R S Blumberg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 11:648-56. 1999
  2. ncbi Prospects for research in inflammatory bowel disease
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    JAMA 285:643-7. 2001
  3. ncbi Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1)
    K Badizadegan
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 278:G895-904. 2000
  4. ncbi Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling
    S P Colgan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:13938-43. 1999
  5. ncbi Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form
    K Somnay-Wadgaonkar
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 11:383-92. 1999
  6. ncbi Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium
    S P Balk
    Hematology Oncology Division, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215
    Science 265:259-62. 1994
  7. ncbi Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury
    A Nakajima
    Gastroenterology Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 120:460-9. 2001
  8. ncbi Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis
    H S Kim
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Mol Immunol 37:861-8. 2000
  9. ncbi Characterization of CD1d in mucosal immune function: an immunotherapeutic target for inflammatory bowel disease
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Keio J Med 50:39-44. 2001
  10. ncbi Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice
    L J Saubermann
    Division of Gastroenterology and the Harvard Digestive Diseases Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Gastroenterology 119:119-28. 2000

Collaborators

Detail Information

Publications18

  1. ncbi Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Curr Opin Immunol 11:648-56. 1999
    ....
  2. ncbi Prospects for research in inflammatory bowel disease
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    JAMA 285:643-7. 2001
    ..This article reviews current knowledge of the role of immune factors in inflammatory bowel disease and the potential therapeutic strategies that target the pathways of T(H)1- or T(H)2-induced inflammation...
  3. ncbi Heterogeneity of detergent-insoluble membranes from human intestine containing caveolin-1 and ganglioside G(M1)
    K Badizadegan
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Gastrointest Liver Physiol 278:G895-904. 2000
    ..We find direct evidence for the presence of caveolin-1 in DIGs from human intestinal epithelia but find that these membranes are heterogeneous and that caveolin-1 is not a structural component of apical membrane DIGs that contain CT...
  4. ncbi Ligation of intestinal epithelial CD1d induces bioactive IL-10: critical role of the cytoplasmic tail in autocrine signaling
    S P Colgan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:13938-43. 1999
    ..These results define signaling through surface CD1d, and, importantly, they demonstrate that this pathway may serve to dampen epithelial proinflammatory signals...
  5. ncbi Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form
    K Somnay-Wadgaonkar
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 11:383-92. 1999
    ..These studies show that CD1d is located in an ideal position for luminal antigen sampling and presentation to subjacent intraepithelial lymphocytes...
  6. ncbi Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium
    S P Balk
    Hematology Oncology Division, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215
    Science 265:259-62. 1994
    ..These data indicate that IECs use a specialized pathway for CD1d synthesis and that a beta 2M-independent class Ib protein may be the normal ligand for some intestinal T cells...
  7. ncbi Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury
    A Nakajima
    Gastroenterology Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 120:460-9. 2001
    ..We sought to determine whether PPAR gamma could function as an endogenous anti-inflammatory pathway in a murine model of intestinal ischemia-reperfusion (I/R) injury...
  8. ncbi Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis
    H S Kim
    Division of Gastroenterology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Mol Immunol 37:861-8. 2000
    ..This suggests that P4H association with CD1d during its biosynthesis results in a novel post-translational modification of CD1d...
  9. ncbi Characterization of CD1d in mucosal immune function: an immunotherapeutic target for inflammatory bowel disease
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Keio J Med 50:39-44. 2001
    ....
  10. ncbi Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice
    L J Saubermann
    Division of Gastroenterology and the Harvard Digestive Diseases Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Gastroenterology 119:119-28. 2000
    ..1(+) T cells. These NK T cells exhibit important immunoregulatory functions in several autoimmune disease models...
  11. ncbi CD1 expression on antigen-presenting cells
    S K Dougan
    Gastroenterology Division, Department of Medicine, Brigham and Women s Hospital, 75 Francis St, Thorn 1415, Boston, MA 02115, USA
    Curr Top Microbiol Immunol 314:113-41. 2007
    ..Altered expression of CD 1 in cancer, autoimmunity, and infectious disease is well documented, and the implication of CD 1 expression in these diseases is discussed...
  12. ncbi Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes
    A Anumanthan
    Department of Adult Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 161:2780-90. 1998
    ....
  13. ncbi Current concepts in mucosal immunity. II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function
    R S Blumberg
    Gastroenterology Division, Brighan and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol 274:G227-31. 1998
    ....
  14. ncbi MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells
    X Zhu
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:3266-76. 2001
    ....
  15. ncbi Evidence against T-cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression
    M E Taplin
    Division of Hematology Oncology, Beth Israel Hospital, Boston, MA 02215, USA
    Immunology 87:402-7. 1996
    ....
  16. ncbi Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain
    S P Balk
    Hematology Oncology Division, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
    Int Immunol 7:1237-41. 1995
    ..This indicates that the distinct properties of human iIEL are not associated with substitutions of the Fc epsilon RI gamma chain in the TCR-CD3 complex...
  17. ncbi The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Acta Odontol Scand 59:139-44. 2001
    ..Many of these genes, including CD1, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology...
  18. ncbi Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells
    R S Blumberg
    Gastroenterology Division, Brigham and Women s Hospital, Boston, MA 02215
    J Immunol 147:2518-24. 1991
    ..The prominent expression of CD1d by intestinal epithelial cells suggests that this molecule may be an important ligand for T lymphocytes within the gut-associated lymphoid tissue...