Lloyd G Tillman

Summary

Affiliation: Isis Pharmaceuticals
Country: USA

Publications

  1. ncbi Oral delivery of antisense oligonucleotides in man
    Lloyd G Tillman
    Isis Pharmaceuticals, Inc, 1896 Rutherford Road, Carlsbad, CA 92008, USA
    J Pharm Sci 97:225-36. 2008
  2. ncbi Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer
    Keiko Tsutsumi
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA
    J Pharm Sci 97:350-67. 2008

Collaborators

  • Richard S Geary
  • Keiko Tsutsumi
  • Richard V Hymas
  • Ching-Leou Teng
  • William I Higuchi
  • Norman F H Ho
  • Gregory E Hardee
  • S Kevin Li
  • Ching Leou Teng

Detail Information

Publications2

  1. ncbi Oral delivery of antisense oligonucleotides in man
    Lloyd G Tillman
    Isis Pharmaceuticals, Inc, 1896 Rutherford Road, Carlsbad, CA 92008, USA
    J Pharm Sci 97:225-36. 2008
    ..96-27.5%. The totality of the data suggests that formulations can be devised that allow oral administration of oligonucleotides that maintain systemic concentrations associated with inhibition of targeted human mRNA...
  2. ncbi Systematic studies on the paracellular permeation of model permeants and oligonucleotides in the rat small intestine with chenodeoxycholate as enhancer
    Keiko Tsutsumi
    Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Salt Lake City, UT 84112, USA
    J Pharm Sci 97:350-67. 2008
    ..5 x 10(-6) and 6 x 10(-6) cm/s, whereas ON6 was enhanced up to twofold in the jejunum and fivefold in the ileum with permeabilities between 0.3 x 10(-6) and 2 x 10(-6) cm/s...