuan Shi
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Nat Methods 1:141-7. 2004
    ..Preliminary evidence indicates that reactions can be multiplexed. This assay may find applications in the diagnosis of genetic disorders and the management of patients with cancer and infectious diseases...
  85. ncbi Diagnosing pancreatic cancer using methylation specific PCR analysis of pancreatic juice
    Noriyoshi Fukushima
    Department of' Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205-2196, USA
    Cancer Biol Ther 2:78-83. 2003
    ..methylated in pancreatic secretions, detection of methylated ppENK and pi6 in pure pancreatic juice obtained by direct cannulation of the pancreatic duct to avoid duodenal secretions may suggest the presence of pancreatic adenocarcinoma..
  86. ncbi Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers
    B Ryu
    Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Cancer Res 61:1833-8. 2001
    ..This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets...
  87. ncbi Comparison of myocardial oxygen consumption using 11C acetate positron emission tomography scanning in a working and non-working heart transplant model
    K J Zehr
    Department of Cardiac Surgery, Johns Hopkins Medical Institution, MD 21287, Baltimore, USA
    Eur J Cardiothorac Surg 19:74-81. 2001
    ..It has a low myocardial oxygen consumption. Creation of a working model with normal myocardial oxygen consumption would enhance validity of non-human studies...
  88. ncbi Familial pancreatic cancer
    A P Klein
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Cancer J 7:266-73. 2001
    ..The identification of such high-risk individuals will help clinicians target screening programs and develop preventive interventions with the hope of reducing the mortality of pancreatic cancer in these families...
  89. ncbi Genomic sequencing of DPC4 in the analysis of familial pancreatic carcinoma
    C A Moskaluk
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Diagn Mol Pathol 6:85-90. 1997
    ..No mutations in the coding sequences of the DPC4 gene were found; hence, it appears that germline mutations in DPC4 cannot account for many of the familial aggregations of pancreatic carcinoma...
  90. ncbi p16 Inactivation in pancreatic intraepithelial neoplasias (PanINs) arising in patients with chronic pancreatitis
    Christophe Rosty
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Surg Pathol 27:1495-501. 2003
    ..This alteration, common to pancreatic cancer-associated PanINs, may contribute to the predisposition of patients with chronic pancreatitis to develop pancreatic ductal adenocarcinoma...
  91. ncbi Resected periampullary adenocarcinoma: 5-year survivors and their 6- to 10-year follow-up
    Taylor S Riall
    Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Surgery 140:764-72. 2006
    ..Many studies have reported 5-year survival data after pancreaticoduodenectomy for periampullary adenocarcinoma. This study evaluates 10-year survival in patients surviving 5 years after initial surgery...
  92. ncbi Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays
    Eric S Calhoun
    Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutes, Baltimore, MD 21231, USA
    Cancer Res 66:7920-8. 2006
    ..This study provides previously unavailable high-resolution allelotype and deletion breakpoint maps in widely shared pancreatic cancer cell lines and effectively eliminates the need for matched normal tissue to define informative loci...
  93. ncbi Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations
    Susan C Abraham
    Department of Pathology, Division of Gastrointestinal Liver Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:1361-9. 2002
    ..Overexpression of p53 was limited to only 3 of 19 (15.8%) SPTs. These results emphasize the two distinct, divergent genetic pathways of neoplastic progression in pancreatic ductal and nonductal neoplasms...
  94. ncbi Cholecystectomy, liver resection, and pylorus-preserving pancreaticoduodenectomy for gallbladder cancer: report of five cases
    John R Doty
    Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Gastrointest Surg 6:776-80. 2002
    ..There is a select group of patients, however, in whom adding a pylorus-preserving pancreaticoduodenectomy can result in a potentially curative operation by removing extensive regional spread to the peripancreatic lymph nodes...
  95. ncbi Accelerated graft arteriosclerosis in cardiac transplants: complement activation promotes progression of lesions from medium to large arteries
    Z Qian
    Department of Pathology, Ross Research Bldg, Room 664 D, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2196, USA
    Transplantation 72:900-6. 2001
    ..1A (RT1a) rats are rejected acutely (7-9 days) by fully MHC-incompatible C6-sufficient PVG.1L (RT11) recipients, but they survive significantly longer in untreated C6-deficient PVG.1L recipients (19 to >60 days)...
  96. ncbi Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation
    E M Jaffee
    Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 19:145-56. 2001
    ..To determine its safety and ability to induce antitumor immune responses, we conducted a phase I trial in patients with surgically resected adenocarcinoma of the pancreas...
  97. ncbi DPC4 gene in various tumor types
    M Schutte
    Gepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Res 56:2527-30. 1996
    ..The tissue restriction of alterations in DPC4, as in many other tumor-suppressor genes, emphasizes the complexity of rate-limiting checkpoints in human tumorigenesis...
  98. ncbi Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection
    Z Qian
    Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circulation 104:2369-75. 2001
    ..Prevention of Weibel-Palade body release might be a mechanism by which NO protects the vessel wall from inflammatory disorders such as atherosclerosis or graft arteriosclerosis...
  99. ncbi The pigmented "black" neuroendocrine tumor of the pancreas: a question of origin
    A E Smith
    Department of Pathology, Weinberg 2242, The Johns Hopkins Medical Institutions, 401 N Broadway, Baltimore, MD 21231, USA
    Cancer 92:1984-91. 2001
    ..One patient had an incidental (0.5 cm) finding, and the second patient had a well-demarcated, 4.5-cm mass identified by computerized tomography that was consistent with an islet cell tumor...
  100. ncbi Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
    G H Su
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Cancer Res 58:2339-42. 1998
    ..Coexistent mutations of other tumor suppressor genes in MKK4-deficient tumors suggest that MKK4 may participate in a tumor suppressive signaling pathway distinct from DPC4, p16, p53, and BRCA2...
  101. ncbi Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis
    A W Heldman
    Division of Cardiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circulation 103:2289-95. 2001
    ..We tested whether paclitaxel-coated coronary stents are effective at preventing neointimal proliferation in a porcine model of restenosis...