Research Topics
| H F FernandezSummaryAffiliation: H. Lee Moffitt Cancer Center and Research Institute Country: USA Publications
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Detail Information
Publications
Pharmacokinetic targeting of intravenous busulfan reduces conditioning regimen related toxicity following allogeneic hematopoietic cell transplantation for acute myelogenous leukemiaJoseph Pidala
Department of Blood and Marrow Transplantation, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
J Hematol Oncol 3:36. 2010..However, multivariable analysis did not demonstrate significant differences in overall survival (p = 0.78) or non-relapse mortality (p = 0.6) according to conditioning regimen delivered...
Autotransplant conditioning regimens for aggressive lymphoma: are we on the right road?H F Fernandez
Division of Blood and Marrow Transplant, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
Bone Marrow Transplant 40:505-13. 2007..Finally, we will present novel strategies, which can enhance the anti-lymphoma effect, at the same time reducing toxicity, to improve the outcome of ASCT in NHL patients...
Tyrosine kinase inhibitors and allogeneic hematopoietic cell transplantation for chronic myeloid leukemia: targeting both therapeutic modalitiesHugo F Fernandez
Department of Blood and Marrow Transplantation at the H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer Control 16:153-7. 2009..Due to its curative potential, allogenic hematopoietic transplantation (HCT) was a mainstay of treatment for chronic myeloid leukemia (CML), but the advent of tyrosine kinase inhibitors (TKIs) has markedly altered the use of allogeneic HCT...
Anthracycline dose intensification in acute myeloid leukemiaHugo F Fernandez
Department of Blood and Marrow Transplantation, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
N Engl J Med 361:1249-59. 2009..We evaluated the use of cytarabine plus either standard-dose or high-dose daunorubicin as induction therapy, followed by intensive consolidation therapy, in inducing complete remission to improve overall survival...
Induction therapy in acute myeloid leukemia: intensifying and targeting the approachHugo F Fernandez
Department of Blood and Marrow Transplantation, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Curr Opin Hematol 17:79-84. 2010..In the present review we will present new data from recently completed trials that have demonstrated advances in the treatment of AML...
New trends in the standard of care for initial therapy of acute myeloid leukemiaHugo F Fernandez
Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Hematology Am Soc Hematol Educ Program 2010:56-61. 2010..Newer agents targeted to specific molecular abnormalities or survival mechanisms in the leukemic cell are being studied as future additions to the current standard therapy...
Autologous transplantation gives encouraging results for young adults with favorable-risk acute myeloid leukemia, but is not improved with gemtuzumab ozogamicinHugo F Fernandez
Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, Tampa, FL 33612, USA
Blood 117:5306-13. 2011..The addition of a single dose of GO in this setting did not improve outcomes...
Sirolimus for treatment of steroid-refractory acute graft-versus-host diseaseD Hoda
Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Bone Marrow Transplant 45:1347-51. 2010..Median OS after initiation of sirolimus was 5.6 months, and 1-year OS was 44% (95% CI: 27-60%). Sirolimus is effective in controlling steroid-refractory aGVHD...
5-Azacitidine for myelodysplasia before allogeneic hematopoietic cell transplantationT Field
Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Bone Marrow Transplant 45:255-60. 2010..5-Azacitidine may be of value in stabilizing the disease, thereby allowing time for patients to reach transplant and does not appear to affect transplant outcomes...
