Andrew R Osborne

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Protein translocation by the Sec61/SecY channel
    Andrew R Osborne
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 21:529-50. 2005
  2. ncbi A role for the two-helix finger of the SecA ATPase in protein translocation
    Karl J Erlandson
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 455:984-7. 2008
  3. ncbi Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation
    Karl J Erlandson
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:15709-15. 2008
  4. ncbi Ribosome binding of a single copy of the SecY complex: implications for protein translocation
    Jean François Ménétret
    Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118 2526, USA
    Mol Cell 28:1083-92. 2007
  5. ncbi Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel
    Andrew R Osborne
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:97-110. 2007
  6. ncbi RecA-like motor ATPases--lessons from structures
    Jiqing Ye
    Department of Cell Biology, Harvard Medical School, HHMI, 240 Longwood Ave, LHRRB 613, Boston, MA 02115, USA
    Biochim Biophys Acta 1659:1-18. 2004
  7. ncbi A large conformational change of the translocation ATPase SecA
    Andrew R Osborne
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10937-42. 2004

Collaborators

  • M Groll
  • Bert van den Berg
  • Tom Rapoport
  • Steven Gygi
  • Karl J Erlandson
  • Jean François Ménétret
  • Jiqing Ye
  • Eran Or
  • Yunsun Nam
  • Stephanie B M Miller
  • Jochen Zimmer
  • Sigrid S Skånland
  • Christopher W Akey
  • Julia Schaletzky
  • Eunyong Park
  • Steven J Ludtke
  • William M Clemons
  • Carilee Denison
  • Don S Kirkpatrick

Detail Information

Publications7

  1. ncbi Protein translocation by the Sec61/SecY channel
    Andrew R Osborne
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Cell Dev Biol 21:529-50. 2005
    ..We review these translocation mechanisms, relating biochemical and genetic observations to the structures of the protein-conducting channel and its binding partners...
  2. ncbi A role for the two-helix finger of the SecA ATPase in protein translocation
    Karl J Erlandson
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 455:984-7. 2008
    ....
  3. ncbi Analysis of polypeptide movement in the SecY channel during SecA-mediated protein translocation
    Karl J Erlandson
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:15709-15. 2008
    ..The channel itself does not bind the polypeptide chain but provides "friction" that minimizes backsliding when ADP-bound SecA resets to "grab" the next segment of the substrate...
  4. ncbi Ribosome binding of a single copy of the SecY complex: implications for protein translocation
    Jean François Ménétret
    Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118 2526, USA
    Mol Cell 28:1083-92. 2007
    ..We also show that point mutations of basic residues within either loop abolish ribosome binding. We suggest that SecY binds to this primary site on the ribosome and subsequently captures and translocates the nascent chain...
  5. ncbi Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel
    Andrew R Osborne
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:97-110. 2007
    ..Oligomeric channels with only one active pore likely mediate protein translocation in all organisms...
  6. ncbi RecA-like motor ATPases--lessons from structures
    Jiqing Ye
    Department of Cell Biology, Harvard Medical School, HHMI, 240 Longwood Ave, LHRRB 613, Boston, MA 02115, USA
    Biochim Biophys Acta 1659:1-18. 2004
    ..The structures determined for different RecA-like motor ATPases begin to reveal how they move macromolecules...
  7. ncbi A large conformational change of the translocation ATPase SecA
    Andrew R Osborne
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:10937-42. 2004
    ..We propose that the open form of SecA represents an activated state...