Research Topics
| M D HolmesSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Physical activity and breast cancer survivalAdeyemi A Ogunleye
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
Breast Cancer Res 11:106. 2009..Randomized trials are ongoing but trials of lifestyle factors are notoriously challenging to perform. Women with breast cancer have little to lose and may possibly gain from moderate exercise...- Lifestyle correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrationsMichelle D Holmes
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 11:862-7. 2002..This is the first report of an inverse association of circulating IGF-I levels with parity. This association may represent one mechanism by which parity exerts its protective effect on some cancers... - Physical activity and survival after breast cancer diagnosisMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
JAMA 293:2479-86. 2005..Physical activity has been shown to decrease the incidence of breast cancer, but the effect on recurrence or survival after a breast cancer diagnosis is not known... - Does diet affect breast cancer risk?Michelle D Holmes
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
Breast Cancer Res 6:170-8. 2004..Nevertheless, available evidence is strong that breast cancer risk can be reduced by avoiding weight gain during adult years, and by limiting alcohol consumption... - Smoking and survival after breast cancer diagnosisMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 120:2672-7. 2007..We conclude that a history of smoking increased mortality following diagnosis with breast cancer, but did not increase mortality from breast cancer... - Dietary carbohydrates, fiber, and breast cancer riskMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 159:732-9. 2004..This study also confirmed the lack of an overall association between intake of fiber and fiber types and breast cancer risk observed in other prospective studies... - Validation of a food frequency questionnaire measurement of selected nutrients using biological markers in African-American menM D Holmes
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
Eur J Clin Nutr 61:1328-36. 2007..To validate selected nutrients assessed by the food frequency questionnaire (FFQ) used in the Harvard cohort studies in an African-American group... - COX-2 expression predicts worse breast cancer prognosis and does not modify the association with aspirinMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res Treat 130:657-62. 2011..The survival benefit associated with aspirin use did not differ by COX-2 status. COX-2 breast cancer expression is associated with worse prognosis. If aspirin truly impacts breast cancer survival, then it is not solely via COX-2... - Meat, fish and egg intake and risk of breast cancerMichelle D Holmes
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
Int J Cancer 104:221-7. 2003..89 (0.79-1.00) for all meat. Results did not differ by menopausal status or family history of breast cancer. We found no evidence that intake of meat or fish during mid-life and later was associated with risk of breast cancer... - Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrationsMichelle D Holmes
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 11:852-61. 2002..We conclude that higher energy, protein, and milk intakes were associated with higher levels of IGF-I. These associations raise the possibility that diet could affect cancer risk through influencing IGF-I level... - Physical activity's impact on the association of fat and fiber intake with survival after breast cancerMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Epidemiol 170:1250-6. 2009..40), P = 0.59. Results of simple models adjusted additionally for physical activity were similar to those for full multivariate models. Results show that physical activity strongly confounds the association between diet and survival... - Aspirin intake and survival after breast cancerMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 28:1467-72. 2010..Animal and in vitro studies suggest that aspirin may inhibit breast cancer metastasis. We studied whether aspirin use among women with breast cancer decreased their risk of death from breast cancer... - Dietary fat, fat subtypes, and breast cancer risk: lack of an association among postmenopausal women with no history of benign breast diseaseCelia Byrne
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 11:261-5. 2002..We found no increase in the rate of breast cancer with greater intake of dietary fat and fat subtypes among postmenopausal women without a history of BBD... - Physical activity and survival after colorectal cancer diagnosisJeffrey A Meyerhardt
Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 24:3527-34. 2006..Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown... - Choline and betaine intake and risk of breast cancer among post-menopausal womenE Cho
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
Br J Cancer 102:489-94. 2010..No prospective study among post-menopausal women has examined choline and betaine intakes in relation to breast cancer risk... - Dietary glycemic load assessed by food-frequency questionnaire in relation to plasma high-density-lipoprotein cholesterol and fasting plasma triacylglycerols in postmenopausal womenS Liu
Division of Preventive Medicine and the Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 73:560-6. 2001..In epidemiologic studies, dietary glycemic load (GL) is positively associated with risk of coronary artery disease and type 2 diabetes... - Milk consumption and acne in adolescent girlsClement A Adebamowo
Department of Nutrition, Harvard School of Public Health, Boston, USA
Dermatol Online J 12:1. 2006..We found a positive association between intake of milk and acne. This finding supports earlier studies and suggests that the metabolic effects of milk are sufficient to elicit biological responses in consumers... - Dietary patterns and the risk of postmenopausal breast cancerTeresa T Fung
Department of Nutrition, Simmons College, Boston, MA 02115, USA
Int J Cancer 116:116-21. 2005..However, a Western-type diet may elevate risk of breast cancer among smokers, and a prudent diet may protect against estrogen receptive-negative tumors... - Electric blanket use and breast cancer in the Nurses' Health StudyF Laden
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 152:41-9. 2000..While 95% confidence intervals for these estimates did not exclude small risks, overall, results did not support an association between breast cancer risk and exposure to EMFs from electric blankets... - Advancing public health genomics in Africa through prospective cohort studiesS Dalal
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
J Epidemiol Community Health 64:585-6. 2010..Combining powerful genomic tools with epidemiology through large cohort studies could dramatically advance public health in Africa... - High school dietary dairy intake and teenage acneClement A Adebamowo
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Am Acad Dermatol 52:207-14. 2005..We examined data from the Nurses Health Study II to retrospectively evaluate whether intakes of dairy foods during high school were associated with physician-diagnosed severe teenage acne... - Caregiving stress, endogenous sex steroid hormone levels, and breast cancer incidenceCandyce H Kroenke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 159:1019-27. 2004..7.46 pg/ml (95% confidence interval: 6.36, 8.76)) and bioavailable estradiol (geometric mean, 1.86 pg/ml vs. 1.35 pg/ml (95% confidence interval: 1.00, 1.82)). Stress from caregiving did not appear to increase breast cancer risk... - Diet and breast cancerEleni Linos
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
Curr Oncol Rep 9:31-41. 2007..Diet during early life may play a substantial role in later cancer risk, but data are limited. In addition, physical activity and the prevention of weight gain can improve survival after a breast cancer diagnosis... - Functional impact of breast cancer by age at diagnosisCandyce H Kroenke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 22:1849-56. 2004..To explore changes in physical and psychosocial function before and after breast cancer by age at diagnosis... - Risk factors for breast cancer according to estrogen and progesterone receptor statusGraham A Colditz
Cancer Epidemiology Program, Dana Farber Harvard Cancer Center, and Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115 5899, USA
J Natl Cancer Inst 96:218-28. 2004..To address this issue, we conducted a prospective evaluation of risk factors for breast cancer classified according to receptor status... - Coffee, tea, caffeine and risk of breast cancer: a 22-year follow-upDavaasambuu Ganmaa
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 122:2071-6. 2008..However, our results suggested a weak inverse association between caffeine-containing beverages and risk of postmenopausal breast cancer... - Milk consumption and acne in teenaged boysClement A Adebamowo
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
J Am Acad Dermatol 58:787-93. 2008..We sought to examine the association between dietary dairy intake and teenaged acne among boys... - Dietary correlates of urinary 6-sulfatoxymelatonin concentrations in the Nurses' Health Study cohortsEva S Schernhammer
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Clin Nutr 90:975-85. 2009..Although melatonin is a direct derivative of the essential amino acid tryptophan, little is known about the relation of diet with melatonin concentrations... - Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancerShumin M Zhang
Department of Epidemiology, Harvard School of Public Health, Division of Preventive Medicine, Boston, MA 02115, USA
J Natl Cancer Inst 95:373-80. 2003..However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study... - Assessment of a dietary questionnaire in cancer patients receiving cytotoxic chemotherapyJeffrey A Meyerhardt
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
J Clin Oncol 23:8453-60. 2005..Although several comprehensive dietary questionnaires have been validated and calibrated in healthy populations, similar studies have not been performed among cancer patients... - Meat mutagens and breast cancer in postmenopausal women--a cohort analysisKana Wu
Department of Nutrition, Harvard School of Public Health, and Department of Medicine, Brigham and Women s Hospital, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 19:1301-10. 2010..Mutagenic compounds produced when meats are cooked at high temperatures have been hypothesized to increase risk of breast cancer... - White rice, brown rice, and risk of type 2 diabetes in US men and womenQi Sun
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Arch Intern Med 170:961-9. 2010..We examined white and brown rice consumption in relation to type 2 diabetes risk prospectively in the Health Professionals Follow-up Study and the Nurses' Health Study I and II... - Physical activity and risk of breast cancer among postmenopausal womenA Heather Eliassen
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 170:1758-64. 2010..Although greater activity has been related to lower postmenopausal breast cancer risk, important details remain unclear, including type, intensity, and timing of activity and whether the association varies by subgroups... - Dietary fat and risk of postmenopausal breast cancer in a 20-year follow-upEsther H J Kim
Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 164:990-7. 2006..These results suggest a reduction in breast cancer risk for women with insulin resistance syndrome who consume high-fat diets and no association between specific sources of fat during midlife and risk of postmenopausal breast cancer... - Dietary patterns and the risk of breast cancerClement A Adebamowo
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Ann Epidemiol 15:789-95. 2005..We examined data from the Nurses Health Study II to evaluate the association between major dietary patterns and the risk of breast cancer among pre-menopausal women... - Correlates of use of different types of complementary and alternative medicine by breast cancer survivors in the nurses' health studyCatherine Buettner
Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, MA 02215 3325, USA
Breast Cancer Res Treat 100:219-27. 2006..Among breast cancer survivors, we identified the prevalence and correlates of use of different types of complementary and alternative medicine (CAM)... - Weight, weight gain, and survival after breast cancer diagnosisCandyce H Kroenke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
J Clin Oncol 23:1370-8. 2005..To determine whether weight prior to diagnosis and weight gain after diagnosis are predictive of breast cancer survival... - Unopposed estrogen therapy and the risk of invasive breast cancerWendy Y Chen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Arch Intern Med 166:1027-32. 2006..We sought to assess the relationship between longer-term use of unopposed estrogen and the risk of invasive breast cancer over an extended follow-up period... - Dietary flavonols and flavonol-rich foods intake and the risk of breast cancerClement A Adebamowo
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Int J Cancer 114:628-33. 2005..76 (0.57, 1.00; p-value for test of trend=0.03). While we found no overall association between intake of flavonols and risk of breast cancer, there was an inverse association with intake of beans or lentils that merits further evaluation... - Racial differences in premenopausal endogenous hormonesSimone P Pinheiro
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:2147-53. 2005..Further research is needed to explore differences across racial groups and the link between endogenous hormones and breast cancer risk... - Depressive symptoms and prospective incidence of colorectal cancer in womenCandyce H Kroenke
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 162:839-48. 2005..04). Associations appeared stronger in overweight women. However, depressive symptoms were unrelated to risk of colorectal adenomas. Associations are consistent with a possible role in late promotion of the disease... - Intake of dairy products, calcium, and vitamin d and risk of breast cancerMyung-Hee Shin
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
J Natl Cancer Inst 94:1301-11. 2002..Similar inverse associations were seen with components (calcium and vitamin D) of dairy foods, but their independent associations with breast cancer are difficult to distinguish... - Association of hormone replacement therapy to estrogen and progesterone receptor status in invasive breast carcinomaWendy Y Chen
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Cancer 101:1490-500. 2004.... - Diet quality is associated with the risk of estrogen receptor-negative breast cancer in postmenopausal womenTeresa T Fung
Department of Nutrition, Simmons College, Boston, MA, USA
J Nutr 136:466-72. 2006..01) with the vegetable component of the scores. We conclude that women who scored high in AHEI, RFS, and aMed had a lower risk of ER- breast cancer. The HEI and DQI-R appeared to be of limited value in predicting breast cancer risk... - Prospective changes in quality of life after ductal carcinoma-in-situ: results from the Nurses' Health StudyLarissa Nekhlyudov
Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, Boston, MA 02215, USA
J Clin Oncol 24:2822-7. 2006..However, uncertainties exist about its prognosis, optimal treatment, and effect on women's health-related quality-of-life (HRQoL). Our study assessed the prospective changes in HRQoL in women diagnosed with DCIS... - Disparities across the breast cancer continuumJudyann Bigby
Department of Medicine, Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
Cancer Causes Control 16:35-44. 2005..We performed a structured review of the literature to identify areas of greater and lesser knowledge of the nature of disparities across the breast cancer continuum from risk and prevention to treatment and mortality... - Plasma 25-hydroxyvitamin D levels and risk of incident hypertensionJohn P Forman
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hypertension 49:1063-9. 2007..31 (95% CI: 2.03 to 2.63) in men and 1.57 (95% CI: 1.44 to 1.72) in women. Plasma 25(OH)D levels are inversely associated with risk of incident hypertension... - Prostate cancer mortality in Connecticut, Iowa and New Mexico African American menLuis G Escobedo
Public Health Division, New Mexico Department of Health, 1170 North Solano, Suite L, Las Cruces, NM 88001, USA
Cancer Detect Prev 28:375-80. 2004.... - Dietary patterns and survival after breast cancer diagnosisCandyce H Kroenke
University of California, Robert Wood Johnson Health and Society Scholars Program, San Francisco, CA 94118, USA
J Clin Oncol 23:9295-303. 2005..There is little prior study of major dietary patterns and breast cancer survival... - Social networks, social support, and survival after breast cancer diagnosisCandyce H Kroenke
Robert Wood Johnson Health and Society Scholars, University of California, San Francisco, Center for Health and Community, San Francisco, CA 94118, USA
J Clin Oncol 24:1105-11. 2006..We prospectively examined social ties and survival after breast cancer diagnosis... - Beyond treatment: lifestyle choices after breast cancer to enhance quality of life and survivalMichelle D Holmes
Womens Health Issues 14:11-3. 2004 - Social networks and health-related quality of life in breast cancer survivors: a prospective studyYvonne L Michael
School of Community Health, College of Urban and Public Affairs, Portland State University, PO Box 751, OR 97207, USA
J Psychosom Res 52:285-93. 2002..To examine prospectively the influence of social networks on health-related quality of life (HRQoL) among breast cancer survivors...
Research Grants
- Vitamin D Intake and Breast Cancer SurvivalMichelle Holmes; Fiscal Year: 2005..A polymorphism in VDR (FOK1) has been shown to influence breast cancer risk. We hypothesize that women homozygous for this polymorphism will have an increased risk of death from breast cancer. ..