Chadi A Hage

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 50:85-92. 2010
  2. ncbi Diagnosis of histoplasmosis by antigen detection in BAL fluid
    Chadi A Hage
    Department of Medicine, Roudebush VA Medical Center, Indiana University, Indianapolis, IN 46202, USA
    Chest 137:623-8. 2010
  3. ncbi Histoplasmosis
    Kenneth S Knox
    University of Arizona College of Medicine and Southern Arizona VA HealthCare System, Tucson, Arizona, USA
    Proc Am Thorac Soc 7:169-72. 2010
  4. ncbi Blastomycosis in indiana: digging up more cases
    W Graham Carlos
    Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, Indianapolis, IN 46202, USA
    Chest 138:1377-82. 2010
  5. ncbi Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay
    Chadi A Hage
    Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Pulmonary Critical Care Medicine, Indianapolis, Indiana 46202, USA
    Clin Vaccine Immunol 18:661-6. 2011
  6. ncbi Antigen detection in bronchoalveolar lavage fluid for diagnosis of fungal pneumonia
    Chadi A Hage
    Department of Medicine, Indiana University, Roudebush VA Medical Center, 1481 W 10th Street, Indianapolis, IN 46202, USA
    Curr Opin Pulm Med 17:167-71. 2011
  7. ncbi Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, 1481 W 10th St, 111P IU, Indianapolis, IN 46202, USA
    Antimicrob Agents Chemother 55:4447-50. 2011
  8. ncbi Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassay
    Chadi A Hage
    Department of Medicine, Indiana University, 111P IU, Indianapolis, IN 46202, USA
    Respir Med 101:43-7. 2007
  9. ncbi A multicenter evaluation of tests for diagnosis of histoplasmosis
    Chadi A Hage
    Pulmonary Critical Care Medicine, Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 53:448-54. 2011
  10. ncbi Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy
    Kenneth S Knox
    Southern Arizona VA Healthcare System and Arizona Respiratory Center and Division of Pulmonary and Critical Care Medicine, University of Arizona, Tucson, Arizona 85723, USA
    J Virol 84:9010-8. 2010

Detail Information

Publications33

  1. ncbi Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 50:85-92. 2010
    ..Prescribers should become aware of the recognition, diagnosis, and treatment of histoplasmosis and educate recipients about decreasing their risk of exposure and both recognizing and reporting signs of early infection...
  2. ncbi Diagnosis of histoplasmosis by antigen detection in BAL fluid
    Chadi A Hage
    Department of Medicine, Roudebush VA Medical Center, Indiana University, Indianapolis, IN 46202, USA
    Chest 137:623-8. 2010
    ..The purpose of this study is to compare the sensitivity of the quantitative antigen detection assay with cytopathology and culture of BAL specimens...
  3. ncbi Histoplasmosis
    Kenneth S Knox
    University of Arizona College of Medicine and Southern Arizona VA HealthCare System, Tucson, Arizona, USA
    Proc Am Thorac Soc 7:169-72. 2010
    ..We present an overview of this important endemic mycosis with emphasis on diagnosis and treatment recommendations for the different clinical syndromes of histoplasmosis...
  4. ncbi Blastomycosis in indiana: digging up more cases
    W Graham Carlos
    Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, Indianapolis, IN 46202, USA
    Chest 138:1377-82. 2010
    ..We propose that this surge was related to major highway construction around Indianapolis...
  5. ncbi Histoplasma antigen clearance during treatment of histoplasmosis in patients with AIDS determined by a quantitative antigen enzyme immunoassay
    Chadi A Hage
    Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, Pulmonary Critical Care Medicine, Indianapolis, Indiana 46202, USA
    Clin Vaccine Immunol 18:661-6. 2011
    ..Antigenuria declines earlier with amphotericin B than with itraconazole...
  6. ncbi Antigen detection in bronchoalveolar lavage fluid for diagnosis of fungal pneumonia
    Chadi A Hage
    Department of Medicine, Indiana University, Roudebush VA Medical Center, 1481 W 10th Street, Indianapolis, IN 46202, USA
    Curr Opin Pulm Med 17:167-71. 2011
    ..The purpose of this review is to describe important findings published during the past 18 months using bronchoalveolar lavage (BAL) for diagnosis of pulmonary mycoses...
  7. ncbi Investigation of the efficacy of micafungin in the treatment of histoplasmosis using two North American strains of Histoplasma capsulatum
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Roudebush VA Medical Center and Indiana University, 1481 W 10th St, 111P IU, Indianapolis, IN 46202, USA
    Antimicrob Agents Chemother 55:4447-50. 2011
    ..Micafungin was active in vitro against the mold but not the yeast form but was ineffective in vivo. Micafungin appears to be ineffective in treatment of histoplasmosis...
  8. ncbi Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassay
    Chadi A Hage
    Department of Medicine, Indiana University, 111P IU, Indianapolis, IN 46202, USA
    Respir Med 101:43-7. 2007
    ..0%). Specificity was 98.2% in both assays in controls with other pulmonary infections. These findings support the diagnostic utility of the second-generation assay in patients with pulmonary histoplasmosis and blastomycosis...
  9. ncbi A multicenter evaluation of tests for diagnosis of histoplasmosis
    Chadi A Hage
    Pulmonary Critical Care Medicine, Richard L Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana 46202, USA
    Clin Infect Dis 53:448-54. 2011
    ..The goal of this study was to determine the sensitivity of the current antigen assay in different categories of histoplasmosis...
  10. ncbi Reconstitution of CD4 T cells in bronchoalveolar lavage fluid after initiation of highly active antiretroviral therapy
    Kenneth S Knox
    Southern Arizona VA Healthcare System and Arizona Respiratory Center and Division of Pulmonary and Critical Care Medicine, University of Arizona, Tucson, Arizona 85723, USA
    J Virol 84:9010-8. 2010
    ..Taken together, these data suggest mechanisms for mucosal CD4 T-cell depletion and interventions that might aid in the reconstitution of mucosal CD4 T cells...
  11. ncbi Histoplasmosis as a cause for a positive Fungitell (1 --> 3)-beta-D-glucan test
    Lindsey Egan
    MiraVista Diagnostics, 4444 Decatur Boulevard, Suite 300, Indianapolis, IN 46241, USA
    Med Mycol 46:93-5. 2008
    ..Therefore, there is a need to conduct confirmatory tests for histoplasmosis in the appropriate clinical setting...
  12. ncbi Detection of Histoplasma capsulatum antigenuria by ultrafiltration of samples with false-negative results
    Lindsey Egan
    MiraVista Diagnostics, 4444 Decatur Blvd, Suite 300, Indianapolis, IN 46241, USA
    Clin Vaccine Immunol 15:726-8. 2008
    ..Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity...
  13. ncbi Functional impairment of CD4 T cells despite normalization of T cell number in HIV
    Kenneth S Knox
    Pulmonary Division, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Cell Immunol 242:46-51. 2006
    ..Enriching for CD4 T cells had no effect on antigen responses in patients with low CD4 lymphocyte counts. These findings support the concept that CD4 T cells in late stage HIV have inherent qualitative defects...
  14. ncbi Pulmonary cryptococcosis after initiation of anti-tumor necrosis factor-alpha therapy
    Chadi A Hage
    Pulmonary Critical Care, Department of Medicine, Indiana University School of Medicine, 1001 West Tenth Street, Indianapolis, IN 46202, USA
    Chest 124:2395-7. 2003
    ..A diagnosis was made early in the disease course, and the patient responded quickly to antifungal therapy. This case should alert clinicians to the increased incidence of pulmonary mycoses in patients receiving anti-TNF-alpha therapy...
  15. ncbi Pulmonary histoplasmosis
    Chadi A Hage
    Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Semin Respir Crit Care Med 29:151-65. 2008
    ..Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes...
  16. ncbi Cytometric analysis of BAL T cells labeled with a standardized antibody cocktail correlates with immunohistochemical staining
    Patricia A Smith
    Pulmonary Division, Indiana University School of Medicine, Indianapolis, 46202, USA
    Cytometry B Clin Cytom 70:170-8. 2006
    ....
  17. ncbi Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy
    Karen L Wood
    Division of Pulmonary and Critical Care, Department of Medicine, Infectious Disease, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Respir Crit Care Med 167:1279-82. 2003
    ..In summary, patients receiving anti-TNF-alpha therapy are at risk for developing disseminated histoplasmosis. This may be due to a defect in the TH1 arm of cellular immunity...
  18. ncbi Blastomyces dermatitidis antigen detection by quantitative enzyme immunoassay
    Patricia Connolly
    MiraVista Diagnostics, Indianapolis, Indiana, USA
    Clin Vaccine Immunol 19:53-6. 2012
    ..Pretreatment increased the sensitivity for detection of antigenemia. Differentiation of histoplasmosis and blastomycosis is not possible by antigen detection...
  19. ncbi Human immunodeficiency virus gp120 downregulates CD1d cell surface expression
    Chadi A Hage
    Indiana University School of Medicine, Indianapolis, IN, USA
    Immunol Lett 98:131-5. 2005
    ..These data suggest that CD1d-mediated responses are altered during HIV infection and may thus contribute to the global immunodeficiency seen in these patients...
  20. ncbi Macrophages exposed to lymphotropic and monocytotropic HIV induce similar CTL responses despite differences in productive infection
    Kenneth S Knox
    Division of Pulmonary Critical Care Medicine and Infectious Diseases, Department of Medicine, Indiana University Medical Center, Indianapolis, IN 46202, USA
    Cell Immunol 229:130-8. 2004
    ....
  21. ncbi Traditional and emerging antifungal therapies
    Tamra M Arnold
    Division of Clinical Pharmacy, Roudebush VA Medical Center, Indianapolis, Indiana, USA
    Proc Am Thorac Soc 7:222-8. 2010
    ..In this article we discuss the three major classes of antifungal agents: the polyens, the triazoles, and the echinocandins. The emphasis is placed on their clinical use, side effects, drug interactions, and other practical issues...
  22. ncbi A 24-year-old man with mediastinal mass, dyspnea, and a pleural effusion
    Anthony S Rose
    Division of Pulmonary and Critical Care Medicine, Roudebush VA Medical Center, Indiana University, 1481 West Tenth St, VA 111P-IU, Indianapolis, IN 46202, USA
    Chest 134:200-3. 2008
  23. ncbi Aspergillus infections in the critically ill
    Radek Dutkiewicz
    Pulmonary Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Proc Am Thorac Soc 7:204-9. 2010
    ..Diagnostic methods and recommended treatments are also presented. The emphasis is placed on early diagnosis and use of new and sensitive diagnostic tools...
  24. ncbi Corticosteroids for blastomycosis-induced ARDS: a report of two patients and review of the literature
    Tim Lahm
    Department of Medicine, Division of Pulmonary, Allergy, Critical Care and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Chest 133:1478-80. 2008
    ..Both patients survived and did well on follow-up. We suggest that treatment with corticosteroids may be of benefit in patients with blastomycosis-induced ARDS. This may be due to a decrease in the severity of the inflammatory response...
  25. ncbi Endemic mycoses: Overlooked causes of community acquired pneumonia
    Chadi A Hage
    Pulmonary Critical Care and Infectious Diseases, Indiana University and Richard L Roudebush VA Medical Center, 1481 W 10th St, 111P IU, Indianapolis, IN, USA
    Respir Med 106:769-76. 2012
    ..We discuss their epidemiology, clinical presentations, methods of diagnosis and current treatment strategies...
  26. ncbi A 30-year-old man with HIV infection and fever with cough 2 months after starting antiretroviral therapy
    Denisa Xhani
    Department of Medicine, Indiana University, Indianapolis, IN, USA
    Chest 132:354-7. 2007
  27. ncbi Defective nitric oxide production by alveolar macrophages during Pneumocystis pneumonia
    Mark E Lasbury
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202 5113, USA
    Am J Respir Cell Mol Biol 44:540-7. 2011
    ..These data suggest that NO is important in the defense against Pc infection, but that the production of NO in AMs during PCP is defective because of the reduced dimerization of iNOS...
  28. ncbi An 81-year-old man with lactic acidosis, refractory hypoglycemia, and lymphocytosis
    Khalil Diab
    Department of Medicine, Pulmonary-Critical Care Medicine, Indiana University, Indianapolis, IN 46202, USA
    Chest 133:306-10. 2008
  29. ncbi Invasive fungal infections in the era of biologics
    Tamra M Arnold
    Division of Clinical Pharmacy, Roudebush VA Medical Center, Indianapolis, IN 46202, USA
    Clin Chest Med 30:279-86, vi. 2009
    ..Rapid diagnosis and initiation of antifungal therapy are of utmost importance...
  30. ncbi Pathogenesis of pleural infection
    Chadi A Hage
    Infectious Diseases and Pulmonary Critical Care Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Respirology 9:12-5. 2004
    ..In this review, we discuss the different virulence factors that allow microorganisms to infect the pleura and the role of the pleural mesothelial cells in bridging the innate and acquired immune responses...
  31. ncbi Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center VRC, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 112:2826-35. 2008
    ..Finally, these data may help account for the nonprogressive nature of nonpathogenic SIV infection in sooty mangabeys...
  32. ncbi Plasmalyte as a cause of false-positive results for Aspergillus galactomannan in bronchoalveolar lavage fluid
    Chadi A Hage
    J Clin Microbiol 45:676-7. 2007
  33. ncbi Infliximab does not affect dendritic cells' mediated lymphoproliferative response to Histoplasma capsulatum
    Chadi A Hage
    Clin Infect Dis 41:1685-7; author reply 1687. 2005