Eli E Bar

Summary

Affiliation: Johns Hopkins University
Country: USA

Publications

  1. ncbi New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination
    Eli E Bar
    Johns Hopkins University School of Medicine, Department of Pathology, 720 Rutland Avenue, Ross Building 558, Baltimore, MD 21205, USA
    Expert Opin Investig Drugs 17:185-95. 2008
  2. ncbi Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma
    Eli E Bar
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neuropathol Exp Neurol 67:878-87. 2008
  3. ncbi Hedgehog signaling promotes medulloblastoma survival via Bc/II
    Eli E Bar
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Building 558, Baltimore, MD 21205, USA
    Am J Pathol 170:347-55. 2007
  4. ncbi Glioblastoma, cancer stem cells and hypoxia
    Eli E Bar
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain Pathol 21:119-29. 2011
  5. ncbi Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres
    Eli E Bar
    Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD 21287, USA
    Am J Pathol 177:1491-502. 2010
  6. ncbi Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
    Eli E Bar
    Johns Hopkins University School of Medicine, Department of Pathology, 720 Rutland Avenue, Ross Building 558, Baltimore, Maryland 21205, USA
    Stem Cells 25:2524-33. 2007
  7. ncbi The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance
    Karisa C Schreck
    Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 16:6060-70. 2010
  8. ncbi A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors
    Kah Jing Lim
    Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Biol Ther 11:464-73. 2011
  9. ncbi BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants
    Alex Lin
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 71:66-72. 2012
  10. ncbi Notch signaling promotes growth and invasion in uveal melanoma
    Laura Asnaghi
    Authors Affiliations Department of Pathology, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, Maryland and Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
    Clin Cancer Res 18:654-65. 2012

Collaborators

Detail Information

Publications10

  1. ncbi New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination
    Eli E Bar
    Johns Hopkins University School of Medicine, Department of Pathology, 720 Rutland Avenue, Ross Building 558, Baltimore, MD 21205, USA
    Expert Opin Investig Drugs 17:185-95. 2008
    ..The safety of such approach, however, still needs to be tested in animal models of the disease before its application in human patients...
  2. ncbi Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma
    Eli E Bar
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neuropathol Exp Neurol 67:878-87. 2008
    ..These data indicate that focal gains at chromosome 7q34 and increased BRAF-MEK-ERK signaling are common findings in sporadic pilocytic astrocytomas...
  3. ncbi Hedgehog signaling promotes medulloblastoma survival via Bc/II
    Eli E Bar
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross Building 558, Baltimore, MD 21205, USA
    Am J Pathol 170:347-55. 2007
    ..These data demonstrate that BclII is an important mediator of Hh activity in medulloblastoma and suggest new strategies for combined chemotherapeutic regimens...
  4. ncbi Glioblastoma, cancer stem cells and hypoxia
    Eli E Bar
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Brain Pathol 21:119-29. 2011
    ..This review examines the recently described effects of hypoxia on CSC in GBM, and the potential promise in targeting the hypoxic pathway therapeutically...
  5. ncbi Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres
    Eli E Bar
    Johns Hopkins University School of Medicine, Department of Pathology, Baltimore, MD 21287, USA
    Am J Pathol 177:1491-502. 2010
    ....
  6. ncbi Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
    Eli E Bar
    Johns Hopkins University School of Medicine, Department of Pathology, 720 Rutland Avenue, Ross Building 558, Baltimore, Maryland 21205, USA
    Stem Cells 25:2524-33. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  7. ncbi The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance
    Karisa C Schreck
    Department of Neuroscience, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 16:6060-70. 2010
    ..We investigated whether brain tumors show resistance to therapies against Notch, and whether targeting multiple pathways simultaneously would kill brain tumor cells more effectively than monotherapy...
  8. ncbi A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors
    Kah Jing Lim
    Graduate Program in Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Cancer Biol Ther 11:464-73. 2011
    ..Our data suggest that curcumin nanoparticles can inhibit malignant brain tumor growth through the modulation of cell proliferation, survival and stem cell phenotype...
  9. ncbi BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants
    Alex Lin
    Division of Neuropathology, Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA
    J Neuropathol Exp Neurol 71:66-72. 2012
    ..The prognostic and therapeutic significance of this alteration is unclear and merits further study...
  10. ncbi Notch signaling promotes growth and invasion in uveal melanoma
    Laura Asnaghi
    Authors Affiliations Department of Pathology, Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, Maryland and Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri
    Clin Cancer Res 18:654-65. 2012
    ..To determine whether uveal melanoma, the most common primary intraocular malignancy in adults, requires Notch activity for growth and metastasis...