Research Topics
Species | B C AstorSummaryAffiliation: Johns Hopkins Bloomberg School of Public Health Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic StudyAudrey Y Chu
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
BMC Med Genet 10:108. 2009..However, few data are available in non-European ethnic groups or in a population-based cohort...- Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities StudiesAnna Kottgen
Department of Epidemiology and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
BMC Med Genet 9:49. 2008..The study of 70,987 single nucleotide polymorphisms (SNPs) in 1,010 FHS participants provides a list of SNPs showing the strongest associations with renal traits which need to be verified in independent study samples... - N-terminal prohormone brain natriuretic peptide as a predictor of cardiovascular disease and mortality in blacks with hypertensive kidney disease: the African American Study of Kidney Disease and Hypertension (AASK)B C Astor
Welch Center for Prevention, Epidemiology and Clinical Research, 2024 E Monument St, Suite 2 600, Baltimore, MD 21205, USA
Circulation 117:1685-92. 2008..Higher levels of N-terminal prohormone brain-type natriuretic peptide (NT-proBNP) predict cardiovascular disease (CVD) in several disease states, but few data are available in patients with chronic kidney disease or in blacks... - Kidney function and anemia as risk factors for coronary heart disease and mortality: the Atherosclerosis Risk in Communities (ARIC) StudyBrad C Astor
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am Heart J 151:492-500. 2006..Mildly to moderately decreased kidney function is far more common and also is associated with an elevated prevalence of anemia and CHD risk. Recent data suggest an even higher risk of CHD when both conditions are present... - Type of vascular access and survival among incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for ESRD (CHOICE) StudyBrad C Astor
Johns Hopkins Department of Epidemiology, Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, 2024 East Monument Street, Suite 2 600 Baltimore, Maryland 21205, USA
J Am Soc Nephrol 16:1449-55. 2005.... - Method of glomerular filtration rate estimation affects prediction of mortality riskBrad C Astor
Department of Epidemiology, Bloomberg School of Public Health, School of Medicine, Johns Hopkins University, Welch Center for Prevention, Baltimore, Maryland 21287, USA
J Am Soc Nephrol 20:2214-22. 2009..In conclusion, despite better performance in terms of estimating GFR, equations based on both cystatin C and creatinine do not predict mortality as well as equations based on cystatin C alone... - Mortality after aortic valve replacement: results from a nationally representative databaseB C Astor
Center for Devices and Radiological Health, Food and Drug Administration, Rockville, Maryland, USA
Ann Thorac Surg 70:1939-45. 2000.... - Association of kidney function and hemoglobin with left ventricular morphology among African Americans: the Atherosclerosis Risk in Communities (ARIC) studyBrad C Astor
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Kidney Dis 43:836-45. 2004..It is unknown whether kidney function and lower hemoglobin levels are associated with LV morphological characteristics among African Americans with moderate kidney dysfunction, independent of blood pressure... - Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US populationBrad C Astor
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Am J Epidemiol 167:1226-34. 2008..These data support recent recommendations defining chronic kidney disease and stratifying subsequent risks based on both decreased GFR and albuminuria... - Trefoil factor 3 predicts incident chronic kidney disease: a case-control study nested within the Atherosclerosis Risk in Communities (ARIC) studyBrad C Astor
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, 2024 East Monument Street, Baltimore, MD 21287, USA
Am J Nephrol 34:291-7. 2011..35; 95% CI: 1.11, 1.64). Conclusions: Higher urinary TFF3 levels may indicate ongoing repair of damage in the kidney. Additional studies are needed to confirm whether TFF3 can be useful as a marker of increased risk for CKD... - Race-specific association of lipoprotein(a) with vascular access interventions in hemodialysis patients: the CHOICE StudyBrad C Astor
Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, 2024 East Monument Street, Baltimore, MD 21205, USA
Kidney Int 61:1115-23. 2002..Lp(a) may be more atherothrombotic in whites than in blacks. Data on the relation of Lp(a) and apo(a) isoform size to hemodialysis vascular access complications are limited... - Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994)Brad C Astor
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Arch Intern Med 162:1401-8. 2002..Kidney failure is known to cause anemia, which is associated with a higher risk of cardiac failure and mortality. The impact of milder decreases in kidney function on hemoglobin levels and anemia in the US population, however, is unknown... - Remodeling of carotid arteries detected with MR imaging: atherosclerosis risk in communities carotid MRI studyBrad C Astor
Welch Center for Prevention, Epidemiology and Clinical Research and Departments of Epidemiology and Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
Radiology 256:879-86. 2010..To determine the extent of thickening of the carotid arterial walls that may be accommodated by outward remodeling... - Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: results from the atherosclerosis risk in communities studyPaul Muntner
Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Avenue, SL 18, New Orleans, LA 70112, USA
J Am Soc Nephrol 16:529-38. 2005..CHD risk factors in the general population remain predictive among patients with CKD. Given the high risk for CHD among patients with CKD, control of these risk factors may have a substantial impact on their excess burden of CHD... - Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination SurveyJosef Coresh
Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD, USA
Am J Kidney Dis 41:1-12. 2003.... - Novel and traditional cardiovascular risk factors for peripheral arterial disease in incident-dialysis patientsBernard G Jaar
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Adv Chronic Kidney Dis 14:304-13. 2007..This study identifies several novel risk factors (eg, Lp(a) and total homocysteine) and underscores the need for further research to reduce the burden of PAD in this high-risk group of patients... - Correlates of N-terminal prohormone brain natriuretic peptides in African Americans with hypertensive chronic kidney disease: the African American Study of Kidney Disease and HypertensionS Yi
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA
Am J Nephrol 29:292-8. 2009..Few correlates of NT-proBNP levels have been identified in persons with moderate chronic kidney disease (CKD), and data from those without heart failure and from African Americans are especially limited... - Orthostatic hypotension and incident chronic kidney disease: the atherosclerosis risk in communities studyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
Hypertension 56:1054-9. 2010..These findings suggest that orthostatic hypotension increases the risk of chronic kidney disease in middle-aged persons, but race effects vary by choice of chronic kidney disease definition... - Blood pressure, atherosclerosis, and albuminuria in 10,113 participants in the atherosclerosis risk in communities studyCharles C Hsu
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Hypertens 27:397-409. 2009..Albuminuria predicts cardiovascular risk, but its function as a marker of endothelial damage and atherosclerosis is uncertain, as is the complex relationship with hypertension and diabetes... - Albuminuria and estimated glomerular filtration rate independently associate with acute kidney injuryMorgan E Grams
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Soc Nephrol 21:1757-64. 2010..Patterns persisted within subgroups of age, race, and gender. In summary, albuminuria and eGFR have strong, independent associations with incident AKI... - Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisKunihiro Matsushita
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
Lancet 375:2073-81. 2010..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality... - Prevalence of kidney disease in anaemia differs by GFR-estimating method: the Third National Health and Nutrition Examination Survey (1988-94)Michelle M Estrella
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
Nephrol Dial Transplant 25:2542-8. 2010..Serum cystatin C is purportedly a more sensitive marker of kidney disease and a better predictor of mortality than serum creatinine. However, studies suggest that extrarenal factors also influence cystatin C levels... - Timing of nephrologist referral and arteriovenous access use: the CHOICE StudyB C Astor
Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins University, Baltimore, MD, USA
Am J Kidney Dis 38:494-501. 2001..Thus, further efforts to improve both referral patterns and preparation for dialysis after referral are needed... - Multiple loci associated with indices of renal function and chronic kidney diseaseAnna Kottgen
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Genet 41:712-7. 2009..Our findings provide new insights into CKD pathogenesis and underscore the importance of common genetic variants influencing renal function and disease... - Predictors of amputation and survival following lower extremity revascularization in hemodialysis patientsBernard G Jaar
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Kidney Int 65:613-20. 2004..We studied the prognosis of ESRD patients undergoing their first revascularization procedure... - Intensive blood-pressure control in hypertensive chronic kidney diseaseLawrence J Appel
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
N Engl J Med 363:918-29. 2010..Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients... - Carotid Plaque Neovascularization and Hemorrhage Detected by MR Imaging are Associated with Recent Cerebrovascular Ischemic EventsY Qiao
Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, Baltimore, Maryland
AJNR Am J Neuroradiol 33:755-60. 2012..Our aim was to determine the associations of these features in carotid plaques with previous cerebrovascular ischemic events by using high-resolution CE-MRI... - Heart rate variability predicts ESRD and CKD-related hospitalizationDaniel J Brotman
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Soc Nephrol 21:1560-70. 2010..These results suggest that autonomic dysfunction may be an important risk factor for ESRD and CKD-related hospitalizations and call for further studies to define the mechanisms that underlie these associations... - Glycated hemoglobin and the risk of kidney disease and retinopathy in adults with and without diabetesElizabeth Selvin
Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Diabetes 60:298-305. 2011.... - Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) StudyKunihiro Matsushita
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, MD 21287, USA
Am J Kidney Dis 55:648-59. 2010..Although the CKD-EPI equation estimates GFR more precisely compared with the MDRD Study equation, whether this equation improves risk prediction is unknown... - Risk of incident ESRD: a comprehensive look at cardiovascular risk factors and 17 years of follow-up in the Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
Am J Kidney Dis 55:31-41. 2010..Previous studies suggest that other cardiovascular risk factors also may increase the risk of ESRD; however, risk associated with a comprehensive cardiovascular risk-factor assessment has not been quantified in a population-based sample... - Increased risk of type 2 diabetes from a family history of coronary heart disease and type 2 diabetesEdwina H Yeung
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
Diabetes Care 30:154-6. 2007 - Defining incident chronic kidney disease in the research setting: The ARIC StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21201, USA
Am J Epidemiol 170:414-24. 2009..3, confidence interval: 4.4, 8.9). Associations with gender differed in direction and magnitude across definitions. Case definition can impact relative risk estimates for CKD risk factors... - Confounding of the relation between homocysteine and peripheral arterial disease by lead, cadmium, and renal functionEliseo Guallar
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Am J Epidemiol 163:700-8. 2006..The association of lead and cadmium with PAD risk deserves further investigation... - Inflammation, hemostasis, and the risk of kidney function decline in the Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21201, USA
Am J Kidney Dis 53:596-605. 2009..Inflammation and hemostasis may increase the risk of kidney function decline; however, data from prospective studies are sparse... - Poor glycemic control in diabetes and the risk of incident chronic kidney disease even in the absence of albuminuria and retinopathy: Atherosclerosis Risk in Communities (ARIC) StudyLori D Bash
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Arch Intern Med 168:2440-7. 2008.... - Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rateJosef Coresh
Department of Epidemiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
Am J Kidney Dis 39:920-9. 2002..73 m2), but result in progressively larger differences at higher GFRs. Both clinical and research use of serum creatinine or equations to estimate GFR require knowledge of the calibration of the serum creatinine assay... - The impact of reclassifying moderate CKD as a coronary heart disease risk equivalent on the number of US adults recommended lipid-lowering treatmentAmanda D Hyre
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
Am J Kidney Dis 49:37-45. 2007..59 mmol/L]) for adults with coronary heart disease risk equivalents. Chronic kidney disease is associated with increased coronary heart disease risk but is not included as a risk equivalent in these guidelines... - The impact of kidney function at highly active antiretroviral therapy initiation on mortality in HIV-infected womenMichelle M Estrella
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
J Acquir Immune Defic Syndr 55:217-20. 2010..We re-examined this association in the later HAART period to determine whether chronic kidney disease remains a predictor of death after HAART initiation... - Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000Josef Coresh
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
J Am Soc Nephrol 16:180-8. 2005..Despite a high prevalence, CKD awareness in the U.S. population is low. In contrast to the dramatic increase in treated kidney failure, overall CKD prevalence in the U.S. population has been relatively stable... - Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third National Health and Nutrition Examination SurveRuth M Belin
Division of Endocrinology and Metabolism, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Clin Endocrinol Metab 89:6077-86. 2004..Understanding the underlying mechanism could help identify potential pathways for the prevention of autoimmune thyroid disease... - Identification of intraplaque hemorrhage on MR angiography images: a comparison of contrast-enhanced mask and time-of-flight techniquesY Qiao
The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, Maryland, USA
AJNR Am J Neuroradiol 32:454-9. 2011..We sought to determine the accuracy and reliability of these MRA sequences to detect IPH... - MRI measurements of carotid plaque in the atherosclerosis risk in communities (ARIC) study: methods, reliability and descriptive statisticsBruce A Wasserman
The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Magn Reson Imaging 31:406-15. 2010..To measure carotid plaque components using MRI and estimate reliability in the population-based Atherosclerosis Risk in Communities (ARIC) study... - Wash-in kinetics for gadolinium-enhanced magnetic resonance imaging of carotid atheromaBruce A Wasserman
Russell H Morgan Department of Radiology and Radiological Sciences, Baltimore, Maryland, USA
J Magn Reson Imaging 21:91-5. 2005..To determine the wash-in kinetics of intravenous gadolinium into the fibrous cap and lipid core of carotid atheroma, and identify the time following gadolinium administration that maximizes contrast between the cap and core... - Arterial reactivity in lower extremities is progressively reduced as cardiovascular risk factors increase: comparison with upper extremities using magnetic resonance imagingHarry A Silber
Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Am Coll Cardiol 49:939-45. 2007..Our goal was to investigate whether the association between established cardiovascular risk factors and arterial reactivity differs between the lower and upper extremities... - Change in estimated GFR associates with coronary heart disease and mortalityKunihiro Matsushita
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Welch Center for Prevention, Epidemiology, and Clinical Research, 2024 E Monument Street, Baltimore, MD 21287, USA
J Am Soc Nephrol 20:2617-24. 2009..In conclusion, a steeper than average decline in eGFR associates with a higher risk for CHD and all-cause mortality. Increases in eGFR among participants with chronic kidney disease associate with similar increased risks... - Mortality risks for all causes and cardiovascular diseases and reduced GFR in a middle-aged working population in TaiwanTing Yuan David Cheng
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Am J Kidney Dis 52:1051-60. 2008..Effects of decreased estimated glomerular filtration rate (eGFR) on cardiovascular disease (CVD) mortality are uncertain in Chinese general populations... - Influence of intravenous drug abuse on vascular access placement and survival in HIV-seropositive patientsJoseph A Eustace
Division of Nephrology, The Welch Center for Disease Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Nephron Clin Pract 100:c38-45. 2005..The influence of intravenous drug abuse (IVDA) on hemodialysis access placement practices and access survival in HIV-infected patients is unknown... - Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritisLisa Christopher-Stine
Department of Medicine, The Johns Hopkins Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland, USA
J Rheumatol 31:1557-9. 2004..To evaluate the 24-hour urine protein-to-creatinine (U pr:cr) ratio compared to 24-h urine total protein excretion as a measure of proteinuria in patients with lupus nephritis... - Screening for proteinuria in patients with lupus: a survey of practice preferences among American rheumatologistsMark J Siedner
Divisions of Nephrology and Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Rheumatol 34:973-7. 2007..Recent studies have called into question the validity of qualitative proteinuria measurements. We set out to assess if American rheumatologists have changed their practice preferences in response to these data... - International comparison of the relationship of chronic kidney disease prevalence and ESRD riskStein I Hallan
Department of Medicine, Division of Nephrology, St Olav University Hospital, N 7006 Trondheim, Norway
J Am Soc Nephrol 17:2275-84. 2006..In conclusion, CKD prevalence in Norway was similar to that in the United States, suggesting that lower progression to ESRD rather than a smaller pool of individuals at risk accounts for the lower incidence of ESRD in Norway... - Association of kidney function with serum lipoprotein(a) level: the third National Health and Nutrition Examination Survey (1991-1994)Csaba P Kovesdy
Division of Renal Medicine, Salem Veterans Affairs Medical Center, Salem, VA 24153, USA
Am J Kidney Dis 40:899-908. 2002..Elevated lipoprotein(a) (Lp[a]) levels have been observed in patients on dialysis therapy. However, few studies explored the relationship between kidney function and Lp(a) levels in patients with mild to moderate chronic kidney disease... - Mild elevations of urine albumin excretion are associated with atherogenic lipoprotein abnormalities in the Multi-Ethnic Study of Atherosclerosis (MESA)Ian H De Boer
Division of Nephrology, University of Washington, Seattle, WA 98195, USA
Atherosclerosis 197:407-14. 2008.... - Lipoprotein abnormalities associated with mild impairment of kidney function in the multi-ethnic study of atherosclerosisIan H De Boer
Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
Clin J Am Soc Nephrol 3:125-32. 2008..Abnormal lipoprotein metabolism has been implicated as a possible cause of these complications, but lipoproteins have not been described at the earliest stages of kidney disease...
Research Grants
- Longitudinal Study of Predictors and Consequences of Chronic Kidney DiseaseBrad Astor; Fiscal Year: 2007..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
- Longitudinal Study of Predictors and Consequences of Chronic Kidney DiseaseBrad C Astor; Fiscal Year: 2010..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..
- Longitudinal Study of Predictors and Consequences of Chronic Kidney DiseaseBrad C Astor; Fiscal Year: 2010..In addition, it will provide much-needed data to be shared with the larger scientific community on serologic and genetic risk factors for CKD, a growing public health concern in the US. ..