Research Topics
| Miles Gregory CunninghamSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
| Collaborators |
Detail Information
Publications
Amygdalar GABAergic-rich neural grafts attenuate anxiety-like behavior in ratsMiles Gregory Cunningham
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
Behav Brain Res 205:146-53. 2009..Our results raise the possibility that distinct components of emotion can be modulated by strategic neural engraftment...- Preclinical evaluation of a novel intracerebral microinjection instrument permitting electrophysiologically guided delivery of therapeuticsMiles G Cunningham
Laboratory for Neural Reconstruction, Program in Neuroscience, Harvard Medical School, and Department of Psychiatry, McLean Hospital, Belmont, Massachusetts, USA
Neurosurgery 54:1497-507; discussion 1507. 2004..This series of studies was designed to evaluate the function of a new neurosurgical instrument for precision injection of therapeutics within the central nervous system... - Diminished serotonergic innervation of adult medial prefrontal cortex after 6-OHDA lesions in the newborn ratMiles Gregory Cunningham
Laboratory for Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Brain Res Dev Brain Res 157:124-31. 2005..We present a model based on neurotrophic interactions at the cortical and brainstem levels that could potentially explain these unexpected results... - A versatile, low-cost adaptor for stereotaxic and electrophysiologic spinal preparations in juvenile and adult rodentsMiles G Cunningham
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
Brain Res Bull 68:157-62. 2005..Proof of concept is demonstrated with results from spinal cord injections and electrophysiologic recordings... - Construction and implantation of a microinfusion system for sustained delivery of neuroactive agentsMiles Gregory Cunningham
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA 02478, United States
J Neurosci Methods 167:213-20. 2008..We demonstrate reliable sustained delivery of a dye having a representative molecular weight using an in vitro model and in vivo studies in rats... - Coalescence of psychiatry, neurology, and neuropsychology: from theory to practiceMiles G Cunningham
Department of Psychiatry, Harvard Medical School, USA
Harv Rev Psychiatry 14:127-40. 2006..The practical functioning of the team is described, and case vignettes are presented to illustrate the team's collaborative synergism in practice... - Antidepressant effect of stem cell-derived monoaminergic graftsMiles G Cunningham
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Neuroreport 18:1663-7. 2007..These results suggest that transplantation of customized stem cells might perhaps be useful in the study treatment of psychiatric disorders... - Zincergic innervation of medial prefrontal cortex by basolateral projection neuronsMiles G Cunningham
Laboratory for Neural Reconstruction, McLean Hospital, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Neuroreport 18:531-5. 2007..We conclude that zinc may act as a neuromodulator for a substantial proportion of basolateral-medial prefrontal cortical innervation, therefore implicating zinc in corticolimbic function as well as pathology... - Amygdalo-cortical sprouting continues into early adulthood: implications for the development of normal and abnormal function during adolescenceMiles Gregory Cunningham
Laboratory of Structural Neuroscience, McLean Hospita, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02478, USA
J Comp Neurol 453:116-30. 2002.... - Architecture of neuropsychiatric disease: highlights of the 15th Annual Meeting of the American Neuropsychiatric Association, February 21-24, 2004, Bal Harbour, FLMiles G Cunningham
Laboratory for Neural Reconstruction, Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Rev Neurol Dis 1:202-6. 2004 - Amygdala-dependent regulation of electrical properties of hippocampal interneurons in a model of schizophreniaBarbara Gisabella
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02478, USA
Biol Psychiatry 65:464-72. 2009..In the present work we tested the hypothesis that BLA activation in this rodent model of SZ leads to changes in the electrical properties of interneurons located in sector CA2/3... - Increasing Interaction of amygdalar afferents with GABAergic interneurons between birth and adulthoodMiles G Cunningham
Laboratory of Structural Neuroscience, McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
Cereb Cortex 18:1529-35. 2008..The establishment of this circuitry, largely during adolescence, may contribute to the integration of emotional responses with attentional and other cognitive processes mediated within this region during corticolimbic development... - Mechanisms of Mind: Highlights of the 17th Annual Meeting of the American Neuropsychiatric Association, February 18-21, 2006, San Diego, CAMiles G Cunningham
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
Rev Neurol Dis 3:123-8. 2006..Also discussed are the brain mechanisms behind creative innovation, and an overview is presented of several of this year's outstanding contributions to clinical and basic neuroscience...
Research Grants
- Neural Transplantation within Amygdalar CircuitryMiles Cunningham; Fiscal Year: 2007..This proposal may provide new insights into the treatment of these pervasive conditions, as it presents a novel approach to the study of the cellular and molecular function of the fear response. ..