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Genomes and Genes | R A BlackSummaryAffiliation: Immunex Corporation Country: USA Publications
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Publications
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cellsR A Black
Immunex Corporation, Seattle, Washington 98101, USA
Nature 385:729-33. 1997..Our results should facilitate the development of therapeutically useful inhibitors of TNF-alpha release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins...- The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic librariesK Poindexter
Immunex Corporation, Seattle, WA 98101, USA
Gene 237:61-70. 1999..1, 8p23, and 14q24.1, respectively. An ancestral analysis of all known ADAMs indicates that the zinc-binding motif in the catalytic domain arose once in a common ancestor and was lost by those members lacking this motif... - Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzymeP Reddy
Department of Cell Sciences, Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 275:14608-14. 2000..IL-1R-II shedding required the cysteine-rich domain of TACE as well as the catalytic domain, whereas TNF and p75 TNFR shedding required only the tethered TACE catalytic domain... - Isolation of two novel metalloproteinase-disintegrin (ADAM) cDNAs that show testis-specific gene expressionD P Cerretti
Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
Biochem Biophys Res Commun 263:810-5. 1999..An ancestral analysis of all known mammalian ADAMs indicates that the zinc-binding motif in the catalytic domain arose once in a common ancestor and was subsequently lost by those members lacking this motif... - An essential role for ectodomain shedding in mammalian developmentJ J Peschon
Immunex Corporation, Seattle, WA 98101, USA
Science 282:1281-4. 1998..The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo... - Expression and purification of correctly processed, active human TACE catalytic domain in Saccharomyces cerevisiaeH R Clarke
Immunex Corporation, Seattle, Washington 98101, USA
Protein Expr Purif 13:104-10. 1998..Mass spectrometry of the purified catalytic domain showed that removal of both N-linked sites results in a homogeneous sized polypeptide lacking further posttranslational modifications... - Further evidence for a common mechanism for shedding of cell surface proteinsJ Mullberg
Immunex Corporation, Seattle, WA 98101, USA
FEBS Lett 401:235-8. 1997.... - Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25D P Cerretti
Immunex Corporation, 51 University St, Seattle, WA, 98101, USA
Cytokine 11:541-51. 1999..The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25... - Stimulation-induced down-regulation of tumor necrosis factor-alpha converting enzymeJ R Doedens
Department of Research Administration, Immunex Corporation, Seattle, Washington 98101, USA
J Biol Chem 275:14598-607. 2000..Thus, PMA activates shedding and causes the down-regulation of a major "sheddase," suggesting that induced shedding may be regulated by a mechanism that decreases the amount of active TACE on the cell surface... - Purification of interleukin-1 beta converting enzyme, the protease that cleaves the interleukin-1 beta precursorS R Kronheim
Protein Chemistry Department, Immunex Corporation, Seattle, Washington 98101
Arch Biochem Biophys 296:698-703. 1992..An antiserum raised against a peptide based on the N-terminus was used to precipitate the protease, confirming our identification of the 22,000-Da protein as the IL-1 beta converting enzyme... - Unaltered cleavage and secretion of angiotensin-converting enzyme in tumor necrosis factor-alpha-converting enzyme-deficient miceR Sadhukhan
Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 274:10511-6. 1999..We demonstrate that soluble ACE-secretase from both sources failed to cleave its substrate in solution, suggesting a requirement for anchoring to the membrane... - A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACEC Brou
Unité de Biologie Moléculaire de l Expression Génique, URA 1773 CNRS, Institut Pasteur, Paris, France
Mol Cell 5:207-16. 2000..Furthermore, experiments carried out on TACE-/- bone marrow-derived monocytic precursor cells suggest that this metalloprotease plays a prominent role in the activation of the Notch pathway... - Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymaseH Mizutani
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
J Exp Med 174:821-5. 1991..Mast cells lie in close apposition to blood vessels in dermis; therefore, chymase mediated conversion of 31 kD IL-1 beta might be expected to have a critical role in the initiation of the inflammatory response in skin... - Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzymeK Maskos
Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
Proc Natl Acad Sci U S A 95:3408-12. 1998.... - Acetylenic TACE inhibitors. Part 1. SAR of the acyclic sulfonamide hydroxamatesJ I Levin
Wyeth Research, 401 N Middletown Rd, Pearl River, NY 10965, USA
Bioorg Med Chem Lett 13:2799-803. 2003.... - Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' groupJ I Levin
Wyeth Ayerst Research, 401N Middletown Road, Pearl River, NY 10965, USA
Bioorg Med Chem Lett 12:1199-202. 2002..In particular, compound 4t bearing a butynyloxy P1' moiety has excellent in vitro potency against isolated TACE enzyme and in cells, good selectivity over MMP-1 and oral activity in an in vivo model of TNF-alpha production... - Skeletal muscle cell hypertrophy induced by inhibitors of metalloproteases; myostatin as a potential mediatorC Huet
The Burnham Institute, La Jolla, California 92037, USA
Am J Physiol Cell Physiol 281:C1624-34. 2001.... - Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysisY Zhang
Department of Medicine, Division of Endocrinology and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Biol Chem 276:24565-73. 2001..The implications of these findings with regard to GH signaling and GHR down-regulation are discussed... - Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generationY Zhang
Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
Endocrinology 141:4342-8. 2000..We conclude that TACE is an enzyme required for PMA-induced GHBP shedding and that PMA-induced down-regulation of GHR abundance may in significant measure be attributable to TACE-mediated GHR proteolysis... - Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursorJ D Buxbaum
Departments of Psychiatry and Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 273:27765-7. 1998..Furthermore, we show that inhibiting this enzyme affects both APP secretion and Abeta formation in cultured cells... - Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzymeC A Ray
Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina 27710
Cell 69:597-604. 1992..These viral countermeasures to host defenses against infection may contribute significantly to the pathology associated with poxvirus infections... - Molecular cloning of the murine IL-1 beta converting enzyme cDNAM A Nett
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110
J Immunol 149:3254-9. 1992..These studies establish that the IL-1 beta convertase is an evolutionarily conserved, widely expressed enzyme that can be regulated at a pretranslational level... - Complex patterns of genetic and phenotypic divergence in an island bird and the consequences for delimiting conservation unitsA B Phillimore
Division of Biology, Imperial College London, Silwood Park, Ascot, Berkshire, SL5 7PY, UK
Mol Ecol 17:2839-53. 2008..A continuum of divergence and a degree of discordance between different characters are both to be expected under simple models of evolution, but they present problems in terms of delimiting conservation units...