Research Topics
Genomes and Genes | Federica Del MonteSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Publications
Intracellular devastation in heart failureFederica Del Monte
Cardiovascular Research, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Heart Fail Rev 13:151-62. 2008..In this article, we will review the changes in calcium cycling that occur in myopathic hearts and how they can be effectively targeted. We will also focus on protein misfolding in the setting of cardiac dysfunction...- Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusionFabrice Prunier
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA
Circulation 118:614-24. 2008..We inquired whether sarcoplasmic reticulum Ca2+ ATPase pump (SERCA2a) overexpression could reduce ischemic ventricular arrhythmias by modulating Ca2+ overload... - Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat modelSusumu Sakata
Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, CNY 4, Charlestown, MA 02129, USA
Am J Physiol Heart Circ Physiol 292:H1204-7. 2007..In conclusion, in DM failing hearts, SERCA2a gene transfer can increase coronary blood flow and reduce cardiomyocyte size without reduction in collagen production... - Rescue of Ca2+ overload-induced left ventricular dysfunction by targeted ablation of phospholambanTsuyoshi Tsuji
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Physiol Heart Circ Physiol 296:H310-7. 2009..We conclude that SERCA2a function enhanced by adenoviral gene transfer of asPLB prevents Ca2+ overload-induced LV contractile dysfunction in terms of mechanical work and especially energetics... - Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteinsSusumu Sakata
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02114, USA
J Mol Cell Cardiol 42:852-61. 2007..Therefore enhancement of calcium handling either by resequestration into the SR or by intracellular buffering improves not only mechanical but energetic function in failing hearts... - Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transferSusumu Sakata
Cardiovascular Research Center, Cardiology Laboratory of Integrative Physiology and Imaging, Massachusetts General Hospital, 149 13th Street, CNY-4, Charlestown, MA 02129, USA
Mol Ther 13:987-96. 2006..SERCA2a gene transfer transforms this inefficient energy utilization into a more efficient state and restores systolic and diastolic function to normal... - In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosisDjamel Lebeche
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Mass 02129, USA
Circulation 110:3435-43. 2004..3 can restore these electrical parameters and abrogate the hypertrophic response via the calcineurin pathway... - Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cyclingFederica Del Monte
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 101:5622-7. 2004..SERCA2a group was consistent throughout the 48 h of monitoring. These results show that improving intracellular Ca(2+) handling by overexpression of SERCA2a restores contractile function and reduces ventricular arrhythmias during I/R... - Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexesTomas G Neilan
Cardiac Ultrasound Laboratory, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02115 2696, USA
Am J Physiol Heart Circ Physiol 294:H2106-11. 2008..001). Therefore, in a chronic model of MR, serial echocardiography demonstrated that MR begets MR and that those TD-derived indexes that initially increased post-MR decreased to baseline before any changes in LV ejection fraction... - Catheter-based antegrade intracoronary viral gene delivery with coronary venous blockadeMotoya Hayase
Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, CNY-4, Charlestown, MA 02129-2060, USA
Am J Physiol Heart Circ Physiol 288:H2995-3000. 2005..01) in the left ventricular wall and 0.91 +/- 0.1 vs. 0.66 +/- 0.07 ng (P </= 0.05) in the right ventricular wall. PAMGT with selective coronary venous blockade is feasible, reproducible, and safely achieved in a large-animal model... - Human cardiac stem cell differentiation is regulated by a mircrine mechanismToru Hosoda
Departments of Anesthesia and Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Circulation 123:1287-96. 2011..However, the interaction of CSCs with postmitotic myocytes results in the formation of cells with adult characteristics... - Cardiomyogenesis in the adult human heartJan Kajstura
Department of Anesthesia and Medicine, and Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Circ Res 107:305-15. 2010..The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by different laboratories varies from none to nearly 20% per year... - Efficient viral gene transfer to rodent hearts in vivoFederica Del Monte
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, USA
Methods Mol Biol 219:179-93. 2003 - Targeted gene transfer in heart failure: implications for novel gene identificationFederica Del Monte
Harvard Medical School, Massachusetts General Hospital, Cardiology Division, Cardiology Laboratory of Integrative Physiology and Imaging, 55 Fruit Street, Boston, MA 02115, USA
Curr Opin Mol Ther 6:381-94. 2004..In addition, gene-based reconstitution of a normal phenotype allows us to closely examine the behavior of a large number of transcripts as the heart fails and is rescued by genetic manipulations... - Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensationRonen Beeri
Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Am Coll Cardiol 51:476-86. 2008..We examined whether mitral regurgitation (MR) augments post-myocardial infarction (MI) remodeling... - SERCA2a in heart failure: role and therapeutic prospectsDavide Gianni
Cardiovascular Research Centre, Heart Failure Center, Massachusetts General Hospital, Boston, Massachusetts, USA
J Bioenerg Biomembr 37:375-80. 2005..This review focuses on the molecular characteristics of the pump, its role during the cardiac cycle and the prospects derived from the manipulation of SERCA2a for heart failure treatment... - The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarctionPolina Goichberg
Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Circ Res 108:1071-83. 2011..Understanding the mechanisms that regulate trafficking of human cardiac stem cells (hCSCs) may lead to development of new therapeutic approaches for the failing heart... - Gene therapy for the treatment of heart failure--calcium signalingOliver Y Bernecker
Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Semin Thorac Cardiovasc Surg 15:268-76. 2003..This article reviews recent advances in gene delivery techniques aimed at global myocardial transfection and discusses molecular therapeutic targets identified within intracellular calcium signaling pathways in heart failure... - Modulating signaling pathways in hypertrophy and heart failure by gene transferFawzia Huq
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
J Card Fail 8:S389-400. 2002.... - Targeting calcium cycling proteins in heart failure through gene transferFederica Del Monte
Program in Cardiovascular Gene Therapy, Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Physiol 546:49-61. 2003..In this review, we will examine our current understanding of these various factors. Gene transfer provides not only a potential therapeutic modality but also an approach to identifying and validating molecular targets... - Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repairBernhard Kuhn
Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Med 13:962-9. 2007..Thus, periostin and the pathway that it regulates may provide a target for innovative strategies to treat heart failure... - Targeting phospholamban by gene transfer in human heart failureFederica Del Monte
Cardiovascular Research Center, Massachusetts General Hospital, Heart Failure and Cardiac Transplantation Center, Boston, Mass 02129, USA
Circulation 105:904-7. 2002..CONCLUSION: These results show that gene transfer of asPL can improve the contractile function in failing human myocardium. Targeting phospholamban may provide therapeutic benefits in human heart failure... - Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failureFederica Del Monte
Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital. Harvard Medical School, Boston, MA, USA
Physiol Genomics 9:49-56. 2002..Furthermore, our approach to delivery of transgenes results in homogenous gene expression in both hypertrophied and failing hearts... - Targeting Ca2+ cycling proteins and the action potential in heart failure by gene transferRoger Kaprielian
Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, CNY-4, 4215, Charlestown, MA 02129, USA
Basic Res Cardiol 97:I136-45. 2002..Gene transfer, which serves initially as an experimental tool, may provide a novel therapeutic approach... - Transgenic models of heart failure: elucidation of the molecular mechanisms of heart diseaseDjamel Lebeche
Massachusetts General Hospital, Charlestown, MA 02129, USA
Heart Fail Clin 1:219-36. 2005 - PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injuryTomohisa Nagoshi
Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 115:2128-38. 2005..These data demonstrate that PI3K-dependent but Akt-independent effectors are required for full cardioprotection and suggest a mechanism by which chronic Akt activation can become maladaptive... - Transcriptional changes following restoration of SERCA2a levels in failing rat heartsFederica Del Monte
Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
FASEB J 18:1474-6. 2004..The microarray analysis identified new genes following SERCA2a restoration in heart failure, which will give us insights into their role in the normalization of multiple pathways within the failing cell... - Functional near-infrared fluorescence imaging for cardiac surgery and targeted gene therapyAkira Nakayama
Beth Israel Deaconess Medical Center, HIM-1023, 330 Brookline Avenue, Boston, MA 02215, USA
Mol Imaging 1:365-77. 2002..This imaging system may prove useful for the refinement of revascularization techniques, and for the administration of cardiac gene therapy... - Protein aggregates and novel presenilin gene variants in idiopathic dilated cardiomyopathyDavide Gianni
Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA 02125, USA
Circulation 121:1216-26. 2010..In the brain of patients with dementia, proteinaceous aggregates and abnormal oligomeric assemblies of beta-amyloid impair cell function and lead to cell death... - Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathwayJianru Shi
Cardiac Muscle Research Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:4188-93. 2010.... - Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cellsFabrice Prunier
Cardiovascular Research Center, Massachusetts General Hospital, 149 13th St, CNY 4, Rm 4215, Charlestown, MA 02129, USA
Am J Physiol Heart Circ Physiol 292:H522-9. 2007..We found that chronic EPO treatment reduces MI size and improves cardiac function only at a dose that induces EPC mobilization in blood and that increases capillary density in the infarct border zone... - Myocyte turnover in the aging human heartJan Kajstura
Department of Anesthesia and Medicine and Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circ Res 107:1374-86. 2010..The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology...
Research Grants
- Role of Presenilin in Idiopathic Dilated CardiomyopathyFederica Del Monte; Fiscal Year: 2010..Preliminary evidence suggests that iDCM may be included among these misfolding diseases and dissecting the mechanisms is instrumental for potential interventions targeted to the cause of the dysfunction. ..