T Boehm

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    T Boehm
    Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 390:404-7. 1997
  2. ncbi Zinc-binding of endostatin is essential for its antiangiogenic activity
    T Boehm
    The Children s Hospital, and Departments of Surgery and Cellular Biology, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 252:190-4. 1998
  3. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
  4. ncbi Disruption of the KEX1 gene in Pichia pastoris allows expression of full-length murine and human endostatin
    T Boehm
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Yeast 15:563-72. 1999
  5. ncbi The role of matrix metalloproteinase activity in the maturation of human capillary endothelial cells in vitro
    B M Kräling
    Surgical Research Laboratory, Division of Plastic Surgery and Children s Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Sci 112:1599-609. 1999

Collaborators

Detail Information

Publications5

  1. ncbi Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    T Boehm
    Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 390:404-7. 1997
    ..An unexpected finding is that repeated cycles of antiangiogenic therapy are followed by prolonged tumour dormancy without further therapy...
  2. ncbi Zinc-binding of endostatin is essential for its antiangiogenic activity
    T Boehm
    The Children s Hospital, and Departments of Surgery and Cellular Biology, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 252:190-4. 1998
    ..An H1/3A double, an H11A, and a D76A single mutant of endostatin were not able to regress Lewis lung carcinoma. We conclude that the ability of endostatin to bind Zn2+ is essential for its antiangiogenic activity...
  3. ncbi Endostatin: an endogenous inhibitor of angiogenesis and tumor growth
    M S O'Reilly
    Department of Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 88:277-85. 1997
    ..Together with angiostatin data, these findings validate a strategy for identifying endogenous angiogenesis inhibitors, suggest a theme of fragments of proteins as angiogenesis inhibitors, and demonstrate dormancy therapy...
  4. ncbi Disruption of the KEX1 gene in Pichia pastoris allows expression of full-length murine and human endostatin
    T Boehm
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Yeast 15:563-72. 1999
    ..Addition of a lysine to the C-terminus of recombinant proteins may protect the C-terminus from degradation by other carboxypeptidases...
  5. ncbi The role of matrix metalloproteinase activity in the maturation of human capillary endothelial cells in vitro
    B M Kräling
    Surgical Research Laboratory, Division of Plastic Surgery and Children s Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Sci 112:1599-609. 1999
    ..These data suggest that our cell culture assay provides a simple and feasible model system for the study of capillary endothelial cell differentiation and vessel maturation in vitro...