Research Topics
| Lucinda G CarrSummaryAffiliation: Indiana University Country: USA Publications
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Detail Information
Publications
AA and ANA rats exhibit the R100Q mutation in the GABAA receptor alpha 6 subunitLucinda G Carr
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Alcohol 31:93-7. 2003..The absence of the R100Q mutation in the other rat lines that were selectively bred for alcohol consumption and alcohol preference may be due to genetic diversity among the Wistar stocks used to develop the various lines...- Development of congenic rat strains for alcohol consumption derived from the alcohol-preferring and nonpreferring ratsLucinda G Carr
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Behav Genet 36:285-90. 2006..These congenic animals will be an invaluable resource for fine mapping the QTL region and for the identification of the gene(s) that influences the drinking behavior of the iP and iNP rats... - Identification of candidate genes for alcohol preference by expression profiling of congenic rat strainsLucinda G Carr
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Alcohol Clin Exp Res 31:1089-98. 2007..This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains... - Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 ratsLucinda G Carr
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Alcohol Clin Exp Res 27:1710-7. 2003..Previously, a 20-cM genome screen identified quantitative trait loci (QTLs) on chromosomes 5, 10, 12, and 16 by using F2 progeny from HAD1 and LAD1 animals... - Influence of ADH1B polymorphism on alcohol use and its subjective effects in a Jewish populationLucinda G Carr
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Am J Med Genet 112:138-43. 2002..The ADH1B polymorphism is associated with unpleasant reactions after alcohol consumption, and frequency of alcohol consumption in these Jewish samples... - Genome screen for bone mineral density phenotypes in Fisher 344 and Lewis rat strainsDaniel L Koller
Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street, IB 130, Indianapolis, Indiana, 46202, USA
Mamm Genome 16:578-86. 2005..0. The region on rat Chromosome 8 is syntenic to human Chromosome 15, where linkage to spine and femur BMD has been previously reported and confirmed in a sample of premenopausal women... - Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumptionRichard L Bell
Department of Psychiatry, Indiana University Purdue University at Indianapolis, Indianapolis, IN 46202, USA
Pharmacol Biochem Behav 94:131-47. 2009..Conversely, chronic MSA drinking, with its associated protracted withdrawal periods, results in genomic changes that may be masked by tight regulation of these genes following repeated experiences of ethanol withdrawal... - Genetic loci affecting bone structure and strength in inbred COP and DA ratsQiwei Sun
Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Bone 42:547-53. 2008..Our study demonstrates strong evidence of linkage for bone structure and strength to multiple rat chromosomes... - Identification of genes influencing skeletal phenotypes in congenic P/NP ratsImranul Alam
Department of Biomedical Engineering, Indiana University Purdue University Indianapolis IUPUI, Indianapolis, IN 46202, USA
J Bone Miner Res 25:1314-25. 2010..We identified several candidate genes, including some novel genes on chromosome 4 segregating for skeletal phenotypes in reciprocal congenic P and NP rats... - Fine mapping and expression of candidate genes within the chromosome 10 QTL region of the high and low alcohol-drinking ratsPaula J Bice
Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Indianapolis, IN 46202, USA
Alcohol 44:477-85. 2010..All six genes showed differential expression in at least one brain region. Of the genes tested in this study, Crebbp and Mapk8ip3 may be the most promising candidates with regard to alcohol drinking... - Sex-specific genetic loci for femoral neck bone mass and strength identified in inbred COP and DA ratsImranul Alam
Department of Biomedical Engineering, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Bone Miner Res 23:850-9. 2008..The purpose of this study is to identify sex-independent and sex-specific quantitative trait loci (QTLs) for femoral neck density, structure, and strength in inbred Copenhagen 2331 (COP) and Dark Agouti (DA) rats... - Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring ratsZachary A Rodd
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, United States
Pharmacol Biochem Behav 89:481-98. 2008..g., Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories. Overall, the results suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of EtOH... - Identification of QTLs influencing alcohol preference in the High Alcohol Preferring (HAP) and Low Alcohol Preferring (LAP) mouse linesPaula J Bice
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
Behav Genet 36:248-60. 2006..19; p<0.0008) than male mice (LOD=1.19). This study provides additional evidence and confirmation that specific regions on chromosomes 9 and perhaps 2 are important for alcohol preference... - Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic ratsTiebing Liang
Indiana University School of Medicine, Department of Medicine, IB424G, 975 West Walnut Street, Indianapolis, IN 46202, USA
Genome Biol 11:R11. 2010..NP congenic rats: amygdala, nucleus accumbens, hippocampus, caudate putamen, and frontal cortex... - Confirmation of alcohol preference quantitative trait loci in the replicate high alcohol drinking and low alcohol drinking rat linesTatiana Foroud
Department of Medical and Molecular Genetics, Indiana University School of Medicine, 975 West Walnut Street IB 155, Indianapolis, IN 46202, USA
Psychiatr Genet 13:155-61. 2003.... - alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring ratsTiebing Liang
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Proc Natl Acad Sci U S A 100:4690-5. 2003..These results suggest that differential expression of the alpha-synuclein gene may contribute to alcohol preference in the iP rats... - Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regionsMark W Kimpel
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, USA
Alcohol 41:95-132. 2007..The many regional and overall gene expression differences between the iP and iNP rat lines may contribute to the divergent alcohol drinking phenotypes of these rats... - Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring ratsTiebing Liang
Department of Medicine, Indiana University School of Medicine, 975 W. Walnut Street, Indianapolis, IN 46202, USA
Alcohol Clin Exp Res 28:1622-8. 2004..CONCLUSION: There is regional variation of rGST 8-8 expression in the brain, at both the mRNA and protein level, and the iP strain has lower innate rGST 8-8 levels than the iNP strain in discrete brain regions... - From QTL to candidate gene: a genetic approach to alcoholism researchJohn P Spence
Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatry, Indianapolis, IN 46202, USA
Curr Drug Abuse Rev 2:127-34. 2009.... - Bone mass and strength: phenotypic and genetic relationship to alcohol preference in P/NP and HAD/LAD ratsImranul Alam
Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Alcohol Clin Exp Res 29:1769-76. 2005.... - Drd2 expression in the high alcohol-preferring and low alcohol-preferring micePaula J Bice
Department of Medicine, Indiana University School of Medicine, Medical Research and Library Building, Room 411, 975 W Walnut St, Indianapolis, IN, 46202, USA
Mamm Genome 19:69-76. 2008..These results suggest that the SNP may play a role in the differential expression of Drd2 between the HAP and LAP mice and that the polymorphism in Drd2 may contribute to alcohol preference... - Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring ratsTiebing Liang
Department of Medicine, Indiana University School of Medicine, Indianapolis, 46202, USA
J Neurochem 99:470-82. 2006..These results suggest that regulation of rat Snca gene expression is complex and may contribute to alcohol preference in the iP rats... - Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish populationMonika Fischer
Department of Medicine, Indiana University School of Medicine and the Richard Roudebush Veteran s Affairs Medical Center, Indianapolis, Indiana, USA
Alcohol Clin Exp Res 31:1654-9. 2007..The A allele is predicted to be less active transcriptionally than the G allele. Therefore, we hypothesized that individuals with 1 or 2 A alleles would have exaggerated reactions to alcohol... - Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis ratsImranul Alam
Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Bone Miner Res 20:1589-96. 2005..A genome-wide genetic linkage analysis identified several chromosomal regions influencing bone strength and structure in F2 progeny of Fischer 344 x Lewis inbred rats... - Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populationsJohn P Spence
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA
Alcohol Clin Exp Res 27:1389-94. 2003.... - Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preferenceJames M Murphy
Department of Psychology, Purdue School of Science, Indiana University Purdue University Indianapolis, 46202 1375, USA
Behav Genet 32:363-88. 2002..The elucidation of the genotypes and phenotypes that result in excessive alcohol intake may lead to a better understanding of alcohol abuse and alcoholism and could guide strategies for potential treatment and prevention... - Protective effects of the alcohol dehydrogenase-ADH1B allele in children exposed to alcohol during pregnancySandra W Jacobson
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48207, USA
J Pediatr 148:30-7. 2006..To examine alcohol use for mothers with and without an ADH1B*3 allele and the moderating effects of the maternal and child ADH1B*3 allele on a broad range of infant and 7.5-year outcomes... - Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish populationYehuda D Neumark
Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
Alcohol Clin Exp Res 28:10-4. 2004..The mechanism by which this allelic effect is mediated is not yet clearly understood. This study examined the effect of ADH2*2 on alcohol-elimination rates (AER) under experimental conditions... - Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and womenSusan E Luczak
Department of Psychiatry, University of California, San Diego 92161 2002, USA
J Stud Alcohol 63:74-82. 2002..The present study was designed to determine whether similar levels of response to alcohol, using objective and subjective measurements, are seen in men and women with different ALDH2 genotypes... - Ethnic differences in level of response to alcohol between Chinese Americans and Korean AmericansNicole C E Duranceaux
Department of Psychiatry, University of California, San Diego, CA, USA
J Stud Alcohol Drugs 69:227-34. 2008..The current study examined self-report level of response to alcohol, ALDH2 and ADH1B, country of origin, and family history of alcoholism in 154 Chinese- and 181 Korean-American college students... - Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidenceSubhash C Pandey
Department of Psychiatry, Psychiatric Institute, University of Illinois, IL 60612, USA
Alcohol Clin Exp Res 27:149-54. 2003..Pandey; (4) Involvement of NPY in alcohol dependence: from animal models to human genetics, by Markus Heilig; and (5) Association of neuropeptide Y polymorphism with the occurrence of type 1 and type 2 alcoholism, by Erkki Ilveskoski... - Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission IndiansTamara L Wall
Department of Neuropharmacology, Scripps Research Institute, San Diego, CA, USA
Am J Psychiatry 160:41-6. 2003..An additional goal was to determine if any associations exist between these polymorphisms and the endophenotype, maximum number of drinks ever consumed in a 24-hour period... - Binge drinking in Jewish and non-Jewish white college studentsSusan E Luczak
University of California, San Diego, School of Medicine, USA
Alcohol Clin Exp Res 26:1773-8. 2002..More research is needed to identify additional factors, including other religious, cultural, genetic, and biological influences, that protect Jewish Americans from heavy drinking... - Stability of heavy episodic drinking in Chinese- and Korean-American college students: effects of ALDH2 gene status and behavioral undercontrolNeal Doran
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
J Stud Alcohol Drugs 68:789-97. 2007..The purpose of this longitudinal study was to examine the roles of ALDH2 and behavioral undercontrol (a temperamental trait that is associated with conduct disorder) in stability of heavy episodic drinking... - Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California IndiansCindy L Ehlers
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 28:1481-6. 2004..The aim of this study was to determine the prevalence of these polymorphisms in a sample of Southwest California Indians and to test for associations with alcohol dependence and other substance-related behaviors... - Variations in alcohol-metabolizing enzymes in people of East Indian and African descent from Trinidad and TobagoShelley Moore
Department of Pharmacology, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago
Alcohol Res Health 30:28-30. 2007..However, a variant in the gene encoding cytosolic ALDH1A (i.e. ALDH1A1*1/*2) was found to be associated with an increase in alcohol dependence in Indo-Trinidadians... - ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American college studentsSusan E Luczak
Department of Psychiatry, University of California, San Diego, USA
J Stud Alcohol 67:349-53. 2006.... - Associations of variations in alcohol dehydrogenase genes with the level of response to alcohol in non-AsiansNicole C E Duranceaux
Department of Psychiatry, University of California, San Diego, California 92161, USA
Alcohol Clin Exp Res 30:1470-8. 2006..Variations in the ADH1B and ADH1C genes may influence the LR to alcohol by increasing levels of acetaldehyde during alcohol metabolism, although most data on this question come from Asian populations... - Genetic associations of alcohol dehydrogenase with alcohol use disorders and endophenotypes in white college studentsTamara L Wall
Department of Psychiatry, University of California, San Diego, San Diego, CA 92161, USA
J Abnorm Psychol 114:456-65. 2005..These findings are consistent with the hypothesis that enhanced sensitivity to alcohol and lower levels of alcohol use reflect the mechanism by which ADH1B*2 protects against developing an AUD... - Association of the ADHIB*3 allele with alcohol-related phenotypes in TrinidadCindy L Ehlers
Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California, USA
Alcohol Clin Exp Res 31:216-20. 2007..The relationship between these alleles and alcohol-associated phenotypes has not been previously investigated in individuals living in the Caribbean... - Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and TobagoShelly Moore
Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago
J Stud Alcohol Drugs 68:192-6. 2007..The present study sought to determine whether an association exists between ALDH1A1 genotypes, alcohol dependence, drinking history, and liver function tests in the two major ethnic groups of Trinidad and Tobago (TT)... - Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian AmericansTravis A R Cook
Department of Psychiatry, University of California, San Diego, USA
J Stud Alcohol 66:196-204. 2005..This study was designed to determine whether the ADH1B genotype is associated with more intense reactions to alcohol after controlling for the ALDH2 genotype... - Effect of ADH1B genotype on alcohol consumption in young Israeli JewsBaruch Spivak
Beer Yaa kov Mental Hospital, Tel Aviv, Israel
Alcohol Clin Exp Res 31:1297-301. 2007..Alcohol consumption is increasing among younger Israeli Jews, reflecting environmental influences. We investigated whether the relationship of ADH1B genotype with alcohol consumption differed between younger and older adult Israelis... - Religious influences on heavy episodic drinking in Chinese-American and Korean-American college studentsSusan E Luczak
Department of Psychiatry, University of California, San Diego, California, USA
J Stud Alcohol 64:467-71. 2003..Moreover, service attendance appears to more strongly influence heavy drinking in individuals who are not already protected by an ALDH2*2 allele... - Psychosocial, cultural and genetic influences on alcohol use in Asian American youthChristian S Hendershot
Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
J Stud Alcohol 66:185-95. 2005..The present study assessed parental alcohol use, acculturation and ALDH2 gene status in relation to lifetime, current and heavy episodic drinking among Chinese and Korean American undergraduates... - ALDH2 status and conduct disorder mediate the relationship between ethnicity and alcohol dependence in Chinese, Korean, and White American college studentsSusan E Luczak
University of California, San Diego and Veterans Medical Research Foundation, 92161, USA
J Abnorm Psychol 113:271-8. 2004..Results suggest that different rates of risk (e.g., conduct disorder) and protective (e.g., ALDH2 status) factors partially account for ethnic differences in rates of alcohol dependence...
Research Grants
- Gene Mapping of Alcohol-Related Traits in Rat LinesLucinda Carr; Fiscal Year: 2003..Candidate genes within the confirmed QTL regions will be identified and prioritized for sequencing using the rat informatic resources. ..
- QTL MAPPING OF ALCOHOL PREFERENCE IN SELECTED RAT LINESLucinda Carr; Fiscal Year: 2000..The QTL identified in animals can then be tested in human studies to determine their effect on the alcoholism phenotype. ..
- Gene Identification for an Alcohol Preference QTL in RatLucinda Carr; Fiscal Year: 2005..These experiments will combine an outstanding animal model of alcoholism and molecular techniques to provide a comprehensive approach that will identify with certainty candidate genes that influence alcohol drinking. ..