Research Topics
Genomes and GenesSpecies | Zhigang XieSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migrationZhigang Xie
Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Cell 114:469-82. 2003..Taken together, these results suggest that Cdk5 phosphorylation of FAK is critical for neuronal migration through regulation of a microtubule fork important for nuclear translocation...- Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor poolZhigang Xie
Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 56:79-93. 2007..We propose that sustaining INM may be a mechanism by which microtubule-regulating proteins maintain the neural progenitor pool during neocortical development... - Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cellsZhigang Xie
Department of Neurosurgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Neurosurg Focus 24:E25. 2008..Finally, they discuss preliminary evidence that mechanisms of BTSC-associated infiltrativeness may be similar to those underlying the migration of NPSCs and neurons... - Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migrationZhigang Xie
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Cycle 3:108-10. 2004..Our study reveals a similarity between Cdk5 and Cdk1 in the regulation of neuronal migration and cell division, respectively. In addition, our study implicates FAK in a signaling pathway that directly regulates microtubules... - Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migrationZhigang Xie
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Cereb Cortex 16:i64-8. 2006.... - Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioningTianzhi Shu
Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Neuron 44:263-77. 2004..These results provide strong evidence that Ndel1 interacts with LIS1 to sustain the function of dynein, which in turn impacts microtubule organization, nuclear translocation, and neuronal positioning... - Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowthDavid A Davis
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
PLoS Biol 7:e1000208. 2009..Together, these data suggest that Capzb2 plays an important role in growth cone formation and neurite outgrowth and that the underlying mechanism may involve direct interaction between Capzb2 and microtubules... - Brain tumor stem cellsZhigang Xie
Department of Neurosurgery, Boston University School of Medicine, 720 Harrison Avenue, Suite 7600, Boston, MA 02118, USA
Neurochem Res 34:2055-66. 2009..Targeting these pathways and the vascular niche could be a principle in novel brain tumor therapies aimed to eliminate BTSCs... - FMRP regulates the transition from radial glial cells to intermediate progenitor cells during neocortical developmentRoya Saffary
Department of Neurosurgery, Boston Medical Center, Boston, MA 02118, USA
J Neurosci 31:1427-39. 2011..Our data suggest that FMRP suppresses the transition from RGCs to IPCs during neocortical development by an actin-dependent mechanism...