Krzysztof Trzcinski

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Construction of otherwise isogenic serotype 6B, 7F, 14, and 19F capsular variants of Streptococcus pneumoniae strain TIGR4
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Appl Environ Microbiol 69:7364-70. 2003
  2. ncbi Single-step capsular transformation and acquisition of penicillin resistance in Streptococcus pneumoniae
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Bacteriol 186:3447-52. 2004
  3. ncbi Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Room 903, Building 1, 665 Huntington Ave, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 49:1591-2. 2005
  4. ncbi Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells
    Krzysztof Trzcinski
    Harvard School of Public Health, Department of Epidemiology, 665 Huntington Avenue, Building 1, Room 903, Boston, MA 02115, USA
    Infect Immun 76:2678-84. 2008
  5. ncbi Incremental increase in fitness cost with increased beta -lactam resistance in pneumococci evaluated by competition in an infant rat nasal colonization model
    Krzysztof Trzcinski
    Department of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Infect Dis 193:1296-303. 2006
  6. ncbi Pneumococcal capsular polysaccharide structure predicts serotype prevalence
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    PLoS Pathog 5:e1000476. 2009
  7. ncbi Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Infect Dis 196:1221-7. 2007
  8. ncbi SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model
    Gili Regev-Yochay
    Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Bacteriol 189:6532-9. 2007
  9. ncbi Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence
    Alan Basset
    Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston, Enders 861 3, Boston, MA 02115, USA
    J Clin Microbiol 45:1684-9. 2007
  10. ncbi Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model
    Krzysztof Trzcinski
    Department of Epidemiology and Immunology, Harvard School of Public Health, Boston, MA 02115, USA
    Infect Immun 73:7043-6. 2005

Detail Information

Publications14

  1. ncbi Construction of otherwise isogenic serotype 6B, 7F, 14, and 19F capsular variants of Streptococcus pneumoniae strain TIGR4
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Appl Environ Microbiol 69:7364-70. 2003
    ..The constructed capsular variants of TIGR4 are suitable for use in studies on the role of S. pneumoniae capsular polysaccharide in immunity, colonization, and pathogenesis...
  2. ncbi Single-step capsular transformation and acquisition of penicillin resistance in Streptococcus pneumoniae
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Bacteriol 186:3447-52. 2004
    ..This suggests that in natural settings selection by host immunity and selection by antibiotics may be interrelated because of "hitchhiking" effects due to linkage of resistance determinants and the capsule locus...
  3. ncbi Capsule homology does not increase the frequency of transformation of linked penicillin binding proteins PBP 1a and PBP 2x in Streptococcus pneumoniae
    Krzysztof Trzcinski
    Department of Epidemiology, Harvard School of Public Health, Room 903, Building 1, 665 Huntington Ave, Boston, Massachusetts 02115, USA
    Antimicrob Agents Chemother 49:1591-2. 2005
    ..Transformation rates in homologous donor-recipient pairs were no higher than expected, falsifying this hypothesis...
  4. ncbi Protection against nasopharyngeal colonization by Streptococcus pneumoniae is mediated by antigen-specific CD4+ T cells
    Krzysztof Trzcinski
    Harvard School of Public Health, Department of Epidemiology, 665 Huntington Avenue, Building 1, Room 903, Boston, MA 02115, USA
    Infect Immun 76:2678-84. 2008
    ..These results are consistent with the recruitment and/or activation of phagocytic or other nonspecific effectors by antigen-specific CD4(+) T cells...
  5. ncbi Incremental increase in fitness cost with increased beta -lactam resistance in pneumococci evaluated by competition in an infant rat nasal colonization model
    Krzysztof Trzcinski
    Department of Epidemiology and Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Infect Dis 193:1296-303. 2006
    ....
  6. ncbi Pneumococcal capsular polysaccharide structure predicts serotype prevalence
    Daniel M Weinberger
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, USA
    PLoS Pathog 5:e1000476. 2009
    ....
  7. ncbi Strain characteristics of Streptococcus pneumoniae carriage and invasive disease isolates during a cluster-randomized clinical trial of the 7-valent pneumococcal conjugate vaccine
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    J Infect Dis 196:1221-7. 2007
    ..If sustained, such patterns provide some cause for optimism that rapid evolution of PCV escape strains with drug resistance or high virulence is unlikely...
  8. ncbi SpxB is a suicide gene of Streptococcus pneumoniae and confers a selective advantage in an in vivo competitive colonization model
    Gili Regev-Yochay
    Department of Epidemiology and Department of Immunology and Infectious Diseases, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Bacteriol 189:6532-9. 2007
    ..We conclude that a suicide gene of pneumococcus is spxB, which induces an apoptosis-like death in pneumococci and confers a selective advantage in nasopharyngeal cocolonization...
  9. ncbi Association of the pneumococcal pilus with certain capsular serotypes but not with increased virulence
    Alan Basset
    Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston, Enders 861 3, Boston, MA 02115, USA
    J Clin Microbiol 45:1684-9. 2007
    ..3% after 2000; P = 0.019). Therefore, our data show that the pilus is present in a minority of strains and is associated with certain serotypes and that its frequency has been reduced by the conjugate pneumococcal vaccine...
  10. ncbi Antibodies to conserved pneumococcal antigens correlate with, but are not required for, protection against pneumococcal colonization induced by prior exposure in a mouse model
    Krzysztof Trzcinski
    Department of Epidemiology and Immunology, Harvard School of Public Health, Boston, MA 02115, USA
    Infect Immun 73:7043-6. 2005
    ..Concentrations of antibodies to conserved pneumococcal antigens may be correlates of protection without being effectors of protection...
  11. ncbi CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization
    Richard Malley
    Division of Infectious Diseases, Department of Medicine, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:4848-53. 2005
    ..Thus, we find that immunity to pneumococcal colonization can be induced in the absence of antibody, independent of the capsular type, and this protection requires the presence of CD4(+) T cells at the time of challenge...
  12. ncbi Re-emergence of the type 1 pilus among Streptococcus pneumoniae isolates in Massachusetts, USA
    Gili Regev-Yochay
    Division of Infectious Diseases, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Vaccine 28:4842-6. 2010
    ..These emerging piliated non-VT strains are mostly novel clones, with some exceptions. The rise in pilus type 1 frequency across multiple distinct genetic backgrounds suggests that the pilus may confer an intrinsic advantage...
  13. ncbi Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae
    Gili Regev-Yochay
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Bacteriol 188:4996-5001. 2006
    ..These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies...
  14. ncbi MYBBP1A: a new Ipr1's binding protein in mice
    Lei Cai
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 667 Huntington Avenue, Boston, MA 02115, USA
    Mol Biol Rep 37:3863-8. 2010
    ..1 clone 21 cells using co-immunoprecipitation method. And with the constructed high-confidence Ipr1-involved network, we suggested that Ipr1 might be involved in apoptosis pathway via MYBBP1A...