Paul M Hassoun

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi Hypoxia decreases expression of soluble guanylate cyclase in cultured rat pulmonary artery smooth muscle cells
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 30:908-13. 2004
  2. ncbi Lung involvement in systemic sclerosis
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Presse Med 40:e3-e17. 2011
  3. ncbi Pulmonary arterial hypertension complicating connective tissue diseases
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Semin Respir Crit Care Med 30:429-39. 2009
  4. ncbi Inflammation, growth factors, and pulmonary vascular remodeling
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 54:S10-9. 2009
  5. ncbi Activated protein C protects against ventilator-induced pulmonary capillary leak
    James H Finigan
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1002-11. 2009
  6. ncbi Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury
    Mahendra Damarla
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4600. 2009
  7. ncbi Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension
    Stephen C Mathai
    Divisions of Pulmonary and Critical Care Medicine, Cardiology, and Rheumatology, Department of Medicine, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA
    J Rheumatol 38:2410-8. 2011
  8. ncbi The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice
    Narsa M Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 180:867-74. 2009
  9. ncbi Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
    Raja Elie E Abdulnour
    Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006
  10. ncbi Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury
    Anne Le
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol 105:1282-90. 2008

Detail Information

Publications61

  1. ncbi Hypoxia decreases expression of soluble guanylate cyclase in cultured rat pulmonary artery smooth muscle cells
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Cell Mol Biol 30:908-13. 2004
    ....
  2. ncbi Lung involvement in systemic sclerosis
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21287, USA
    Presse Med 40:e3-e17. 2011
    ..This review focuses on clinical, diagnostic, and therapeutic features of PAH and ILD as well as other frequent but less debilitating lung complications of scleroderma...
  3. ncbi Pulmonary arterial hypertension complicating connective tissue diseases
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Semin Respir Crit Care Med 30:429-39. 2009
    ..g., esophageal involvement, aspiration with SSc)...
  4. ncbi Inflammation, growth factors, and pulmonary vascular remodeling
    Paul M Hassoun
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Am Coll Cardiol 54:S10-9. 2009
    ....
  5. ncbi Activated protein C protects against ventilator-induced pulmonary capillary leak
    James H Finigan
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 296:L1002-11. 2009
    ..blood vessel development) and specific gene (e.g., MAPK-associated kinase 2 and integrin-beta(6)) levels. These findings indicate that APC is barrier-protective in VILI and that EPCR is a critical participant in APC-mediated protection...
  6. ncbi Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury
    Mahendra Damarla
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4600. 2009
    ..Our results suggest that p38 MAP kinase and its downstream effector MK2 mediate lung permeability in ventilator associated lung injury by regulating HSP25 phosphorylation and actin cytoskeletal remodeling...
  7. ncbi Tricuspid annular plane systolic excursion is a robust outcome measure in systemic sclerosis-associated pulmonary arterial hypertension
    Stephen C Mathai
    Divisions of Pulmonary and Critical Care Medicine, Cardiology, and Rheumatology, Department of Medicine, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA
    J Rheumatol 38:2410-8. 2011
    ..But its role in systemic sclerosis (SSc)-associated PAH has not been established. Our objective was to validate the TAPSE in the assessment of RV function and prediction of survival in SSc-PAH...
  8. ncbi The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice
    Narsa M Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 180:867-74. 2009
    ..Moreover, we have recently demonstrated that Nrf2-deficiency impairs the resolution of lung injury and inflammation after nonlethal hyperoxia exposure...
  9. ncbi Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
    Raja Elie E Abdulnour
    Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006
    ..We conclude that XOR enzymatic activity is significantly increased by mechanical stress via activation of p38 MAP kinase and ERK and plays a critical role in the pathogenesis of pulmonary edema associated with VILI...
  10. ncbi Alveolar cell apoptosis is dependent on p38 MAP kinase-mediated activation of xanthine oxidoreductase in ventilator-induced lung injury
    Anne Le
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Appl Physiol 105:1282-90. 2008
    ....
  11. ncbi Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension
    Aránzazu Campo
    MD, Division of Pulmonary and Critical Care Medicine, 1830 E Monument St, Fifth Floor, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 182:252-60. 2010
    ..Objectives: To identify risk factors of mortality in a well-characterized cohort of patients with PAH related to systemic sclerosis (SSc-PAH)...
  12. ncbi Increased right ventricular Septomarginal trabeculation mass is a novel marker for pulmonary hypertension: comparison with ventricular mass index and right ventricular mass
    Jens Vogel-Claussen
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Invest Radiol 46:567-75. 2011
    ....
  13. ncbi Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury
    Bryan J McVerry
    Division of Pulmonary and Critical Care Medicine, Center for Translational Respiratory Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Am J Respir Crit Care Med 170:987-93. 2004
    ..Together, these results indicate that Sph 1-P represents a novel therapeutic intervention for the prevention of pulmonary edema related to inflammatory injury and increased vascular permeability...
  14. ncbi Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice
    Alexis Bierman
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Transl Res 152:265-72. 2008
    ..However, intratracheal instillation of EGF alone failed to induce lung injury. Collectively, our findings suggest that EGFR-activated signaling is necessary but not sufficient to produce acute lung injury in mice...
  15. ncbi Regression of chronic hypoxic pulmonary hypertension by simvastatin
    Reda E Girgis
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1105-10. 2007
    ..001). We conclude that simvastatin attenuates and induces regression of established CHPH through inhibition of HMG-CoA reductase. Inhibition of ROCK expression and activity may be an important mechanism of statin effect...
  16. ncbi Pulmonary capillary wedge pressure augments right ventricular pulsatile loading
    Ryan J Tedford
    Division of Cardiology, Johns Hopkins Medical Institutions, Ross 858, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circulation 125:289-97. 2012
    ....
  17. ncbi Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice
    Srinivas Papaiahgari
    Department of Environmental Health Sciences Division of Physiology, Room E7547, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 176:1222-35. 2007
    ..Mechanical ventilation (MV) is an indispensable therapy for critically ill patients with acute lung injury and the adult respiratory distress syndrome. However, the mechanisms by which conventional MV induces lung injury remain unclear...
  18. ncbi Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension
    Daniel J Angelini
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 361, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 41:553-61. 2009
    ..These results suggest that RELM-beta may be involved in the development of scleroderma-associated pulmonary hypertension...
  19. ncbi Differential gene expression in chronic hypoxic pulmonary hypertension: effect of simvastatin treatment
    Reda E Girgis
    Johns Hopkins University, Baltimore, MD 21205, USA
    Chest 128:579S. 2005
  20. ncbi Identification of candidate genes in scleroderma-related pulmonary arterial hypertension
    Dmitry N Grigoryev
    Division of Allergy and Clinical Immunology, Johns Hopkins University, Baltimore, MD 21224, USA
    Transl Res 151:197-207. 2008
    ..Deciphering the role of genes involved in vascular remodeling and PAH development may reveal new treatment targets for this devastating disorder...
  21. ncbi Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice
    Eric P Schmidt
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 295:L1056-65. 2008
    ..We conclude that HV(T)-induced endothelial barrier dysfunction resulted from a simultaneous increase in NO/sGC-derived cGMP and PDE2A expression causing decreased cAMP...
  22. ncbi Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice
    Narsa M Reddy
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    J Immunol 182:7264-71. 2009
    ....
  23. ncbi Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease
    Stephen C Mathai
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Arthritis Rheum 60:569-77. 2009
    ..This study was undertaken to characterize determinants of survival among SSc patients with either type of PH who received PAH-specific therapy...
  24. ncbi Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension
    Micah R Fisher
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 179:615-21. 2009
    ..However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently be inaccurate...
  25. ncbi Inducible nitric oxide synthase contributes to ventilator-induced lung injury
    Xinqi Peng
    Division of Pulmonary and Critical Care Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 172:470-9. 2005
    ..Inducible nitric oxide synthase (iNOS) has been implicated in the development of acute lung injury. Recent studies indicate a role for mechanical stress in iNOS and endothelial NOS (eNOS) regulation...
  26. ncbi Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice
    Narsa M Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Room E7610, 615 North Wolfe Street, Baltimore, Maryland 21205, USA
    J Immunol 183:4601-8. 2009
    ..Thus, loss of Nrf2 impairs lung innate immunity and promotes susceptibility to bacterial infection after hyperoxia exposure, ultimately leading to death of the host...
  27. ncbi EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation
    Srinivas Papaiahgari
    Division of Physiology, Department of Environmental Health Sciences, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Cell Mol Biol 36:304-12. 2007
    ..Collectively, these novel findings suggest that EGFR-activated signaling and actin remodeling act in concert to regulate the CS-induced Nrf2-ARE transcriptional response and subsequent AOE expression...
  28. ncbi Therapy for pulmonary arterial hypertension associated with systemic sclerosis
    Stephen C Mathai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Curr Opin Rheumatol 21:642-8. 2009
    ..Systemic sclerosis is commonly complicated by pulmonary arterial hypertension (PAH-SSc) and is a leading cause of death in this population. We will review existing challenges and recent advances in the treatment of this disease...
  29. ncbi Redox imbalance and ventilator-induced lung injury
    Sekhar P Reddy
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Antioxid Redox Signal 9:2003-12. 2007
    ..Potential therapeutic avenues for the treatment of VILI with exogenous administration of antioxidants also are discussed...
  30. ncbi p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor
    Rachel Damico
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Am J Respir Cell Mol Biol 44:323-32. 2011
    ..We conclude that MIF can protect human vascular endothelium from the toxic effects of CSE via the antagonism of p53-mediated apoptosis...
  31. ncbi A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension
    Ari L Zaiman
    Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, The Johns Hopkins Asthma and Allergy Center, 5A 58, 5501 Hopkins Bayview Circle, Baltimore, MD 21224
    Circulation 124:2533-42. 2011
    ..In this study, we test the hypothesis that ARC expression is essential for the development of chronic hypoxia-induced PH...
  32. ncbi Systemic sclerosis-associated pulmonary arterial hypertension
    Jerome Le Pavec
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University Department of Medicine, 1830 East Monument Street, Baltimore, MD 21287, USA
    Am J Respir Crit Care Med 181:1285-93. 2010
    ....
  33. ncbi Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling
    Monda L Shehata
    Department of Radiology, Johns Hopkins University, 600 N Wolfe St, Nelson Basement, MRI 143, Baltimore, MD 21287, USA
    AJR Am J Roentgenol 196:87-94. 2011
    ....
  34. ncbi Systemic sclerosis-related pulmonary hypertension associated with interstitial lung disease: impact of pulmonary arterial hypertension therapies
    Jerome Le Pavec
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Arthritis Rheum 63:2456-64. 2011
    ..This study was undertaken to evaluate our experience with PH-ILD with regard to the efficacy and safety of PAH therapies in this patient cohort...
  35. ncbi PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support
    Ryan J Tedford
    Divisions of Cardiology and Pulmonary and Critical Care Medicine, Department of Medicine, The Johns Hopkins Medical Institutions, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Circ Heart Fail 1:213-9. 2008
    ..We tested the hypothesis that when PH persists after adequate left ventricle unloading via recent left ventricular assist device (LVAD) therapy, phosphodiesterase type 5A inhibition would decrease PH in this population...
  36. ncbi Real-time single-heartbeat fast strain-encoded imaging of right ventricular regional function: normal versus chronic pulmonary hypertension
    Monda L Shehata
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Magn Reson Med 64:98-106. 2010
    ..Information derived from Fast-SENC allows characterization of RV regional function in normal individuals and in pulmonary hypertension patients...
  37. ncbi Endothelial dysfunction in pulmonary hypertension
    Rohit Budhiraja
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Circulation 109:159-65. 2004
  38. ncbi Pulmonary arterial hypertension associated with systemic sclerosis
    Stephen C Mathai
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Expert Rev Respir Med 5:267-79. 2011
    ....
  39. ncbi Use of consomic rats for genomic insights into ventilator-associated lung injury
    Stephanie A Nonas
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 293:L292-302. 2007
    ..We speculate that the consomic-microarray-SAM approach is a time- and resource-efficient tool for the genetic dissection of complex diseases including VALI...
  40. ncbi Regulation of endothelial barrier function by reactive oxygen and nitrogen species
    Adel Boueiz
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Microvasc Res 77:26-34. 2009
    ..This article will review the available evidence implicating ROS and RNS in endothelial barrier dysfunction, explore potential underlying mechanisms, and identify areas of further research...
  41. ncbi Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases
    Reda E Girgis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Heart Lung Transplant 24:1626-31. 2005
    ..Scant data are available regarding PAH associated with the scleroderma spectrum of diseases (APAH-SSD). Here we review our experience with bosentan in these 2 groups...
  42. ncbi Tricuspid annular displacement predicts survival in pulmonary hypertension
    Paul R Forfia
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins Hospital, Asthma and Allergy Center, Baltimore, MD 21224, USA
    Am J Respir Crit Care Med 174:1034-41. 2006
    ..05-1.30; p = 0.006), which persisted after adjusting for other echocardiographic and hemodynamic variables and baseline treatment status. CONCLUSIONS: TAPSE powerfully reflects RV function and prognosis in PAH...
  43. ncbi Right and left ventricular myocardial perfusion reserves correlate with right ventricular function and pulmonary hemodynamics in patients with pulmonary arterial hypertension
    Jens Vogel-Claussen
    Department of Radiology, Johns Hopkins University School of Medicine, Nelson Basement MRI 143, 600 N Wolfe St, Baltimore, MD 21287, USA
    Radiology 258:119-27. 2011
    ....
  44. ncbi Cardiac complications of systemic sclerosis: recent progress in diagnosis
    Adel Boueiz
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Curr Opin Rheumatol 22:696-703. 2010
    ..This article reviews the current information about cardiac dysfunction in scleroderma, with special emphasis on its detection and prognostic implications...
  45. ncbi Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury
    Xinqi Peng
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 169:1245-51. 2004
    ....
  46. ncbi Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
    Reda E Girgis
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, 1830 E Monument, 5th Floor, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 285:H938-45. 2003
    ..Enhancement of lung eNOS expression does not appear to be involved in mediating this effect...
  47. ncbi Portopulmonary hypertension: a tale of two circulations
    Rohit Budhiraja
    Pulmonary and Critical Care Division, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Chest 123:562-76. 2003
    ....
  48. ncbi One hundred years of research in the pathogenesis of pulmonary hypertension
    Ari Zaiman
    Department of Pathology, Division of Cardiopulmonary Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 33:425-31. 2005
  49. ncbi Xanthine oxidoreductase in respiratory and cardiovascular disorders
    Adel Boueiz
    Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Johns Hopkins Univ School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L830-40. 2008
    ..This will hopefully provide new opportunities for therapeutic intervention. This article reviews the available evidence involving XOR in oxidative states with specific emphasis on respiratory and cardiovascular diseases...
  50. ncbi Outcomes of hospitalisation for right heart failure in pulmonary arterial hypertension
    A Campo
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Baltimore, MD 21205, USA
    Eur Respir J 38:359-67. 2011
    ..Early recognition of these factors may guide decisions regarding more aggressive therapy, including consideration for lung transplantation...
  51. ncbi Hypoxia alters biophysical properties of endothelial cells via p38 MAPK- and Rho kinase-dependent pathways
    Steven S An
    Physiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Physiol Cell Physiol 289:C521-30. 2005
    ..Together, these findings suggest that hypoxia differentially regulates endothelial cell contraction and cellular-ECM adhesion...
  52. ncbi Estrogen modulates xanthine dehydrogenase/xanthine oxidase activity by a receptor-independent mechanism
    Rohit Budhiraja
    Pulmonary and Critical Care Division, Tupper Research Institute, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Antioxid Redox Signal 5:705-11. 2003
    ..In conclusion, 17alpha- and 17beta-estradiol modulate the hypoxia-induced regulation of XDH/XO activity at a posttranscriptional level by a receptor-independent mechanism...
  53. ncbi Modulation of inducible nitric oxide synthase by hypoxia in pulmonary artery endothelial cells
    Javier J Zulueta
    Pulmonary and Critical Care Division, Department of Medicine/Tupper Research Institute, New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Respir Cell Mol Biol 26:22-30. 2002
    ....
  54. ncbi Cytoskeletal changes in hypoxic pulmonary endothelial cells are dependent on MAPK-activated protein kinase MK2
    Usamah S Kayyali
    Pulmonary and Critical Care Division, Department of Medicine/Tupper Research Institute, Tufts-New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 277:42596-602. 2002
    ..Taken together these results indicate that hypoxia stimulates the p38-MK2-HSP27 pathway leading to significant alteration in the actin cytoskeleton...
  55. ncbi Activation of the STAT pathway in acute lung injury
    Mariano Severgnini
    Pulmonary and Critical Care Division, Tufts New England Medical Center, Boston, MA 02111, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1282-92. 2004
    ..Finally, STATs are activated in the lung long before signs of ALI are present, suggesting that the STAT transcription factors may play a role in initiating the inflammatory response seen in the lung...
  56. ncbi Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension
    Paul R Forfia
    Cardiovascular Division, Heart Failure Transplant Program, University of Pennsylvania School of Medicine, 3400 Spruce Street, 6 Penn Tower, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 177:1364-9. 2008
    ..Hyponatremia is associated with decompensated heart failure and poor prognosis in patients with left ventricular systolic dysfunction...
  57. ncbi Clinical differences between idiopathic and scleroderma-related pulmonary hypertension
    Micah R Fisher
    Emory University, Atlanta, Georgia, USA
    Arthritis Rheum 54:3043-50. 2006
    ..The presence of left heart disease, although more common in PAH-Scl, was not predictive of the higher mortality in these patients...
  58. ncbi N-terminal brain natriuretic peptide in scleroderma-associated pulmonary arterial hypertension
    Stephen C Mathai
    Eur Heart J 28:140-1; author reply 141. 2007
  59. ncbi Prediction of pulmonary artery pressure
    Micah R Fisher
    Chest 128:466-7; author reply 467. 2005
  60. ncbi Upregulation of xanthine oxidase by tobacco smoke condensate in pulmonary endothelial cells
    Usamah S Kayyali
    Pulmonary and Critical Care Division, Tupper Research Institute, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Toxicol Appl Pharmacol 188:59-68. 2003
    ..Furthermore, actinomycin D blocked the activation of XO by TSC. In conclusion, our results indicate that tobacco smoke condensate causes upregulation of XO transcription and activity...
  61. ncbi Pulmonary hypertension as a risk factor for death in patients with sickle cell disease
    Paul M Hassoun
    N Engl J Med 350:2521-2; author reply 2521-2. 2004