Research Topics
Genomes and Genes | Tomas Maira-LitranSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Immunochemical properties of the staphylococcal poly-N-acetylglucosamine surface polysaccharideTomas Maira-Litran
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Infect Immun 70:4433-40. 2002..These results further clarify the chemical structure of PS/A and help to differentiate it from PIA on the basis of immunogenicity, molecular size, and solubility...- Comparative opsonic and protective activities of Staphylococcus aureus conjugate vaccines containing native or deacetylated Staphylococcal Poly-N-acetyl-beta-(1-6)-glucosamineTomas Maira-Litran
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Infect Immun 73:6752-62. 2005..aureus infection, including capsular polysaccharide types 5 and 8 and an untypable strain... - Poly-N-acetylglucosamine production in Staphylococcus aureus is essential for virulence in murine models of systemic infectionAndrea Kropec
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Infect Immun 73:6868-76. 2005..Thus, PNAG confers on S. aureus resistance to killing mediated by these innate host immune mediators. Overall, PNAG production by S. aureus appears to be a critical virulence factor as assessed in murine models of systemic infection... - Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in miceDavid Skurnik
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 120:3220-33. 2010..aureus infections in humans could be due, in part, to interference in OPK when antibodies to CP and PNAG antigens are both present. This information could be used to better design S. aureus vaccine components... - Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in miceVictoria L Campodónico
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Infect Immun 79:3455-64. 2011..Conjugation of PMA to FLA appears to be a promising path for developing a broadly protective vaccine against P. aeruginosa... - Poly-N-acetyl-?-(1-6)-glucosamine is a target for protective immunity against Acinetobacter baumannii infectionsLeticia V Bentancor
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Infect Immun 80:651-6. 2012..This was true for all four A. baumannii strains tested. Overall, these results highlight the potential of PNAG as a vaccine component for active immunization or as a target for passive antibody immunotherapy... - Biologic properties and vaccine potential of the staphylococcal poly-N-acetyl glucosamine surface polysaccharideTomas Maira-Litran
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Vaccine 22:872-9. 2004..Animal studies have shown purified PNAG can elicit protective immunity against both CoNS and S. aureus, suggesting its potential as a broadly protective vaccine for many clinically important strains of staphylococci... - Molecular basis for preferential protective efficacy of antibodies directed to the poorly acetylated form of staphylococcal poly-N-acetyl-beta-(1-6)-glucosamineNuno Cerca
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Infect Immun 75:3406-13. 2007..Retention of dPNAG on the surface of S. aureus is key to increased survival during bacteremia and also provides a molecular mechanism explaining the superior opsonic and protective activity of antibody to dPNAG... - The pgaABCD locus of Acinetobacter baumannii encodes the production of poly-beta-1-6-N-acetylglucosamine, which is critical for biofilm formationAlexis H K Choi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Bacteriol 191:5953-63. 2009..Biofilm-dependent production of PNAG could be an important virulence factor for this emerging pathogen that has few known virulence factors... - Evaluation of flagella and flagellin of Pseudomonas aeruginosa as vaccinesVictoria L Campodónico
Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
Infect Immun 78:746-55. 2010..aeruginosa based on flagellar antigens may require additional components beyond type a and type b proteins from prototype strains... - Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharideNuno Cerca
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:7528-33. 2007..coli strains expressing PNAG. PNAG expression by both Gram-negative and Gram-positive organisms could make this antigen a conserved vaccine target for multiple pathogenic species of bacteria...