Research Topics
| Anne M ComiSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Publications
Increased fibronectin expression in sturge-weber syndrome fibroblasts and brain tissueAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Pediatr Res 53:762-9. 2003..The reproducible differences in fibronectin gene expression between the SWS port-wine-derived fibroblasts and the SWS normal skin-derived fibroblasts are consistent with the presence of a hypothesized somatic mutation underlying SWS...- Encephalofacial angiomatosis sparing the occipital lobe and without facial nevus: on the spectrum of Sturge-Weber syndrome variants?Anne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Child Neurol 18:35-8. 2003..This diagnosis should be considered in any child presenting with seizures or complicated migraines and intracranial calcifications... - Pathophysiology of Sturge-Weber syndromeAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Child Neurol 18:509-16. 2003..Neurologic deterioration in Sturge-Weber syndrome is likely secondary to impaired blood flow to the brain and is worsened by the presence of seizures. Insights from related areas are discussed, and future research studies are suggested... - Strain variability, injury distribution, and seizure onset in a mouse model of stroke in the immature brainAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Dev Neurosci 27:127-33. 2005.... - Sturge-Weber syndrome: altered blood vessel fibronectin expression and morphologyAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
J Child Neurol 20:572-7. 2005..Altered blood vessel fibronectin expression in Sturge-Weber syndrome could contribute to abnormal vascular structure and function in this disorder... - Neuropsychological features and risk factors in children with Sturge-Weber syndrome: four case reportsT Andrew Zabel
Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD 21231, USA
Clin Neuropsychol 24:841-59. 2010..We discuss the need for broad-based assessment in this medical population, as various impairment combinations (e.g., perceptual, language, executive) create unique presentations as well as the need for individualized intervention... - Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemiaBeatrix S Traa
Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Pediatr Res 64:81-5. 2008..When analyzed by animal sex, the data suggest that gabapentin may more effectively reduce acute seizures and injury in male pups vs. female pups... - Quantitative EEG asymmetry correlates with clinical severity in unilateral Sturge-Weber syndromeLaura A Hatfield
Department of Neurology, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Epilepsia 48:191-5. 2007..SWS results in ischemic brain injury, seizures, and neurologic deficits. We hypothesized that a decrease in quantitative EEG (qEEG) power, on the affected side, correlates with clinical severity in subjects with SWS... - Immature mouse unilateral carotid ligation model of strokeAnne M Comi
Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University, Baltomore, MD 21205, USA
J Child Neurol 20:980-3. 2005..In addition, more work is needed to delineate the long-term consequences of the insult in this new model... - Use of quantitative EEG in infants with port-wine birthmark to assess for Sturge-Weber brain involvementJoshua B Ewen
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
Clin Neurophysiol 120:1433-40. 2009..The current study looks at the ability of qEEG to differentiate between infants with radiographically demonstrated SWS and those without... - Impact of age and strain on ischemic brain injury and seizures after carotid ligation in immature miceAnne M Comi
Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
Int J Dev Neurosci 27:271-7. 2009..We also found that the age at which ligation is performed and genetic strain have a strong influence on the severity of injury... - Dextromethorphan protects male but not female mice with brain ischemiaAnne M Comi
Departments of aNeurology and Developmental Medicine bNeuroscience, Kennedy Krieger Research Institute Departments of cNeurology dPediatrics eNeuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Neuroreport 17:1319-22. 2006..These results suggest that dextromethorphan neuroprotection against ischemic injury in the immature brain is sex-dependent... - Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injuryLavinia Alberi
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Stroke 41:S64-71. 2010..The purpose of this study was to understand whether Notch-2 is induced after neonatal stroke and to investigate its functional relevance... - A new model of stroke and ischemic seizures in the immature mouseAnne M Comi
Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD 21287, USA
Pediatr Neurol 31:254-7. 2004..This new model should be useful for examining the pathogenesis of stroke in the immature brain and the potential contribution of seizures to final outcome... - An infantile-onset, severe, yet sporadic seizure pattern is common in Sturge-Weber syndromeEric H Kossoff
The Johns Hopkins Hospital, Baltimore, MD 21287 1000, USA
Epilepsia 50:2154-7. 2009..This seizure pattern appears to be common with SWS and leads to difficult treatment decisions, especially in regard to the timing of potential surgical resection... - Hemiparesis is a clinical correlate of general adaptive dysfunction in children and adolescents with Sturge-Weber syndromeJennifer Reesman
Kennedy Krieger Institute, Baltimore, Maryland 21231, USA
J Child Neurol 24:701-8. 2009..Information obtained during neurological examination of children and adolescents with Sturge-Weber syndrome particularly hemiparetic status is useful for identifying children who may need additional intervention... - Chronic brain injury and behavioral impairments in a mouse model of term neonatal strokesShilpa D Kadam
Department of Neurology and Developmental Medicine, Hugo W Moser Research Institute at Kennedy Krieger, Baltimore, MD 21205, USA
Behav Brain Res 197:77-83. 2009..Overall, our results demonstrate that ischemia induced by our neonatal stroke model produces behavioral deficits that are consistent with the brain injury... - Neural stem cells reduce brain injury after unilateral carotid ligationAnne M Comi
Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Pediatr Neurol 38:86-92. 2008..Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern... - Physiatric findings in individuals with Sturge-Weber syndromeStacy J Suskauer
Kennedy Krieger Institute, Baltimore, Maryland, USA
Am J Phys Med Rehabil 89:323-30. 2010.... - Presentation, diagnosis, pathophysiology, and treatment of the neurological features of Sturge-Weber syndromeAnne M Comi
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Departments of Neurology and Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA
Neurologist 17:179-84. 2011..Some of these clinical features have only recently been described... - Transcranial Doppler ultrasound in children with Sturge-Weber syndromeLori C Jordan
Department of Neurology, The Johns Hopkins University School of Medicine, USA
J Child Neurol 23:137-43. 2008..Further study of Transcranial Doppler in children with Sturge-Weber syndrome is indicated... - Myoclonic-astatic epilepsy in a child with Sturge-Weber syndromeJoshua B Ewen
Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Pediatr Neurol 36:115-7. 2007..In such cases, treatment with a broad-spectrum antiepileptic may be advantageous... - Central hypothyroidism and Sturge-Weber syndromeAnne M Comi
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Pediatr Neurol 39:58-62. 2008..Therefore, it is important that patients with Sturge-Weber syndrome undergo routine thyroid-function testing, especially in the face of any clinical manifestations... - The pharmacokinetics of commonly used antiepileptic drugs in immature CD1 miceGeoffrey J Markowitz
Department of Neurology and Developmental Medicine, Kennedy Krieger Research Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Neuroreport 21:452-6. 2010..Brain-to-blood ratios were comparable with adult ratios. AEDs tested had longer half-lives and maintained therapeutic plasma concentrations longer than reported in mature mice, making clinically relevant protocols feasible... - Effect of a single application of pulsed dye laser treatment of port-wine birthmarks on intraocular pressureSusan Y Quan
Departments of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Arch Dermatol 146:1015-8. 2010..Pressures before and after laser treatment were measured to determine pressure difference in 15 patients receiving laser treatment... - Survey of aspirin use in Sturge-Weber syndromeMihee J Bay
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA
J Child Neurol 26:692-702. 2011..Our study showed a significant relative reduction in both self-reported seizure frequency and stroke-like episodes after starting aspirin. It also suggests that low-dose aspirin can be safely used in these patients... - Sturge-Weber syndrome and epilepsy: an argument for aggressive seizure management in these patientsAnne M Comi
Department of Neurology, Kennedy Krieger Institute and Johns Hopkins Medicine, Baltimore, MD, USA
Expert Rev Neurother 7:951-6. 2007..Continued efforts are needed to develop a multicentered network for SWS clinical trials. Future research should be focused on this goal and on studies to improve our understanding of the cause(s) and molecular neuropathology of SWS... - Sturge-Weber syndrome associated with other abnormalities: a medical record and literature reviewAnne M Comi
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Arch Neurol 62:1924-7. 2005..To develop hypotheses regarding the relationship between Sturge-Weber syndrome (SWS) and other abnormalities in a subset of patients... - Quantitative analysis of cerebral cortical atrophy and correlation with clinical severity in unilateral Sturge-Weber syndromeThomas M Kelley
Department of Neurology, Johns Hopkins University, Baltimore, MD 21297-1000, USA
J Child Neurol 20:867-70. 2005..This method offers the advantages of relative simplicity, objectivity, and wide applicability to films from outside institutions, as would be encountered in clinical practice... - Dynamic MR perfusion and proton MR spectroscopic imaging in Sturge-Weber syndrome: correlation with neurological symptomsDoris D M Lin
Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Magn Reson Imaging 24:274-81. 2006..To investigate physiological alterations in Sturge-Weber syndrome (SWS) using MR perfusion imaging (PWI) and proton spectroscopic imaging (MRSI), and their association with neurological status... - A pilot study of the modified Atkins diet for Sturge-Weber syndromeEric H Kossoff
The John M Freeman Pediatric Epilepsy Center, Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Epilepsy Res 92:240-3. 2010..Five children aged 4-18 years with SWS and at least monthly intractable seizures were started prospectively on the MAD for 6 months. All children had urinary ketosis and seizure improvement, including 3 with > 50% seizure reduction... - Comorbidity of epilepsy and headache in patients with Sturge-Weber syndromeEric H Kossoff
Department of Neurology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Child Neurol 20:678-82. 2005..Correlations of family history with both age at symptom onset and behavior problems suggest that genetic substrate could be one factor determining the variable neurologic manifestations seen in Sturge-Weber syndrome... - Advances in Sturge-Weber syndromeAnne M Comi
Neurology and Pediatrics, Kennedy Krieger Institute and Johns Hopkins Medicine, 707 N Broadway, Baltimore, MD 21205, USA
Curr Opin Neurol 19:124-8. 2006..Recent neuroimaging, clinical and molecular neuropathologic studies have provided new insights into the neurologic aspects of Sturge-Weber syndrome and are summarized here... - Self-reported treatment patterns in patients with Sturge-Weber syndrome and migrainesEric H Kossoff
Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Child Neurol 22:720-6. 2007..The small sample size precludes any safety analysis, however, and future prospective trials of both treatment options are needed... - Behavioral and psychiatric features of Sturge-Weber syndromeElizabeth Turin
Kennedy Krieger Institute, Department of Psychiatry, Baltimore, MD 21205, USA
J Nerv Ment Dis 198:905-13. 2010..Problems with mood, attention, sleep, learning, and substance use were common. Disruptive behavior disorders and their association with medical conditions should be further investigated... - Cell proliferation and oxidative stress pathways are modified in fibroblasts from Sturge-Weber syndrome patientsShilpa D Kadam
Departments of Neurology and Developmental Medicine, Hugo Moser Kennedy Krieger Research Institute, Baltimore, MD, USA
Arch Dermatol Res 304:229-35. 2012..The significant toxicologic list pathway in all four observations was oxidative stress mediated by Nrf2. This proteomics study highlights oxidative stress also consistent with a possible mutation in the RASA1 gene or pathway in SWS... - Sturge-Weber syndrome: ear, nose, and throat issues and neurologic statusNatasha D Irving
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Pediatr Neurol 43:241-4. 2010..Furthermore, patients with facial tissue hypertrophy may be at risk for obstructive sleep apnea, and should be appropriately evaluated... - Cerebrospinal fluid and serum markers of inflammation in autismAndrew W Zimmerman
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore Maryland 21205, USA
Pediatr Neurol 33:195-201. 2005..Alternatively, they may be produced by microglia but remain localized and not expressed in cerebrospinal fluid... - Update on Sturge-Weber syndrome: diagnosis, treatment, quantitative measures, and controversiesAnne M Comi
Neurology and Developmental Medicine, Kennedy Krieger Institute, Department of Neurology and Pediatrics, Johns Hopkins School of Medicine Baltimore, MD 21205, USA
Lymphat Res Biol 5:257-64. 2007....