C Lange

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Genetic model testing and statistical power in population-based association studies of quantitative traits
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Genet Epidemiol 31:358-62. 2007
  2. ncbi Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000197. 2008
  3. ncbi Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
  4. ncbi Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
  5. ncbi Mapping quantitative trait Loci using generalized estimating equations
    C Lange
    School of Applied Statistics, University of Reading, Reading RG6 6FN, United Kingdom
    Genetics 159:1325-37. 2001
  6. ncbi Family-based association tests for survival and times-to-onset analysis
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Stat Med 23:179-89. 2004
  7. ncbi A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 56:10-7. 2003
  8. ncbi Using the noninformative families in family-based association tests: a powerful new testing strategy
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 73:801-11. 2003
  9. ncbi A multivariate family-based association test using generalized estimating equations: FBAT-GEE
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 4:195-206. 2003
  10. ncbi Power and design considerations for a general class of family-based association tests: quantitative traits
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 71:1330-41. 2002

Detail Information

Publications83

  1. ncbi Genetic model testing and statistical power in population-based association studies of quantitative traits
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Genet Epidemiol 31:358-62. 2007
    ..Our observations were confirmed by analyzing an existing genetic association dataset in which we detect the effect of a KCNJ11 variant on insulinogenic index in unrelated non-diabetic individuals...
  2. ncbi Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000197. 2008
    ....
  3. ncbi Comparison of linkage and association strategies for quantitative traits using the COGA dataset
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    BMC Genet 6:S96. 2005
    ..We compare the results from the PBAT analysis to that of quantitative linkage analysis on chromosome 4 using the Collaborative Study on the Genetics of Alcoholism data, as released through Genetic Analysis Workshop 14...
  4. ncbi Genomic screening in family-based association testing
    Amy Murphy
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    BMC Genet 6:S115. 2005
    ..004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association...
  5. ncbi Mapping quantitative trait Loci using generalized estimating equations
    C Lange
    School of Applied Statistics, University of Reading, Reading RG6 6FN, United Kingdom
    Genetics 159:1325-37. 2001
    ..In this article we rectify this deficiency by developing a QTL-mapping approach based on generalized estimating equations (GEE). Simulation experiments are used to illustrate the application of the GEE-based approach...
  6. ncbi Family-based association tests for survival and times-to-onset analysis
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Stat Med 23:179-89. 2004
    ..Based on the results of the simulation study, we suggest rules of thumb about which statistics to use in a given situation. An application of all three tests to an Alzheimer study illustrates the practical relevance of our discussion...
  7. ncbi A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 56:10-7. 2003
    ..The practical importance of our testing strategy is illustrated by applications to the Childhood Asthma Management Program asthma data sets...
  8. ncbi Using the noninformative families in family-based association tests: a powerful new testing strategy
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 73:801-11. 2003
    ....
  9. ncbi A multivariate family-based association test using generalized estimating equations: FBAT-GEE
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 4:195-206. 2003
    ..Application of the proposed test to an asthma study illustrates the power of the approach...
  10. ncbi Power and design considerations for a general class of family-based association tests: quantitative traits
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 71:1330-41. 2002
    ..We also compare the general FBAT approach with PDT and QTDT. The practical relevance of our theoretical considerations is illustrated by their application to an asthma study...
  11. ncbi Power calculations for a general class of family-based association tests: dichotomous traits
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, 02115, USA
    Am J Hum Genet 71:575-84. 2002
    ..When the population prevalence is high, it can be worthwhile to genotype unaffected offspring. For many scenarios, high power can be achieved with reasonable sample sizes, even when no parental information is available...
  12. ncbi On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 23:165-80. 2002
    ..The proposed methodology is illustrated with a genetic study of asthma...
  13. ncbi A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  14. ncbi Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations
    Craig P Hersh
    Channing Laboratory, Pulmonary and Critical Care Division, and Hematology Oncology Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 33:71-8. 2005
    ..03). Although some evidence for replication was found for SFTPB and HMOX1, none of the previously published COPD genetic associations was convincingly replicated across both study designs...
  15. ncbi IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  16. ncbi On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice
    David Fardo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 31:376-82. 2007
    ..The guidelines are illustrated by an application to an asthma study...
  17. ncbi Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations
    Jessica Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1345-54. 2008
    ..Replication of these results is necessary in order to confirm the proposed genetic variants for ADHD...
  18. ncbi Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder
    Jessica Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1355-8. 2008
    ..Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene...
  19. ncbi Variants in FAM13A are associated with chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 42:200-2. 2010
    ..2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83)...
  20. ncbi TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples
    Ross Lazarus
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 170:594-600. 2004
    ..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk...
  21. ncbi Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program
    Edwin K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 112:870-6. 2003
    ..Beta2-adrenergic receptor (B2AR) polymorphisms have been associated with a variety of asthma-related phenotypes, but association results have been inconsistent across different studies...
  22. ncbi An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes
    Jessica Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Eur J Hum Genet 18:720-5. 2010
    ..This program is available in the PBAT analysis package...
  23. ncbi MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  24. ncbi Recovering unused information in genome-wide association studies: the benefit of analyzing SNPs out of Hardy-Weinberg equilibrium
    David W Fardo
    Department of Biostatistics, University of Kentucky College of Public Health, Lexington, KY 40536, USA
    Eur J Hum Genet 17:1676-82. 2009
    ..However, association findings for SNPs that are out of HWE must be treated more carefully than 'regular' findings, for example, by re-genotyping the SNP in the same study using a different genotyping technology...
  25. ncbi On prediction of genetic values in marker-assisted selection
    C Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genetics 159:1375-81. 2001
    ..The advantages of the new approach are illustrated by a simulation study in which the new approximation outperforms both the standard approach and phenotypic selection...
  26. ncbi Parsing the effects of individual SNPs in candidate genes with family data
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 69:91-103. 2010
    ..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati...
  27. ncbi Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program
    D L DeMeo
    Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Genet Epidemiol 23:335-48. 2002
    ..No evidence for association was found between Arg130Gln and airway responsiveness, asthma diagnosis, or asthma severity...
  28. ncbi PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Hum Genomics 2:67-9. 2005
    ..Moreover, PBAT is computationally fast. A genome scan of 300,000 SNPs in 2,000 trios takes 4 central processing unit (CPU)-days. PBAT is available for Linux, Sun Solaris and Windows XP...
  29. ncbi Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma
    Audrey H Poon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pharmacogenet Genomics 18:373-82. 2008
    ..We aim to assess associations between genetic variants of CRHR2 and acute bronchodilator response in asthma...
  30. ncbi Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  31. ncbi The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn DeMeo
    Channing Laboratory, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:502. 2006
  32. ncbi Overview of the pharmacogenetics of asthma treatment
    S T Weiss
    Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA
    Pharmacogenomics J 6:311-26. 2006
    ..Identification of such replicable loci is the next step towards the goal of 'individualized therapy' for asthma...
  33. ncbi Statistical challenges for genome-wide association studies of suicidality using family data
    J Lasky-Su
    Channing Laboratory, Brigham and Women s Hospital, Boston, 181, Longwood Ave, Boston, MA 02115, USA
    Eur Psychiatry 25:307-9. 2010
    ..As our intention is to describe how statistical methodology may work to identify disease variants for suicidality, we avoid the mathematical details of the methodologies presented...
  34. ncbi Estimating the number of unseen variants in the human genome
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:5008-13. 2009
    ..Finally, our results also show a much higher diversity in environmental response genes compared with the average genome, especially in African populations...
  35. ncbi Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:1084-90. 2009
    ..Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma...
  36. ncbi Impact of population stratification on family-based association tests with longitudinal measurements
    Xiao Ding
    Harvard School of Public Health
    Stat Appl Genet Mol Biol 8:Article 17. 2009
    ..An application of these approaches to the Childhood Asthma Management Program (CAMP) study data for testing an association between body mass index and a previously reported candidate SNP is given as an example...
  37. ncbi Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1449-56. 2002
    ..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility...
  38. ncbi The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  39. ncbi FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests
    Cyril S Rakovski
    Department of Biostatistics, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Hum Hered 66:122-6. 2008
    ..Develop a new test for family-based association studies and continuous traits that incorporates power- enhancing techniques from two existing testing strategies...
  40. ncbi On the frequency of copy number variants
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Bioinformatics 24:2350-5. 2008
    ....
  41. ncbi ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts
    Augusto A Litonjua
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 178:688-94. 2008
    ..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients...
  42. ncbi Gene-environment interaction tests for dichotomous traits in trios and sibships
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 33:691-9. 2009
    ..Lastly, we apply these three tests to a group of nuclear families ascertained according to affection with Bipolar Disorder...
  43. ncbi Inferring genetic causal effects on survival data with associated endo-phenotypes
    Peter J Lipman
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Genet Epidemiol 35:119-24. 2011
    ....
  44. ncbi A Bayesian approach to genetic association studies with family-based designs
    Melissa G Naylor
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 34:569-74. 2010
    ..We then applied the approach to a genome-wide association scan to search for associations between single nucleotide polymorphisms and body mass index in the Childhood Asthma Management Program data...
  45. ncbi Using canonical correlation analysis to discover genetic regulatory variants
    Melissa G Naylor
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 5:e10395. 2010
    ..We assess the potential of applying canonical correlation analysis to partitioned genomewide data as a method for discovering regulatory variants...
  46. ncbi On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls
    Jessica Lasky-Su
    Channing Laboratories, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 86:573-80. 2010
    ..We illustrate the approach by an application to a GWAS of attention deficit hyperactivity disorder parent-offspring trios and publicly available controls...
  47. ncbi Development of a Pharmacogenetic Predictive Test in asthma: proof of concept
    Ann Chen Wu
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215 5301, USA
    Pharmacogenet Genomics 20:86-93. 2010
    ..To assess the feasibility of developing a Combined Clinical and Pharmacogenetic Predictive Test, comprised of multiple single nucleotide polymorphisms (SNPs) that is associated with poor bronchodilator response (BDR)...
  48. ncbi Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene
    Dawn L DeMeo
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 85:493-502. 2009
    ..4 x 10(-4). IREB2 protein and mRNA were increased in lung-tissue samples from COPD subjects in comparison to controls. In summary, gene-expression and genetic-association results have implicated IREB2 as a COPD susceptibility gene...
  49. ncbi Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 12:1973-9. 2003
    ..Fine mapping efforts for these loci are warranted...
  50. ncbi IL1B polymorphisms modulate cystic fibrosis lung disease
    Hara Levy
    Division of Pulmonary Medicine, Children s Hospital, Boston, MA, USA
    Pediatr Pulmonol 44:580-93. 2009
    ....
  51. ncbi Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, 02138, USA
    Am J Hum Genet 84:581-93. 2009
    ..Further study of PDE4D variants might lead to improved understanding of the role of PDE4D in asthma pathophysiology and the efficacy of PDE4 inhibitor medications...
  52. ncbi On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
    Genet Epidemiol 32:273-84. 2008
    ..A software implementation of the approach is freely available at http://www.hsph.harvard.edu/research/iuliana-ionita/software. The approach has also been completely integrated in the PBAT software package...
  53. ncbi The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
    ..IL12B may be an important asthma gene...
  54. ncbi P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R
    Thomas Hoffmann
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Bioinformatics 22:3103-5. 2006
    ..AVAILABILITY: The P2BAT package is available as the R package 'pbatR' which can be downloaded from http://cran.r-project.org/. The PBAT-software is available at http://www.biostat.harvard.edu/~clange/...
  55. ncbi Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1294-301. 2004
    ..LOD scores of greater than two were also observed for chromosomes 16, 20, and 22 with the smokers-only analysis, which may suggest gene-by-smoking interactions in these regions...
  56. ncbi ADAM33 polymorphisms and phenotype associations in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1071-8. 2004
    ..However, genetic linkage of asthma phenotypes to chromosome 20p13 (the location of ADAM33) has not been observed in most asthma genome scans, and it is unclear whether these associations with ADAM33 are broadly generalizable...
  57. ncbi Family-based association test for time-to-onset data with time-dependent differences between the hazard functions
    Hongyu Jiang
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Genet Epidemiol 30:124-32. 2006
    ..In addition to power increases of 100% over the original FBAT-Logrank test, we also gain insight into the age at which a genotype exerts the greatest influence on disease risk...
  58. ncbi The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  59. ncbi Association of vitamin D receptor gene polymorphisms with childhood and adult asthma
    Benjamin A Raby
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1057-65. 2004
    ..These results suggest that VDR influences asthma and allergy susceptibility in a complex manner...
  60. ncbi The SERPINE2 gene is associated with chronic obstructive pulmonary disease
    Dawn L DeMeo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Hum Genet 78:253-64. 2006
    ....
  61. ncbi Family-based designs in the age of large-scale gene-association studies
    Nan M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Rev Genet 7:385-94. 2006
    ..Furthermore, the fact that family-based designs contain both within- and between-family information has substantial benefits in terms of multiple-hypothesis testing, especially in the context of whole-genome association studies...
  62. ncbi New powerful approaches for family-based association tests with longitudinal measurements
    Xiao Ding
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Hum Genet 73:74-83. 2009
    ..Application of these approaches for testing an association between Body Mass Index and a previously reported candidate SNP confirms our results...
  63. ncbi Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  64. ncbi Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 172:687-92. 2005
    ..The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively...
  65. ncbi Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
    ..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...
  66. ncbi Paternal history of asthma and airway responsiveness in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:552-8. 2005
    ..Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma...
  67. ncbi Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Hum Genet 81:607-14. 2007
    ..The proposed method is of general applicability; it extends to any setting in which prior, independent ranking of hypotheses is available...
  68. ncbi Comprehensive testing of positionally cloned asthma genes in two populations
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:849-57. 2007
    ..Replication of gene-disease associations has become a requirement in complex trait genetics...
  69. ncbi Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder
    J Lasky-Su
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Ann Hum Genet 71:648-59. 2007
    ..Although definitive conclusions await independent replication, these results suggest that a variant in DRD5 may affect age at onset for ADHD...
  70. ncbi On the parsing of statistical information in family-based association testing
    Matthew B McQueen
    Nat Genet 39:281-2. 2007
  71. ncbi Family-based methods for linkage and association analysis
    Nan M Laird
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Adv Genet 60:219-52. 2008
    ..This chapter focuses on family-based designs. We describe some basic study designs as well as general approaches to analysis for qualitative, quantitative, and complex traits. Finally, we review available software...
  72. ncbi Testing and estimating gene-environment interactions in family-based association studies
    Stijn Vansteelandt
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281, S9, B 9000 Gent, Belgium
    Biometrics 64:458-67. 2008
    ..Simulation studies show that the proposed methodology is sufficiently powered for realistic sample sizes and that it provides valid tests and effect size estimators in the presence of admixture and stratification...
  73. ncbi Family-based association between Alzheimer's disease and variants in UBQLN1
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
    N Engl J Med 352:884-94. 2005
    ..The gene encoding ubiquilin 1 (UBQLN1) is one of several candidate genes for Alzheimer's disease located near a well-established linkage peak on chromosome 9q22...
  74. ncbi Family-based association analysis of a statistically derived quantitative traits for ADHD reveal an association in DRD4 with inattentive symptoms in ADHD individuals
    Jessica Lasky-Su
    Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 147:100-6. 2008
    ..This analysis adds to previous findings by suggesting that variants at these loci may be specifically associated with inattentive symptoms...
  75. ncbi On the replication of genetic associations: timing can be everything!
    Jessica Lasky-Su
    SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Hum Genet 82:849-58. 2008
    ..If the specifics of age- or time-varying genetic effects are not considered in the selection of both the follow-up samples and in the statistical analysis, important genetic associations may be missed...
  76. ncbi Exploring candidate gene associations with neuropsychological performance
    Matthew B McQueen
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 144:987-91. 2007
    ....
  77. ncbi Genomics and genome-wide association studies: an integrative approach to expression QTL mapping
    James H Degnan
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Genomics 92:129-33. 2008
    ..We demonstrate that our family-based screening approach performs well in the analysis of integrative genomic datasets and that screening using either heritability or conditional power produces similar, though not identical, results...
  78. ncbi Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
    ..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity...
  79. ncbi Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples
    Lars Bertram
    Am J Hum Genet 79:180-3; author reply 183-4. 2006
  80. ncbi Most antiviral CD8 T cells during chronic viral infection do not express high levels of perforin and are not directly cytotoxic
    Dong Zhang
    Center for Blood Research, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Blood 101:226-35. 2003
    ..Impaired antiviral cytotoxicity during chronic infection is not specific to HIV but likely represents the immune response to chronic antigenic exposure...
  81. ncbi PBAT: tools for family-based association studies
    Christoph Lange
    Am J Hum Genet 74:367-9. 2004
  82. ncbi Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function
    M Nedim Ince
    CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Immunology 112:531-42. 2004
    ..Thus, ILT2 expression, increased on antiviral CD8 cells in chronic infection, may interfere with protective CD8 T-cell function by suppressing IFN-gamma production...
  83. ncbi The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation
    Antje Blumenthal
    Division of Molecular Infection Biology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    Blood 108:965-73. 2006
    ..Our findings implicate the evolutionarily conserved WNT/Frizzled signaling system in bridging innate and adaptive immunity to infections...