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Genomes and Genes | Keith R SolomonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Ezetimibe is an inhibitor of tumor angiogenesisKeith R Solomon
Dept of Orthopaedic Surgery, Harvard Medical School, Boston, MA 02115, USA
Am J Pathol 174:1017-26. 2009....- The complex interplay between cholesterol and prostate malignancyKeith R Solomon
The Urological Diseases Research Center, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Urol Clin North Am 38:243-59. 2011..The data strongly point to hypercholesterolemia as a risk factor for prostate cancer progression and suggest clinical opportunities for the use of cholesterol-lowering therapies to alter disease course... - Do the cholesterol-lowering properties of statins affect cancer risk?Keith R Solomon
Department of Orthopaedic Surgery, Children s Hospital Boston, Boston, MA 02115, USA
Trends Endocrinol Metab 19:113-21. 2008..Our hypothesis provides a perspective from which mechanistic studies of cholesterol-lowering drugs and cancer, in addition to prospective trials in patients, might be designed... - Cholesterol sensitivity of endogenous and myristoylated AktRosalyn M Adam
Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Cancer Res 67:6238-46. 2007.... - Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenograftsLiyan Zhuang
The Urological Diseases Research Center, Department of Urology, Children's Hospital Boston, Boston, Massachusetts 02115, USA
J Clin Invest 115:959-68. 2005..Our results implicate membrane cholesterol in Akt signaling in both normal and malignant cells and provide evidence that PCa cells can become dependent on a cholesterol-regulated Akt pathway for cell survival... - Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthaseDolores Di Vizio
The Urological Diseases Research Center and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell Cycle 7:2257-67. 2008..These findings suggest that FASN and Cav-1 physically and functionally interact in PCa cells. They also imply that palmitoylation within this complex is involved in tumor growth and survival... - Cholesterol and benign prostate diseaseMichael R Freeman
The Urological Diseases Research Center, Children s Hospital Boston, Enders Research Laboratories, 300 Longwood Ave, Boston, MA 02115, USA
Differentiation 82:244-52. 2011..Here we review the evidence that cholesterol metabolism plays a role in the incidence of benign prostate disease and we highlight possible therapeutic approaches based on this concept... - Cholesterol and cholesterol-rich membranes in prostate cancer: an updateDolores Di Vizio
The Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Tumori 94:633-9. 2008..This hypothesis provides new avenues for mechanistic studies as well as therapeutic intervention... - Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranesMichael R Freeman
Urological Diseases Research Center, Department of Urology, Children s Hospital Boston, Boston, MA 02115, United States
Steroids 72:210-7. 2007..Understanding the manner in which these pathways converge within cholesterol-rich membranes may present new avenues for therapeutic intervention in hormone-dependent cancers... - Involvement of cholesterol-rich lipid rafts in interleukin-6-induced neuroendocrine differentiation of LNCaP prostate cancer cellsJayoung Kim
The Urologic Laboratory, John F. Enders Research Laboratories, Room 1161, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Endocrinology 145:613-9. 2004..Our results also suggest a mechanistic role for membrane cholesterol in cell signaling events relevant to PCa progression... - Ezetimibe reduces enlarged prostate in an animal model of benign prostatic hyperplasiaKristine Pelton
Department of Orthopaedic Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
J Urol 184:1555-9. 2010..We report that the Bio 87.20 hamster strain (Bio Breeders, Watertown, Massachusetts) shows 5?-reductase-sensitive prostate enlargement and a decrease in circulating cholesterol reduces prostate size... - Cholesterol-regulated stress fiber formationMaosong Qi
Department of Orthopaedic Surgery, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Cell Biochem 106:1031-40. 2009..These results demonstrate that cholesterol is a critical regulator of membrane-cytoskeletal dynamics and suggest that altered cholesterol concentrations may result in dramatic changes in cellular responses mediated by the cytoskeleton... - Two different PDGF beta-receptor cohorts in human pericytes mediate distinct biological endpointsChristian Sundberg
Department of Orthopaedic Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
Am J Pathol 175:171-89. 2009..Thus, growth factor receptors are segregated into specific cell membrane compartments that are preferentially activated through different mechanisms of ligand delivery, resulting in distinct biological endpoints... - The role of cholesterol in prostate cancerMartin H Hager
The Urological Diseases Research Center, Department of Urology, Children's Hospital Boston, Massachusetts 02115, USA
Curr Opin Clin Nutr Metab Care 9:379-85. 2006..The identification of cholesterol as a critical component in signal transduction events in prostate cancer cells has not only provided new mechanistic insights but also opened up new avenues for chemotherapeutic intervention... - A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cellsDawn L MacLellan
Department of Urology, The Urological Diseases Research Center, Boston, MA, USA
Proteomics 5:4733-42. 2005..In addition, eight Rho family members were localized to rafts by ICAT analysis. Collectively, these observations suggest a role for lipid rafts in regulation of PDGF-stimulated changes in the cytoskeleton... - Prohibitin is a cholesterol-sensitive regulator of cell cycle transitPei Dong
Department of Orthopaedic Surgery, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
J Cell Biochem 111:1367-74. 2010..We also demonstrate that prohibitin protects cells from apoptosis caused by cholesterol insufficiency. This is the first study tying cholesterol homeostasis to a specific cell cycle regulator that inhibits apoptosis... - Cholesterol and prostate cancerMichael R Freeman
The Urological Diseases Research Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Cell Biochem 91:54-69. 2004.... - HMG-CoA reductase inhibitors induce apoptosis in pericytesKelly Boucher
Department Orthopaedic Surgery, Children's Hospital Boston, Boston, MA 02115, USA
Microvasc Res 71:91-102. 2006.... - Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate developmentPing Ke Fang
Urological Diseases Research Center, Department of Orthopaedic Surgery, Children s Hospital Boston, Harvard Medical School, Enders Research Laboratories, Suite 1161, 300 Longwood Ave, Boston, MA 02115, USA
Am J Pathol 169:2209-22. 2006..Cav-1alpha and -1beta morphants also exhibited disruption in the actin cytoskeleton. These results support important and previously unanticipated roles for the Caveolin-1 isoforms in vertebrate organogenesis... - High-throughput tool for discovery of bone regulating factorsParul Sharma
Childrens Hospital Boston, Boston, MA 02115, USA
Biotechniques 41:539-40, 542. 2006 - Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cellsLiyan Zhuang
The Urologic Laboratory, Department of Urology, Harvard Medical School, Boston, MA 02115, USA
Cancer Res 62:2227-31. 2002..These results suggest that cholesterol present in membrane microdomains is a prominent mediator of survival in prostate cancer cells... - CD109 represents a novel branch of the alpha2-macroglobulin/complement gene familyKeith R Solomon
Department of Orthopaedic Surgery, Children s Hospital, Boston, MA 02115, USA
Gene 327:171-83. 2004..elegans (ZK337.1) and E. coli homologs, we propose CD109 represents a novel and independent branch of the alpha2-macroglobulin/complement gene family (AMCOM) and may be its oldest member... - Toxicity of human pharmaceuticals and personal care products to benthic invertebratesEve B Dussault
Department of Environmental Biology, University of Guelph, Guelph, ON, Canada
Environ Toxicol Chem 27:425-32. 2008..In contrast, our data also indicate that considering the low concentrations currently detected in the environment, ATO and EE(2) pose negligible risks to benthic invertebrates... - Statins and the risk of cancerMichael R Freeman
JAMA 295:2720-1; author reply 2721-2. 2006 - Platelet derived growth factor-BB is a potent mitogen for rat ureteral and human bladder smooth muscle cells: dependence on lipid rafts for cell signalingMaximilain Stehr
J Urol 169:1165-70. 2003.... - Role of temperature and enzyme induction in the biotransformation of polychlorinated biphenyls and bioformation of hydroxylated polychlorinated biphenyls by rainbow trout (Oncorhynchus mykiss)Andrea H Buckman
Department of Environmental Biology, University of Guelph, Guelph, ON, Canada N1G 2W1
Environ Sci Technol 41:3856-63. 2007..The results of this study provide the first in vivo evidence that rainbow trout are responsive to CYP2B-like induction by PCBs and that this enzyme system can influence PCB concentrations and OH-PCB formation in fish...