Research Topics
| Glenn RosenSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Persistent spatial working memory deficits in rats with bilateral cortical microgyriaR Holly Fitch
Department of Psychology Behavioral Neuroscience, University of Connecticut, Storrs, CT, 06269, USA
Behav Brain Funct 4:45. 2008..abstract:..- Brain weight differences associated with induced focal microgyriaAnn M Peiffer
Department of Psychology Behavioral Neuroscience Division, University of Connecticut, USA
BMC Neurosci 4:12. 2003..In this experiment, we investigated changes in brain weight as an index of global disruption of neural systems caused by focal damage to the developing cortical plate... - The genetic control of neocortex volume and covariation with neocortical gene expression in miceShiv M Gaglani
Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
BMC Neurosci 10:44. 2009..Here we use unbiased stereological techniques to map quantitative trait loci (QTLs) that modulate the volume of neocortex... - Age at developmental cortical injury differentially alters corpus callosum volume in the ratSteven W Threlkeld
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, 806 Babbidge Road, Storrs, CT 06269 4154, USA
BMC Neurosci 8:94. 2007.... - Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouseBjörn Reinius
Department of Evolution and Development, EBC, Uppsala University, Sweden
BMC Genomics 11:614. 2010.... - Histometric changes and cell death in the thalamus after neonatal neocortical injury in the ratG D Rosen
Dyslexia Research Laboratory and Charles A Dana Research Institute, Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neuroscience 141:875-88. 2006..In addition, there was evidence of greater cell death in males at this age. Taken together, these results support the notion that males are more severely affected by early injury to the cerebral cortex than females... - Disruption of neuronal migration by RNAi of Dyx1c1 results in neocortical and hippocampal malformationsGlenn D Rosen
Dyslexia Research Laboratory and Charles A Dana Research Institute, Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Cereb Cortex 17:2562-72. 2007..These results support the hypothesis that targeted disruption of the candidate dyslexia susceptibility gene, Dyx1c1, results in neuronal migration disorders similar to those seen in the brains of dyslexics... - Informatics center for mouse genomics: the dissection of complex traits of the nervous systemGlenn D Rosen
Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Neuroinformatics 1:327-42. 2003..Finally, WebQTL provides statistical and graphical analysis of linkage between phenotypes and genotypes... - Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred miceG D Rosen
Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Genes Brain Behav 8:296-308. 2009..Using bioinformatic tools and the corresponding expression database, we have identified positional candidates in these quantitative trait locus intervals... - Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the ratT J Burbridge
The Dyslexia Research Laboratory, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Neuroscience 152:723-33. 2008..These results support the claim that knockdown of Dcdc2 expression results in neuronal migration disorders similar to those seen in the brains of dyslexics... - Birthdates of neurons in induced microgyriaG D Rosen
Dyslexia Research Laboratory, Beth Israel Hospital, Boston, MA 02215, USA
Brain Res 727:71-8. 1996..These results are considered in light of recent work demonstrating postnatal neocortical neurogenesis in response to early neocortical injury... - Effects of neonatal freeze lesions on expression of parvalbumin in rat neocortexG D Rosen
Dyslexia Research Laboratory and Charles A Dana Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Cereb Cortex 8:753-61. 1998..These results indicate that early injury to the cortical plate gives rise to both focal and more widespread changes in cortical architecture... - Complex trait analysis of the mouse striatum: independent QTLs modulate volume and neuron numberG D Rosen
Dyslexia Research Laboratory and Charles A, Dana Research Institute, Beth Israel Deaconess Medical Center, Boston, MA, USA
BMC Neurosci 2:5. 2001..We analyzed variation in striatal volume and neuron number in mice and initiated a complex trait analysis to discover polymorphic genes that modulate the structure of the basal ganglia... - Unilateral induced neocortical malformation and the formation of ipsilateral and contralateral barrel fieldsG D Rosen
Dyslexia Research Laboratory and Charles A Dana Research Institute and Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Neuroscience 103:931-9. 2001..These results are another example of both local and widespread disruption of connectional architecture following induction of focal microgyria... - Single cause, polymorphic neuronal migration disorders: an animal modelG D Rosen
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Dev Med Child Neurol 42:652-62. 2000..These results suggest that a single etiologic event of varying severity during neuronal migration to the neocortex can induce widely disparate malformations of the cortex... - Changes in efferent and afferent connectivity in rats with induced cerebrocortical microgyriaG D Rosen
Dyslexia Research Laboratory and Charles A Dana Research Institute, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Boston Massachusetts 02215, USA
J Comp Neurol 418:423-40. 2000..These connectional changes may help explain disturbances in architecture, physiology, and behavior associated with these focal malformations... - Sex differences in the effects of early neocortical injury on neuronal size distribution of the medial geniculate nucleus in the rat are mediated by perinatal gonadal steroidsG D Rosen
Dyslexia Research Laboratory and Charles A Dana Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Cereb Cortex 9:27-34. 1999..These findings suggest that perinatal gonadal steroids mediate the sex difference in thalamic response to induction of microgyria in the rat cortex... - Rapid auditory processing and learning deficits in rats with P1 versus P7 neonatal hypoxic-ischemic injuryMelissa M McClure
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, Unit 1020, 406 Babbidge Rd, Storrs, CT 06269-1020, USA
Behav Brain Res 172:114-21. 2006.... - Developmental timeframes for induction of microgyria and rapid auditory processing deficits in the ratSteven W Threlkeld
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, 806 Babbidge Road, Storrs, CT 06269-4154, USA
Brain Res 1109:22-31. 2006.... - From genes to behavior in developmental dyslexiaAlbert M Galaburda
Department of Neurology, Division of Behavioral Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Nat Neurosci 9:1213-7. 2006..Thus, we propose a tentative pathway between a genetic effect, developmental brain changes, and perceptual and cognitive deficits associated with dyslexia... - Independent quantitative trait loci influence ventral and dorsal hippocampal volume in recombinant inbred strains of miceMaureen V Martin
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Genes Brain Behav 5:614-23. 2006..These findings suggest that the development of the ventral and dorsal components of the hippocampus is influenced by separate genetic loci... - Detection of silent gaps in white noise following cortical deactivation in ratsSteven W Threlkeld
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, Storrs, Connecticut 06269 1020, USA
Neuroreport 19:893-8. 2008..However, only intact rats could reliably detect 75-ms gaps, suggesting possible subcortical anomalies in subjects with early cortical disturbances... - An informatics approach to systems neurogeneticsGlenn D Rosen
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Methods Mol Biol 401:287-303. 2007..Taken together, these tools enable the user to begin to assess complex interactions of gene networks, and facilitate analysis of traits using a systems approach... - Purkinje cell loss accompanies motor impairment in rats developing at altered gravityElizabeth M Sajdel-Sulkowska
Deparment of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 021115, USA
Neuroreport 16:2037-40. 2005..7-25.3%. These results imply that exposure to altered gravity during Purkinje cell birth may affect their proliferation, resulting in a decrease in Purkinje cell number, which, in turn, leads to motor impairment... - Sex differences in rapid auditory processing deficits in ectopic BXSB/MpJ miceAnn M Peiffer
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Neuroreport 13:2277-80. 2002.... - Differential tissue shrinkage and compression in the z-axis: implications for optical disector counting in vibratome-, plastic- and cryosectionsDean Gardella
Department of Physiology and Cell Biology, Mailstop 352, University of Nevada School of Medicine, Reno 89557, USA
J Neurosci Methods 124:45-59. 2003..Minimal bias can be achieved by either adjusting the placement and extent of counting boxes and guard spaces for sampling, or by applying a correction factor in cases when guard spaces are deemed essential for particle recognition... - Quantitative trait loci modulate ventricular size in the mouse brainCorinna C Zygourakis
Charles A Dana Research Institute, Division of Behavioral Neurology, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 461:362-9. 2003..These three QTLs, labeled Vent8a, Vent4b, and Vent7c, are close to genes that have been previously implicated in hydrocephalus... - Genetic control of interconnected neuronal populations in the mouse primary visual systemDave J Seecharan
Institute for Neuroscience, Center of Genomics and Bioinformatics, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
J Neurosci 23:11178-88. 2003..33; p < 0.01). We conclude that numbers of these two functionally coupled neuron populations are modulated over a wide range by independent genetic and developmental mechanisms... - Sex differences in rapid auditory processing deficits in microgyric ratsAnn M Peiffer
Behavioral Neuroscience Division, Department of Psychology, University of Connecticut Unit 4154, 3107 Horse Barn Hill Road, Storrs, CT 06269-4154, USA
Brain Res Dev Brain Res 148:53-7. 2004.... - Impaired gap detection in juvenile microgyric ratsAnn M Peiffer
Behavioral Neuroscience Division, Department of Psychology, University of Connecticut, 3107 Horse Barn Hill Road, Unit 4154, Storrs, CT 06269-4154, USA
Brain Res Dev Brain Res 152:93-8. 2004..g., simple gap detection), but may require "higher-order" auditory discrimination tasks (e.g., tone sequences, phonemic discriminations) to be elicited later in life... - Auditory processing deficits in unilaterally and bilaterally injured hypoxic-ischemic ratsMelissa M McClure
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, Storrs, Connecticut, USA
Neuroreport 16:1309-12. 2005.... - Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1Steven W Threlkeld
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, 806 Babbidge Road, Storrs, CT 06269 1020, USA
Brain Res Bull 71:508-14. 2007..01, two-tail). In conclusion, in utero RNAi of Dyx1c1 results in heterogeneous malformations that correspond to distinct behavioral impairments in auditory processing, and spatial learning... - Severity of focal microgyria and associated rapid auditory processing deficitsAnn M Peiffer
Department of Psychology, Behavioral Neuroscience Division, University of Connecticut, 3107 Horse Barn Hill Rd. U-4154, Storrs, CT 06269-4154, USA
Neuroreport 15:1923-6. 2004..Greater disruptions are also seen in the MGN of double-pair compared to single-pair bilateral microgyric subjects... - Rapid auditory processing and MGN morphology in microgyric rats reared in varied acoustic environmentsAnn M Peiffer
Department of Psychology, University of Connecticut, Unit 4154, 3107 Horse Barn Hill Rd, Storrs, CT 06269-4154, USA
Brain Res Dev Brain Res 138:187-93. 2002..These findings suggest that a more active form of acoustic stimulation (e.g., training) may be required to ameliorate the deleterious behavioral and anatomical consequences of focal microgyric lesions... - PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft modelColm T Leonard
Division of Pulmonary and Critical Care Medicine, Department of Histopathology, Stanford University Medical Center, Stanford, California, USA
J Heart Lung Transplant 21:1314-8. 2002.... - How replicable are mRNA expression QTL?Jeremy L Peirce
Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Mamm Genome 17:643-56. 2006..Finally, we note that while trans-acting QTL do not replicate well between data sets in general, at least one cluster of trans-acting QTL on distal Chr 1 is notably preserved between data sets... - Auditory processing deficits in rats with neonatal hypoxic-ischemic injuryMelissa M McClure
Department of Psychology, Behavioral Neuroscience Division, Unit 4154, 3107 Horse Barn Hill Rd, Storrs, CT 06269-4154, USA
Int J Dev Neurosci 23:351-62. 2005..As such, the current model may have critical implications for the study of neurophysiological underpinnings of cognitive deficits in premature/VLBW infants... - The nature and identification of quantitative trait loci: a community's viewOduola Abiola
Nat Rev Genet 4:911-6. 2003..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?.. - The Collaborative Cross, a community resource for the genetic analysis of complex traitsGary A Churchill
The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA
Nat Genet 36:1133-7. 2004..The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease... - Optical disector counting in cryosections and vibratome sections underestimates particle numbers: effects of tissue qualityTyson S Ward
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
Microsc Res Tech 71:60-8. 2008..These results may explain, in part, the significant numerical differences reported from different labs and should help investigators select optimal conditions for quantitative morphological studies... - Counting cells in sectioned material: a suite of techniques, tools, and tipsRobert W Williams
University of Tennessee Health Science Center, Memphis, Tennessee, USA
Curr Protoc Neurosci . 2003....
Research Grants
- QTL mapping of cell number in the mouse CNSGlenn Rosen; Fiscal Year: 2007..The extension of current transcriptome databases to encompass gene expression analysis at various stages of development will enable a systems genetic approach to understanding fundamental aspects of brain development. ..
- QTL mapping of cell number in the mouse CNSGlenn D Rosen; Fiscal Year: 2010..The extension of current transcriptome databases to encompass gene expression analysis at various stages of development will enable a systems genetic approach to understanding fundamental aspects of brain development. ..