Research Topics
| ROLAND GRIFFITHSSummaryAffiliation: Johns Hopkins University Country: USA Publications
Research Grants
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Detail Information
Publications
Relative abuse liability of hypnotic drugs: a conceptual framework and algorithm for differentiating among compoundsRoland R Griffiths
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Clin Psychiatry 66:31-41. 2005....- Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamineMiriam Z Mintzer
Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 13:336-47. 2005.... - Ramelteon: a novel hypnotic lacking abuse liability and sedative adverse effectsMatthew W Johnson
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Arch Gen Psychiatry 63:1149-57. 2006.... - Is caffeine a flavoring agent in cola soft drinks?R R Griffiths
Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Arch Fam Med 9:727-34. 2000..The soft drink manufacturers' justification to regulatory agencies and the public for adding caffeine to soft drinks is that caffeine is a flavoring agent... - Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months laterRr Griffiths
Department of Psychiatry and Behavioral Sciences and Department of Neuroscience, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
J Psychopharmacol 22:621-32. 2008.... - Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significanceR R Griffiths
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510, Nathan Shock Drive, Baltimore, MD 21224 6823, USA
Psychopharmacology (Berl) 187:268-83; discussion 284-92. 2006..Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects... - Psilocybin occasioned mystical-type experiences: immediate and persisting dose-related effectsRoland R Griffiths
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
Psychopharmacology (Berl) 218:649-65. 2011..This dose-effect study extends previous observations showing that psilocybin can occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior... - Principles of initial experimental drug abuse liability assessment in humansRoland R Griffiths
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 70:S41-54. 2003..g. behavioral performance, observer-rated assessments, physiological measures)... - Caffeine as a model drug of dependence: recent developments in understanding caffeine withdrawal, the caffeine dependence syndrome, and caffeine negative reinforcementR R Griffiths
Department of Psychiatry, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Nihon Shinkei Seishin Yakurigaku Zasshi 20:223-31. 2000..Survey data suggest that 9% to 30% percent of caffeine consumers may be caffeine dependent according to DSM-IV criteria... - Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboonsAmy K Goodwin
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 189:71-82. 2006..CONCLUSIONS: These data indicate that, like GHB, chronic GBL dosing produced physical dependence that likely involved the GABA-B receptor... - Cognitive, psychomotor, and subjective effects of sodium oxybate and triazolam in healthy volunteersLawrence P Carter
Department of Psychiatry, Center for Addiction Research, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
Psychopharmacology (Berl) 206:141-54. 2009..Illicit gamma-hydroxybutyrate (GHB) has received attention as a "date rape drug" that produces robust amnesia; however, there is little experimental evidence in support of GHB's amnestic effects... - Relative abuse liability of GHB in humans: A comparison of psychomotor, subjective, and cognitive effects of supratherapeutic doses of triazolam, pentobarbital, and GHBLawrence P Carter
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 31:2537-51. 2006..Although the likelihood for GHB to be abused is intermediate to triazolam and pentobarbital, the possibility of accidental overdose (ie greater sedation than intended) with GHB appears to be greater... - Transdermal nicotine maintenance attenuates the subjective and reinforcing effects of intravenous nicotine, but not cocaine or caffeine, in cigarette-smoking stimulant abusersBai-Fang X Sobel
Department of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 29:991-1003. 2004..The results of the present study demonstrate that chronic nicotine maintenance produces tolerance to the effects of intravenous nicotine, but does not affect the subjective or reinforcing effects of cocaine or caffeine... - Cognitive and subjective acute dose effects of intramuscular ketamine in healthy adultsMichelle R Lofwall
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA
Exp Clin Psychopharmacol 14:439-49. 2006.... - Relative abuse liability of indiplon and triazolam in humans: a comparison of psychomotor, subjective, and cognitive effectsLawrence P Carter
Departments of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Pharmacol Exp Ther 322:749-59. 2007..Together, these data suggest that although the abuse potential of indiplon is not different from that of triazolam at these doses, psychomotor and cognitive impairment after large doses of indiplon might be less... - Oral caffeine maintenance potentiates the reinforcing and stimulant subjective effects of intravenous nicotine in cigarette smokersHendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
Psychopharmacology (Berl) 165:280-90. 2003..Epidemiological, clinical and pre-clinical observations suggest that caffeine can potentiate the reinforcing and discriminative effects of nicotine... - A triazolam/amphetamine dose-effect interaction study: dissociation of effects on memory versus arousalMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 192:425-40. 2007..Thus, it is possible that the observed amnestic effects are secondary to more global sedative effects and do not reflect a specific primary benzodiazepine effect on memory mechanisms... - Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Bayview Behavioral Biology Research Center, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 89:206-13. 2007..These data indicate that GABA(B) agonists may reduce relapse to cocaine taking... - Differential effects of scopolamine and lorazepam on working memory maintenance versus manipulation processesMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University, Baltimore, Maryland 21224, USA
Cogn Affect Behav Neurosci 7:120-9. 2007..In addition, the results suggested greater overall slowing of working memory processes with lorazepam... - Dose effects of triazolam and alcohol on cognitive performance in healthy volunteersBethea A Kleykamp
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 18:1-16. 2010..g., error detection on a choice reaction time task). Future research might examine the clinical implications of the performance impairments reported here given the widespread use of benzodiazepines and alcohol... - Dose effects of triazolam and scopolamine on metamemoryMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Exp Clin Psychopharmacol 18:17-31. 2010.... - Triazolam-amphetamine interaction: dissociation of effects on memory versus arousalMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Behavioural Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Psychopharmacol 17:17-29. 2003.... - Dose effects of triazolam on brain activity during episodic memory encoding: a PET studyMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 188:445-61. 2006..Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect... - Lorazepam and scopolamine: A single-dose comparison of effects on human memory and attentional processesMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224 6823, USA
Exp Clin Psychopharmacol 11:56-72. 2003.... - Principles of drug abuse liability assessment in laboratory animalsNancy A Ator
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins School of Medicine, Hopkins Bayview Campus, 5510 Nathan Shock Drive, Ste 3000, Baltimore, MD 21224 6823, USA
Drug Alcohol Depend 70:S55-72. 2003..A key consideration for cross-cutting and specific methodological issues is that choices made enable confident interpretation of both positive and negative results... - A paradoxical dissociation in the effects of midazolam on recollection and automatic processes in the process dissociation procedureMiriam Z Mintzer
Department of Psychiatry and Behavioral Sciences, Behavioral Biology Research Center, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Am J Psychol 116:213-37. 2003..Such evidence raises important questions about the use of the PDP... - Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposureMiriam Z Mintzer
Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 178:259-67. 2005..However, few parametric studies have been conducted in human participants... - Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 179:678-87. 2005..gamma-Hydroxybuyrate (GHB) is a current drug of abuse that may produce physical dependence... - Self-injection of flunitrazepam alone and in the context of methadone maintenance in baboonsNancy A Ator
Behavioral Biology Research Center, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, 5510 Nathan Shock Dr, Suite 3000, Baltimore, MD 21224, USA
Drug Alcohol Depend 78:113-23. 2005..Lower doses maintained higher self-injection during and shortly after methadone maintenance. Further research should explore the duration of higher self-injection rates following methadone maintenance... - Effects of GABAergic modulators on food and cocaine self-administration in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University, Behavioral Biology Research Center, 5510 Nathan Shock Dr Suite 3000, Baltimore, MD 21224 6823, USA
Drug Alcohol Depend 80:369-76. 2005..Thus, the effects of alprazolam were specific for cocaine-maintained behavior, where as the effects of baclofen and CGP44532 were not... - Comparison of the behavioral effects of bretazenil and flumazenil in triazolam-dependent and non-dependent baboonsElise M Weerts
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, MD 21224, USA
Eur J Pharmacol 519:103-13. 2005..Thus, bretazenil can function as an antagonist under conditions of benzodiazepine physical dependence... - The adenosine receptor antagonist CGS15943 reinstates cocaine-seeking behavior and maintains self-administration in baboonsElise M Weerts
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychopharmacology (Berl) 168:155-63. 2003..Caffeine and the adenosine A(1) and A(2A) receptor antagonist CGS15943 produce many behavioral effects that are similar to those produced by classic stimulant drugs (e.g. cocaine and amphetamines)... - Caffeine withdrawal, acute effects, tolerance, and absence of net beneficial effects of chronic administration: cerebral blood flow velocity, quantitative EEG, and subjective effectsStacey C Sigmon
Department of Psychiatry, University of Vermont College of Medicine, SATC UHC, Room 1415, Burlington, VT, 05401, USA
Psychopharmacology (Berl) 204:573-85. 2009..Although the subjective effects of caffeine abstinence, acute and chronic administration, and tolerance are well described, the corresponding neurophysiological effects are not... - Caffeinated energy drinks--a growing problemCHAD J REISSIG
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 99:1-10. 2009..Several studies suggest that energy drinks may serve as a gateway to other forms of drug dependence. Regulatory implications concerning labeling and advertising, and the clinical implications for children and adolescents are discussed... - Illicit gamma-hydroxybutyrate (GHB) and pharmaceutical sodium oxybate (Xyrem): differences in characteristics and misuseLawrence P Carter
Department of Psychiatry, University of Arkansas for Medical Sciences, 4301 W Markham Street 843, Little Rock, AR 72205, USA
Drug Alcohol Depend 104:1-10. 2009..Differences in the accessibility, purity, dosing, and misuse of illicit GHB and sodium oxybate suggest that risks associated with illicit GHB are greater than those associated with the pharmaceutical product sodium oxybate... - Caffeine dependence in combination with a family history of alcoholism as a predictor of continued use of caffeine during pregnancyDace S Svikis
Department of Psychology, Virginia Commonwealth University, 1101 East Marshall St, Sanger Hall, Room 11 028, Box 980343, Richmond, VA 23298 0343, USA
Am J Psychiatry 162:2344-51. 2005..The purpose of the study was to examine whether caffeine dependence and a family history of alcoholism are associated with continued use of caffeine during pregnancy... - A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated featuresLaura M Juliano
Department of Psychology, American University, 4400 Massachusetts Avenue, Washington, DC 20016, USA
Psychopharmacology (Berl) 176:1-29. 2004..CONCLUSIONS: The caffeine-withdrawal syndrome has been well characterized and there is sufficient empirical evidence to warrant inclusion of caffeine withdrawal as a disorder in the DSM and revision of diagnostic criteria in the ICD... - Impact of formulation on the abuse liability, safety and regulation of medications: the expert panel reportCharles Grudzinskas
NDA Partners LLC, 720 Riverview Terrace, Annapolis, MD 21401, USA
Drug Alcohol Depend 83:S77-82. 2006..Finally, knowledge and experience are needed to translate scientific work into a predictable, transparent and reliable regulatory process...
Research Grants
- Licit and Illicit Abused Stimulant DrugsROLAND GRIFFITHS; Fiscal Year: 2009..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
- ANALYSIS OF INTRAVENOUS DRUG SELF-ADMINISTRATIONROLAND GRIFFITHS; Fiscal Year: 1980..Another set of studies will use a discrete-trial choice procedure to explore the influence of a series of mixed agonist/antagonists on intravenous heroin reinforcement...
- LICIT AND ILLICIT ABUSED DRUGS/BEHAVIORAL INTERACTIONROLAND GRIFFITHS; Fiscal Year: 1993..In addition to providing new information about determinants of two licit forms of drug taking behavior which produce significant health risk, these studies will provide an improved understanding of the nature of the addictive process...
- EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSEROLAND GRIFFITHS; Fiscal Year: 2001..This research should contribute to efforts to develop new classes of sedative-anxiolytic compounds which have reduced potential for abuse by drug abusers as well as reduced potential for inappropriate chronic use among patients. ..
- Licit and Illicit Abused Stimulant DrugsROLAND GRIFFITHS; Fiscal Year: 2006..Ultimately, this project should have relevance to the development of prevention and treatment strategies for stimulant drug abuse. ..
- Experimental Analysis of Novel Drugs of AbuseROLAND GRIFFITHS; Fiscal Year: 2006....
- ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINEROLAND GRIFFITHS; Fiscal Year: 2002....
- BENZODIAZEPINES USE/ABUSE--EFFECTS ON MEMORY MECHANISMSROLAND GRIFFITHS; Fiscal Year: 2001..Ultimately, these data may also contribute to the development of improved drug abuse treatment strategies and to the development of anxiolytic/hypnotic compounds with reduced memory-impairing potential. ..
- EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSEROLAND GRIFFITHS; Fiscal Year: 1993..More generally, the data will contribute to an understanding of anziolytic-sedative drug abuse and will ultimately contribute to development of improved prevention, control and treatment procedures...
- EXPERIMENTAL ANALYSIS OF SEDATIVE/STIMULANT ABUSEROLAND GRIFFITHS; Fiscal Year: 1991....
- ABUSE LIABILITY OF BENZODIAZEPINES AND CAFFEINEROLAND GRIFFITHS; Fiscal Year: 1992..Two experiments will investigate optimal conditions for maintaining maximal intravenous and oral caffine self- administration and one experiment will characterize spontaneous withdrawal effects after high chronic doses of caffine...