Research Topics
Genomes and GenesSpecies | David S PatersonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunctionDavid S Paterson
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Neuropathol Exp Neurol 64:1018-27. 2005..These data suggest hypotheses concerning 5-HT modulation of vagal function for testing in MeCP2 knockout mice to understand mechanisms underlying autonomic dysfunction in patients with Rett syndrome...- Medullary serotonin defects and respiratory dysfunction in sudden infant death syndromeDavid S Paterson
Department of Pathology, Enders Building Room 1109, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Respir Physiol Neurobiol 168:133-43. 2009..Here we review the evidence from postmortem human studies and animal studies to support this hypothesis and discuss how the pathogenesis of SIDS is likely to originate in utero during fetal development... - Serotonergic and glutamatergic neurons at the ventral medullary surface of the human infant: Observations relevant to central chemosensitivity in early human lifeDavid S Paterson
Department of Pathology, Enders 1111, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, United States Harvard Medical School, Boston, MA 02115, USA
Auton Neurosci 124:112-24. 2006..These data are important towards delineating the role of the human Arc in modulation of homeostasis, and its dysfunction in brainstem-associated pathologies such as the sudden infant death syndrome... - Multiple serotonergic brainstem abnormalities in sudden infant death syndromeDavid S Paterson
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
JAMA 296:2124-32. 2006..Previously, abnormalities in 5-HT receptor binding in the medullae of infants dying from sudden infant death syndrome (SIDS) were identified, suggesting that medullary 5-HT dysfunction may be responsible for a subset of SIDS cases... - 5-HT2A receptors are concentrated in regions of the human infant medulla involved in respiratory and autonomic controlDavid S Paterson
Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Auton Neurosci 147:48-55. 2009.... - Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego DatasetDavid S Paterson
Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 68:409-13. 2010..These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS... - Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndromeKevin G Broadbelt
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Neuropathol Exp Neurol 70:799-810. 2011..026). These data suggest that medullary GABAA receptors are abnormal in SIDS infants and that SIDS is a complex disorder of a homeostatic network in the medulla that involves deficits of the GABAergic and 5-HT systems... - Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medullaKevin G Broadbelt
Department of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
Auton Neurosci 154:30-41. 2010..The developmental profile of GABAergic markers changed dramatically relative to the 5-HT markers. These data provide baseline information for medullary studies of human pediatric disorders, such as sudden infant death syndrome... - Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndromeKevin G Broadbelt
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Proteomics 11:M111.009530. 2012..These data suggest a potential molecular defect in SIDS related to TPH2 regulation, as 14-3-3 is critical in this process... - The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasisHannah C Kinney
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, United States
J Chem Neuroanat 41:182-99. 2011..The delineation of the development and organization of the human caudal 5-HT system provides the critical foundation for the neuropathologic elucidation of its disorders directly in the human brain... - Brainstem serotonergic deficiency in sudden infant death syndromeJhodie R Duncan
Department of Pathology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
JAMA 303:430-7. 2010..Abnormalities of serotonin (5-hydroxytryptamine [5-HT]) receptor binding in regions of the medulla oblongata involved in this control have been reported in infants dying from SIDS... - Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American populationKevin G Broadbelt
Department of Pathology, Enders Building Room 1111, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Pediatr Res 66:631-5. 2009..128-(191_192)dupA). The polymorphism seems to be a common, likely nonpathogenic, variant in the African-American population... - The development of nicotinic receptors in the human medulla oblongata: inter-relationship with the serotonergic systemJhodie R Duncan
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Auton Neurosci 144:61-75. 2008..This study indicates parallel dynamic and complex changes in the medullary nicotinic and 5-HT systems throughout early life, i.e., the period of risk for SIDS... - The development of the medullary serotonergic system in early human lifeHannah C Kinney
Department of Pathology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
Auton Neurosci 132:81-102. 2007..Thus, protracted changes occur from the prenatal period through infancy. These data provide a foundation for 5-HT neuronal analysis in pediatric brainstem disorders, as proposed in the sudden infant death syndrome... - Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medullaDavid S Paterson
Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Comp Neurol 472:221-31. 2004..This study provides important baseline data that serve as a foundation for future work in pediatric 5-HT brainstem disorders, including sudden infant death syndrome... - Comparative anatomical assessment of the piglet as a model for the developing human medullary serotonergic systemMary M Niblock
Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
Brain Res Brain Res Rev 50:169-83. 2005..Collectively, when certain species differences are considered, these data support the use of the piglet as a model for the human infant medullary 5-HT system...