Research Topics
| Ambuj KumarSummaryAffiliation: H. Lee Moffitt Cancer Center and Research Institute Country: USA Publications
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Detail Information
Publications
Tandem versus single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysisAmbuj Kumar
Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA
J Natl Cancer Inst 101:100-6. 2009..We performed a systematic review and meta-analysis to synthesize the existing evidence related to the effectiveness of tandem vs single AHCT in patients with MM...- Systematic review of high dose chemotherapy and autologous haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: what is the published evidence?Mohamed A Kharfan-Dabaja
Division of Blood and Marrow Transplantation, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Rsearch Institute, University of South Florida, Tampa, FL 33612, USA
Br J Haematol 139:234-42. 2007..It is uncertain whether autograft is superior to conventional therapy. The high incidence of myelodysplastic syndrome (9-12%) is particularly concerning in CLL, where median survival is 9 years... - Are experimental treatments for cancer in children superior to established treatments? Observational study of randomised controlled trials by the Children's Oncology GroupAmbuj Kumar
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
BMJ 331:1295. 2005.... - Role of high-dose chemotherapy and autologous hematopoietic cell transplantation in primary systemic amyloidosis: a systematic reviewRahul Mhaskar
Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida 33612, USA
Biol Blood Marrow Transplant 15:893-902. 2009..But the quality of our evidence is low, indicating a need for well-designed and adequately powered RCTs to better address the role of AHCT in AL amyloidosis... - Instrumental variable meta-analysis of individual patient data: application to adjust for treatment non-complianceBranko Miladinovic
Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
BMC Med Res Methodol 11:55. 2011..Our objective is to correct for bias in non-experimental data from previously published individual patient data meta-analysis by applying IV methods.. - Bisphosphonates in multiple myelomaRahul Mhaskar
Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
Cochrane Database Syst Rev 3:CD003188. 2010..Also, with the baseline risk of 35% to 86% for SREs without treatment, we estimate that between six and 15 MM patients should be treated to prevent SRE(s) in one patient. No bisphoshphonate appears to be superior to others... - Management of multiple myeloma: a systematic review and critical appraisal of published studiesAmbuj Kumar
Interdisciplinary Oncology Program of the H Lee Moffitt Cancer and Research Institute, University of South Florida, Tampa, FL 33612, USA
Lancet Oncol 4:293-304. 2003..We conclude that the quality of total evidence supporting treatment recommendations in myeloma is modest at best and has an ample scope for improvement... - Treatment success in cancer: new cancer treatment successes identified in phase 3 randomized controlled trials conducted by the National Cancer Institute-sponsored cooperative oncology groups, 1955 to 2006Benjamin Djulbegovic
H Lee Moffitt Cancer Center, 12902 Magnolia Dr, MRC, Room 2067H, Tampa, FL 33612, USA
Arch Intern Med 168:632-42. 2008..We assessed how often experimental cancer treatments that undergo testing in randomized clinical trials (RCTs) result in discovery of successful new interventions... - Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groupsAmbuj Kumar
H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33612, USA
J Clin Oncol 25:1272-6. 2007..A systematic review to assess the accurate participation of elderly patients in RCTs has not been performed... - Evidence-based medicine for rare diseases: implications for data interpretation and clinical trial designMadhusmita Behera
Malignant Hematology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Control 14:160-6. 2007..The randomized, controlled trial (RCT) is the "gold standard" for establishing the effect of any intervention. This approach, however, is often not feasible with rare diseases such as cutaneous T-cell lymphoma... - Optimism bias leads to inconclusive results-an empirical studyBenjamin Djulbegovic
Department of Medicine, Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL 33612, USA
J Clin Epidemiol 64:583-93. 2011..We assessed the impact of optimism bias on a proportion of trials that did not answer their research question successfully and explored whether poor accrual or optimism bias is responsible for inconclusive results... - Multiple myeloma: detecting the effects of new treatmentsBenjamin Djulbegovic
Division of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
Lancet 371:1642-4. 2008 - What kind of evidence do patients and practitioners need: evidence profiles based on 5 key evidence-based principles to summarize data on benefits and harmsBenjamin Djulbegovic
Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Treat Rev 32:572-6. 2006 - Evidence profiles for colo-rectal cancer: benefit/harms data based on the totality of randomized evidenceAmbuj Kumar
H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Department of Interdisciplinary Oncology and Cancer Prevention and Control, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Treat Rev 32:577-80. 2006 - Systematic review and meta-analysis of ovarian cancers: estimation of microsatellite-high frequency and characterization of mismatch repair deficient tumor histologyTuya Pal
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Clin Cancer Res 14:6847-54. 2008.... - Efficacy and safety of prophylactic vaccines against cervical HPV infection and diseases among women: a systematic review & meta-analysisBeibei Lu
Risk Assessment, Detection and Intervention Program, H, Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
BMC Infect Dis 11:13. 2011..We conducted a systematic review and meta-analysis to assess efficacy and safety of prophylactic HPV vaccines against cervical cancer precursor events in women... - Salvage radiotherapy increases survival in people with residual disease after chemotherapy for advance diffuse large cell lymphomaAmbuj Kumar
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Cancer Treat Rev 32:487-90. 2006 - Bad reporting does not mean bad methods for randomised trials: observational study of randomised controlled trials performed by the Radiation Therapy Oncology GroupHeloisa P Soares
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
BMJ 328:22-4. 2004..Reviewing research protocols and contacting trialists for more information may improve quality assessment... - Efficacy of rituximab in the setting of steroid-refractory chronic graft-versus-host disease: a systematic review and meta-analysisMohamed A Kharfan-Dabaja
Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, Florida, USA
Biol Blood Marrow Transplant 15:1005-13. 2009.... - Do community health worker interventions improve rates of screening mammography in the United States? A systematic reviewKristen J Wells
University of South Florida, Tampa, FL 33612, USA
Cancer Epidemiol Biomarkers Prev 20:1580-98. 2011..Community health workers (CHW) are lay individuals who are trained to serve as liaisons between members of their communities and health care providers and services... - Allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia (ALL) in first complete remissionJoseph Pidala
Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center, Division of Oncologic Sciences, University of South Florida, Tampa, Florida, USA
Cochrane Database Syst Rev 10:CD008818. 2011.... - Totality of evidence: one of the keys to better oncology managementAmbuj Kumar
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr, Tampa, FL 33612, USA
J Oncol Manag 14:12-4. 2005..Systematic review is the most promising technique to critically appraise and synthesize the findings and also argues for the totality of evidence, which is important for effective oncology management... - Nonmyeloablative allogeneic stem-cell transplantation for hematologic malignancies: a systematic reviewBenjamin Djulbegovic
Malignant Hematology Program, H Lee Moffitt Cancer Center Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Control 10:17-41. 2003..They hypothesize that NM-allo-SCT is equally efficacious to standard allo-SCT but produces less regimen-related toxicity... - Why evidence based oncology managementAmbuj Kumar
Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
J Oncol Manag 11:13-6. 2002