Research Topics
Species | Francine BenesSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Regulation of cell cycle and DNA repair in post-mitotic GABA neurons in psychotic disordersFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 60:1232-42. 2011..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...- Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanismsFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Schizophr Bull 33:932-6. 2007..The ultimate goal is to characterize their respective underlying genotypes... - Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolarsFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02178, USA
Proc Natl Acad Sci U S A 104:10164-9. 2007..In BD, however, a suppression of transcription factors involved in cell differentiation may contribute to GABA dysfunction... - Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolarsFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 105:20935-40. 2008..The extensive and intricate data that has come from this study has provided insights into how a complex circuit, like the trisynaptic pathway, may be regulated in human hippocampus in both health and disease... - Strategies for improving sensitivity of gene expression profiling: regulation of apoptosis in the limbic lobe of schizophrenics and bipolarsFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, Mailman Research Center, 115 Mill Street, Belmont, MA 02178, USA
Prog Brain Res 158:153-72. 2006 - Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolarsFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 106:11731-6. 2009.... - Amygdalocortical circuitry in schizophrenia: from circuits to moleculesFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA
Neuropsychopharmacology 35:239-57. 2010.... - Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathologyFilip Simunovic
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Brain 132:1795-809. 2009..Our data provide a 'molecular fingerprint identity' of late-stage Parkinson's disease DA neurons that will advance our understanding of the molecular pathology of this disease... - DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophreniaNed Buttner
Laboratories for Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA, United States
Schizophr Res 93:33-41. 2007..These findings suggest that non-GABAergic cells may be selectively vulnerable to oxidative stress in patients with bipolar disorder... - Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorderTsung-Ung W Woo
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Arch Gen Psychiatry 61:649-57. 2004..Future studies will address whether subpopulations of these neurons may be differentially affected in the 2 conditions... - Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenicsHarry Pantazopoulos
Laboratory for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
Synapse 54:147-55. 2004.... - A rodent model of schizophrenia derived from postmortem studiesSabina Berretta
Program in Structural and Molecular Neuroscience and Laboratory for Translational Neuroscience, McLean Hospital, Belmont, MA, United States
Behav Brain Res 204:363-8. 2009.... - Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophreniaStephan Heckers
Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA 02429, USA
Arch Gen Psychiatry 59:521-9. 2002..Cellular GAD(67) mRNA expression was normal in both groups. CONCLUSION: We have found a region-specific deficit of GAD(65) and GAD(67) mRNA expression in bipolar disorder... - A disturbance of late myelination as a trigger for Alzheimer's diseaseFrancine M Benes
Program in Structural and Molecular Neuroscience, Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
Neurobiol Aging 25:41-3. 2004 - Molecular evidence for mitochondrial dysfunction in bipolar disorderChristine Konradi
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Arch Gen Psychiatry 61:300-8. 2004..The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder... - Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneuronsSabina Berretta
Program for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
Hippocampus 14:876-94. 2004..These similarities suggest that, in this disease, a disruption of GABAergic transmission within the amygdala may play a significant role in the induction of abnormalities in the hippocampus... - DNA fragmentation decreased in schizophrenia but not bipolar disorderFrancine M Benes
Laboratories for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
Arch Gen Psychiatry 60:359-64. 2003..Apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder... - N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorderTsung Ung W Woo
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA mail
Biol Psychiatry 64:803-9. 2008..In this study, we hypothesized that the subset of GABA interneurons that contained the calcium-binding protein calbindin (CB), by virtue of their preferential localization to layer 2, might be particularly affected... - Increasing Interaction of amygdalar afferents with GABAergic interneurons between birth and adulthoodMiles G Cunningham
Laboratory of Structural Neuroscience, McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
Cereb Cortex 18:1529-35. 2008..The establishment of this circuitry, largely during adolescence, may contribute to the integration of emotional responses with attentional and other cognitive processes mediated within this region during corticolimbic development... - Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdalaEvgeny Tsvetkov
McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neuron 34:289-300. 2002.... - A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brainMark S Todtenkopf
Laboratory for Structural Neuroscience, McLean Hospital, 115 Mill Street, 333 MRC, Belmont, MA 02478, USA
Schizophr Res 73:79-89. 2005.... - Differential alterations of kainate receptor subunits in inhibitory interneurons in the anterior cingulate cortex in schizophrenia and bipolar disorderTsung Ung W Woo
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
Schizophr Res 96:46-61. 2007.... - Regulation of synaptic plasticity in a schizophrenia modelBarbara Gisabella
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
Proc Natl Acad Sci U S A 102:13301-6. 2005..We demonstrate that GABA dysfunction increases long-term potentiation through activation of the cholinergic system, offering a new mechanism for pharmacological strategies of this disorder... - Rat modeling for GABA defects in schizophreniaFrancine M Benes
Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts, USA
Adv Pharmacol 54:73-93. 2006 - Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophreniaJohn E Lisman
Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
Trends Neurosci 31:234-42. 2008..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia... - Schizophrenia, II: amygdalar fiber alteration as etiology?Francine M Benes
Am J Psychiatry 160:1053. 2003 - A rat model for neural circuitry abnormalities in schizophreniaSabina Berretta
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Protoc 1:833-9. 2006..This has established the construct and predictive validity of this model for studying limbic-lobe circuitry abnormalities. We propose that this modeling strategy may provide a valid alternative to isomorphic models of these diseases...
Research Grants
- CORTICOLIMBIC SYSTEM IN SCHIZOPHRENIC BRAIN--ANALYSISFrancine Benes; Fiscal Year: 1993....
- CORTICOLIMBIC ABNORMALITIES IN SCHIZOPHRENIC BRAINFrancine Benes; Fiscal Year: 2001....
- BRAIN TISSUE RESOURCE FOR NEUROPSYCHIATRIC RESEARCHFrancine Benes; Fiscal Year: 2002..Over the next five years, all of these changes will enhance the "brain bank" in its role as a vital national resource. ..
- Gene Expression in Hippocampal Circuits of Bipolars and SchizophrenicsFrancine Benes; Fiscal Year: 2009....
- Gene Expression in Hippocampal Circuits of Bipolars and SchizophrenicsFrancine M Benes; Fiscal Year: 2010....