Research Topics
Genomes and GenesSpecies | Ulrike S EggertSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targetsUlrike S Eggert
Department of Systems Biology, Harvard Medical School Boston, Massachusetts, USA
PLoS Biol 2:e379. 2004..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...- Small molecule screening by imagingUlrike S Eggert
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Curr Opin Chem Biol 10:232-7. 2006..We discuss the use of model organisms such as zebrafish in screens and review different methods of target identification. The emerging field of automated image analysis is also introduced... - Animal cytokinesis: from parts list to mechanismsUlrike S Eggert
Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Biochem 75:543-66. 2006..We also discuss the extent to which classic questions have been answered and identify major outstanding questions... - Small molecules in an RNAi worldUlrike S Eggert
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
Mol Biosyst 2:93-6. 2006..In this Opinion, we compare and contrast small molecules and RNAi. We discuss the advantages and disadvantages of both technologies focusing on timing, specificity, dose and therapeutic use... - Actin-aggregating cucurbitacins from Physocarpus capitatusKatherine N Maloney
Department of Biological Chemistry and Molecular Pharmacology, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Nat Prod 71:1927-9. 2008..Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division... - Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screensNorbert Perrimon
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Drug Discov Today 12:28-33. 2007..We then illustrate how the combination of RNAi and small-molecule HTS can lead to effective identification of targets in drug discovery... - Small molecules discovered in a pathway screen target the Rho pathway in cytokinesisAdam B Castoreno
Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
Nat Chem Biol 6:457-63. 2010..Rhodblocks differentially perturb Rho pathway proteins in cells and can be used to dissect the mechanism of the Rho pathway during cytokinesis... - Small molecule probes of cellular pathways and networksAdam B Castoreno
Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States
ACS Chem Biol 6:86-94. 2011.... - Making the cut: the chemical biology of cytokinesisG Ekin Atilla-Gokcumen
Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
ACS Chem Biol 5:79-90. 2010..In this review, we discuss the use of small molecule probes to perturb cytokinesis, as well as the role naturally occurring small molecule metabolites such as lipids play during cytokinesis... - Drugs in actionUlrike S Eggert
Dana-Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Chem Biol 4:7-11. 2008