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Genomes and Genes | Clifford B SaperSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The neuroscience peer review consortiumClifford B Saper
Behavioral and Brain Functions, University of Oslo, Oslo, Norway
Behav Brain Funct 5:4. 2009..In order to encourage dissemination of the details outlined in this Editorial, it will also be published in other journals in the Neuroscience Peer Review Consortium...- The hypothalamic integrator for circadian rhythmsClifford B Saper
Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Trends Neurosci 28:152-7. 2005.... - A guide to the perplexed on the specificity of antibodiesClifford B Saper
Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
J Histochem Cytochem 57:1-5. 2009..In this review, I consider the principles of antibody action and how they define a set of rules for what information should be obtained by the investigator before using an antibody in a serious scientific investigation... - Hypothalamic regulation of sleep and circadian rhythmsClifford B Saper
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02215, USA
Nature 437:1257-63. 2005..These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival... - Standards of evidence in chronobiology: A responsePatrick M Fuller
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
J Circadian Rhythms 7:9. 2009.... - Sleep-dependent memory consolidationRobert Stickgold
Department of Psychiatry, Harvard Medical School, and Centre for Sleep and Cognition, Beth Israel Deaconess Medical Centre, 330 Brookline Avenue FD 861, Boston, Massachusetts 02215, USA
Nature 437:1272-8. 2005..Nevertheless, converging evidence, from the molecular to the phenomenological, leaves little doubt that offline memory reprocessing during sleep is an important component of how our memories are formed and ultimately shaped... - Homeostatic, circadian, and emotional regulation of sleepClifford B Saper
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Comp Neurol 493:92-8. 2005..Understanding the pathways that underlie the regulation of sleep and wakefulness may provide important insights into how the cognitive and emotional systems interact with basic homeostatic and circadian drives for sleep... - The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signalingClifford B Saper
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neuron 65:4-6. 2010.... - Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythmsClifford B Saper
Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Prog Brain Res 153:243-52. 2006..We also review the role of the subparaventricular nucleus and the dorsomedial nucleus of the hypothalamus in circadian integration and modulation of both feeding and wake-sleep patterns... - Biomedicine. Life, the universe, and body temperatureClifford B Saper
Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Science 314:773-4. 2006 - Sleep state switchingClifford B Saper
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Neuron 68:1023-42. 2010..We also review how homeostatic, circadian, and allostatic drives help regulate sleep state switching and discuss how breakdown of the switching mechanism may contribute to sleep disorders such as narcolepsy... - Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environmentHeinrich S Gompf
Department of Neurology, Program in Neuroscience and Division of Sleep Medicine Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Neurosci 30:14543-51. 2010..Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention... - Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythmsThomas C Chou
Department of Neurobiology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 23:10691-702. 2003..Through these pathways, the DMH may influence a wide range of behavioral circadian rhythms... - Parallel preoptic pathways for thermoregulationKyoko Yoshida
Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 29:11954-64. 2009..Our data suggest that the MnPO and DLPO provide parallel inhibitory pathways that tonically inhibit the DMH/DHA and the RMR at baseline, and that hyperthermia requires the release of this inhibition from both nuclei... - Reassessment of the structural basis of the ascending arousal systemPatrick M Fuller
Division of Sleep Medicine, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Comp Neurol 519:933-56. 2011.... - Differential rescue of light- and food-entrainable circadian rhythmsPatrick M Fuller
Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Science 320:1074-7. 2008..These results demonstrate that the dorsomedial hypothalamus contains a Bmal1-based oscillator that can drive food entrainment of circadian rhythms... - EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responsesMichael Lazarus
Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nat Neurosci 10:1131-3. 2007..These observations demonstrate that the EP3R-bearing neurons in the median preoptic nucleus are required for fever responses... - Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleusElda Arrigoni
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Eur J Neurosci 30:2112-20. 2009..LTP in VLPO-lesioned animals was partially restored by adenosine antagonists, suggesting that adenosine accumulation in VLPO-lesioned animals could account for some of the observed synaptic plasticity deficits... - Lateral hypothalamic acetylcholinesterase-immunoreactive neurons co-express either orexin or melanin concentrating hormoneThomas C Chou
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neurosci Lett 370:123-6. 2004..Furthermore, most orexin neurons and MCH neurons appear to contain AChE. AChE immunoreactivity appears to be a key feature of nearly all of the diffusely-projecting cortical systems... - The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythmsJoshua J Gooley
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Nat Neurosci 9:398-407. 2006..These results establish that the neurons of the DMH have a critical role in the expression of food-entrainable circadian rhythms... - A putative flip-flop switch for control of REM sleepJun Lu
Department of Neurology and Program in Neuroscience, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Nature 441:589-94. 2006..The mutually inhibitory interactions of the REM-on and REM-off areas may form a flip-flop switch that sharpens state transitions and makes them vulnerable to sudden, unwanted transitions-for example, in narcolepsy... - Neural circuitry of stress-induced insomnia in ratsGeorgina Cano
Department of Neurology, Beth Israel Deaconess Medical Center, Division of Sleep Medicine and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
J Neurosci 28:10167-84. 2008..These results suggest that shutting down the residual activity of the limbic-arousal system might be a better approach to treat stress-induced insomnia, rather than potentiation of the sleep system, which remains fully active... - Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleepJun Lu
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 22:4568-76. 2002..The connections and physiological activity of the extended VLPO suggest a specialized role in the regulation of REM sleep... - Afferents to the ventrolateral preoptic nucleusThomas C Chou
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 22:977-90. 2002..These robust pathways suggest candidate mechanisms by which sleep may be influenced by brain systems regulating arousal, autonomic, limbic, and circadian functions... - Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptorsTakakazu Oka
Department of Neurology, Beth Israel Deaconess Medical Center and Program in Neuroscience and Harvard Medical School, Boston, MA 02115, USA
J Physiol 551:945-54. 2003.... - Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brainJoseph F Kelly
Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
Diabetes 53:911-20. 2004..Our findings support the hypothesis that CNTF and leptin engage distinct CNS sites and CNTF possesses inflammatory properties distinct from leptin... - A broad role for melanopsin in nonvisual photoreceptionJoshua J Gooley
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 23:7093-106. 2003.... - Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedbackPatrick M Fuller
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Room 814, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
J Biol Rhythms 21:482-93. 2006.... - A neural mechanism for exacerbation of headache by lightRodrigo Noseda
Department of Anesthesia, Boston, Massachusetts, USA
Nat Neurosci 13:239-45. 2010..We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons... - COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in miceDaniel Vardeh
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
J Clin Invest 119:287-94. 2009..Mechanical pain is a major symptom of most inflammatory conditions, such as postoperative pain and arthritis, and induction of COX2 in neural cells in the CNS seems to contribute to this... - A consensus definition of cataplexy in mouse models of narcolepsyThomas E Scammell
Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Sleep 32:111-6. 2009..This working definition provides helpful insights into murine cataplexy and should allow objective and accurate comparisons of cataplexy in future studies using mouse models of narcolepsy... - The ventrolateral preoptic nucleus is not required for isoflurane general anesthesiaMatthias Eikermann
Department of Anesthesia, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
Brain Res 1426:30-7. 2011..We conclude that the sleep loss caused by ablation of VLPO neurons sensitizes animals to the general anesthetic effects of isoflurane, but that the sedation produced by VLPO neurons themselves is not required for isoflurane anesthesia... - Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vectorThomas E Scammell
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Neurosci 23:5762-70. 2003..This transduction knock-out technique holds enormous potential for dissecting the functions of different CNS pathways... - Expression of melanocortin 4 receptor mRNA in the central nervous system of the ratToshiro Kishi
Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 457:213-35. 2003..The distribution of MC4-R mRNA is consistent with the proposed roles of central melanocortin systems in feeding and autonomic regulation... - Expression of ghrelin receptor mRNA in the rat and the mouse brainJeffrey M Zigman
Department of Medicine and Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 494:528-48. 2006.... - Role of endogenous sleep-wake and analgesic systems in anesthesiaJun Lu
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 508:648-62. 2008.... - Is food-directed behavior an appropriate measure of circadian entrainment to restricted daytime feeding?Joshua J Gooley
Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA
J Biol Rhythms 22:479-83. 2007 - The pontine REM switch: past and presentPatrick M Fuller
Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Physiol 584:735-41. 2007..Our findings demonstrating independent pathways mediating atonia and the EEG components of REM provide a basis for their occasional dissociation in pathological states, e.g. REM sleep behaviour disorder... - Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matterJun Lu
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Neurosci 26:193-202. 2006.... - Central neurogenic hyperventilation: a case report and discussion of pathophysiologyAndrew W Tarulli
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Arch Neurol 62:1632-4. 2005..Central neurogenic hyperventilation is a rare condition with poorly understood pathophysiology... - Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neuronsHiroshi Yamamoto
Department of Medicine and Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
J Clin Invest 110:43-52. 2002..These findings suggest that the central GLP-1 system represents a regulator of sympathetic outflow leading to downstream activation of cardiovascular responses in vivo... - The need to feed: homeostatic and hedonic control of eatingClifford B Saper
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neuron 36:199-211. 2002..We also examine the mechanisms for taste and reward systems that provide food with its intrinsically reinforcing properties and explore the links between the homeostatic and hedonic systems that ensure intake of adequate nutrition... - Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brainYi Hong Zhang
Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Comp Neurol 463:3-12. 2003..Although COX-2 plays a dominant role in mediating fever responses to i.v. LPS, at least some components of the response, including avoiding hypothermia and the induction of Fos in the NTS, VLM, PB, and PVH, appear to depend on COX-1. J... - Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization studyDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital East, Room 2625, 149 13th Street, Charlestown, MA 02129, USA
Biol Psychiatry 58:408-16. 2005..In a previous postmortem study, we found a reduction in the density of striatal interneurons that stain immunohistochemically for choline acetyltransferase (ChAT) in schizophrenia... - Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysisAndrew S P Lim
Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Sleep 34:1569-81. 2011..We then applied this to the study of the temporal dynamics of rest-activity patterns in older individuals... - The central autonomic nervous system: conscious visceral perception and autonomic pattern generationClifford B Saper
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Annu Rev Neurosci 25:433-69. 2002..These pattern generators are located at multiple levels of the central nervous system, and they can be combined in temporal and spatial patterns to subserve a wide range of behavioral needs... - Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in ratsTakakazu Oka
Department of Neurology and Program in Neuroscience, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
Brain Res 968:256-62. 2003..In contrast, ONO-AE1-329, an EP4 receptor agonist, decreased the T(c). These findings suggest that the EP1, EP3, and EP4 receptors all may contribute to the thermoregulatory response to PGE2, but each may have a different role... - Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in ratsDmitry Gerashchenko
West Roxbury Veterans Affairs Medical Center, West Roxbury, Massachusetts 02132, USA
Sleep 27:1275-81. 2004..CONCLUSION: The absence of gross changes in sleep after extensive loss of histaminergic neurons suggests that this system is not critical for spontaneous wakefulness... - Orexin, drugs and motivated behaviorsThomas E Scammell
Nat Neurosci 8:1286-8. 2005 - The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effectsLaura E Nelson
Department of Anaesthetics, Imperial College of Science, Technology and Medicine, London, United Kingdom
Anesthesiology 98:428-36. 2003..The increased release of GABA at the terminals of the VLPO inhibits TMN firing, which is required for the sedative response... - Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptorsHiroyoshi Tsuchiya
Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences and Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
J Biol Chem 283:11064-71. 2008..These results indicate that PGE(2)-EP3 signaling elicits G(i/o) activation in preoptic thermocenter neurons, and we propose the possibility that a rapid decrease in preoptic GABA(A) expression may be involved in PGE(2)-induced fever... - Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndromePaul S A Kalanithi
Child Study Center and Department of Neurobiology, Yale University, New Haven, CT 06520
Proc Natl Acad Sci U S A 102:13307-12. 2005..The imbalance in striatal and GPi inhibitory neuron distribution suggests that the functional dynamics of cortico-striato-thalamic circuitry are fundamentally altered in severe, persistent TS... - Orexins: looking forward to sleep, back at addictionThomas E Scammell
Nat Med 13:126-8. 2007 - REM sleep behavior disorder: a dopaminergic deficiency disorder?Jean K Matheson
Neurology 61:1328-9. 2003 - Modafinil: a drug in search of a mechanismClifford B Saper
Sleep 27:11-2. 2004 - Movement suppression during anesthesia: neural projections from the mesopontine tegmentum to areas involved in motor controlInna Sukhotinsky
Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Comp Neurol 489:425-48. 2005..Analysis of MPTA connectivity has the potential for furthering our understanding of the neural circuitry responsible for the various functional components of general anesthesia...
Research Grants
- NEURONAL MECHANISMS OF FEVERClifford Saper; Fiscal Year: 2009....
- NEURONAL MECHANISMS OF FEVERClifford Saper; Fiscal Year: 2004..These studies should advance our understanding of the molecular and cellular mechanisms that underlie the autonomic, endocrine, and behaviora1 responses associated with fever ..
- Circuitry for circadian rhythmsClifford B Saper; Fiscal Year: 2010....