Research Topics
Genomes and Genes | Eric J VallenderSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Expanding whole exome resequencing into non-human primatesEric J Vallender
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
Genome Biol 12:R87. 2011..If the tools that have been developed in humans for complete exome resequencing can be applied to closely related non-human primate species, then these difficulties can be circumvented...- Quantitative molecular assessment of chimerism across tissues in marmosets and tamarinsCarolyn G Sweeney
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
BMC Genomics 13:98. 2012..abstract:.. - Genetic correlates of the evolving primate brainEric J Vallender
New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
Prog Brain Res 195:27-44. 2012..Nevertheless, a strong foundation has been built upon which future studies will emerge... - Bioinformatic approaches to identifying orthologs and assessing evolutionary relationshipsEric J Vallender
Division of Neurosciences, New England Primate Research Center, Harvard Medical School, Pine Hill Drive, Southborough Campus, Southborough, MA 01772, USA
Methods 49:50-5. 2009..Through these steps any researcher seeking to make use of non-human primate genetic information will have the tools at their disposal to ascertain where errors exist and to remedy them once encountered... - Genetic basis of human brain evolutionEric J Vallender
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Trends Neurosci 31:637-44. 2008..Here, we provide a general review of recent findings into the genetic basis of human brain evolution, highlight the most notable trends that have emerged and caution against over-interpretation of current data... - Exploring the origins of the human brain through molecular evolutionEric J Vallender
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Brain Behav Evol 72:168-77. 2008.... - Uncovering the mutation-fixation correlation in short lineagesEric J Vallender
Howard Hughes Medical Institute, Department of Human Genetics, and Committee on Genetics, University of Chicago, USA
BMC Evol Biol 7:168. 2007..Alternatively, it may reflect a biologically meaningful difference between various lineages. Finally, the lack of positive correlation in short lineages may be the result of methodological artifacts... - Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogsEric J Vallender
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
BMC Evol Biol 10:51. 2010..Other trace amine associated receptors appear to relate to environmental perception and show a birth-and-death pattern in mammals similar to olfactory receptors... - Comparative genetic approaches to the evolution of human brain and behaviorEric J Vallender
New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
Am J Hum Biol 23:53-64. 2011.... - Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiensNitzan Mekel-Bobrov
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Science 309:1720-2. 2005..These findings, especially the remarkably young age of the positively selected variant, suggest that the human brain is still undergoing rapid adaptive evolution... - Microcephalin, a gene regulating brain size, continues to evolve adaptively in humansPatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Science 309:1717-20. 2005..It also makes Microcephalin an attractive candidate locus for studying the genetics of human variation in brain-related phenotypes... - Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic associationZhihua Xie
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
J Neurosci Res 86:3435-46. 2008..Together, the data reveal that TAAR6 is unresponsive to brain monoamines and is not expressed in rhesus monkey brain monoaminergic nuclei, suggesting TAAR6 lacks direct association with brain monoaminergic neuronal function... - Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineagePatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 103:18178-83. 2006..The interhaplogroup divergence test developed here may be broadly applicable to the detection of introgression at other loci in the human genome or in genomes of other species... - Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primatesSteve Dorus
Department of Human Genetics, Howard Hughes Medical Institute, USA
Hum Mol Genet 15:2031-7. 2006.... - Accelerated evolution of nervous system genes in the origin of Homo sapiensSteve Dorus
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Cell 119:1027-40. 2004.... - SPEED: a molecular-evolution-based database of mammalian orthologous groupsEric J Vallender
Department of Human Genetics and Committee on Genetics, Howard Hughes Medical Institute, University of Chicago 920 East 58th Street, Chicago, IL 60637, USA
Bioinformatics 22:2835-7. 2006..AVAILABILITY: See http://bioinfobase.umkc.edu/speed/ for access... - A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathwayEric J Vallender
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL, USA
Hum Mol Genet 15:3034-40. 2006..Our results also lend further support to the hypothesis that genes regulating brain size during development might have played a particularly important role in transforming brain size during evolution... - Human expression variation in the mu-opioid receptor is paralleled in rhesus macaqueEric J Vallender
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
Behav Genet 38:390-5. 2008..Together, the functional variations reported here have implications for future studies seeking to model the opioid system and its associated phenotypes in rhesus macaques... - Normal thermoregulatory responses to 3-iodothyronamine, trace amines and amphetamine-like psychostimulants in trace amine associated receptor 1 knockout miceHelen N Panas
Division of Neuroscience, Harvard Medical School NEPRC, Southborough, MA, USA
J Neurosci Res 88:1962-9. 2010..Accordingly, TAAR1-directed compounds will likely not affect thermoregulation nor are they likely to be cryogens... - The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysisGuo Lin Chen
Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
Horm Behav 57:184-91. 2010..Our findings strengthen the involvement of G x E interactions at the loci of serotonergic genes and the utility of the nonhuman primate to model G x E interactions in the development of human neuropsychiatric diseases... - Reconstructing the evolutionary history of microcephalin, a gene controlling human brain sizePatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 13:1139-45. 2004..We therefore propose that genes regulating brain size during development may have the general propensity to contribute to brain evolution in primates and particularly humans... - Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJPatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Gene 375:75-9. 2006.... - Polymorphisms in the 3' UTR of the serotonin transporter are associated with cognitive flexibility in rhesus macaquesEric J Vallender
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
Am J Med Genet B Neuropsychiatr Genet 150:467-75. 2009.... - A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rateGerald J Wyckoff
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Trends Genet 21:381-5. 2005..This finding cannot be reconciled with current theories. It suggests that we should re-evaluate the current paradigms of coding-sequence evolution, and that the wide use of K(a)/K(s) as a measure of selective strength needs reassessment... - Diverse fates of paralogs following segmental duplication of telomeric genesAndrew Wong
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Genomics 84:239-47. 2004..This study shows the importance of paralogous regions in the generation of transcriptional diversity and highlights the significance that large-scale telomeric duplication may play in this process... - Effects of chromosomal rearrangements on human-chimpanzee molecular evolutionEric J Vallender
Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA
Genomics 84:757-61. 2004..Our results offer a general cautionary note on the importance of controlling for hidden factors in studies involving bioinformatic surveys... - Growth-associated protein-43 and ephrin B3 induction in the brain of adult SIV-infected rhesus macaquesSusan V Westmoreland
Division of Comparative Pathology, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
J Neurovirol 17:455-68. 2011.... - Rhesus monkey trace amine-associated receptor 1 signaling: enhancement by monoamine transporters and attenuation by the D2 autoreceptor in vitroZhihua Xie
Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Southborough, MA 01772, USA
J Pharmacol Exp Ther 321:116-27. 2007.... - Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitroGuo Lin Chen
New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772 9102, USA
Hum Genet 122:645-57. 2008..In conclusion, our present study demonstrates that both the 5'-UTR and common polymorphisms (especially the 90A/G) in the 5' regulatory region of human TPH2 have a significant impact on gene expression... - Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humansPatrick D Evans
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 13:489-94. 2004..We therefore conclude that ASPM underwent strong adaptive evolution in the descent of Homo sapiens, which is consistent with its putative role in the evolutionary enlargement of the human brain... - A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeysEric J Vallender
New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
Drug Alcohol Depend 109:252-6. 2010..Naltrexone, an antagonist at the receptor, has been used to treat alcoholism in humans and has been reported to show differences in effectiveness depending on genotype... - Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selectionOmer Gokcumen
Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Genome Biol 12:R52. 2011..Copy number variants (CNVs), defined as losses and gains of segments of genomic DNA, are a major source of genomic variation... - Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomesSun Shim Choi
Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, USA
Mol Biol Evol 23:2131-3. 2006..Through this analysis, we offer quantitative information on how 3D structural contexts affect the level of selective constraint... - Multiple independent origins of sex chromosomes in amniotesEric J Vallender
New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, Southborough, MA 01772-9102, USA
Proc Natl Acad Sci U S A 103:18031-2. 2006 - Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1Cindy Achat-Mendes
Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, United States
Pharmacol Biochem Behav 101:201-7. 2012..Collectively, these findings provide support for a regulatory role of TAAR1 in methamphetamine signaling... - How mammalian sex chromosomes acquired their peculiar gene contentEric J Vallender
Howard Hughes Medical Institute and Department of Human Genetics, University of Chicago, IL 60637, USA
Bioessays 26:159-69. 2004..Our discussion will focus on the mammalian sex chromosomes, but will cross reference other species where appropriate... - Positive selection on the human genomeEric J Vallender
Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA
Hum Mol Genet 13:R245-54. 2004..Here, we present a comprehensive review of these genes, and their implications for human evolution... - Evolutionary and biomedical insights from the rhesus macaque genomeRichard A Gibbs
Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA
Science 316:222-34. 2007..The complete description of the macaque genome blueprint enhances the utility of this animal model for biomedical research and improves our understanding of the basic biology of the species... - Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent hostAndy Peng Xiang
Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, Guangzhou 510080, China
Hum Mol Genet 17:27-37. 2008..Furthermore, our study demonstrates that mammalian evolution can proceed at two starkly contrasting levels: significant divergence in genome and proteome sequence, yet striking conservation in developmental programs... - The X chromosome: not just her brother's keeperEric J Vallender
Nat Genet 37:343-5. 2005 - Analysis of copy number variation in the rhesus macaque genome identifies candidate loci for evolutionary and human disease studiesArthur S Lee
Department of Pathology, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
Hum Mol Genet 17:1127-36. 2008..Therefore, the rhesus macaque offers an intriguing, non-human primate outbred model organism with which hypotheses concerning the specific functions of phenotypically relevant human CNVs can be tested...
Research Grants
- Functional genetic evolution of human brain and behaviorEric J Vallender; Fiscal Year: 2010..This work will allow us to better understand how the human brain works, what goes wrong in neuropsychiatric disorders and ways in which we might develop better animal models for studying human disease. ..
- Modeling the Neurogenetics of Serotonin RegulationERIC VALLENDER; Fiscal Year: 2007..Developing non-human primate models of this variation allows not only for a greater examination of the mechanisms and pathologies of the disease, but also allows for the development of highly translational novel treatments. ..