Research Topics
Genomes and Genes | S M KraneSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The importance of proline residues in the structure, stability and susceptibility to proteolytic degradation of collagensStephen M Krane
Department of Medicine, Harvard Medical School and the Massachusetts General Hospital, Center for Immunology and Inflammatory Diseases, Building 149, 13th Street, Room 8301, Boston, MA 02129, USA
Amino Acids 35:703-10. 2008..Targeted mutations in mice in the collagenase cleavage domain have profound effects on collagen turnover and the function of connective tissues. Prolines are thus critical determinants of collagen structure and function...- Is a single infusion of zoledronic acid more effective than oral risedronate for the treatment of patients with Paget's disease?Stephen M Krane
Harvard Medical School and Massachusetts General Hospital, Center for Immunology and Inflammatory Diseases, Department of Medicine, Boston, MA 02129, USA
Nat Clin Pract Rheumatol 2:186-7. 2006 - Identifying genes that regulate bone remodeling as potential therapeutic targetsStephen M Krane
Harvard Medical School and Massachusetts General Hospital, Boston, MA 02129, USA
J Exp Med 201:841-3. 2005..A newly described inhibitor of osteoblast differentiation, Ciz, interferes with bone morphogenic protein signaling. As a consequence, Ciz-deficient mice develop increased bone mass... - Elucidation of the potential roles of matrix metalloproteinases in skeletal biologyStephen M Krane
Department of Medicine, Harvard Medical School, Center for Immunology and Inflammatory Diseases, Charlestown, Massachusetts, USA
Arthritis Res Ther 5:2-4. 2003..Insights gained from such studies can be used to design new therapies to interrupt these catabolic events... - Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagenW Zhao
Department of Medicine, Harvard Medical School, Medical Services Arthritis Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Invest 106:941-9. 2000.... - The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine boneB Lanske
Endocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 139:5194-204. 1998..The PTH/PTHrP receptor, therefore, mediates distinct physiologic actions of both PTH and PTHrP... - Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant miceW Zhao
Department of Medicine, Harvard Medical School, Medical Services Arthritis Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Invest 103:517-24. 1999..Calcemic responses, 0.5-10 hours after intraperitoneal injection of PTH, were blunted in r/r mice versus +/+ mice. Thus, collagenase cleavage of type I collagen is necessary for PTH induction of osteoclastic bone resorption... - Matrix metalloproteinases and boneStephen M Krane
Department of Medicine, Harvard Medical School and the Massachusetts General Hospital, Center for Immunology and Inflammatory Diseases, Building 149 13th Street, Room 8301, Boston, MA 02129, USA
Bone 43:7-18. 2008..Potential mechanisms to account for effects of these mutations are considered in this review... - Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transductionA H Gorn
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 95:2680-91. 1995.... - Characterization of the structural and functional properties of cloned calcitonin receptor cDNAsS R Goldring
Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston
Horm Metab Res 25:477-80. 1993..Additional studies will help to establish the structural basis for this functional property as well as the evolutionary relationship of the members of this newly identified family of receptors... - Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaquesJun o Deguchi
Donald W Reynolds Cardiovascular Clinical Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circulation 112:2708-15. 2005..Interstitial collagen plays a crucial structural role in arteries. Matrix metalloproteinases (MMPs), including MMP-13/collagenase-3, likely contribute to collagen catabolism in atherosclerotic plaques... - Different collagenase gene products have different roles in degradation of type I collagenS M Krane
Department of Medicine, Harvard Medical School and the Arthritis Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 271:28509-15. 1996..All activities were inhibited by TIMP-1, 1,10-phenanthroline, and EDTA. Sequences in the distal two-thirds of the catalytic domain determine the aminotelopeptide-degrading capacity of MMP-13... - Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaquesYoshihiro Fukumoto
Donald W Reynolds Cardiovascular Clinical Research Center, Department of Medicine, and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 110:1953-9. 2004..However, no direct in vivo evidence links collagenases with the regulation of collagen content in atherosclerotic plaques... - Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossificationMasaki Inada
Center for Immunology and Inflammatory Diseases, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Building 149, 13th Street, Room 8301, Boston, MA 02129, USA
Proc Natl Acad Sci U S A 101:17192-7. 2004..Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development... - Effect of a cleavage-resistant collagen mutation on left ventricular remodelingMerry L Lindsey
Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
Circ Res 93:238-45. 2003..We were not able to detect collagen cleavage fragments, and could not, therefore, rule out the possibility of collagen cleavage at additional sites... - Genetic control of bone remodeling--insights from a rare diseaseStephen M Krane
N Engl J Med 347:210-2. 2002 - Variable impairment of wound healing in the heterozygous collagenase-resistant mouseAlice H M Beare
United Kingdom Center for Tissue Engineering and Division of Immunology, Microbiology, Development and Repair, School of Biological Sciences, University of Manchester, Manchester, United Kingdom
Wound Repair Regen 13:27-40. 2005.... - A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolismKeiichi Inoue
Laboratory for Behavioral Genetics, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
J Biol Chem 281:33814-24. 2006..Our results indicate that MMP-2 plays a crucial role in forming and maintaining the osteocytic canalicular network, and we propose that osteocytic network formation is a determinant of bone remodeling and mineralization... - Differential regulation of platelet-derived growth factor stimulated migration and proliferation in osteoblastic cellsMeenal Mehrotra
University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
J Cell Biochem 93:741-52. 2004..The JNK pathway was involved in both migration and proliferation, whereas the p38 pathway was predominantly involved in migration and the ERK pathway predominantly involved in proliferation... - Severely impaired wound healing in the collagenase-resistant mouseAlice H M Beare
Division of Immunology, Microbiology and Development, and UK Centre for Tissue Engineering, School of Biological Sciences, University of Manchester, UK
J Invest Dermatol 120:153-63. 2003..There was no significant difference in scarring between Col1a1(r/r) and Col1a1+/+ wounds after 70 d... - Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8)Ana Gutierrez-Fernandez
Departamento de Bioquimica y Biologia Molecular, Universidad de Oviedo, 33006 Oviedo, Spain
FASEB J 21:2580-91. 2007..Taken together, these data indicate that MMP-8 participates in wound repair by contributing to the resolution of inflammation and open the possibility to develop new strategies for treating wound healing defects... - Activity and expression of Xenopus laevis matrix metalloproteinases: identification of a novel role for the hormone prolactin in regulating collagenolysis in both amphibians and mammalsJae Chang Jung
Department of Biology, Kyungpook National University, Daegu 702 701, Korea
J Cell Physiol 201:155-64. 2004.... - MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)Ann M Kennedy
Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM, Churchill Hospital, Oxford, United Kingdom
J Clin Invest 115:2832-42. 2005..Thus, the F56S mutation results in deficiency of MMP13, which leads to the human skeletal developmental anomaly of SEMD(MO)...
Research Grants
- Remodeling Extracellular Matrix:Degradation of CollagenStephen Krane; Fiscal Year: 2007..We will analyze the skeletal and extraskeletal phenotype of mice with a null mutation in the "neutrophil" collagenase, MMP-8, another collagenase expressed in the skeleton, as well as mice with double null MMP-8/MMP-13. ..
- REMODELING EXTRACELLULAR MATRIX--DEGRADATION OF COLLAGENStephen Krane; Fiscal Year: 2002..Specific Aim 3: Target mutations that encode collagenase resistance into the murine type II collagen (Col2a-1) gene. ..