S J Warden

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration
    Tien-Min G Chu
    Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Biomed Sci Instrum 42:42-7. 2006
  2. ncbi Cyclo-oxygenase-2 inhibitors : beneficial or detrimental for athletes with acute musculoskeletal injuries?
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, 46202, USA
    Sports Med 35:271-83. 2005
  3. ncbi Throwing induces substantial torsional adaptation within the midshaft humerus of male baseball players
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 45:931-41. 2009
  4. ncbi Stress fracture risk factors in female football players and their clinical implications
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    Br J Sports Med 41:i38-43. 2007
  5. ncbi Ultrasound produced by a conventional therapeutic ultrasound unit accelerates fracture repair
    Stuart J Warden
    Department of Physical Therapy, Indiana University, CF 326, Indianapolis, IN 46202, USA
    Phys Ther 86:1118-27. 2006
  6. ncbi Stress fractures: pathophysiology, epidemiology, and risk factors
    Stuart J Warden
    Department of Physical Therapy, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Curr Osteoporos Rep 4:103-9. 2006
  7. ncbi The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5)
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 46:4-12. 2010
  8. ncbi Comparative accuracy of magnetic resonance imaging and ultrasonography in confirming clinically diagnosed patellar tendinopathy
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    Am J Sports Med 35:427-36. 2007
  9. ncbi Patellar taping and bracing for the treatment of chronic knee pain: a systematic review and meta-analysis
    Stuart J Warden
    School of Health and Rehabilitation Sciences, Indiana University, Indianapolis 46202, USA
    Arthritis Rheum 59:73-83. 2008
  10. ncbi Low-intensity pulsed ultrasound for chronic patellar tendinopathy: a randomized, double-blind, placebo-controlled trial
    S J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Rheumatology (Oxford) 47:467-71. 2008

Research Grants

  1. Sustainability of exercise-induced gains in bone structure and estimated strength
    Stuart J Warden; Fiscal Year: 2010

Detail Information

Publications46

  1. ncbi Preliminary evaluation of a load-bearing BMP-2 carrier for segmental defect regeneration
    Tien-Min G Chu
    Department of Biomedical Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Biomed Sci Instrum 42:42-7. 2006
    ..Histology analysis shows that a normal fatty bone marrow was restored and mineralized callus formed and bridged the segmental defect...
  2. ncbi Cyclo-oxygenase-2 inhibitors : beneficial or detrimental for athletes with acute musculoskeletal injuries?
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, 46202, USA
    Sports Med 35:271-83. 2005
    ..However, they do not appear to be associated with adverse cardiovascular effects, and they are effective pain relievers and cheaper alternatives...
  3. ncbi Throwing induces substantial torsional adaptation within the midshaft humerus of male baseball players
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 45:931-41. 2009
    ....
  4. ncbi Stress fracture risk factors in female football players and their clinical implications
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    Br J Sports Med 41:i38-43. 2007
    ..This paper discusses these risk factors and their implications in terms of developing prevention and management strategies for stress fractures in female football players...
  5. ncbi Ultrasound produced by a conventional therapeutic ultrasound unit accelerates fracture repair
    Stuart J Warden
    Department of Physical Therapy, Indiana University, CF 326, Indianapolis, IN 46202, USA
    Phys Ther 86:1118-27. 2006
    ..The aim of this study was to investigate the effect on fracture repair of ultrasound produced by a conventional therapeutic ultrasound unit as used by physical therapists...
  6. ncbi Stress fractures: pathophysiology, epidemiology, and risk factors
    Stuart J Warden
    Department of Physical Therapy, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Curr Osteoporos Rep 4:103-9. 2006
    ..This article discusses these extrinsic and intrinsic risk factors, as well as the pathophysiology and epidemiology of stress fractures...
  7. ncbi The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5)
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 46:4-12. 2010
    ..This paper discusses the mounting evidence for skeletal effects of 5-HT and the ability of gut-derived 5-HT to satisfactorily explain the skeletal effects of LRP5...
  8. ncbi Comparative accuracy of magnetic resonance imaging and ultrasonography in confirming clinically diagnosed patellar tendinopathy
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    Am J Sports Med 35:427-36. 2007
    ..The comparative accuracy of these modalities has not been established...
  9. ncbi Patellar taping and bracing for the treatment of chronic knee pain: a systematic review and meta-analysis
    Stuart J Warden
    School of Health and Rehabilitation Sciences, Indiana University, Indianapolis 46202, USA
    Arthritis Rheum 59:73-83. 2008
    ..To evaluate the evidence for patellar taping and bracing in the management of chronic knee pain...
  10. ncbi Low-intensity pulsed ultrasound for chronic patellar tendinopathy: a randomized, double-blind, placebo-controlled trial
    S J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Rheumatology (Oxford) 47:467-71. 2008
    ..The aim of this study was to investigate the clinical efficacy of LIPUS in the management of PT symptoms...
  11. ncbi Skeletal effects of serotonin (5-hydroxytryptamine) transporter inhibition: evidence from in vitro and animal-based studies
    S J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 8:121-32. 2008
    ....
  12. ncbi Serotonin (5-hydroxytryptamine) transporter inhibition causes bone loss in adult mice independently of estrogen deficiency
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Menopause 15:1176-83. 2008
    ..This study aimed to explore the influence of an SSRI (fluoxetine hydrochloride) on the bone changes associated with estrogen deficiency in adult mice...
  13. ncbi Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 44:485-94. 2009
    ..These data suggest that PTH may have utility in the treatment of acute bone fractures, whereas LIPUS at an I(SATA) of 100 mW/cm(2) does not appear to be indicated in the management of closed, diaphyseal fractures...
  14. ncbi Development and use of animal models to advance tendinopathy research
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Front Biosci 14:4588-97. 2009
    ..With further development of animal models of tendinopathy, new strategies for the prevention and treatment of tendinopathy in humans may be generated...
  15. ncbi Low-intensity pulsed ultrasound accelerates and a nonsteroidal anti-inflammatory drug delays knee ligament healing
    Stuart J Warden
    Department of Physical Therapy, Indiana University, Indianapolis, 46202, USA
    Am J Sports Med 34:1094-102. 2006
    ..Low-intensity pulsed ultrasound and nonsteroidal anti-inflammatory drugs are used to treat ligament injuries; however, their individual and combined effects are not established...
  16. ncbi Does exercise during growth influence osteoporotic fracture risk later in life?
    S J Warden
    Department of Physical Therapy, Indiana University, Indianapolis, IN 46202, USA
    J Musculoskelet Neuronal Interact 5:344-6. 2005
  17. ncbi Knee ligament mechanical properties are not influenced by estrogen or its receptors
    Stuart J Warden
    Dept of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Am J Physiol Endocrinol Metab 290:E1034-40. 2006
    ....
  18. ncbi Inhibition of the serotonin (5-hydroxytryptamine) transporter reduces bone accrual during growth
    Stuart J Warden
    Department of Orthopaedic Surgery, Indiana University, 1140 West Michigan Street, CF 326, Indianapolis, Indiana 46202, USA
    Endocrinology 146:685-93. 2005
    ..These findings indicate a role for the 5-HTT in the regulation of bone accrual in the growing skeleton and point to a need for further research into the prescription of SSRIs to children and adolescents...
  19. ncbi Animal models for the study of tendinopathy
    S J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Br J Sports Med 41:232-40. 2007
    ..It is hoped that with further development of animal models of tendinosis, new strategies for the prevention and treatment of tendinopathy in humans will be generated...
  20. ncbi Mechanotransduction in the cortical bone is most efficient at loading frequencies of 5-10 Hz
    S J Warden
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Bone 34:261-70. 2004
    ..The obtained findings may relate to the mechanism of mechanotransduction within the bone. This requires further investigation...
  21. ncbi Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:809-16. 2005
    ..This indicates that a moderate exercise program may be an effective preventative strategy for stress fractures...
  22. ncbi Psychotropic drugs have contrasting skeletal effects that are independent of their effects on physical activity levels
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Bone 46:985-92. 2010
    ....
  23. ncbi Prophylactic use of NSAIDs by athletes: a risk/benefit assessment
    Stuart J Warden
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN 46202, USA
    Phys Sportsmed 38:132-8. 2010
    ..The latter side effects appear paradoxical to the rationale for prophylactic use of NSAIDs. This article discusses current observations regarding athlete use of NSAIDs, and the possible benefits and potential risks of their use...
  24. ncbi Neural regulation of bone and the skeletal effects of serotonin (5-hydroxytryptamine)
    Stuart J Warden
    Department of Physical Therapy, Indiana University, 1140 W Michigan Street, CF 326, Indianapolis, IN 46202, USA
    Mol Cell Endocrinol 242:1-9. 2005
    ..Initial data suggest that exposure to these agents at different stages during the lifespan may have significant effects on the skeleton...
  25. ncbi The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment
    Kimihiko Sawakami
    Department of Orthopedic Surgery, Biomechanics and Biomaterials Research Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Biol Chem 281:23698-711. 2006
    ....
  26. ncbi In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy
    Meredith R Golomb
    Division of Pediatric Neurology, Indiana University School of Medicine, Indianapolis, IN, USA
    Arch Phys Med Rehabil 91:1-8.e1. 2010
    ..Golomb MR, McDonald BC, Warden SJ, Yonkman J, Saykin AJ, Shirley B, Huber M, Rabin B, AbdelBaky M, Nwosu ME, Barkat-Masih M, Burdea GC. In-home virtual reality videogame telerehabilitation in adolescents with hemiplegic cerebral palsy...
  27. ncbi Maintained hand function and forearm bone health 14 months after an in-home virtual-reality videogame hand telerehabilitation intervention in an adolescent with hemiplegic cerebral palsy
    Meredith R Golomb
    Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Child Neurol 26:389-93. 2011
    ..The implications of this work for the future of rehabilitation in children with neurological disabilities are discussed in this article...
  28. ncbi Low-intensity pulsed ultrasound and nonsteroidal anti-inflammatory drugs have opposing effects during stress fracture repair
    Jiliang Li
    Department of Biology, School of Science, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, USA
    J Orthop Res 25:1559-67. 2007
    ..LIPUS accelerated stress fracture healing, whereas the NSAID delayed repair. When used in combination, the beneficial LIPUS effect was not impaired by the detrimental NSAID effect...
  29. ncbi Low-amplitude, broad-frequency vibration effects on cortical bone formation in mice
    Alesha B Castillo
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University School of Medicine, 1120 South Drive, Indianapolis, IN 46202, USA
    Bone 39:1087-96. 2006
    ..Our data suggest that low-amplitude, broad-frequency vibration superimposed onto an osteogenic waveform or vibration alone does not enhance cortical bone adaptation at the frequencies, amplitudes and loading periods tested...
  30. ncbi Instrument-assisted cross-fiber massage accelerates knee ligament healing
    M Terry Loghmani
    Departmento of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA
    J Orthop Sports Phys Ther 39:506-14. 2009
    ..Controlled laboratory study...
  31. ncbi Genetic effects on bone mechanotransduction in congenic mice harboring bone size and strength quantitative trait loci
    Alexander G Robling
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 22:984-91. 2007
    ..Bone size was not consistently associated with mechano-responsiveness, indicating that the genetic regulation of mechanotransduction is a complex process that involves a number of genes and is sex-specific...
  32. ncbi Cellular accommodation and the response of bone to mechanical loading
    Jennifer L Schriefer
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, IN 46202, USA
    J Biomech 38:1838-45. 2005
    ..After the initial weeks of loading, bone stopped responding so the degree of adaptation was proportional to the initial peak load magnitude...
  33. ncbi Mechanobiology of the skeleton
    Charles H Turner
    Departments of Orthopaedic Surgery and Biomedical Engineering, IUPUI, Indianapolis, IN 46202, USA
    Sci Signal 2:pt3. 2009
    ..In particular, focal adhesion kinase and proline-rich tyrosine kinase 2 appear to be sensors of mechanical loads in bone cells...
  34. ncbi Exercise when young provides lifelong benefits to bone structure and strength
    Stuart J Warden
    Department of Physical Therapy, Indiana University, Indianapolis, USA
    J Bone Miner Res 22:251-9. 2007
    ..Consequently, exercise when young may reduce the risk for fractures later in life, and the old exercise adage of "use it or lose it" may not be entirely applicable to the skeleton...
  35. ncbi Segmental bone regeneration using a load-bearing biodegradable carrier of bone morphogenetic protein-2
    Tien Min G Chu
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    Biomaterials 28:459-67. 2007
    ..Our results demonstrated that the load-bearing BMP-2 scaffold can maintain bone length and allow successfully regeneration in segmental defects...
  36. ncbi A comparison of mechanical properties derived from multiple skeletal sites in mice
    Jennifer L Schriefer
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Purdue University, Indianapolis, IN, USA
    J Biomech 38:467-75. 2005
    ..Of the bones tested, the radius was preferred for mechanical testing because of its high aspect ratio, minimal measurement error, and low variability...
  37. ncbi Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene
    Imranul Alam
    Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Bone Miner Res 20:438-46. 2005
    ..However, using mice with a null mutation of the COX-2 gene, we found that a functional COX-2 gene is not required for mechanotransduction. This paradoxical finding may have resulted, in part, from mechanically induced COX-1 activity...
  38. ncbi Models for the study of tendinopathy
    R C Dirks
    Center for Translational Musculoskeletal Research, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, IN, USA
    J Musculoskelet Neuronal Interact 11:141-9. 2011
    ..By improving on these models, new methods for the prevention and treatment of tendinopathy may be explored with the ultimate outcome being a reduction in the occurrence and effects of the condition in humans...
  39. ncbi Factors affecting short-term precision of musculoskeletal measures using peripheral quantitative computed tomography (pQCT)
    R R Swinford
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W Michigan St, CF 326, Indianapolis, IN 46202, USA
    Osteoporos Int 21:1863-70. 2010
    ..These findings have implications for both investigators and clinicians utilizing pQCT outcomes...
  40. ncbi Clinical features of patellar tendinopathy and their implications for rehabilitation
    Kay M Crossley
    Centre for Health, Exercise and Sports Medicine, School of Physiotherapy, The University of Melbourne, Victoria, Australia
    J Orthop Res 25:1164-75. 2007
    ..These findings indicate that unilateral and bilateral PT represent distinct entities, and that thigh strength appears particularly important in PT as it predicted both symptoms and function in PT...
  41. ncbi Delayed- and non-union following opening wedge high tibial osteotomy: surgeons' results from 182 completed cases
    Stuart J Warden
    Centre for Health, Exercise and Sports Medicine, School of Physiotherapy, University of Melbourne, Parkville, Victoria, Australia
    Knee Surg Sports Traumatol Arthrosc 13:34-7. 2005
    ..6%) non-united. The results of this study demonstrate that the rate of delayed- and non-union following OWHTO for medial compartment arthritis of the knee is relatively low and comparable to that reported for traditional CWHTO...
  42. ncbi Ultrasound usage and dosage in sports physiotherapy
    Stuart J Warden
    Centre for Sports Medicine Research and Education, School of Physiotherapy, The University of Melbourne, Parkville, Vic, Australia
    Ultrasound Med Biol 28:1075-80. 2002
    ..Reasons for this lack of evidence are discussed. The results of this study provide a profile of US usage and dosage in sports physiotherapy and highlight the need for further research into its effects...
  43. ncbi Patellar tendinopathy
    Stuart J Warden
    Centre for Sports Medicine Research and Education, University of Melbourne, Victoria 3010, Australia
    Clin Sports Med 22:743-59. 2003
    ..There is a definite need for further prospective studies into etiological factors and randomized controlled trials into treatment choices...
  44. ncbi Aetiology of rib stress fractures in rowers
    Stuart J Warden
    Centre for Sports Medicine Research and Education, School of Physiotherapy, The University of Melbourne, Melbourne, Victoria, Australia
    Sports Med 32:819-36. 2002
    ..Identification of these factors will generate a better understanding of the aetiology of this injury, which is required for improved prevention and treatment strategies...
  45. ncbi Breaking the rules for bone adaptation to mechanical loading
    Stuart J Warden
    J Appl Physiol 100:1441-2. 2006
  46. ncbi A new direction for ultrasound therapy in sports medicine
    Stuart J Warden
    Centre for Sports Medicine Research and Education, School of Physiotherapy, The University of Melbourne, Parkville, Victoria, Australia
    Sports Med 33:95-107. 2003
    ..In time this may lead to accelerated recovery from injury and subsequent earlier return to activity...

Research Grants1

  1. Sustainability of exercise-induced gains in bone structure and estimated strength
    Stuart J Warden; Fiscal Year: 2010
    ..This proposal will investigate the role of exercise during adolescence on bone health later in life. ..