Research Topics
| Marie DemaySummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Mechanism of vitamin D receptor actionMarie B Demay
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, 50 Blossom St, Boston, MA 02114, USA
Ann N Y Acad Sci 1068:204-13. 2006..In contrast, the cutaneous phenotype of VDR ablation is a direct consequence of absence of ligand-independent VDR actions in epidermal keratinocytes...- Role of the vitamin D receptor in hair follicle biologyMarie B Demay
Endocrine Unit Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, MA 02114, USA
J Steroid Biochem Mol Biol 103:344-6. 2007..Investigations are currently underway to define the mechanism by which the unliganded VDR maintains hair follicle homeostasis... - Vitamin D receptor is essential for normal keratinocyte stem cell functionLuisella Cianferotti
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 104:9428-33. 2007..Thus, absence of the VDR impairs canonical Wnt signaling in keratinocytes and leads to the development of alopecia due to a defect in keratinocyte stem cells... - Muscle: a nontraditional 1,25-dihydroxyvitamin D target tissue exhibiting classic hormone-dependent vitamin D receptor actionsMarie Demay
Endocrine Unit, Wellman 501, Massachusetts General Hospital and Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
Endocrinology 144:5135-7. 2003 - Calcium and vitamin D: what is known about the effects on growing boneMarie B Demay
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Pediatrics 119:S141-4. 2007..The major receptor-dependent actions of 1,25-dihydroxyvitamin D on skeletal development are indirect and are a reflection of the role of this hormone on intestinal calcium absorption... - Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone developmentFrancesca Gori
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Dev Biol 295:498-506. 2006..Overall, our findings suggest that Wdr5 accelerates osteoblast differentiation in association with activation of the canonical Wnt pathway... - Rickets in VDR null mice is secondary to decreased apoptosis of hypertrophic chondrocytesMegan M Donohue
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 143:3691-4. 2002.... - Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasisKristi Skorija
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Mol Endocrinol 19:855-62. 2005..These studies demonstrate that the effects of the VDR on the hair follicle are ligand independent and point to novel molecular and cellular actions of this nuclear receptor... - Hypophosphatemia leads to rickets by impairing caspase-mediated apoptosis of hypertrophic chondrocytesYves Sabbagh
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 102:9637-42. 2005.... - Perichondrial expression of Wdr5 regulates chondrocyte proliferation and differentiationFrancesca Gori
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Dev Biol 329:36-43. 2009..These findings support a model in which overexpression of Wdr5 in the perichondrium promotes chondrocyte differentiation by modulating the expression of Twist-1 and FGF18... - Phosphate regulates embryonic endochondral bone developmentAlena A Zalutskaya
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Cell Biochem 108:668-74. 2009.... - BIG-3, a novel WD-40 repeat protein, is expressed in the developing growth plate and accelerates chondrocyte differentiation in vitroFrancesca Gori
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Endocrinology 145:1050-4. 2004.... - Wdr5 is essential for osteoblast differentiationEric D Zhu
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 283:7361-7. 2008..These studies demonstrate that Wdr5 suppression interferes with the canonical Wnt signaling pathway at multiple stages and that optimal Wdr5 levels are required for induction of the osteoblast phenotype... - The receptor-dependent actions of 1,25-dihydroxyvitamin D are required for normal growth plate maturation in NPt2a knockout miceSusanne U Miedlich
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 151:4607-12. 2010..These studies demonstrate that the receptor-dependent actions of 1,25-dihydroxyvitamin D are required for maintenance of a normal growth plate phenotype in the Npt2a null mice... - VDR-mediated inhibition of DKK1 and SFRP2 suppresses adipogenic differentiation of murine bone marrow stromal cellsLuisella Cianferotti
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Cell Biochem 101:80-8. 2007..Thus, the VDR inhibits adipogenesis of BMSCs at least in part by suppressing the expression of inhibitors of the canonical Wnt signaling pathway... - Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitroKaren Sooy
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Wellman 501, 50 Blossom Street, Boston, Massachuettts 02114, USA
J Cell Biochem 94:81-7. 2005..These studies demonstrate that the VDR attenuates osteoblast differentiation in vitro and suggest that other endocrine and paracrine factors modulate the effect of the VDR on osteoblast differentiation in vivo... - Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- miceGabriel M Gutierrez
Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 105:18402-7. 2008..This increased pool of osteoprogenitor cells may be susceptible to additional transforming events leading to osteosarcoma, and is therefore key to understanding RB1 as a target in malignancy... - The effects of BIG-3 on osteoblast differentiation are not dependent upon endogenously produced BMPsFrancesca Gori
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Exp Cell Res 304:287-92. 2005..These observations suggest that BIG-3 accelerates osteoblast differentiation in MC3T3-E1 cells by inducing phosphorylation and nuclear translocation of Smad1 independently of endogenously produced BMPs... - The vitamin D receptor, the skin and stem cellsHilary F Luderer
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, 50 Blossom St, Thier 11, Boston, MA 02114, USA
J Steroid Biochem Mol Biol 121:314-6. 2010.... - Phosphate-induced apoptosis of hypertrophic chondrocytes is associated with a decrease in mitochondrial membrane potential and is dependent upon Erk1/2 phosphorylationSusanne U Miedlich
Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 285:18270-5. 2010..Thus, these investigations point to an important role for phosphate in regulating mitochondrial membrane potential in hypertrophic chondrocytes and growth plate maturation by the parathyroid hormone-related protein signaling pathway... - Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2Nathan A Wigner
Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, MA, USA
J Bone Miner Res 25:724-33. 2010..Thus phosphate plays an important role in the skeleton that extends beyond mineralized matrix formation and growth plate maturation and is critical for endochondral bone repair... - Genetic dissection of phosphate- and vitamin D-mediated regulation of circulating Fgf23 concentrationsXijie Yu
Department of Medical and Molecular Genetics, 975 West Walnut Street, IB130, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Bone 36:971-7. 2005..Normalization of serum phosphate by diet in VDR(-/-) mice increases Fgf23. Thus, our results demonstrate that Fgf23 is independently regulated by phosphate and by vitamin D... - Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouseSonoko Masuda
Department of Biochemistry, Queen s University, Kingston Ontario, Canada K7L 3N6
Endocrinology 146:825-34. 2005..These results suggest that the absence of CYP24A1 or VDR retards catabolism of 1alpha,25(OH)2D3 and 25(OH)D3, reinforcing the physiological importance of CYP24A1 in vitamin D homeostasis...
Research Grants
- GENETIC REGULATION OF CALCIUM METABOLISMMarie Demay; Fiscal Year: 2005..Keratinocyte stem cells, thought to provide a source of cells for cyclic regeneration of the lower part of the hair follicle, will also be quantitatively and qualitatively assessed. ..
- REGULATION OF OSTEOBLAST GENE EXPRESSIONMarie Demay; Fiscal Year: 2007....
- VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCESMarie Demay; Fiscal Year: 2007..Thus, using the keratinocyte as a model, these studies will identify the novel molecular actions of the VDR which prevent the development of alopecia, a direct consequence of VDR ablation. ..
- VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCESMarie Demay; Fiscal Year: 2010..Thus, using the keratinocyte as a model,these studies will identify the novel molecular actions of the VDRwhich prevent the development of alopecia, a direct consequence ofVDR ablation. ..
- GENETIC REGULATION OF CALCIUM METABOLISMMarie Demay; Fiscal Year: 2001..Studies in receptor negative osteoblastic cells will identify actions of 1,25D that are independent of the nuclear receptor and may provide a system for studying the molecular basis of the non-genomic actions of 1,25D. ..
- REGULATION OF OSTEOBLAST GENE EXPRESSIONMarie Demay; Fiscal Year: 2001....
- REGULATION OF BONE CELL GENES BY 1,25-DIHYDROXYVITAMIN DMarie Demay; Fiscal Year: 1993..Understanding the regulation of these factors, and how they interact with the osteocalcin gene will help to define the phenotype of the mature osteoblast...
- GENETIC REGULATION OF CALCIUM METABOLISMMarie Demay; Fiscal Year: 1993....
- Comparison of Bisphosphonate Treatment Regimens on Skeletal Growth & BiomechanicsMarie Demay; Fiscal Year: 2010..The studies in this proposal will examine the effects of these agents on the growing skeleton. ..