Research Topics
| John J MariniSummaryAffiliation: HealthPartners Research Foundation Country: USA Publications
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Publications
Unproven clinical evidence in mechanical ventilationJohn J Marini
University of Minnesota, Minneapolis St Paul, Minnesota, USA
Curr Opin Crit Care 18:1-7. 2012..To describe the management principles that have not been verified or tested but nonetheless successfully guide the logic of everyday practice at the bedside...- Thirty years of critical care medicineJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
Crit Care 14:311. 2010..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years... - Partitioning the work-sparing effects of partial ventilatory support in airflow obstructionJohn J Marini
University of Minnesota, USA
Crit Care 8:101-2. 2004..The effects of manipulating airway pressure in the setting of airflow obstruction depend heavily on the nature and severity of disease, as well as on the presence of airflow limitation during tidal breathing... - Advances in the understanding of acute respiratory distress syndrome: summarizing a decade of progressJohn J Marini
Department of Medicine, University of Minnesota, Minneapolis/St. Paul, and Pulmonary/Critical Care Division, Regions Hospital, St. Paul, Minnesota 55101, USA
Curr Opin Crit Care 10:265-71. 2004 - Reluctant horses at the digital riverJohn J Marini
University of Minnesota, USA
Crit Care 8:313-4. 2004..Whether their limitless promise will be embraced or forgone will depend as much on human as on technological practice... - Limitations of clinical trials in acute lung injury and acute respiratory distress syndromeJohn J Marini
University of Minnesota, Minneapolis St Paul, Minnesota 55101, USA
Curr Opin Crit Care 12:25-31. 2006..To review the challenges and limitations of randomized clinical trials in acute respiratory distress syndrome, with special emphasis on those pertaining to ventilatory management... - A lung-protective approach to ventilating ARDSJ J Marini
Department of Medicine, University of Minnesota, USA
Respir Care Clin N Am 4:633-63, viii. 1998..This article reviews the basis for concern about traditional ventilatory support in ARDS and develops an approach based on current evidence and newer options for management... - Ventilatory management of acute respiratory distress syndrome: a consensus of twoJohn J Marini
University of Minnesota, Regions Hospital, St Paul 55101, USA
Crit Care Med 32:250-5. 2004..To synthesize the emerging body of experimental, observational, and clinical trial data into a practical guideline for safe and effective ventilatory management of acute respiratory distress syndrome... - Propagation prevention: a complementary mechanism for "lung protective" ventilation in acute respiratory distress syndromeJohn J Marini
Department of Medicine, University of Minnesota, Minneapolis, Saint Paul, MN, USA
Crit Care Med 36:3252-8. 2008..To describe the clinical implications of an often neglected mechanism through which localized acute lung injury may be propagated and intensified... - Dynamic hyperinflation and auto-positive end-expiratory pressure: lessons learned over 30 yearsJohn J Marini
Pulmonary and Critical Care Medicine, University of Minnesota, St Paul, MN 55101 2595, USA
Am J Respir Crit Care Med 184:756-62. 2011..This discussion reviews some of the more important aspects of AP that bear on the care of the ventilated patient with critical illness... - Acoustic monitoring--super sonics?John J Marini
University of Minnesota, Minneapolis St Paul, Minnesota Regions Hospital, Pulmonary and Critical Care Medicine, MS11203B, 640 Jackson St, St Paul, Minnesota 55101, USA
Crit Care 13:162. 2009..These emerging options complement current 'static/global' monitoring of mechanics and gas exchange with dynamic regional information long missing from the optimal care of the ventilated patient with critical illness... - Can we prevent the spread of focal lung inflammation?John J Marini
University of Minnesota, Minneapolis, MN, USA
Crit Care Med 38:S574-81. 2010.... - Spontaneously regulated vs. controlled ventilation of acute lung injury/acute respiratory distress syndromeJohn J Marini
University of Minnesota, St Paul, Minnesota, USA
Curr Opin Crit Care 17:24-9. 2011.... - Transient hemodynamic effects of recruitment maneuvers in three experimental models of acute lung injurySung-Chul Lim
Pulmonary/Critical Care Medicine, Regions Hospital/HealthPartners, University of Minnesota, St. Paul, MN 55101, USA
Crit Care Med 32:2378-84. 2004..The results imply that a lung recruiting maneuver should be used with caution, especially when using sustained inflation in the setting of pneumonia... - Intercomparison of recruitment maneuver efficacy in three models of acute lung injurySung-Chul Lim
Department of Pulmonary/Critical Care Medicine, Regions Hospital, University of Minnesota, St. Paul, MN, USA
Crit Care Med 32:2371-7. 2004..Although RM may improve PaO2 in certain injury settings when traditional tidal volumes are used, sustained improvement depends on the post-RM positive end-expiratory pressure value... - Time course of physiologic variables in response to ventilator-induced lung injuryDavid J Dries
Pulmonary Research Laboratory, Regions Hospital, St Paul, Minnesota, USA
Respir Care 52:31-7. 2007..Similarly, the regional topographies of pleural pressure and tissue edema have not been carefully mapped for this injury process... - Cardiovascular and metabolic effects of high-dose insulin in a porcine septic shock modelJoel S Holger
Department of Emergency Medicine, Regions Hospital, St Paul, MN, USA
Acad Emerg Med 17:429-35. 2010..In an animal model of severe septic shock, this study compared the effects of HDI treatment to normal saline (NS) resuscitation alone... - Tracheal gas insufflation during late exhalation efficiently reduces PaCO(2) in experimental acute lung injuryChristopher Carter
Regions Hospital, Pulmonary Research, 640 Jackson Street, St. Paul, MN 55101, USA
Intensive Care Med 28:504-8. 2002..These findings suggest that TGI is most effectively applied in a phasic manner in late expiration, with its duration titrated to effect... - Agreement between functional residual capacity estimated via automated gas dilution versus via computed tomography in a pleural effusion modelJeronimo Graf
Department of Pulmonary Research, Regions Hospital, 640 Jackson Street, St Paul MN 55101, USA
Respir Care 55:1464-8. 2010..We simultaneously evaluated FRC-CT and FRC determined by a ventilator-incorporated wash-in/wash-out (FRC-WI/WO) method in an animal model of unilateral pleural effusion that varied the fluid volume instilled and the applied PEEP... - Pressure-flow signatures of central-airway mucus pluggingMaryam Zamanian
University of Minnesota, Minneapolis-St. Paul, MN, USA
Crit Care Med 34:223-6. 2006..MAIN RESULTS: Four newly observed signs were recorded that may serve to identify occult central airway mucus plugging in the ventilated asthmatic patient... - Lung injury--settle for a sketch or design a blueprint?John J Marini
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Crit Care Med 36:2922-5. 2008 - Semi-quantitative tracking of intra-airway fluids by computed tomographyJeronimo Graf
Pulmonary and Critical Care Research, Regions Hospital, St Paul, MN 55101, USA
Clin Physiol Funct Imaging 29:406-13. 2009..Airway secretions are a source of complications for patients with acute and chronic lung diseases, yet lack of techniques to quantitatively track secretions hampers research into clinical measures to reduce their pathologic consequences... - The pragmatics of prone positioningErica Messerole
Department of Medicine, Regions Hospital and University of Minnesota, Minneapolis, Minnesota, USA
Am J Respir Crit Care Med 165:1359-63. 2002 - How best to recruit the injured lung?John J Marini
Pulmonary and Critical Care Medicine, Regions Hospital, University of Minnesota, Minneapolis St Paul, MN 55101, USA
Crit Care 12:159. 2008..Although a wide variety of recruiting maneuvers have been described, the technique that strikes the best balance between efficacy and risk may well vary among patients with differing right heart loading status and lung properties... - Pulmonary microvascular fracture in a patient with acute respiratory distress syndromeJohn R Hotchkiss
Department of Critical Care Medicine, Regions Hospital and University of Minnesota Medical School, St. Paul, MN, USA
Crit Care Med 30:2368-70. 2002..FINDINGS: Multiple gross disruptions of the alveolar walls, suggestive of stress fractures. CONCLUSION: High-pressure mechanical ventilation may promote fracturing of the alveolar blood:airspace barrier... - Bench-to-bedside review: microvascular and airspace linkage in ventilator-induced lung injuryJohn J Marini
Professor, University of Minnesota, Regions Hospital, St Paul, Minnesota, USA
Crit Care 7:435-44. 2003..Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS... - Do airway secretions play an underappreciated role in acute respiratory distress syndrome?Jeronimo Graf
University of Minnesota, Minneapolis St Paul, Minnesota, USA
Curr Opin Crit Care 14:44-9. 2008.... - Oscillations and noise: inherent instability of pressure support ventilation?John R Hotchkiss
Section of Pulmonary and Critical Care and Section of Surgery, Regions Hospital and University of Minnesota, St Paul, Minnesota 55101, USA
Am J Respir Crit Care Med 165:47-53. 2002..In both mathematical and mechanical models, unstable behavior occurred at impedance values and ventilator settings that are clinically realistic... - Dynamic behavior during noninvasive ventilation: chaotic support?J R Hotchkiss
Section of Pulmonary and Critical Care, Regions Hospital and University of Minnesota, St Paul, Minnesota 55101, USA
Am J Respir Crit Care Med 163:374-8. 2001..The unstable behavior was observed in the simplest plausible mathematical models, and occurred at impedance values and ventilator settings that are clinically realistic... - Static and dynamic pressure-volume curves reflect different aspects of respiratory system mechanics in experimental acute respiratory distress syndromeA B Adams
Pulmonary Research Laboratory, Regions Hospital, St Paul, Minnesota 55101 2595, USA
Respir Care 46:686-93. 2001..Dynamic pressure-volume (DPV) curves obtained during tidal ventilation are effortlessly displayed on modern mechanical ventilator monitors and bear a theoretical but unproven relationship to the more labor-intensive SPV curves... - Pro/con clinical debate: the use of prone positioning in the management of patients with acute respiratory distress syndromeJohn J Marini
University of Minnesota, USA
Crit Care 6:15-7. 2002 - Distal projection of insufflated gas during tracheal gas insufflationChristopher S Carter
Regions Hospital, St. Paul, MN 55101, USA
J Appl Physiol 92:1843-50. 2002..We conclude that forward-directed TGI penetrates a substantial distance into the central airways, extending the compartment susceptible to CO2 washout... - A proposed curvilinearity index for quantifying airflow obstructionChang Jiang Zheng
Department of Occupational and Environmental Medicine, Regions Hospital, 640 Jackson Street, St Paul, MN 55101, USA
Respir Care 51:40-5. 2006..Currently there is no available index to quantify a pathological contour of curvilinearity... - Ventilation of patients with asthma and chronic obstructive pulmonary diseaseYin Peigang
Pulmonary Department, Regions Hospital, St. Paul, Minnesota 55101, USA
Curr Opin Crit Care 8:70-6. 2002..When feasible, noninvasive ventilation often facilitates the weaning of ventilator-dependent patients with COPD and shortens the patient's stay in the intensive care unit... - High dose insulin in toxic cardiogenic shockJoel S Holger
Department of Emergency Medicine, Regions Hospital, St Paul, MN 55101, USA
Clin Toxicol (Phila) 47:303-7. 2009..To report the successful use of high dose insulin (HDI) in previously unreported insulin dosing ranges in a patient with severe myocardial toxicity due to an amitriptyline and citalopram overdose... - Safer ventilation of the injured lung: one step closerJohn J Marini
Regions Hospital MS 11203B, University of Minnesota, 640 Jackson Street, St Paul, MN 55101 2595, USA
Crit Care 14:192. 2010..Quantitative bedside imaging techniques that are sensitive to regional mechanics and tidal events hold potential for information delivery that cannot be realized by pressure-volume monitoring alone... - Microvasculature in ventilator-induced lung injury: target or cause?J J Marini
University of Minnesota, St Paul, MN 55101, USA
Minerva Anestesiol 70:167-73. 2004..Raising ventilation frequency may also have cost. Such observations imply that reducing the demands for blood flow and ventilation are important considerations in formulating a lung protective approach to mechanical ventilation of ARDS... - How to recruit the injured lungJ J Marini
Professor of Medicine, University of Minnesota, Minneapolis, MN 55101, USA
Minerva Anestesiol 69:193-200. 2003..In conclusion, The "Open lung" approach should not be applied to every patient; it should be reserved to restore lung volume if deterioration occurs, by means of adequate PEEP level and lowest acceptable FiO(2)... - Effects of mean airway pressure and tidal excursion on lung injury induced by mechanical ventilation in an isolated perfused rabbit lung modelA F Broccard
Division of Pulmonary and Critical Care Medicine, University of Minnesota, Minneapolis, USA
Crit Care Med 27:1533-41. 1999..To study the relative contributions of mean airway pressure (mPaw) and tidal excursion (V(T)) to ventilator-induced lung injury under constant perfusion conditions... - Relative roles of vascular and airspace pressures in ventilator-induced lung injuryJ R Hotchkiss
Department of Pulmonary and Critical Care Medicine, Regions Hospital, University of Minnesota, St. Paul, MN, USA
Crit Care Med 29:1593-8. 2001.... - Lung stress and strain during mechanical ventilation for acute respiratory distress syndromeDavide Chiumello
Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
Am J Respir Crit Care Med 178:346-55. 2008..Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio)... - Monitoring the mechanically ventilated patientVasileios Bekos
Department of Intensive Care, Naval Hospital of Athens, 229 Messogion Avenue, 15561 Cholargos, Athens, Greece
Crit Care Clin 23:575-611. 2007..We concentrate on those modalities and variables that are routinely available or easily calculated from data readily collected at the bedside... - Lung protection in acute respiratory distress syndrome: the neglected vascular sideJohn J Marini
Crit Care Med 35:1796-7. 2007 - Effect of core body temperature on ventilator-induced lung injurySo Suzuki
Department of Traumatology, University of Tokyo, Japan
Crit Care Med 32:144-9. 2004..Similar results from both the in vivo and isolated, perfused lung studies suggest that the observed effects were not due to cardiovascular factors or consequences of heating nonpulmonary organs... - Effects of ventilatory pattern on experimental lung injury caused by high airway pressureDana A Simonson
Department of Pulmonary and Critical Care Medicine, Regions Hospital/HealthPartners and University of Minnesota Medical School, USA
Crit Care Med 32:781-6. 2004..CONCLUSIONS: In this preclinical model, lung injury was attenuated by decreasing inspiratory time. As lung injury occurred, tidal volume increased and airway pressure waveform changed... - Mechanical ventilation in sepsis-induced acute lung injury/acute respiratory distress syndrome: an evidence-based reviewJonathan E Sevransky
Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Crit Care Med 32:S548-53. 2004..Weaning protocols should be in place that include spontaneous breathing trials and criteria for initiating such trials. The role of high-frequency oscillatory ventilation and airway pressure release ventilation in ARDS is uncertain... - Lessons learned: the conditional importance of high positive end-expiratory pressure in acute respiratory distress syndromeJohn J Marini
Crit Care Med 34:1540-2. 2006 - Relative importance of stretch and shear in ventilator-induced lung injuryJohn J Marini
Crit Care Med 32:302-4. 2004 - The "open lung" compromiseJohn J Marini
Intensive Care Med 33:1114-6. 2007 - Breathing patterns as integrative weaning predictors: Variations on a themeJohn J Marini
Crit Care Med 34:2241-3. 2006 - Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008R Phillip Dellinger
Cooper University Hospital, Camden, NJ, USA
Crit Care Med 36:296-327. 2008..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004... - Auto-peep with low tidal volumeJohn J Marini
Am J Respir Crit Care Med 167:1150-1; author reply 1151. 2003 - Efficacy of lung recruiting maneuvers: it's all relativeJohn J Marini
Crit Care Med 31:641-2. 2003 - Early phase of lung-protective ventilation: a place for paralytics?John J Marini
Crit Care Med 34:2851-3. 2006 - Randomized, controlled trials in critical care: an expert interview with John J. Marini, MD [interviewed by Antonios Liolios, MD]John J Marini
MedGenMed 5:26. 2003 - The deceptive complexity of "simple" proningJohn J Marini
Crit Care Med 32:2156-7. 2004 - Optimized positive end-expiratory pressure--an elusive targetDavid J Dries
Crit Care Med 30:1159-60. 2002 - Auto-positive end-expiratory pressure and flow limitation in adult respiratory distress syndrome--intrinsically different?John J Marini
Crit Care Med 30:2140-1. 2002 - Positive end-expiratory pressure in severe airflow obstruction: more than a "one-trick pony"?John J Marini
Crit Care Med 33:1652-3. 2005 - Are recruiting maneuvers needed when ventilating acute respiratory distress syndrome?John J Marini
Crit Care Med 31:2701-3. 2003