Research Topics
Genomes and Genes | Tiebing LiangSummaryAffiliation: Indiana University Country: USA Publications
Research Grants
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Detail Information
Publications
Alteration of gene expression by alcohol exposure at early neurulationFeng C Zhou
Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
BMC Genomics 12:124. 2011..To explore the global gene expression changes which may underline these developmental defects, microarray analyses were performed in a whole embryo mouse culture model that allows control over alcohol and embryonic variables...- Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic ratsTiebing Liang
Indiana University School of Medicine, Department of Medicine, IB424G, 975 West Walnut Street, Indianapolis, IN 46202, USA
Genome Biol 11:R11. 2010..NP congenic rats: amygdala, nucleus accumbens, hippocampus, caudate putamen, and frontal cortex... - Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumptionRichard L Bell
Department of Psychiatry, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
Pharmacol Biochem Behav 94:131-47. 2009..Conversely, chronic MSA drinking, with its associated protracted withdrawal periods, results in genomic changes that may be masked by tight regulation of these genes following repeated experiences of ethanol withdrawal... - Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring ratsZachary A Rodd
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, United States
Pharmacol Biochem Behav 89:481-98. 2008..g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories. Overall, the results suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of EtOH... - Identification of candidate genes for alcohol preference by expression profiling of congenic rat strainsLucinda G Carr
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Alcohol Clin Exp Res 31:1089-98. 2007..This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains... - Fine mapping and expression of candidate genes within the chromosome 10 QTL region of the high and low alcohol-drinking ratsPaula J Bice
Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Indianapolis, IN 46202, USA
Alcohol 44:477-85. 2010..All six genes showed differential expression in at least one brain region. Of the genes tested in this study, Crebbp and Mapk8ip3 may be the most promising candidates with regard to alcohol drinking... - Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regionsMark W Kimpel
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
Alcohol 41:95-132. 2007..The many regional and overall gene expression differences between the iP and iNP rat lines may contribute to the divergent alcohol drinking phenotypes of these rats... - From QTL to candidate gene: a genetic approach to alcoholism researchJohn P Spence
Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatry, Indianapolis, IN 46202, USA
Curr Drug Abuse Rev 2:127-34. 2009.... - Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring ratsTiebing Liang
Department of Medicine, Indiana University School of Medicine, 975 W. Walnut Street, Indianapolis, IN 46202, USA
Alcohol Clin Exp Res 28:1622-8. 2004..CONCLUSION: There is regional variation of rGST 8-8 expression in the brain, at both the mRNA and protein level, and the iP strain has lower innate rGST 8-8 levels than the iNP strain in discrete brain regions... - Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependenceLeah Wetherill
Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Alcohol Clin Exp Res 32:2031-40. 2008..Additional studies suggest that cocaine may affect NPY expression... - Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring ratsTiebing Liang
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
J Neurochem 99:470-82. 2006..These results suggest that regulation of rat Snca gene expression is complex and may contribute to alcohol preference in the iP rats... - Identification of genes influencing skeletal phenotypes in congenic P/NP ratsImranul Alam
Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Indianapolis, IN 46202, USA
J Bone Miner Res 25:1314-25. 2010..We identified several candidate genes, including some novel genes on chromosome 4 segregating for skeletal phenotypes in reciprocal congenic P and NP rats... - Association of alcohol craving with alpha-synuclein (SNCA)Tatiana Foroud
Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
Alcohol Clin Exp Res 31:537-45. 2007..Studies in humans have provided support for an association between SNCA and craving for alcohol... - Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse researchJohn Spence
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Addict Biol 10:47-51. 2005..By evaluating differences in gene expression for linkage to a quantitative trait, this combined approach was implemented to identify alpha-synuclein, a candidate gene for alcohol preference... - Drd2 expression in the high alcohol-preferring and low alcohol-preferring micePaula J Bice
Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Room 411, 975 W Walnut St, Indianapolis, IN, 46202, USA
Mamm Genome 19:69-76. 2008..These results suggest that the SNP may play a role in the differential expression of Drd2 between the HAP and LAP mice and that the polymorphism in Drd2 may contribute to alcohol preference... - A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI studyDavid A Kareken
Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Alcohol Clin Exp Res 34:2169-78. 2010..In this study, we stratified subjects who had participated in an fMRI study of alcohol cue responses according to their genotype at a SNP in GABRA2 (rs279871) shown to be associated with alcohol dependence (Edenberg et al., 2004)... - Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populationsJohn P Spence
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Alcohol Clin Exp Res 27:1389-94. 2003.... - alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring ratsTiebing Liang
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Proc Natl Acad Sci U S A 100:4690-5. 2003..These results suggest that differential expression of the alpha-synuclein gene may contribute to alcohol preference in the iP rats...
Research Grants
- Gene Identification for an Alcohol Preference QTL in RatTiebing Liang; Fiscal Year: 2007..These experiments will combine an outstanding animal model of alcoholism and molecular techniques to provide a comprehensive approach that will identify with certainty candidate genes that influence alcohol drinking. ..