Joseph Italiano

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Clinical relevance of microparticles from platelets and megakaryocytes
    Joseph E Italiano
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Hematol 17:578-84. 2010
  2. ncbi Selective sorting of alpha-granule proteins
    J E Italiano
    Division of Translational Medicine, Brigham and Women s Hospital, Vascular Biology Program, Boston, MA 02115, USA
    J Thromb Haemost 7:173-6. 2009
  3. ncbi Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
    Joseph E Italiano
    Translational Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 111:1227-33. 2008
  4. ncbi Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts
    Hervé Falet
    Division of Hematology, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:16782-7. 2002
  5. ncbi Platelets actively sequester angiogenesis regulators
    Giannoula Lakka Klement
    Children s Hospital, Boston, MA 02115, USA
    Blood 113:2835-42. 2009
  6. ncbi Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles
    Robert Flaumenhaft
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 113:1112-21. 2009
  7. ncbi Platelet- and megakaryocyte-derived microparticles
    Robert Flaumenhaft
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Semin Thromb Hemost 36:881-7. 2010
  8. ncbi Cytoskeletal mechanisms for platelet production
    John H Hartwig
    Hematology Division, Brigham and Women s Hospital, 1 Blackfan Circle, Boston, MA 02115, USA
    Blood Cells Mol Dis 36:99-103. 2006
  9. ncbi Mechanisms and implications of platelet discoid shape
    Joseph E Italiano
    Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 101:4789-96. 2003
  10. ncbi Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change
    Kurt L Barkalow
    Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 285:C797-805. 2003

Research Grants

  1. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2005
  2. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2007
  3. Cytoskeletal Mechanisms of Platelet Formation
    Joseph E Italiano; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. ncbi Clinical relevance of microparticles from platelets and megakaryocytes
    Joseph E Italiano
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Hematol 17:578-84. 2010
    ..This review will address mechanisms of platelet microparticle generation and evaluate our current understanding of their clinical relevance...
  2. ncbi Selective sorting of alpha-granule proteins
    J E Italiano
    Division of Translational Medicine, Brigham and Women s Hospital, Vascular Biology Program, Boston, MA 02115, USA
    J Thromb Haemost 7:173-6. 2009
    ..We consider the implications of this new paradigm of platelet secretion, discuss mechanisms of alpha-granule biogenesis, and review the molecular basis of transport and delivery of alpha-granules to assembling platelets...
  3. ncbi Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released
    Joseph E Italiano
    Translational Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 111:1227-33. 2008
    ....
  4. ncbi Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts
    Hervé Falet
    Division of Hematology, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, 221 Longwood Avenue, LMRC 301, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:16782-7. 2002
    ..We conclude that Arp23 complex contribution to actin filament nucleation in platelets and fibroblasts importantly requires free barbed ends generated by severing and uncapping...
  5. ncbi Platelets actively sequester angiogenesis regulators
    Giannoula Lakka Klement
    Children s Hospital, Boston, MA 02115, USA
    Blood 113:2835-42. 2009
    ....
  6. ncbi Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles
    Robert Flaumenhaft
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 113:1112-21. 2009
    ..These results indicate that direct production by megakaryocytes represents a physiologic means to generate circulating platelet microparticles...
  7. ncbi Platelet- and megakaryocyte-derived microparticles
    Robert Flaumenhaft
    Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Semin Thromb Hemost 36:881-7. 2010
    ..Special emphasis is placed on the mechanisms of microparticle formation and novel functions for microparticles in normal physiology and disease states...
  8. ncbi Cytoskeletal mechanisms for platelet production
    John H Hartwig
    Hematology Division, Brigham and Women s Hospital, 1 Blackfan Circle, Boston, MA 02115, USA
    Blood Cells Mol Dis 36:99-103. 2006
    ..How individual platelets form and release from proplatelets remains poorly understood...
  9. ncbi Mechanisms and implications of platelet discoid shape
    Joseph E Italiano
    Division of Hematology and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Blood 101:4789-96. 2003
    ..Together, these findings highlight the essential requirements of the MK/platelet-restricted beta1-tubulin isoform in platelet structure and suggest that spherocytosis does not impair many aspects of platelet function...
  10. ncbi Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change
    Kurt L Barkalow
    Division of Hematology, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 285:C797-805. 2003
    ....
  11. ncbi The biogenesis of platelets from megakaryocyte proplatelets
    Sunita R Patel
    Hematology Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 115:3348-54. 2005
    ..This Review will describe the process of platelet assembly in detail and discuss several disorders that affect platelet production...
  12. ncbi Alpha-adducin dissociates from F-actin and spectrin during platelet activation
    Kurt L Barkalow
    Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 161:557-70. 2003
    ....
  13. ncbi RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules
    Harald Schulze
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Biol Chem 283:14109-19. 2008
    ..GTP may influence organization of the specialized microtubules required in thrombopoiesis and that RanBP10 might serve as a molecular link between Ran and noncentrosomal microtubules...
  14. ncbi Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules
    Sunita Patel-Hett
    Translational Medicine Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 111:4605-16. 2008
    ..Thus, the dynamic microtubules associated with the marginal band likely function during both resting and activated platelet states...
  15. ncbi Interactions between the megakaryocyte/platelet-specific beta1 tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet functions
    Harald Schulze
    Dana Farber Cancer Institute, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Blood 104:3949-57. 2004
    ..SLPI may thus have unanticipated roles in MK and platelet functions, including regulated proteolysis after activation...
  16. ncbi Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis
    Elisabeth M Battinelli
    Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Curr Opin Hematol 14:419-26. 2007
    ..The aim of this review is to explore the state of the art knowledge on the cell biological and molecular pathways that regulate megakaryopoiesis and lead to platelet production...
  17. ncbi Mechanisms of organelle transport and capture along proplatelets during platelet production
    Jennifer L Richardson
    Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
    Blood 106:4066-75. 2005
    ..These studies demonstrate that the components that form platelets are delivered to and assembled de novo along proplatelets...
  18. ncbi Dynamic visualization of thrombopoiesis within bone marrow
    Tobias Junt
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 317:1767-70. 2007
    ..These results confirm the concept of proplatelet formation in vivo and are consistent with the possibility that blood flow-induced hydrodynamic shear stress is a biophysical determinant of thrombopoiesis...
  19. ncbi Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes
    Sunita R Patel
    Division of Hematology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Blood 106:4076-85. 2005
    ..We conclude that while continuous polymerization of microtubules is necessary to support the enlarging proplatelet mass, the sliding of overlapping microtubules is a vital component of proplatelet elongation...
  20. ncbi ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells
    Akio Shimizu
    Vascular Biology Program, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:27230-8. 2008
    ..Cells treated with p190RhoGAP small interfering RNA also did not inactivate RhoA. Together, these results suggested that ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity...
  21. ncbi A role for Rab27b in NF-E2-dependent pathways of platelet formation
    Sanjay Tiwari
    Dana Farber Cancer Institute, One Jimmy Fund Way, Boston, MA 02115, USA
    Blood 102:3970-9. 2003
    ..These results establish a role for Rab27 in platelet synthesis and suggest that Rab27b in particular may coordinate proplatelet formation with granule transport, possibly by recruiting specific effector pathways...
  22. ncbi Platelet-associated PF-4 as a biomarker of early tumor growth
    David Cervi
    Children s Hospital Boston, Karp Family Research Laboratories, Boston, MA 02115, USA
    Blood 111:1201-7. 2008
    ..We conclude that platelet-associated PF-4, but not its plasma counterpart, may represent a potential biomarker of early tumor presence...
  23. ncbi Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells
    Nicholas Papadantonakis
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cell Cycle 7:2352-6. 2008
    ..This is the first study to document chromosomal segregation patterns during endomitosis ex vivo and to indicate their potential differential regulation in low and high ploidy cells...

Research Grants9

  1. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2005
    ..Understanding the cytoskeletal mechanics of platelet formation may provide insights into how platelets are produced and yield strategies for treatment of thrombocytopenia. ..
  2. Cytoskeletal Mechanisms of Platelet Formation
    Joseph Italiano; Fiscal Year: 2007
    ....
  3. Cytoskeletal Mechanisms of Platelet Formation
    Joseph E Italiano; Fiscal Year: 2010
    ....