Research Topics
| A Heather EliassenSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Urinary estrogens and estrogen metabolites and subsequent risk of breast cancer among premenopausal womenA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 72:696-706. 2012..The inverse associations with parent estrogen metabolites and the parent estrogen metabolite/non-parent estrogen metabolite ratio suggest that women with higher urinary excretion of parent estrogens are at lower risk...- Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studiesA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Adv Exp Med Biol 630:148-65. 2008..Clearly more evaluation is needed to confirm the role of endogenous hormones in premenopausal breast cancer, endometrial cancer and ovarian cancer... - Circulating 2-hydroxy- and 16alpha-hydroxy estrone levels and risk of breast cancer among postmenopausal womenA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:2029-35. 2008..The significant positive associations with 2-OH estrone and the 2-OH:16-OH estrone ratio among women with ER-negative/PR-negative tumors needs to be replicated in future studies... - Circulating insulin and c-peptide levels and risk of breast cancer among predominately premenopausal womenA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 16:161-4. 2007..These associations did not differ by age, body mass index, or waist-to-hip ratio. Overall, higher levels of insulin and c-peptide were not associated with a higher risk of breast cancer among predominantly premenopausal women... - Use of aspirin, other nonsteroidal anti-inflammatory drugs, and acetaminophen and risk of breast cancer among premenopausal women in the Nurses' Health Study IIA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
Arch Intern Med 169:115-21; discussion 121. 2009..In addition, the chemopreventive use of NSAIDs is increasingly common for heart disease and colon cancer. Evidence of a protective association with breast cancer risk has been inconsistent, and few data exist for premenopausal women... - Reproductive factors and family history of breast cancer in relation to plasma prolactin levels in premenopausal and postmenopausal womenA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 120:1536-41. 2007..9 ng/mL vs. 14.3 ng/mL, p=0.04) but not postmenopausal (p=0.73) women. In conclusion, the associations of parity and family history with breast cancer risk may be mediated, at least in part, by prolactin levels... - Reproducibility of fifteen urinary estrogens and estrogen metabolites over a 2- to 3-year period in premenopausal womenA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 18:2860-8. 2009..Within-person reproducibility over time for most EM measures is comparable to or better than that for well-vetted biomarkers such as plasma cholesterol and, in postmenopausal women, estradiol... - Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal womenA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
J Natl Cancer Inst 98:1406-15. 2006..We prospectively evaluated associations between plasma sex hormone levels and breast cancer risk among premenopausal women in a case-control study nested within the Nurses' Health Study II... - Adult weight change and risk of postmenopausal breast cancerA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
JAMA 296:193-201. 2006..Endogenous hormones are a primary cause of breast cancer. Adiposity affects circulating hormones, particularly in postmenopausal women, and may be a modifiable risk factor for breast cancer... - Physical activity and risk of breast cancer among postmenopausal womenA Heather Eliassen
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 170:1758-64. 2010..Although greater activity has been related to lower postmenopausal breast cancer risk, important details remain unclear, including type, intensity, and timing of activity and whether the association varies by subgroups... - Endogenous steroid hormone concentrations and risk of breast cancer: does the association vary by a woman's predicted breast cancer risk?A Heather Eliassen
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
J Clin Oncol 24:1823-30. 2006.... - Biomarker validation of dietary intervention in two multiethnic populationsA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
Prev Chronic Dis 3:A44. 2006..The Healthy Directions intervention studies were designed to increase multivitamin use, fruit and vegetable consumption, and physical activity in working-class, multiethnic populations... - Tubal sterilization in relation to breast cancer riskA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 118:2026-30. 2006.... - Serum lipids, lipid-lowering drugs, and the risk of breast cancerA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
Arch Intern Med 165:2264-71. 2005..The relation between serum cholesterol levels and breast cancer risk is itself unclear; because cholesterol is the precursor to sex steroid hormones, higher levels could plausibly increase risk... - Plasma 25-hydroxyvitamin D and risk of breast cancer in the Nurses' Health Study IIA Heather Eliassen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Breast Cancer Res 13:R50. 2011..Vitamin D comes from dietary intake and sun exposure and plasma levels of 25-hydroxyvitamin D (25(OH)D) are considered the best measure of vitamin D status... - Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal womenStacey A Missmer
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
J Natl Cancer Inst 96:1856-65. 2004..Nor has the relation between breast cancer risk and postmenopausal progesterone levels been investigated. We prospectively investigated these relations in a case-control study nested within the Nurses' Health Study... - Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormonesShelley S Tworoger
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
Cancer Causes Control 18:743-52. 2007..These cross-sectional results suggest that physical activity and inactivity have limited associations with premenopausal sex hormone and growth factor levels, except possibly luteal estrogens... - The association of plasma androgen levels with breast, ovarian and endometrial cancer risk factors among postmenopausal womenKim N Danforth
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 126:199-207. 2010..Future studies are needed to clarify further which lifestyle factors modulate androgen levels... - A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancerShelley S Tworoger
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 25:1482-8. 2007.... - The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal womenShelley S Tworoger
Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 15:967-71. 2006.... - Analgesic use and sex steroid hormone concentrations in postmenopausal womenMargaret A Gates
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 19:1033-41. 2010..04). Among postmenopausal women, regular users of aspirin and other analgesics may have lower estrogen levels than nonusers, which could contribute to a decreased risk of breast or ovarian cancer among analgesic users... - Reproducibility of plasma and urine biomarkers among premenopausal and postmenopausal women from the Nurses' Health StudiesJoanne Kotsopoulos
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 19:938-46. 2010..Temporal variability of biomarkers should be evaluated before their use in epidemiologic studies... - Body shape throughout life and correlations with IGFs and GHEva S Schernhammer
Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, 181 Longwood Avenue, Boston 02115, Massachusetts, USA
Endocr Relat Cancer 14:721-32. 2007..Our results suggest that childhood and adult body size may affect premenopausal breast cancer risk differently than birth weight, through associations with IGF and GH levels... - Birthweight and body size throughout life in relation to sex hormones and prolactin concentrations in premenopausal womenShelley S Tworoger
Channing Laboratory, 181 Longwood Avenue, 3rd Floor, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 15:2494-501. 2006..Our results suggest that effects on premenopausal sex hormone levels may be one mechanism through which adult adiposity, but not birthweight or childhood body size, affects premenopausal breast cancer risk... - Relationship between caffeine intake and plasma sex hormone concentrations in premenopausal and postmenopausal womenJoanne Kotsopoulos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer 115:2765-74. 2009..Caffeine intake may decrease risk of breast and ovarian cancer, although the data are not entirely consistent. Whether or not caffeine affects cancer risk by altering sex hormone levels is currently unknown... - Adult weight change and incidence of premenopausal breast cancerKarin B Michels
Department of Obstetrics, Gynecology and Reproductive Biology, Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 130:902-9. 2012.... - Plasma adiponectin concentrations and risk of incident breast cancerShelley S Tworoger
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Third Floor, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 92:1510-6. 2007..Therefore, we conducted a prospective case-control study nested within the Nurses' Health Study (NHS) and NHSII cohorts examining the association between plasma adiponectin concentrations and breast cancer risk... - Energy balance, early life body size, and plasma prolactin levels in postmenopausal womenXuefen Su
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, 3rd Floor, Boston, MA 02115, USA
Cancer Causes Control 20:253-62. 2009.... - Plasma prolactin concentrations and risk of postmenopausal breast cancerShelley S Tworoger
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Res 64:6814-9. 2004..Our prospective data suggest that plasma prolactin concentrations are associated with an increased risk of postmenopausal breast cancer, particularly for estrogen receptor+/progesterone receptor+ cancers, and independently of estradiol... - Endogenous estrogen, testosterone and progesterone levels in relation to breast cancer riskSusan E Hankinson
Channing Laboratory, Department of Medicine, 181 Longwood Avenue, Harvard Medical School, Brigham and Women s Hospital, MA 02115, USA
J Steroid Biochem Mol Biol 106:24-30. 2007..However, both positive and null associations have been observed with estrogens and progesterone and clearly more evaluation is needed... - Circulating sex steroids and breast cancer risk in premenopausal womenSusan E Hankinson
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
Horm Cancer 1:2-10. 2010..In this review, we summarize current evidence and identify gaps and inconsistencies that need to be addressed in future studies of sex steroids and premenopausal breast cancer risk...