Research Topics
Species | ANANTHA contact SHEKHARSummaryAffiliation: Indiana University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Role of norepinephrine in the dorsomedial hypothalamic panic response: an in vivo microdialysis studyA Shekhar
Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, Indianapolis, IN 46202, USA
Pharmacol Biochem Behav 71:493-500. 2002..Thus, blockade of GABA(A) receptors in the DMH results in NE release and the presence of NE appears to be necessary for eliciting the physiological components of the panic-like responses in this region...- Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamusAnantha Shekhar
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Neurosci 26:9205-15. 2006..Thus, these results implicate A-II pathways and the A-II receptors in the hypothalamus as putative substrates for sodium lactate-induced panic-like responses in vulnerable subjects... - A selective, non-peptide CRF receptor 1 antagonist prevents sodium lactate-induced acute panic-like responsesAnantha Shekhar
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Int J Neuropsychopharmacol 14:355-65. 2011..g. sedation and cognitive impairment) associated with benzodiazepines... - The amygdala, panic disorder, and cardiovascular responsesAnantha Shekhar
Department of Psychiatry, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
Ann N Y Acad Sci 985:308-25. 2003..These results suggest that the BLA has a significant role in regulating anxiety, autonomic responses, and the development of anxiety disorders... - Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxietyAnantha Shekhar
Indiana University School of Medicine, Department of Psychiatry, 1111 West 10th Street, Indianapolis, IN 46202, USA
Stress 8:209-19. 2005..It is further proposed that such a change in the limbic neural circuitry is involved in the transition from normal vigilance responses to pathological anxiety, leading to syndromes such as panic and post-traumatic stress disorders... - Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophreniaAnantha Shekhar
Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th St, Suite 313, Indianapolis, IN 46202, USA
Am J Psychiatry 165:1033-9. 2008..The authors studied xanomeline, a relatively selective muscarinic type 1 and type 4 (M(1) and M(4)) receptor agonist, to determine if this agent is effective in the treatment of schizophrenia... - Amygdala priming results in conditioned place avoidanceShelley K Thielen
Department of Pharmacology, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA
Pharmacol Biochem Behav 71:401-6. 2002..These results suggest that priming may result in phobic-like responses, similar to the avoidance behavior exhibited by panic disorder patients... - LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone ratsA Shekhar
Department of Psychiatry, Pharmacology and Toxicology and Program in Medical Neurobiology, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202, USA
Neuropharmacology 39:1139-46. 2000..LY354740 treatment was equally efficacious as alprazolam in preventing lactate-induced panic attacks in this model. These data suggest that LY354740 could be a novel anti-panic drug, as effective as alprazolam in acute treatment... - Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusionsA Shekhar
Department of Psychiatry, Indiana University Medical Center, Indianapolis 46202, USA
Pharmacol Biochem Behav 55:249-56. 1996..These results indicate that chronic reduction of GABA function in the DMH leads to the development of panic-like disorder in this animal model... - Chronic inhibition of GABA synthesis in the bed nucleus of the stria terminalis elicits anxiety-like behaviorTj Sajdyk
Department of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Psychopharmacol 22:633-41. 2008.... - Anxiety-like behavior is modulated by a discrete subpopulation of interneurons in the basolateral amygdalaW A Truitt
Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
Neuroscience 160:284-94. 2009..Furthermore the phenotypic and regional selectivity of the lesions was also confirmed... - The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorderA Shekhar
Department of Psychiatry, Indiana University Medical Center, Indianapolis, Indiana 46202, USA
J Neurosci 17:9726-35. 1997..These results suggest that the OVLT may be the primary site that detects lactate infusions, activating an anxiety-like response in a compromised DMH, and provide the first neuroanatomical basis for lactate response in panic disorder... - Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panicPl Johnson
Department of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, IN 46223, USA
J Psychopharmacol 22:642-52. 2008.... - A psychobiological approach to personality: examination within anxious outpatientsSusan Ball
J Psychiatr Res 36:97-103. 2002..In addition, the relationship between the underlying temperament dimensions and behavioral coping strategies was also studied using the tri-axial model of coping... - Early stage vision in schizophrenia and schizotypal personality disorderBRIAN F O'DONNELL
Department of Psychology, Indiana University, Bloomington, IN, USA
Schizophr Res 86:89-98. 2006..These results confirm early stage visual deficits in schizophrenia regardless of medication status. SPD subjects, in contrast, show intact early stage visual processing despite the presence of marked schizotypal symptoms... - Exposure to high- and low-light conditions in an open-field test of anxiety increases c-Fos expression in specific subdivisions of the rat basolateral amygdaloid complexMatthew W Hale
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol, BS1 3NY, United Kingdom
Brain Res Bull 71:174-82. 2006.... - Glia mechanisms in mood regulation: a novel model of mood disordersYounglim Lee
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Psychopharmacology (Berl) 191:55-65. 2007..Newly appreciated role of the glia, more specifically astrocytes on neuronal functions combined with reported postmortem abnormalities of glia in patients with mood disorders further supports the role of glia in mood disorders... - From anxiety to autism: spectrum of abnormal social behaviors modeled by progressive disruption of inhibitory neuronal function in the basolateral amygdala in Wistar ratsWilliam A Truitt
Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th Street, Indianapolis, IN 4620, USA
Psychopharmacology (Berl) 191:107-18. 2007..Social behaviors are disrupted in several psychiatric disorders. The amygdala is a key brain region involved in social behaviors, and amygdala pathology has been implicated in disease states ranging from social anxiety disorder to autism... - Differential effects of exposure to low-light or high-light open-field on anxiety-related behaviors: relationship to c-Fos expression in serotonergic and non-serotonergic neurons in the dorsal raphe nucleusJ Adriaan Bouwknecht
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
Brain Res Bull 72:32-43. 2007.... - Sensorimotor gating in manic and mixed episode bipolar disorderChristine A Carroll
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
Bipolar Disord 9:221-9. 2007..The present study aimed to expand the current literature through the investigation of electromyographic (EMG) measures of acoustic startle prepulse inhibition (PPI) in manic and mixed episode BPD... - Neural pathways underlying lactate-induced panicPhilip L Johnson
Department of Psychiatry and Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neuropsychopharmacology 33:2093-107. 2008..These results elucidate neural circuits underlying lactate-induced panic-like responses and the involvement of both sympathetic and parasympathetic systems... - Neonatal amygdala lesions: co-occurring impact on social/fear-related behavior and cocaine sensitization in adult ratsR Andrews Chambers
Laboratory for Translational Neuroscience of Dual Diagnosis and Development, Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Behav Neurosci 121:1316-27. 2007..NAMLs may provide models for understanding a shared neurobiological basis for and complex interactions among psychiatric symptoms, drug exposure history, and addiction vulnerability... - Neuropeptide Y in the amygdala induces long-term resilience to stress-induced reductions in social responses but not hypothalamic-adrenal-pituitary axis activity or hyperthermiaTammy J Sajdyk
Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Neurosci 28:893-903. 2008..These studies suggest one putative physiologic mechanism underlying stress resilience and could identify novel targets for development of therapies that can augment the ability to cope with stress... - Brain imaging studies in mood and anxiety disorders: special emphasis on the amygdalaAmit Anand
Department of Psychiatry, Indiana University School of Medicine, University Hospital, Indianapolis, Indiana 46202, USA
Ann N Y Acad Sci 985:370-88. 2003.... - Perceptual anomalies in schizophrenia co-occur with selective impairments in the gamma frequency component of midlatency auditory ERPsJason K Johannesen
Department of Psychology, Indiana University Purdue University at Indianapolis, Indiana, USA
J Abnorm Psychol 117:106-18. 2008..These findings support hypotheses relating perceptual disturbance in schizophrenia to an early sensory input dysfunction, which is thought to involve gamma-mediated thalamocortical integration of sensory stimuli... - Induction of Fos-immunoreactivity in the rat brain following disinhibition of the dorsomedial hypothalamusMaria V Zaretskaia
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Brain Res 1200:39-50. 2008.... - Switch and maintenance of task set in schizophreniaPaul D Kieffaber
Department of Psychology, Indiana University, Bloomington, IN 47404, USA
Schizophr Res 84:345-58. 2006..The findings suggest that set switching and set maintenance may reflect distinct cognitive deficits in schizophrenia and that they may be associated with unique information processing mechanisms... - Serotoninergic mechanisms in the treatment of obsessive-compulsive disorderAndrew W Goddard
Department of Psychiatry, Indiana University School of Medicine, University Hospital, UH3124, 550 North University Boulevard, Indianapolis, IN 46202, United States
Drug Discov Today 13:325-32. 2008..However, drug treatment approaches that modify function of interrelated neurochemical systems, such as the dopamine and glutamate systems, are also briefly discussed as they promise to complement and enhance SSRI treatment effects... - Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone ratsTammy J Sajdyk
Indiana University Medical Center, Indianapolis, Indiana, USA
Curr Protoc Neurosci . 2003..A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model... - Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptorsPhilip L Johnson
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Neurosci 26:7093-104. 2006..These results suggest that NMDA, and not non-NMDA, type glutamate receptors regulate lactate-induced panic-like responses in rats with GABA dysfunction in the DMH... - The anxiogenic drug FG-7142 increases serotonin metabolism in the rat medial prefrontal cortexAndrew K Evans
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Bristol BS1 3NY, UK
Pharmacol Biochem Behav 84:266-74. 2006.... - Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptorDonald R Gehlert
Neuroscience Division DC0510, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 0510, United States
Eur J Pharmacol 509:145-53. 2005..These results provide further support for the CRF1 receptor in anxiety-like behavior and suggest this pathway is quiescent in unstressed animals... - Different effects of subchronic doses of 17-beta estradiol in two ethologically based models of anxiety utilizing female ratsWendy A Koss
Program in Medical Neurobiology, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Horm Behav 46:158-64. 2004..These results, while seemingly contradictory when interpreted within a unified concept of anxiety, may well reflect the ethological roles of reproductive hormones and their effects on different types of exploratory anxiety... - Haloperidol impairs learning and error-related negativity in humansPatrick J Zirnheld
Indiana University, Bloomington 47405, USA
J Cogn Neurosci 16:1098-112. 2004..These findings support the hypothesis that the DA system is involved in learning and the generation of the ERN... - Interactions between NPY and CRF in the amygdala to regulate emotionalityTammy J Sajdyk
Department of Psychiatry, Indiana University Medical School, 791 Union Drive, Rm M119, Indianapolis, IN 46202, USA
Neuropeptides 38:225-34. 2004.... - Chemical stimulation of the dorsomedial hypothalamus evokes non-shivering thermogenesis in anesthetized ratsMaria V Zaretskaia
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 635 Barnhill Drive, MS-A421 Indianapolis, IN 46202, USA
Brain Res 928:113-25. 2002..These results indicate that activation of neurons in the DMH provokes increases in body temperature resulting in large part from sympathoadrenally-mediated activation of brown fat... - Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesiaKarmen K Yoder
Department of Radiology, Division of Research, Section of Imaging Science, 950 W Walnut St, Research Institute 2, Room E124, Indianapolis, IN 46202, USA
Schizophr Res 71:371-5. 2004..Significant and trend-level inverse correlations were found between DAT BP in the striatum, and especially the severity of negative symptom scores, but also cognitive, and depression/anxiety scores on the PANSS... - Selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind, prospective comparison between paroxetine and sertralineSusan G Ball
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
J Clin Psychiatry 66:94-9. 2005..Therefore, in the present study, we compared the efficacy and tolerability of 2 SSRIs, paroxetine and sertraline, in the treatment of generalized anxiety disorder... - A preliminary open-label study of zonisamide treatment for bipolar depression in 10 patientsAmit Anand
Department of Psychiatry, Indiana University School of Medicine, IN 46202, USA
J Clin Psychiatry 66:195-8. 2005..The purpose of this study was to investigate the effectiveness of zonisamide in the treatment of bipolar depression... - The role of neuropeptide Y in the amygdala on corticotropin-releasing factor receptor-mediated behavioral stress responses in the ratTammy J Sajdyk
Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202, USA
Stress 9:21-8. 2006..These results provide further support that an interaction between NPY and CRF within the BLA may be critical for maintaining a normal homeostatic emotional state... - Corticotrophin releasing factor-induced synaptic plasticity in the amygdala translates stress into emotional disordersDonald G Rainnie
Department of Psychiatry and Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 24:3471-9. 2004.... - Neural synchronization deficits to auditory stimulation in bipolar disorderBRIAN F O'DONNELL
Department of Psychology, Indiana University, Bloomington, IN 47405, USA
Neuroreport 15:1369-72. 2004..Abnormal high frequency neural synchronization may contribute to cognitive deficits in bipolar disorder... - Modulation of anxiety circuits by serotonergic systemsChristopher A Lowry
Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
Stress 8:233-46. 2005.... - Steady state visual evoked potential abnormalities in schizophreniaGiri P Krishnan
Department of Psychology, Indiana University, 1101 E 10th Street, Bloomington, IN 47405, USA
Clin Neurophysiol 116:614-24. 2005..SIGNIFICANCE: Inability to generate or maintain oscillations in neural networks may contribute to deficits in visual processing in schizophrenia... - The amygdala and related structures in the pathophysiology of autismThayne L Sweeten
Department of Psychiatry, Indiana University School of Medicine, 541 Clinical Drive, Room 298, Indianapolis, IN 46202-5111, USA
Pharmacol Biochem Behav 71:449-55. 2002..Although supportive evidence exists for amygdala dysfunction in autism, the currently available data are inconsistent and additional research is needed... - The effects of olanzapine on sensory gating in healthy participantsChristine A Carroll
Schizophr Res 66:187-9. 2004 - Rhabdomyolysis and compartment syndrome with coadministration of risperidone and simvastatinMichael A Webber
Indiana University School of Medicine, Indianapolis, IN 46202, USA
J Psychopharmacol 18:432-4. 2004..Clinicians who pharmacologically treat medical comorbidities in patients receiving atypical antipsychotics must be proactive in anticipating potential drug-drug interactions... - Losartan for treatment of psychogenic polydipsiaMichael A Webber
Ann Pharmacother 38:1750-1. 2004 - A multimethod investigation of the behavioral activation system in bipolar disorderElizabeth P Hayden
Department of Psychology, University of Western Ontario, London, Ontario, N6A 5C2, Canada
J Abnorm Psychol 117:164-70. 2008..Implications of the findings for future research on BPD vulnerability are described... - Visual event-related potentials in schizotypal personality disorder and schizophreniaJenifer L Vohs
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN 47405, USA
J Abnorm Psychol 117:119-31. 2008..These data documented pervasive abnormalities in visual perception and attention in SZ but not in SPD, suggesting that these visual ERP disturbances may not represent a common endophenotype... - Temporal processing dysfunction in schizophreniaChristine A Carroll
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
Brain Cogn 67:150-61. 2008..These findings correlated with parameter estimates obtained from a quantitative model of time estimation, and provide evidence of a fundamental deficit in temporal auditory precision in schizophrenia... - Contributions of subtype and spectral frequency analyses to the study of P50 ERP amplitude and suppression in schizophreniaJason K Johannesen
Indiana University-Purdue University Indianapolis, Department of Psychology, 402 N. Blackford St, Indianapolis, IN 46202, USA
Schizophr Res 78:269-84. 2005..These results replicate previous findings and extend their relevance to schizophrenia subtype distinctions. Implications for the recurrent inhibition model of sensory gating are discussed... - Possible mirtazapine-induced rhabdomyolysisAmaresh B Khandat
Ann Pharmacother 38:1321. 2004 - Event related brain potential evidence for preserved attentional set switching in schizophreniaPaul D Kieffaber
Indiana University Bloomington, United States
Schizophr Res 93:355-65. 2007.... - Cerebellum volume and eyeblink conditioning in schizophreniaChad R Edwards
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
Psychiatry Res 162:185-94. 2008..The lack of a significant correlation between indices of EBC and cerebellar volume within the schizophrenia group suggests an aberrant relationship between cerebellar structure and function...
Research Grants
- Neurobiology of Anxiety and Panic DisordersAnantha Shekhar; Fiscal Year: 2007..Finally, we will study the role of local versus extrinsic GABA neurons by GAD-67/65 gene silencing in the DMH/PeF region. ..
- Neurobiology of Anxiety and Panic DisordersAnantha Shekhar; Fiscal Year: 2009..Finally, we will study the role of local versus extrinsic GABA neurons by GAD-67/65 gene silencing in the DMH/PeF region. ..
- Role of Serotonin and CRF Pathways in Anxiety and HPA RegulationsAnantha Shekhar; Fiscal Year: 2009..The results of these studies could position us to develop novel genetically-targeted treatments and prevention strategies for chronic disabling illnesses such as panic and social anxiety disorder. ..
- Neurobiology of Anxiety and Panic DisordersAnantha Shekhar; Fiscal Year: 2010..Finally, we will study the role of local versus extrinsic GABA neurons by GAD-67/65 gene silencing in the DMH/PeF region. ..
- Serotonin and CRF Pathways in Anxiety & HPA RegulationAnantha Shekhar; Fiscal Year: 2007....
- Role of Serotonin and CRF Pathways in Anxiety and HPA RegulationsANANTHA contact SHEKHAR; Fiscal Year: 2010..The results of these studies could position us to develop novel genetically-targeted treatments and prevention strategies for chronic disabling illnesses such as panic and social anxiety disorder. ..