Research Topics
Species | William HahnSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Telomerase activation, cellular immortalization and cancerW C Hahn
Department of Adult Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Boston, MA 02115, USA
Ann Med 33:123-9. 2001..These applications include inhibiting or targeting telomerase as a novel antineoplastic strategy and using cells immortalized by telomerase for therapeutic applications...- Role of telomeres and telomerase in the pathogenesis of human cancerWilliam C Hahn
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 21:2034-43. 2003..Recent advances in our understanding of telomere biology indicate that the manipulation of telomeres and telomerase will lead to clinically significant applications in the diagnosis, prevention, and treatment of neoplastic disease... - Integrative genomic approaches to understanding cancerWilliam C Hahn
Center for Cancer Genome Discovery, Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Biochim Biophys Acta 1790:478-84. 2009..The integration of these approaches now provides the means to not only derive a complete molecular description of cancer but will also provide well-validated targets for the development of therapeutic agents... - Targeting cancer with telomerase: commentary re Q. Huang et al., a novel conditionally replicative adenovirus vector targeting telomerase-positive tumor cells. Clin. Cancer Res., 10: 1439-1445, 2004William C Hahn
Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Clin Cancer Res 10:1203-5. 2004 - Empty pockets yield more telomere changeWilliam C Hahn
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Dana 710C, Boston, Massachusetts 02115, USA
Cell Cycle 1:406-7. 2002 - Senescence, telomere shortening and telomere maintenanceWilliam C Hahn
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cancer Biol Ther 1:398-400. 2002 - Rules for making human tumor cellsWilliam C Hahn
Department of Medical Oncology, Dana-Farber Cancer Institute, and the Department of Medicine, Brigham and Women's Hospital, Boston 02115, USA
N Engl J Med 347:1593-603. 2002 - Telomere and telomerase dynamics in human cellsW C Hahn
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Curr Mol Med 5:227-31. 2005..Understanding the complexity of telomere biology will provide further insights into chromosome biology in both normal and malignant cells... - Modelling the molecular circuitry of cancerWilliam C Hahn
Whitehead Institute for Biomedical Research, Massachusetts 02142, USA
Nat Rev Cancer 2:331-41. 2002.... - Experimental models of human cancerWilliam C Hahn
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Cell Cycle 3:604-5. 2004 - Immortalization and transformation of human cellsWilliam C Hahn
Department of Adult Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mol Cells 13:351-61. 2002..This review summarizes these recent advances in our understanding of these molecular mechanisms that contribute to human cell immortalization and transformation... - Cancer: surviving on the edgeWilliam C Hahn
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cancer Cell 6:215-22. 2004..This year's Beatson International Cancer Conference focused on recent advances in our understanding of the pathways that regulate senescence, apoptosis, and cancer... - Oncogenic transformation and experimental models of human cancerAnna C Schinzel
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Front Biosci 13:71-84. 2008..Here we review the development of such experimental models and recent work combining such model systems with increasingly powerful genetic and chemical tools to identify and validate genes involved in malignant transformation... - Telomerase contributes to tumorigenesis by a telomere length-independent mechanismSheila A Stewart
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Proc Natl Acad Sci U S A 99:12606-11. 2002..These studies indicate that hTERT confers an additional function that is required for tumorigenesis but does not depend on its ability to maintain telomeres... - Telomerase expression--only half the storyKenkichi Masutomi
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts USA
Cancer Biol Ther 2:685-6. 2003 - Enumeration of the simian virus 40 early region elements necessary for human cell transformationWilliam C Hahn
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Mol Cell Biol 22:2111-23. 2002.... - Unexpected pieces to the senescence puzzleKaren Cichowski
Genetics Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115 USA
Cell 133:958-61. 2008..2008; Kuilman et al., 2008; Wajapeyee et al., 2008). These new studies identify unanticipated contributors to this tumor-suppressing cell state... - Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaborationDavid M Eisenberg
Osher Research Center, Division for Research and Education in Complementary and Integrative Medical Therapies, Harvard Medical School, Boston, MA 02115, USA
Fitoterapia 82:17-33. 2011..It is hoped that these methods will foster scientific discoveries with therapeutic potential and enhance efforts to systematically evaluate commonly used herbal therapies worldwide... - Bladder cancer: modeling and translationJonathan E Rosenberg
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Genes Dev 23:655-9. 2009..Moreover, the anatomy of this urinary malignancy provides a unique opportunity for innovative translational studies... - Telomerase and tumorigenesisKenkichi Masutomi
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Dana 710C, Boston, MA 02115, USA
Cancer Lett 194:163-72. 2003..Here we review recent developments in our understanding of the relationships among telomeres, telomerase, and cancer... - A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere statusJames G Rheinwald
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Mol Cell Biol 22:5157-72. 2002..Our results suggest that such mutations endow keratinocytes with extended replicative potential which may serve to increase the probability of neoplastic progression... - On or off target: mutations, models, and predictionsLevi A Garraway
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Sci Transl Med 2:35ps28. 2010..In this issue of Science Translational Medicine, Whittaker et al. describe research that reconciles some of the bewildering aspects of the discovery and development of drugs that inhibit such protein kinase targets in cancer... - Chemosensitivity linked to p73 functionMeredith S Irwin
Dana-Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 3:403-10. 2003..Mutant p53 can inactivate p73 and downregulation of mutant p53 enhanced chemosensitivity. These findings indicate that p73 is a determinant of chemotherapeutic efficacy in humans... - Proteomic and genetic approaches identify Syk as an AML targetCynthia K Hahn
Department of Pediatric Oncology, Dana Farber Cancer Institute and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 16:281-94. 2009..These results demonstrate the power of integrating diverse chemical, proteomic, and genomic screening approaches to identify therapeutic strategies for cancer... - The telomerase reverse transcriptase regulates chromatin state and DNA damage responsesKenkichi Masutomi
Department of Medical Oncology and Biostatistical Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:8222-7. 2005..Cells lacking hTERT exhibit increased radiosensitivity, diminished capacity for DNA repair, and fragmented chromosomes, demonstrating that loss of hTERT impairs the DNA damage response... - CDK8 is a colorectal cancer oncogene that regulates beta-catenin activityRon Firestein
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
Nature 455:547-51. 2008..Together these observations suggest that therapeutic interventions targeting CDK8 may confer a clinical benefit in beta-catenin-driven malignancies... - Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamicsRichard Possemato
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Mol Cancer Res 6:1582-93. 2008..Manipulating this function of hPOT1 may thus hasten the cytotoxic effects of telomerase inhibition... - Transformation of human and murine fibroblasts without viral oncoproteinsJesse S Boehm
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St, Dana 710C, Boston, MA 02115-6013, USA
Mol Cell Biol 25:6464-74. 2005.... - Cancer genetics: Finding the right mixJesse S Boehm
Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney St, Dana 710C, Boston, MA 02115-6013, USA
Eur J Hum Genet 13:1099-100. 2005 - Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutantsHeidi Greulich
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
PLoS Med 2:e313. 2005..The presence of mutations correlates with tumor sensitivity to the EGFR inhibitors erlotinib and gefitinib, but the transforming potential of specific mutations and their relationship to drug sensitivity have not been described... - Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulatorsHaley Hieronymus
The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Cancer Cell 10:321-30. 2006..Validating this prediction, we demonstrate that celastrol and gedunin inhibit HSP90 activity and HSP90 clients, including AR. Broadly, this work identifies new modes of HSP90 modulation through a gene expression-based strategy... - Integrative genomic approaches identify IKBKE as a breast cancer oncogeneJesse S Boehm
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cell 129:1065-79. 2007..These observations suggest a mechanism for NF-kappaB activation in breast cancer, implicate the NF-kappaB pathway as a downstream mediator of PI3K, and provide a framework for integrated genomic approaches in oncogene discovery... - Functional genomics and cancer drug target discoverySusan E Moody
Dana Farber Cancer Institute, Department of Medical Oncology, 44 Binney Street, Boston, MA 02115, USA
Curr Opin Mol Ther 12:284-93. 2010..This review provides an overview of the tools available for the study of functional genomics, and discusses recent research involving the use of these tools to identify potential novel drug targets in cancer... - An oncogenic role for ETV1 in melanomaJudit Jane-Valbuena
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 70:2075-84. 2010..These observations implicate deregulated ETV1 in melanoma genesis and suggest a pivotal lineage dependency mediated by oncogenic ETS transcription factors in this malignancy... - Feedback circuit among INK4 tumor suppressors constrains human glioblastoma developmentRuprecht Wiedemeyer
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 13:355-64. 2008.... - Telomerase: regulation, function and transformationCarolyn K Dong
Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Crit Rev Oncol Hematol 54:85-93. 2005..In this review, we summarize recent observations that support the concept that telomerase plays multiple roles in facilitating human cell transformation... - Prospects for anti-neoplastic therapies based on telomere biologySheila A Stewart
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Curr Cancer Drug Targets 2:1-17. 2002..Understanding telomerase biology may eventually lead to several types of clinically effective, telomerase-based therapies for neoplastic disease... - Erosion of the telomeric single-strand overhang at replicative senescenceSheila A Stewart
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nat Genet 33:492-6. 2003..We thus provide evidence for a specific molecular alteration in telomere structure at senescence and suggest that this change, rather than overall telomere length, serves to trigger this state... - Immortalization and transformation of primary human airway epithelial cells by gene transferAnte S Lundberg
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Oncogene 21:4577-86. 2002.... - Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytesRobert H Vonderheide
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Clin Cancer Res 10:828-39. 2004..CONCLUSIONS: These results demonstrate the immunological feasibility of vaccinating patients against telomerase and provide rationale for targeting self-antigens with critical roles in oncogenesis... - Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cellsClaudia Scholl
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cell 137:821-34. 2009.... - Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinaseJean J Zhao
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Cancer Cell 3:483-95. 2003..However, elevated c-myc expression cannot replace H-rasV12 for tumorigenesis. These observations begin to define the pathways perturbed during the transformation of HMECs... - Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancerToshiro Migita
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Natl Cancer Inst 101:519-32. 2009..Overexpression of the fatty acid synthase (FASN) gene has been implicated in prostate carcinogenesis. We sought to directly assess the oncogenic potential of FASN... - Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cellsSonam Dolma
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cancer Cell 3:285-96. 2003.... - Cancer genomics: integrating form and functionSo Young Kim
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Carcinogenesis 28:1387-92. 2007.... - Identification of specific PP2A complexes involved in human cell transformationWen Chen
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Cancer Cell 5:127-36. 2004..These observations identify specific PP2A complexes involved in human cell transformation... - Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancerAlec C Kimmelman
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:19372-7. 2008..Like RIOK3, PAK4 promotes pancreas ductal cell motility and invasion. Together, the genomic and functional profiles establish the Rho family GTP-binding proteins as integral to the hallmark invasive nature of this lethal disease... - Profiling critical cancer gene mutations in clinical tumor samplesLaura E MacConaill
Center for Cancer Genome Discovery, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 4:e7887. 2009..We report the implementation of a genotyping and validation algorithm that enables robust tumor mutation profiling in the clinical setting... - BRAF activation initiates but does not maintain invasive prostate adenocarcinomaJoseph H Jeong
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 3:e3949. 2008.... - Telomerase maintains telomere structure in normal human cellsKenkichi Masutomi
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Cell 114:241-53. 2003..Together, these observations support the view that telomerase and telomere structure are dynamically regulated in normal human cells and that telomere length alone is unlikely to trigger entry into replicative senescence... - Androgen-induced differentiation and tumorigenicity of human prostate epithelial cellsRaanan Berger
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
Cancer Res 64:8867-75. 2004..These observations indicate that androgen receptor expression is oncogenic and addictive for the human prostate epithelium... - The role of PP2A A subunits in tumor suppressionAnna A Sablina
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusets, USA
Cell Adh Migr 1:140-1. 2007..These observations provide evidence that dysfunction of particular PP2A complexes regulate specific phosphorylation event necessary for cancer initiation... - A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progressionPradip K Majumder
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer Cell 14:146-55. 2008..These data suggest that a p27(Kip1)-driven checkpoint limits progression of PIN to CaP... - AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancerKrishna M Vasudevan
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 16:21-32. 2009..Thus, PI3K may promote cancer through both AKT-dependent and AKT-independent mechanisms. Knowledge of differential PI3K/PDK1 signaling could inform rational therapeutics in cancers harboring PIK3CA mutations... - CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survivalRon Firestein
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Int J Cancer 126:2863-73. 2010..These data support a potential link between CDK8 and beta-catenin, and suggest that CDK8 may identify a subset of colon cancer patients with a poor prognosis... - Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1David A Barbie
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115 USA
Nature 462:108-12. 2009..These observations indicate that TBK1 and NF-kappaB signalling are essential in KRAS mutant tumours, and establish a general approach for the rational identification of co-dependent pathways in cancer... - Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylaseQing Zhang
Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Cancer Cell 16:413-24. 2009..EglN2 depletion also impairs the fitness of lung, brain, and hematopoietic cancer lines. These findings support the exploration of EglN2 inhibitors as therapeutics for estrogen-dependent breast cancer and other malignancies... - PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomasHongwu Zheng
Belfer Institute for Applied Cancer Science, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Cancer Cell 17:497-509. 2010..The identification of PLAGL2 as a glioma oncogene highlights the importance of a growing class of cancer genes functioning to impart stem cell-like characteristics in malignant cells... - Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBMW Ruprecht Wiedemeyer
Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:11501-6. 2010..More generally, these observations demonstrate that the integration of genomic, functional and pharmacologic data can be exploited to inform the development of targeted therapy directed against specific cancer pathways... - An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaBJunxia Min
Genetics Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Med 16:286-94. 2010..These studies define the mechanism by which two major pathways can be simultaneously activated in metastatic prostate cancer and establish EZH2 as a driver of metastasis... - Roots and stems: stem cells in cancerKornelia Polyak
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nat Med 12:296-300. 2006.... - The origin of cancerEvan Y Yu
Dana-Farber Cancer Institute and Brigham and Women Hospital, Harvard Medical School, Boston, MA 02115, USA
Cancer Treat Res 122:1-22. 2004 - Involvement of PP2A in viral and cellular transformationJason D Arroyo
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Oncogene 24:7746-55. 2005..Unraveling the complexity of PP2A signaling will not only provide further insights into cancer development but may identify novel targets with promise for therapeutic manipulation... - Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9Andrei V Krivtsov
Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115, USA
Nature 442:818-22. 2006..Our findings define progression from normal progenitor to cancer stem cell, and suggest that targeting a self-renewal programme expressed in an abnormal context may be possible... - Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblastsWenyi Wei
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA
Mol Cell Biol 23:2859-70. 2003..The experiments reported here further define specific components of human transformation pathways... - Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesisGitta Goessel
Department of Medicine and Institute for Molecular Medicine and Cell Research, University of Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
Proc Natl Acad Sci U S A 102:15599-604. 2005.... - Expression of telomerase RNA template, but not telomerase reverse transcriptase, is limiting for telomere length maintenance in vivoY Jeffrey Chiang
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Building 10, 4B36, 9000 Rockville Pike, Bethesda, MD 20892, USA
Mol Cell Biol 24:7024-31. 2004.... - A genetically defined model for human ovarian cancerJinsong Liu
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 64:1655-63. 2004..These cells provide a novel model system to study human ovarian cancer... - Nucleolin interacts with telomeraseShilagardi Khurts
Department of Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
J Biol Chem 279:51508-15. 2004..These findings indicate that interaction of hTERT and nucleolin participates in the dynamic intracellular localization of telomerase complex... - Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapyMitsuhiro Nakamura
Department of Obstetrics and Gynecology, Graduate School of Kanazawa University, Kanazawa, Ishikawa 920-8641, Japan
Hum Gene Ther 16:859-68. 2005..These findings suggest that an siRNA-based strategy can be applied to the development of novel telomerase inhibitors, the antitumor effects of which may be enhanced in combination with ionizing radiation and chemotherapy... - In situ human telomerase reverse transcriptase expression pattern in normal and neoplastic ovarian tissuesAtac Baykal
Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Oncol Rep 11:297-302. 2004..We conclude that human telomerase reverse transcriptase mRNA expression does not seem to be a reliable marker for clinical use in differentiating between benign and malignant tumors... - Signaling and transcriptional changes critical for transformation of human cells by simian virus 40 small tumor antigen or protein phosphatase 2A B56gamma knockdownCarlos S Moreno
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Res 64:6978-88. 2004..Our data support a model in which ST promotes survival through constitutive integrin signaling, src phosphorylation, and nuclear factor kappaB activation, while inhibiting cell-cell adhesion pathways... - Analysis of telomeric single-strand overhang length in human endometrial cancersManabu Hashimoto
Department of Obstetrics and Gynecology, Graduate School of Kanazawa University, Ishikawa, Japan
FEBS Lett 579:2959-64. 2005..These findings suggest that erosion of 3'-OH length, rather than overall telomere length, play roles in endometrial carcinogenesis. Furthermore, long 3'-OH may serve as a molecular marker for aggressive phenotype of tumors... - Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicityWen Chen
Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Cancer Res 65:8183-92. 2005..These findings suggest that cancer-associated Aalpha mutations contribute to cancer development by inducing functional haploinsufficiency, disturbing PP2A holoenzyme composition, and altering the enzymatic activity of PP2A... - Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cellsSanne Weijzen
Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, USA
Nat Med 8:979-86. 2002..These observations place Notch signaling among key downstream effectors of oncogenic Ras and suggest that it might be a novel therapeutic target... - Functional genetics and experimental models of human cancerJean J Zhao
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA
Trends Mol Med 10:344-50. 2004..This review highlights the recent progress in combining genetic methods and primary human cells to understand the role of specific genes and pathways in cancer pathogenesis... - Evolving views of telomerase and cancerMaria A Blasco
Department of Immunology and Oncology, National Centre of Biotechnology, Spanish Council for Scientific Research (CSIC, Campus de Cantoblanco, Madrid E-28049, Spain
Trends Cell Biol 13:289-94. 2003..These recent developments indicate that our understanding of telomere biology remains incomplete and implicate additional complexity in the relationships among telomeres, telomerase and cancer... - Liprin alpha1 interacts with PP2A B56gammaJason D Arroyo
Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Dana 1538, Boston, Massachusetts 02115, USA
Cell Cycle 7:525-32. 2008..However, suppression of liprin alpha1 by RNA interference alters cell morphology. These findings suggest a novel role for PP2A B56gamma independent of its regulation of PP2A activity... - Understanding transformation: progress and gapsJesse S Boehm
Department of Medical Oncology, Dana-Farber Cancer Institute, Departments of Medicine and Pathology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Curr Opin Genet Dev 15:13-7. 2005..These studies indicate that many combinations of genetic mutations confer tumorigenicity on human cells and that both cell-type and tumor-stromal interactions play critical roles in dictating the tumor phenotype... - Minimizing the risk of reporting false positives in large-scale RNAi screensChristophe J Echeverri
Cenix BioScience GmbH, Tatzberg 47, Dresden, 10307, Germany
Nat Methods 3:777-9. 2006.... - A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cellsElizabeth Yeh
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Nat Cell Biol 6:308-18. 2004..Thus, Ras-dependent signalling cascades ensure transient and self-limiting accumulation of c-Myc, disruption of which contributes to human cell oncogenesis... - Prostate cancer: Re-focusing on androgen receptor signalingMaria Nieto
Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Int J Biochem Cell Biol 39:1562-8. 2007..The identification of novel survival pathways and effector molecules that drive androgen independent growth is necessary to develop effective therapies for advanced prostate cancers... - The tumor suppressor PP2A Abeta regulates the RalA GTPaseAnna A Sablina
Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 129:969-82. 2007..These observations identify PP2A Abeta as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA... - Malignant astrocytic glioma: genetics, biology, and paths to treatmentFrank B Furnari
Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA
Genes Dev 21:2683-710. 2007..This progress is fueling new opportunities for understanding the fundamental basis for development of this devastating disease and also novel therapies that, for the first time, portend meaningful clinical responses... - Multiple pathways regulated by the tumor suppressor PP2A in transformationJukka Westermarck
Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33520 Tampere, Finland
Trends Mol Med 14:152-60. 2008..Here, we review recent progress in our understanding of how PP2A regulates mitogenic signaling pathways in cancer pathogenesis and how PP2A activity is modulated in human cancers...
Research Grants
- Regulation and Function of Telomerase in Human CellsWilliam Hahn; Fiscal Year: 2007....
- Regulation and function of IKKe in breast cancer initiation and maintenanceWilliam C Hahn; Fiscal Year: 2010..These biochemical, cell and animal-based studies will not only provide insight into the biology of this kinase oncogene but will serve as a foundation for translational studies for the development of novel therapeutic agents. ..
- Regulation and Function of hTERT in Human CellsWilliam C Hahn; Fiscal Year: 2010..These biochemical, cell and animal- based studies will not only provide insight into the biology of TERT complexes but will serve as a foundation for translational studies for the development of novel therapeutic agents. ..
- New Models of Human CancerWilliam Hahn; Fiscal Year: 2005..Robert Weinberg and the unique resources of the Whitehead Institute to develop these new systems and to broaden my research experiences as I make the crucial transition to an independent investigator. ..
- Investigations on the role of the CDK8 oncogene in colon cancerWilliam C Hahn; Fiscal Year: 2010..These biochemical, cell and chemical biological studies will not only provide insight into the biology of this kinase oncogene but will serve as a foundation for translational studies for the development of novel therapeutic agents. ..