Research Topics
| Christine KonradiSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Striatal proenkephalin gene induction: coordinated regulation by cyclic AMP and calcium pathwaysChristine Konradi
Laboratory of Neuroplasticity, McLean Hospital, Harvard Medical School, MRC215, 115 Mill St, Belmont, MA 02478, USA
Brain Res Mol Brain Res 115:157-61. 2003..This synchronization of second messenger pathways provides a coincidence mechanism that gates proenkephalin synthesis in striatal neurons, ensuring that levels are increased only in the presence of activated PKA and depolarization...- Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatmentChristine Konradi
Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
Pharmacol Ther 97:153-79. 2003..Here we discuss how the molecular aspects of glutamate malfunction can explain some of the neuropathology observed in schizophrenia, and how the available treatment intervenes through the glutamate system... - Molecular evidence for mitochondrial dysfunction in bipolar disorderChristine Konradi
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Arch Gen Psychiatry 61:300-8. 2004..The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder... - Transcriptome analysis in a rat model of L-DOPA-induced dyskinesiaChristine Konradi
Laboratory of Neuroplasticity, McLean Hospital, Belmont, MA 02478, USA
Neurobiol Dis 17:219-36. 2004..Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended ATP levels... - L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neuronsMolly E Eaton
Laboratory of Neuroplasticity, McLean Hospital, Harvard Medical School, MRC215, 115 Mill Street Belmont, MA 02478, USA
Brain Res Mol Brain Res 131:65-72. 2004..We conclude that the D1 receptor signal transduction pathway depends on L-type Ca2+ channels to mediate CREB phosphorylation... - Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviorsFrederick A Schroeder
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, MA 01604, USA
Neuropsychopharmacology 33:2981-92. 2008.... - Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signalingJianhong Li
Department of Psychiatry, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, USA
J Neurochem 90:1117-31. 2004..Blockade of D2-like receptors induces H3 phospho-acetylation, H3pS10-acK14, through cAMP-dependent PKA, and post-synaptic NMDA receptor signaling... - Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1Joshua T Dudman
Laboratory of Neuroplacticity, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurochem 87:922-34. 2003..The recruitment of the NMDA receptor signal transduction pathway by D1 receptors may provide a general mechanism for gene regulation that is fundamental for mechanisms of drug addiction and long-term memory... - Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in ratsAllison T Knoll
Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
Biol Psychiatry 70:425-33. 2011..Here, we sought to identify neural circuits that mediate KOR system effects on fear and anxiety in rats... - Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitroElena H Chartoff
Department of Psychiatry, Harvard Medical School at McLean Hospital, Belmont, Massachusetts 02478, USA
Ann N Y Acad Sci 1003:368-71. 2003 - Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the ratMatthew L MacDonald
Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 57:1041-51. 2005..We furthermore found that the gene expression profile of APDs is different between FC and striatum... - Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissueElena H Chartoff
Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
Mol Pharmacol 75:704-12. 2009.... - Brain reward regulated by AMPA receptor subunits in nucleus accumbens shellMark S Todtenkopf
Behavioral Genetics, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:11665-9. 2006..These data suggest that GluR1 and GluR2 in the NAc shell play opposing roles in the regulation of motivated behavior... - Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stressAlipi V Naydenov
Laboratory of Neuroplasticity and Schizophrenia and Bipolar Disorders Program, McLean Hospital, Belmont, MA, USA
Arch Gen Psychiatry 64:555-64. 2007..Bipolar disorder (BPD) is among the top 10 causes of disability worldwide. Recent findings on the etiology of the disease point to a disturbed mitochondrial energy metabolism in the brain of subjects with BPD... - Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequencesRachael M Youngs
Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:6031-9. 2006..Our results indicate that Li administration to the normal brain has the potential for lasting adverse effects... - Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorderMatthew L MacDonald
Laboratory of Neuroplasticity, McLean Hospital, Belmont, MA 02478, USA
Bipolar Disord 8:255-64. 2006..The downregulation of CK transcripts, if translated into protein levels, could explain the reduction of high-energy phosphates previously observed in BPD... - Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescenceYolanda D Black
Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:9656-65. 2006..These findings suggest that exposure to cocaine during adolescence has far-reaching molecular and behavioral consequences in the rat PFC that develop over time and endure long after drug administration has ceased... - Hippocampal pathology in schizophreniaStephan Heckers
Department of Psychiatry, Vanderbilt University, 1601 23rd Avenue South, Room 3060, Nashville, TN 37212, USA
Curr Top Behav Neurosci 4:529-53. 2010..Taken together, this pattern of findings points to a disinhibition of hippocampal pyramidal cells and abnormal cortico-hippocampal interactions in schizophrenia... - Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatumElena H Chartoff
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts, USA
J Neurochem 87:107-18. 2003..Furthermore, they are consistent with in vivo evidence suggesting that increased CREB activation in portions of the striatum (e.g. the NAc) is related to dysphoric states associated with drug withdrawal... - Gene expression microarray studies in polygenic psychiatric disorders: applications and data analysisChristine Konradi
Laboratory of Neuroplasticity, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Brain Res Brain Res Rev 50:142-55. 2005..All results should be verified by independent means. This review is intended to help brain researchers who want to apply gene expression microarray technology to conceptualize research strategies and sample analysis... - Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with moleculesWilliam A Carlezon
Department of Psychiatry, Harvard Medical School and McLean Hospital, MRC 217, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 47:47-60. 2004..It may also identify periods of development during which administration of these agents is particularly safe or risky... - Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptorsJenny E Westin
Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Sweden
Biol Psychiatry 62:800-10. 2007..We examined the activation pattern of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and its dependence on D1 versus D2 dopamine receptors in hemiparkinsonian rats treated with 3,4-dihydroxyphenyl-L-alanine (L-DOPA)...