W Scott Goebel

Summary

Affiliation: Indiana University
Country: USA

Publications

  1. ncbi Serial transplantation resulting in tolerance to an unrelated cord blood graft
    W Scott Goebel
    Department of Pediatrics and the Pediatric Stem Cell Transplantation Program, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202 5200, USA
    Transplantation 81:1596-9. 2006
  2. ncbi Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use
    Brandon C Perry
    General BioTechnology, LLC, Indianapolis, Indiana, USA
    Tissue Eng Part C Methods 14:149-56. 2008
  3. ncbi Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function
    Brahmananda R Chitteti
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 115:3239-48. 2010
  4. ncbi Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity
    Shanbao Cai
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Section of Pediatric Hematology Oncology, The Riley Hospital for Children, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 17:2195-206. 2011
  5. ncbi Unrelated cord blood transplantation for severe congenital neutropenia: report of two cases with very different transplant courses
    Melissa K Markel
    Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202 5200, USA
    Pediatr Transplant 12:896-901. 2008
  6. ncbi Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis
    Sonia Rodriguez
    Herman B Wells Center, Indiana University Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Blood 114:4064-76. 2009
  7. ncbi Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo
    Yan Li
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 113:2342-51. 2009
  8. ncbi Container system for enabling commercial production of cryopreserved cell therapy products
    Erik J Woods
    General BioTechnology, LLC, Indianapolis, IN, USA
    Regen Med 5:659-67. 2010
  9. ncbi In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector
    Shanbao Cai
    Department of Pediatrics, James Whitcomb Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, IN 46202 5525, USA
    Exp Hematol 36:283-92. 2008
  10. ncbi Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A
    Brandon K Wyss
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 5225, USA
    Exp Hematol 37:814-23. 2009

Research Grants

  1. Factors Influencing Engraftment in Submyeloablated Hosts
    W Goebel; Fiscal Year: 2007

Collaborators

  • Erik J Woods
  • Paul R Haut
  • Haiyan Wang
  • Feng Chun Yang
  • Helmut Hanenberg
  • Nadia Carlesso
  • Xiaohua Wu
  • Melissa A Kacena
  • Nan Jia
  • Yan Li
  • Jamie Case
  • David R Jones
  • David Foster
  • Cecilia Barese
  • David A Ingram
  • Mary Dinauer
  • Shanbao Cai
  • Karen E Pollok
  • Anthony L Sinn
  • Brandon K Wyss
  • Brahmananda R Chitteti
  • Aaron Ernstberger
  • Sonia Rodriguez
  • Beth E Juliar
  • Dan Zhou
  • Harm HogenEsch
  • Brandon C Perry
  • Melissa K Markel
  • David L Waning
  • M Jawad Javed
  • Jennifer R Hartwell
  • Arthur R Baluyut
  • Barbara Bailey
  • Rebecca J Chan
  • Lindsey D Mayo
  • Edward F Srour
  • Ying Hua Cheng
  • Sonia Rodriguez-Rodriguez
  • Bradley Poteat
  • Susan Rice
  • Carol A Karlewicz
  • Abigail F W Donnelly
  • Christen Mumaw
  • Luis Fernandez
  • Boyan Goumnerov
  • Hasan Baydoun
  • Angelo Chora
  • Laurence G Rahme
  • David M Dombkowski
  • Olaf Eckermann
  • Laura E Mead
  • Yahaira Naaldijk
  • Justin L Meyers
  • Michael A Byers
  • Waylan K Bessler
  • T M Gabriel Chu
  • Barbara J Bailey
  • Laura S Haneline
  • Kent A Robertson
  • Yvonne Linka
  • Mervin C Yoder
  • Daniel Prater
  • Binghui Li
  • J Jeffrey Hockema
  • Kristin T Chun
  • Jamie A Renbarger
  • Emi Kreklau
  • Ryan J Cooper
  • Rafat Abonour

Detail Information

Publications20

  1. ncbi Serial transplantation resulting in tolerance to an unrelated cord blood graft
    W Scott Goebel
    Department of Pediatrics and the Pediatric Stem Cell Transplantation Program, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN 46202 5200, USA
    Transplantation 81:1596-9. 2006
    ....
  2. ncbi Collection, cryopreservation, and characterization of human dental pulp-derived mesenchymal stem cells for banking and clinical use
    Brandon C Perry
    General BioTechnology, LLC, Indianapolis, Indiana, USA
    Tissue Eng Part C Methods 14:149-56. 2008
    ..These initial studies will facilitate the development of future cGTP protocols for the clinical banking of MSC...
  3. ncbi Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function
    Brahmananda R Chitteti
    Departments of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Blood 115:3239-48. 2010
    ..These data illustrate that OBs promote in vitro maintenance of hematopoietic functions, including repopulating potential by up-regulating Notch-mediated signaling between HSCs and OBs...
  4. ncbi Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity
    Shanbao Cai
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Section of Pediatric Hematology Oncology, The Riley Hospital for Children, Indianapolis, Indiana 46202, USA
    Clin Cancer Res 17:2195-206. 2011
    ..In this study, a xenograft model containing humanized bone marrow is utilized as an in vivo assay to monitor hematotoxicity...
  5. ncbi Unrelated cord blood transplantation for severe congenital neutropenia: report of two cases with very different transplant courses
    Melissa K Markel
    Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202 5200, USA
    Pediatr Transplant 12:896-901. 2008
    ..We conclude that UCB is an acceptable stem cell source for SCN patients, but conditioning must be adequately immunosuppressive to ensure engraftment in patients without prior chemotherapy...
  6. ncbi Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis
    Sonia Rodriguez
    Herman B Wells Center, Indiana University Simon Cancer Center, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Blood 114:4064-76. 2009
    ..Our results establish a previously unrecognized link between HSC regulation and host response in severe sepsis and demonstrate a novel role for TLR4...
  7. ncbi Mesenchymal stem/progenitor cells promote the reconstitution of exogenous hematopoietic stem cells in Fancg-/- mice in vivo
    Yan Li
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 113:2342-51. 2009
    ....
  8. ncbi Container system for enabling commercial production of cryopreserved cell therapy products
    Erik J Woods
    General BioTechnology, LLC, Indianapolis, IN, USA
    Regen Med 5:659-67. 2010
    ..This study investigated the potential for freezing, storing and shipping cell therapy products using novel pharmaceutical-grade Crystal Zenith((R)) (CZ) plastic vials...
  9. ncbi In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector
    Shanbao Cai
    Department of Pediatrics, James Whitcomb Riley Hospital for Children and Indiana University School of Medicine, Indianapolis, IN 46202 5525, USA
    Exp Hematol 36:283-92. 2008
    ....
  10. ncbi Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A
    Brandon K Wyss
    Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202 5225, USA
    Exp Hematol 37:814-23. 2009
    ..Here, we evaluated homing efficiency as a potential mechanism for this engraftment disparity, and whether CD26 inhibition with the tripeptide Diprotin A (DipA) would enhance engraftment of ex vivo cultured cells in submyeloablated hosts...
  11. ncbi Endothelial colony forming cells and mesenchymal stem cells are enriched at different gestational ages in human umbilical cord blood
    M Jawad Javed
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Res 64:68-73. 2008
    ..These studies demonstrate that circulating MSCs and ECFCs appear at different GA in the human UCB, and that 24-28 wk GA UCB may be a novel source of MSCs for therapeutic use in human diseases...
  12. ncbi Granulocyte colony-stimulating factor prior to nonmyeloablative irradiation decreases murine host hematopoietic stem cell function and increases engraftment of donor marrow cells
    Cecilia Barese
    Cancer Research Institute R4 402C, Indiana University School of Medicine, 1044 West Walnut Street, Indianapolis, Indiana 46202, USA
    Stem Cells 25:1578-85. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  13. ncbi Optimized cryopreservation method for human dental pulp-derived stem cells and their tissues of origin for banking and clinical use
    Erik J Woods
    General BioTechnology, LLC, Indianapolis, IN 46202, USA
    Cryobiology 59:150-7. 2009
    ....
  14. ncbi Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis
    David L Waning
    Herman B Wells Center for Pediatric Research, Section of Pediatric Hematology Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 112:320-9. 2008
    ..These recipients died within 9 to 11 days, demonstrating that in hematopoietic cells, Cul4A is essential for survival...
  15. ncbi In vivo effects of myeloablative alkylator therapy on survival and differentiation of MGMTP140K-transduced human G-CSF-mobilized peripheral blood cells
    Shanbao Cai
    Herman B. Wells Center for Pediatric Research, Department of Pediatrics, The Riley Hospital for Children, 1044 West Walnut Street R4 468, Indianapolis, IN 46202-5525, USA
    Mol Ther 13:1016-26. 2006
    ..These data suggest that improved strategies to optimize repair of DNA damage in primitive human hematopoietic cells are needed when using high-intensity anti-cancer therapy...
  16. ncbi Disseminated toxoplasmosis resulting in graft failure in a cord blood stem cell transplant recipient
    W Scott Goebel
    Department of Pediatrics, Pediatric Stem Cell Transplantation Program, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Pediatr Blood Cancer 48:222-6. 2007
    ..Recommendations for toxoplasmosis diagnosis, treatment, and prophylaxis in stem cell transplant recipients are reviewed...
  17. ncbi A murine model of antimetabolite-based, submyeloablative conditioning for bone marrow transplantation: biologic insights and potential applications
    W Scott Goebel
    Herman B Wells Center for Pediatric Research and Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind, USA
    Exp Hematol 32:1255-64. 2004
    ....
  18. ncbi Gene therapy for chronic granulomatous disease
    Cecilia N Barese
    Herman B Wells Center for Pediatric Research and Depatment of Padiatrics (Hematology/Oncology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Expert Opin Biol Ther 4:1423-34. 2004
    ....
  19. ncbi Donor chimerism and stem cell function in a murine congenic transplantation model after low-dose radiation conditioning: effects of a retroviral-mediated gene transfer protocol and implications for gene therapy
    W Scott Goebel
    Herman B. Wells Center for Pediatric Research and Department of Pediatrics, Hematology/Oncology, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, IN, USA
    Exp Hematol 30:1324-32. 2002
    ..Modification of current RMGT protocols may be important for optimizing engraftment under these conditions...
  20. ncbi A novel competitive repopulation strategy to quantitate engraftment of ex vivo manipulated murine marrow cells in submyeloablated hosts
    Brandon K Wyss
    Herman B Wells Center for Pediatric Research
    Exp Hematol 36:513-21. 2008
    ..Here, we developed a novel assay to quantitate engraftment of hematopoietic stem cells in submyeloablated hosts...

Research Grants2

  1. Factors Influencing Engraftment in Submyeloablated Hosts
    W Goebel; Fiscal Year: 2007
    ....