Research Topics
| Adrian BarbulSummaryAffiliation: Johns Hopkins University Country: USA Publications
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Detail Information
Publications
Role of nitric oxide in wound repairMaria B Witte
Department of Surgery, the Sinai Hospital of Baltimore, and the Johns Hopkins Medical Institutions, Baltimore, MD 21215, USA
Am J Surg 183:406-12. 2002..The current review summarizes what is known about the role of NO in wound healing and points out path for further research...- Proline precursors to sustain Mammalian collagen synthesisAdrian Barbul
Department of Surgery, Sinai Hospital of Baltimore and Johns Hopkins Medical Institutions, Sinai Hospital, Baltimore, MD 21215, USA
J Nutr 138:2021S-2024S. 2008..In conclusion, ARG and ORN supplementation are most effective in increasing collagen deposition, but whether this is accomplished by conversion to PRO is uncertain... - Use of exogenous arginine in multiple organ dysfunction syndrome and sepsisAdrian Barbul
Department of Surgery, Sinai Hospital and Johns Hopkins Medical Institutions, Baltimore, MD, USA
Crit Care Med 35:S564-7. 2007.... - Supplemental L-arginine enhances wound healing in diabetic ratsHan Ping Shi
Department of Surgery, the Sinai Hospital of Baltimore, and the Johns Hopkins Medical Institutions, Baltimore, Maryland 21215, USA
Wound Repair Regen 11:198-203. 2003..The data show that the impaired healing of diabetic wounds can be partially corrected by L-arginine supplementation, and that this effect is accompanied by enhanced wound nitric oxide synthesis... - Modulation of growth factor and cytokine expression by nitric oxide during rat colon anastomotic healingDavid T Efron
Department of Surgery, Sinai Hospital of Baltimore and the Johns Hopkins Medical Institutions, Baltimore, MD, USA
J Gastrointest Surg 7:393-9. 2003..This provides in vivo evidence that NO modulates gene expression during anastomotic healing... - Characterization of incisional wound healing in inducible nitric oxide synthase knockout miceDaniel Most
Departments of Surgery, The Johns Hopkins Medical Institutions, and the Sinai Hospital of Baltimore, Baltimore, MD 21215, USA
Surgery 132:866-76. 2002..Their impaired expression of VEGF and IL-4, on the other hand, may partially explain the delayed excisional wound healing noted in these animals... - Arginase inhibition promotes wound healing in miceSandra L Kavalukas
Department of Surgery, Sinai Hospital of Baltimore, Baltimore, MD, USA
Surgery 151:287-95. 2012..In this study, we used a highly potent and specific inhibitor of arginase, namely 2(S)-amino-6-boronohexanoic acid NH4 (ABH) to evaluate the role of arginase function in wound healing... - L-Arginine supplementation enhances diabetic wound healing: involvement of the nitric oxide synthase and arginase pathwaysMaria B Witte
Department of Surgery, Sinai Hospital of Baltimore and the Johns Hopkins Medical Institutions, Baltimore, MD 21215, USA
Metabolism 51:1269-73. 2002.... - Subcutaneous sponge modelsDavid T Efron
Department of Surgery, Sinai Hospital, Johns Hopkins Medical Institution, Baltimore, MD, USA
Methods Mol Med 78:83-93. 2003 - Cellular and physiological effects of arginineBetty C Tong
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Mini Rev Med Chem 4:823-32. 2004..Thus, arginine is a biologically active dietary compound with numerous physiologic and pharmacological activities... - Effect of a specialized amino acid mixture on human collagen depositionJeremy Z Williams
Department of Surgery, Sinai Hospital of Baltimore, Johns Hopkins Medical Institutions, Baltimore, Maryland 21215, USA
Ann Surg 236:369-74; discussion 374-5. 2002..This provides a safe nutritional means for increasing wound repair in patients... - Effect of supplemental ornithine on wound healingHan Ping Shi
Department of Surgery, Sinai Hospital of Baltimore, Johns Hopkins Medical Institutions, Baltimore, Maryland 21215, USA
J Surg Res 106:299-302. 2002..CONCLUSIONS: The results from this study demonstrate that ornithine supplementation enhances wound healing in both WT and KO mice. This suggests that ornithine's effect on wound healing is independent of the iNOS pathway... - Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healingJeffrey Schreiber
Department of Surgery, Sinai Hospital of Baltimore and the Johns Hopkins Medical Institutions, Baltimore, MD 21215, USA
Surgery 138:940-6. 2005..This mechanism appears to be TNF-alpha independent. Inhibition of NF-kappaB may reduce inflammation by reducing the local NOx concentrations... - Nutrition and wound healingMeghan Arnold
Department of Surgery, Sinai Hospital of Baltimore, and the Johns Hopkins Medical Institutions, Baltimore, MD, USA
Plast Reconstr Surg 117:42S-58S. 2006..A summary of the clinical implications of the data is presented, with the acknowledgment that each patient's plan of care must be individualized to optimize the relationship between nutrition and wound healing... - Nitric oxide and wound healingMajida Rizk
Department of Surgery, Sinai Hospital of Baltimore, Johns Hopkins Medical Institutions, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
World J Surg 28:301-6. 2004.... - Intra-abdominal healing: gastrointestinal tract and adhesionsSanjay Munireddy
Department of Surgery, Sinai Hospital of Baltimore, and the Johns Hopkins Medical Institutions, Baltimore, MD, USA
Surg Clin North Am 90:1227-36. 2010..Different aspects of GI and peritoneal healing, with associated factors, are discussed in this article... - Complex wounds and their managementHabeeba Park
Department of Surgery, Sinai Hospital of Baltimore, 2401 West Belvedere Avenue, Baltimore, MD 21215, USA
Surg Clin North Am 90:1181-94. 2010.... - Nutrition and wound healing: an updateSandra L Kavalukas
Department of Surgery, Sinai Hospital, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Plast Reconstr Surg 127:38S-43S. 2011..This review examines many of the advances that have occurred in understanding nutrition/wound interactions... - Nutrition and wound healingJeremy Z Williams
Department of Surgery, Sinai Hospital of Baltimore. 2435 West Belvedere Avenue, Suite 40, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
Surg Clin North Am 83:571-96. 2003..Within this paradigm, the physician should be able to recognize patients who may be expected to have wound healing difficulties and offer early intervention to avoid wound failure... - Understanding the role of immune regulation in wound healingJulie E Park
Department of Surgery, Sinai Hospital of Baltimore and Johns Hopkins Medical Institutions, 2401 West Belvedere Avenue, Baltimore, Maryland 21215, USA
Am J Surg 187:11S-16S. 2004..We review the mechanisms by which the immune system regulates wound healing... - Vessel injury and capillary leakRhonda S Fishel
Department of Surgery, Sinai Hospital of Baltimore, MD 21215, USA
Crit Care Med 31:S502-11. 2003..The implications of extensive edema and the mechanism by which it resolves continue to be the subject of speculation rather than study... - Genesis of the prevention guidelines projectAdrian Barbul
Sinai Hospital and Johns Hopkins University, Baltimore, MD, USA
Wound Repair Regen 16:145-6. 2008 - Effect of preinjury statin use on mortality and septic shock in elderly burn patientsMary D Fogerty
Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Trauma 69:99-103. 2010..This has been ascribed to the pleiotropic, anti-inflammatory effects of HMG-CoA reductase inhibitors. This association has not been investigated in burn victims... - Tacrolimus enhances colon anastomotic healing in ratsTeruo Kiyama
Department of Surgery I, Nippon Medical School, Tokyo, Japan
Wound Repair Regen 10:308-13. 2002..These data suggest that tacrolimus enhances wound strength during acute anastomotic healing despite a reduction in collagen content... - Repair of full-thickness bowel injuryMaria B Witte
Department of Surgery, University of Tuebingen, Germany
Crit Care Med 31:S538-46. 2003..CONCLUSION: Several local and systemic factors negatively affect bowel healing; there is still a small portion of patients who fail to heal, suggesting that intrinsic factors need to be analyzed... - Upregulation of arginase expression in wound-derived fibroblastsMaria B Witte
Department of Surgery, University of Tuebingen, Germany
J Surg Res 105:35-42. 2002..l-Arginine is the sole substrate for iNOS. Arginase is an alternative pathway of l-arginine metabolism in wounds. To clarify the role of l-arginine in wound healing, we investigated arginase expression and activity in WFB... - Arginine therapy for acute myocardial infarctionNaji N Abumrad
JAMA 295:2138-9; author reply 2139-40. 2006 - Bacterial biofilms in woundsVijay A Singh
Wound Repair Regen 16:1. 2008 - Arginine physiology and its implication for wound healingMaria B Witte
Department of Surgery, , , Germany
Wound Repair Regen 11:419-23. 2003..This article reviews the basic biochemistry and cell signaling within which arginine performs its functions. In particular, the requirement for this amino acid in tissue repair is highlighted... - Supplemental L-arginine enhances wound healing following trauma/hemorrhagic shockHan Ping Shi
Department of Surgery, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, Guang Dong, China
Wound Repair Regen 15:66-70. 2007..Arginine treatment had no effect on wound fluid and plasma NO(x). The data demonstrate that the impaired healing subsequent to trauma/hemorrhage can be greatly alleviated by L-arginine supplementation... - Guidelines for the treatment of arterial insufficiency ulcersHarriet W Hopf
University of Utah, Salt Lake City, UT, USA
Wound Repair Regen 14:693-710. 2006 - Exogenous pro-angiogenic stimuli cannot prevent physiologic vessel regressionAnkush Gosain
Department of Cell Biology, Neurobiology and Anatomy, Loyola University Medical Center, Burn and Shock Trauma Institute, Maywood, Illinois, USA
J Surg Res 135:218-25. 2006..Clinical manipulation of anti-angiogenic signals in addition to the currently used pro-angiogenic targets may be needed to achieve therapeutic modulation of blood vessel density... - Guidelines for the treatment of pressure ulcersJoAnne Whitney
University of Washington, Seattle, WA, USA
Wound Repair Regen 14:663-79. 2006