Research Topics
Genomes and GenesSpecies | Robert E MarcSummaryAffiliation: Hampden-Sydney College Country: USA Publications
| Collaborators
|
Detail Information
Publications
Neural reprogramming in retinal degenerationRobert E Marc
Department of Ophthalmology, John A Moran Eye Center, University of Utah, Salt Lake City, Utah 84132
Invest Ophthalmol Vis Sci 48:3364-71. 2007..The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration...- Retinal remodeling in inherited photoreceptor degenerationsRobert E Marc
John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Mol Neurobiol 28:139-47. 2003.... - Exploring the retinal connectomeJames R Anderson
Department of Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, UT, USA
Mol Vis 17:355-79. 2011..Our goal was to produce a connectome data set for the inner plexiform layer of the mammalian retina. This paper describes our first retinal connectome, validates the method, and provides key initial findings... - Trafficking of membrane proteins to cone but not rod outer segments is dependent on heterotrimeric kinesin-IIPrachee Avasthi
Department of Ophthalmology, University of Utah Health Science Center, Salt Lake City, Utah 84132, USA
J Neurosci 29:14287-98. 2009.... - Retinal remodeling triggered by photoreceptor degenerationsBryan W Jones
John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132
J Comp Neurol 464:1-16. 2003..Although remodeling may constrain therapeutic intervals for molecular, cellular, or bionic rescue, it suggests that the neural retina may be more plastic than previously believed... - Neural remodeling in retinal degenerationRobert E Marc
John A. Moran Eye Center, Department of Ophthalmology, University of Utah School of Medicine, 50 N Medical Center, Salt Lake City, UT 84132, USA
Prog Retin Eye Res 22:607-55. 2003..However, survivor neurons appear to be stable, healthy, active cells and given the evidence of their reactivity to deafferentation, it may be possible to influence their emergent rewiring and migration habits... - Extreme retinal remodeling triggered by light damage: implications for age related macular degenerationRobert E Marc
Ophthalmology, University of Utah, John A Moran Eye Center, Salt Lake City, UT 84132, USA
Mol Vis 14:782-806. 2008..An hypothesis emergent from data analysis is that the LIRD model closely mimics late-stage atrophic age relared macular degeneration (AMD)... - Retinoid receptors trigger neuritogenesis in retinal degenerationsYanhua Lin
Department of Ophthalmology, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
FASEB J 26:81-92. 2012..Thus, RXRs are in the final common path and may be therapeutic targets to attenuate retinal remodeling and facilitate global intervention methods in blinding diseases and other neurodegenerative disorders... - A computational framework for ultrastructural mapping of neural circuitryJames R Anderson
Department Ophthalmology, Moran Eye Center, University of Utah, Salt Lake City, USA
PLoS Biol 7:e1000074. 2009..Finally, this framework provides a mechanism for parallelization of ssTEM imaging, volume assembly, and data analysis across an international user base, enhancing the productivity of a large cohort of electron microscopists... - Excitation mapping with the organic cation AGB2+Robert E Marc
John A Moran Eye Center, University of Utah School of Medicine, Salt Lake City, 84132, USA
Vision Res 45:3454-68. 2005.... - Molecular phenotyping of retinal ganglion cellsRobert E Marc
John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
J Neurosci 22:413-27. 2002..Ganglion cell classes display markedly different ionotropic drives, which may partly explain the physiological brisk-sluggish spectrum of ganglion cell spiking patterns... - Proliferative reactive gliosis is compatible with glial metabolic support and neuronal functionFelix R Vazquez-Chona
Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, 65 Mario Capecchi Dr, Salt Lake City, UT 84132, USA
BMC Neurosci 12:98. 2011.... - Retinal remodeling during retinal degenerationBryan W Jones
Moran Eye Center, 75 North Medical Drive, Rm 3339A, Salt Lake City, UT 84132, USA
Exp Eye Res 81:123-37. 2005..As in other central nervous system degenerations, deafferentation activates remodeling. Neuronal remodeling is the common fate of all photoreceptor degenerations... - Functionally intact glutamate-mediated signaling in bipolar cells of the TRKB knockout mouse retinaBaerbel Rohrer
Department of Ophthalmology, Medical University of South Carolina, Charlston, SC 29425, USA
Vis Neurosci 21:703-13. 2004..These data indicate that there does not appear to be evidence for postsynaptic deficits in glutamatergic signaling in the ON and OFF bipolar cells of mice lacking trkB... - Retinal remodellingBryan W Jones
Moran Eye Center, 75 N Medical Drive, Salt Lake City, Utah, 84132, USA
Clin Exp Optom 88:282-91. 2005..Retinal remodelling resembles CNS pathologic remodelling and constitutes a major challenge to all rescue strategies... - Neural plasticity revealed by light-induced photoreceptor lesionsBryan W Jones
Ophthalmology, Univ Utah/Moran Eye Center, Salt Lake City, UT, USA
Adv Exp Med Biol 572:405-10. 2006 - Contribution of a glial glutamate transporter to GABA synthesis in the retinaVijay P Sarthy
Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Neuroreport 15:1895-8. 2004..An increase in GABAergic activity can be expected to affect trigger features such as directional selective response of neurons in the GLAST-/- mouse retina... - Gamma-glutamyl transferase deficiency results in lung oxidant stress in normoxiaJyh Chang Jean
Pulmonary Center at Boston University School of Medicine, Massachusetts 02118, USA
Am J Physiol Lung Cell Mol Physiol 283:L766-76. 2002..These data indicate a critical role for GGT in lung glutathione homeostasis and antioxidant defense in normoxia and hyperoxia...