S L Lake

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
  2. ncbi Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hum Hered 55:56-65. 2003
  3. ncbi Tests of gene-environment interaction for case-parent triads with general environmental exposures
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Hum Genet 68:55-64. 2004
  4. ncbi Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
  5. ncbi Family-based tests of association in the presence and absence of known linkage
    L Bertram
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Genet Epidemiol 21:S292-7. 2001

Collaborators

Detail Information

Publications5

  1. ncbi Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma
    Augusto A Litonjua
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Respir Res 6:52. 2005
    ..Signal transducer and activator of transcription 3 is a transcription factor latent in the cytoplasm; the gene (STAT3) is activated by a wide range of cytokines, and may play a role in lung development and asthma pathogenesis...
  2. ncbi Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hum Hered 55:56-65. 2003
    ..Simulations were run to illustrate the salient features of the method. In addition, the method was used to test for haplotype-smoking exposure interaction with data from the Childhood Asthma Management Program...
  3. ncbi Tests of gene-environment interaction for case-parent triads with general environmental exposures
    S L Lake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Ann Hum Genet 68:55-64. 2004
    ..We present a test, FBAT-I, that can be used to investigate gene-environment interaction. The test uses the case-parent triad design and protects the statistical inference from potential spurious results due to population admixture...
  4. ncbi Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
    ..Since the A2M gene lies in a chromosomal region (chromosome 12p) that consistently has been linked to AD, association tests should be conducted under the null hypothesis that there is linkage but no association...
  5. ncbi Family-based tests of association in the presence and absence of known linkage
    L Bertram
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Genet Epidemiol 21:S292-7. 2001
    ..Our results indicate that both tests generally perform comparably in either setting...