Research Topics
Genomes and Genes
| Michael ZeisbergSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
The role of epithelial-to-mesenchymal transition in renal fibrosisMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
J Mol Med 82:175-81. 2004..Such antagonism results in the repair of injured kidneys, suggesting that modulation of epithelial cell plasticity has therapeutic advantages...- Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidneyMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 280:8094-100. 2005.... - Renal fibroblasts and myofibroblasts in chronic kidney diseaseFrank Strutz
Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Goettingen, Germany
J Am Soc Nephrol 17:2992-8. 2006 - Fibroblasts emerge via epithelial-mesenchymal transition in chronic kidney fibrosisMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Front Biosci 13:6991-8. 2008..While knowledge regarding EMT was previously based on experimental rodent studies, in recent years the evolving evidence demonstrates a role for EMT in human kidney diseases with chronic fibrosis... - Biomarkers for epithelial-mesenchymal transitionsMichael Zeisberg
Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 119:1429-37. 2009.... - Mechanisms of tubulointerstitial fibrosisMichael Zeisberg
Division of Matrix Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Am Soc Nephrol 21:1819-34. 2010..How to prevent chronic kidney disease from progressing to renal failure awaits even deeper biochemical understanding... - Resolved: EMT produces fibroblasts in the kidneyMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Am Soc Nephrol 21:1247-53. 2010..For 15 years, EMT has also been viewed as a principal source of fibroblasts in tissue fibrosis. Because several recent studies question its role in fibrogenesis, it seems like a good time for debate... - Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrinYuki Hamano
Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cancer Cell 3:589-601. 2003..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth... - Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transitionElisabeth M Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Am Soc Nephrol 19:2282-7. 2008..Collectively, our results demonstrate that EndMT contributes to the accumulation of activated fibroblasts and myofibroblasts in kidney fibrosis and suggest that targeting EndMT might have therapeutic potential... - Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney diseaseMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
PLoS Med 3:e100. 2006..The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood... - Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transitionMichael Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts 02215, USA
J Biol Chem 282:23337-47. 2007..Furthermore, our findings suggest that EMT is a promising therapeutic target for the attenuation of liver fibrosis... - Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosisSarah N Flier
Division of Matrix Biology, Dept of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 3 Blackfan Circle, Rm 11090, Boston, MA 02215, USA
J Biol Chem 285:20202-12. 2010.... - De-differentiation of primary human hepatocytes depends on the composition of specialized liver basement membraneMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Mol Cell Biochem 283:181-9. 2006..These findings suggest that the composition of liver basement membrane is important for the maintenance of hepatocyte viability and provide anti-de-differentiation clues... - Animal models of renal fibrosisMichael Zeisberg
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Methods Mol Med 117:261-72. 2005..In this chapter, the mouse models of nephrotoxic serum nephritis, COL4A3-deficiency, and unilateral urethral obstruction, which all result reliably into renal fibrosis, are described... - Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitorsHikaru Sugimoto
Harvard Medical School, Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Diabetes 56:1825-33. 2007..Collectively, our results report a new mouse model for diabetic nephropathy with prominent interstitial inflammation and fibrosis and the selective inhibition of diabetic kidney disease by AGE inhibitors and BMP-7... - Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblastsElisabeth M Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Cancer Res 67:10123-8. 2007.... - Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse modelsMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Am J Physiol Renal Physiol 285:F1060-7. 2003..Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology... - BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injuryMichael Zeisberg
Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Med 9:964-8. 2003..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease... - Methylation determines fibroblast activation and fibrogenesis in the kidneyWibke Bechtel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 16:544-50. 2010..These studies demonstrate that epigenetic modifications may provide a molecular basis for perpetuated fibroblast activation and fibrogenesis in the kidney... - BMP-7 functions as a novel hormone to facilitate liver regenerationHikaru Sugimoto
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
FASEB J 21:256-64. 2007..Collectively, our results argue for the role of BMP-7 as a kidney- and bone-produced endogenous regulator of hepatocyte health... - VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonizationJoyce T O'Connell
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 108:16002-7. 2011..Our study demonstrates a crucial role for local S100A4(+) fibroblasts in providing the permissive "soil" for metastatic colonization, a challenging step in the metastatic cascade... - Integrin alpha1beta1 and alpha2beta1 are the key regulators of hepatocarcinoma cell invasion across the fibrotic matrix microenvironmentChangqing Yang
Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 63:8312-7. 2003.... - Transcriptional regulation of epithelial-mesenchymal transitionYingqi Teng
Division of Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 117:304-6. 2007..Collectively, their results suggest that this complex is an important regulator of the EMT transcriptome... - Endothelial-to-mesenchymal transition contributes to cardiac fibrosisElisabeth M Zeisberg
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Med 13:952-61. 2007..Our findings show that EndMT contributes to the progression of cardiac fibrosis and that rhBMP-7 can be used to inhibit EndMT and to intervene in the progression of chronic heart disease associated with fibrosis... - Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factorsChangqing Yang
Program in Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Gastroenterology 124:147-59. 2003..Additionally, our data provide strong evidence for MMPs in regulation of HSCs migration... - Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient miceParaskevi A Farazi
Department of Medical Oncology and Center for Applied Cancer Science, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cancer Res 66:6622-7. 2006..Thus, p53 deficiency, chronic bile duct injury/proliferation, and the fibrotic matrix microenvironment cooperate to induce intrahepatic CCA, highlighting the key role of the ECM microenvironment in this common liver cancer... - Fibroblasts in cancerRaghu Kalluri
Center for Matrix Biology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Rev Cancer 6:392-401. 2006..Fibroblasts are therefore a key determinant in the malignant progression of cancer and represent an important target for cancer therapies... - Twist: a new link from hypoxia to fibrosisWibke Bechtel
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Kidney Int 75:1255-6. 2009..This study provides clues as to how hypoxia and transforming growth factor-beta can collaborate to drive renal fibrogenesis... - Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrinsAkulapalli Sudhakar
Program in Matrix Biology, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 100:4766-71. 2003..Collectively, such distinct properties of human tumstatin and human endostatin provide the first insight into their diverse antiangiogenic actions and argue for combining them for targeting tumor angiogenesis... - Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cellsMichael Zeisberg
Department of Medicine and the Liver Center, Program in Matrix Biology, Renal, and Gastroenterology Divisions, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Pathol 160:2001-8. 2002.... - Endogenous stimulators and inhibitors of angiogenesis in gastrointestinal cancers: basic science to clinical applicationMalin Sund
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02125, USA
Gastroenterology 129:2076-91. 2005.... - Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cellsMichael Zeisberg
Program in Matrix Biology, Renal and Gastroenterology Divisions, Department of Medicine and the Liver Center, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Biochem Biophys Res Commun 295:401-7. 2002.... - Experimental strategies to reverse chronic renal diseaseMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Blood Purif 22:440-5. 2004..This review summarizes the recent therapeutic advances using experimental models that might translate into novel human therapies to prevent, or significantly delay, requirement of renal replacement therapy... - Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosisHikaru Sugimoto
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Nat Med 18:396-404. 2012..Our studies show that BMP signaling agonists constitute a new line of therapeutic agents with potential utility in the clinic to induce regeneration, repair and reverse established fibrosis... - Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney diseaseMichael Zeisberg
Pediatr Nephrol 23:1395-8. 2008..Here we summarize recent insights into the role of BMP7 in acute and chronic kidney injury and discuss the implications for future directions of antifibrotic therapies... - Are there endogenous molecules that protect kidneys from injury? The case for bone morphogenic protein-7 (BMP-7)Michael Zeisberg
Nephrol Dial Transplant 19:759-61. 2004 - Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformationFrank Strutz
Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
Kidney Int 61:1714-28. 2002....
Research Grants
- Re-Induction of Developmental Programs during Chronic Renal InjuryMichael Zeisberg; Fiscal Year: 2007..The study aims proposed in this application are centered around testing the potential role of fibroblasts in the repair of renal injury and they attempt to further analyze the preliminary phenotypic observation at a molecular level. ..