Research Topics
| Michael J CarrSummaryAffiliation: GlaxoSmithKline Research and Development Country: USA Publications
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Detail Information
Publications
Plasticity of vagal afferent fibres mediating coughMichael J Carr
UCB Research Inc, 840 Memorial Drive, Cambridge, MA 02139, USA
Pulm Pharmacol Ther 17:447-51. 2004....- Influence of mexiletine on action potential discharge and conduction in nodose Adelta afferent neurons innervating guinea pig isolated tracheaMichael J Carr
UCB Research, Inc, 840 Memorial Drive, Cambridge, MA 02138, USA
Pulm Pharmacol Ther 19:258-63. 2006..These findings are indicative of differences in sensitivity to local anesthetics of highly specialized regions of afferent neurons involved in initiation or conduction of impulses... - Antitussives: the pharmacological pipelineMichael J Carr
Respiratory Drug Discovery, GlaxoSmithKline, King of Prussia, PA 19406, USA
Pulm Pharmacol Ther 22:152-4. 2009..Potential next generation antitussives may act on the nervous system to control an inappropriate (pathological) urge-to-cough or, in the case of productive cough, facilitate expectoration, thus reducing the need to cough... - Plasticity of the afferent innervation of the airways: the role of ion channelsMichael J Carr
GlaxoSmithKline, King of Prussia, PA 19406, USA
Pulm Pharmacol Ther 20:412-5. 2007..This modulation of transduction pathways may be an underlying mechanism of cough reflex plasticity... - Plasticity of peripheral mechanisms of coughMichael J Carr
GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, UW 2531, USA
Respir Physiol Neurobiol 152:298-311. 2006..A greater understanding of the mechanisms leading to enhanced cough should lead to the development of more effective therapeutic strategies... - Bronchopulmonary afferent nervesMichael J Carr
UCB Research Inc, Cambridge, MA 02139, USA
Respirology 8:291-301. 2003..A more lucid characterization of bronchopulmonary afferent nerves, and a better understanding of the mechanisms by which these nerves influence pulmonary physiology during health and disease anticipates future research... - Pharmacology of vagal afferent nerve activity in guinea pig airwaysMichael J Carr
UCB Research Inc, 840 Memorial Drive, Cambridge, MA 02139, USA
Pulm Pharmacol Ther 16:45-52. 2003..These effects may contribute to many of the symptoms of inflammatory airway disease. Here we provide a brief overview of some of the mechanisms by which the afferent activity in airway nerves can be pharmacologically modified... - Effect of olvanil on the afferent and efferent function of capsaicin-sensitive C-fibers in guinea pig airwaysKarin J Stebbins
UCB Research Inc, 840 Memorial Drive, Cambridge, MA 02139, USA
Eur J Pharmacol 471:205-11. 2003..These findings are indicative of significant differences in the relative sensitivity of vanilloid VR1 receptor-transfected cells and the peripheral terminals of airway C-fibers to pungent and nonpungent vanilloid VR1 receptor agonists... - Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1Andrew W Leamy
Neuronal Targets DPU, Respiratory Therapy Area Unit, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA
Neurosci Lett 503:157-62. 2011..Taken together, these results demonstrate that curcumin causes activation and subsequent desensitization of native and recombinant TRPA1 ion channels of multiple mammalian species... - The study of airway primary afferent neuron excitabilityMichael J Carr
UCB Research Inc, 840 Memorial Drive, Cambridge, Massachusetts 02139, USA
Curr Opin Pharmacol 2:216-9. 2002.... - Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigsMin Goo Lee
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
Am J Respir Crit Care Med 173:271-5. 2006..Nociceptin/orphanin FQ has been reported to inhibit capsaicin- and mechanically provoked cough in animal models, but the mechanism of this effect has not been elucidated... - Physiology and plasticity of putative cough fibres in the Guinea pigBradley J Undem
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Pulm Pharmacol Ther 15:193-8. 2002..Thus, airway inflammation may not only increase the sensitivity of cough fibres, but may also qualitatively change the role played by sensory neuropeptides in cough reflexes... - Voltage-gated sodium channels in nociceptive versus non-nociceptive nodose vagal sensory neurons innervating guinea pig lungsKevin Kwong
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
J Physiol 586:1321-36. 2008..8 and Na(V)1.9 were present in nearly all neurons. We conclude that contrary to findings in the somatosensory neurons, TTX-R VGSCs are not preferentially expressed in the nociceptive C-fibre population innervating the lungs... - Expression of tachykinins in nonnociceptive vagal afferent neurons during respiratory viral infection in guinea pigsMichael J Carr
The Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
Am J Respir Crit Care Med 165:1071-5. 2002.... - A role for TRPV1 in bradykinin-induced excitation of vagal airway afferent nerve terminalsMichael J Carr
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, USA
J Pharmacol Exp Ther 304:1275-9. 2003..Our data suggest a role for lipoxygenase products in bradykinin B(2) receptor-induced activation of TRPV1 in the peripheral terminals of afferent C-fibers within guinea pig trachea... - Poster discussion: summaryJack A Kastelik
Department of Respiratory Medicine, Castle Hill Hospital, Cottingham, Hull, East Yorkshire HU16 5JQ, UK
Pulm Pharmacol Ther 20:446-51. 2007..This review will focus on the discussions related to the posters... - Molecular epidemiology of human metapneumovirus in IrelandMichael J Carr
National Virus Reference Laboratory, University College Dublin, Dublin, Ireland
J Med Virol 80:510-6. 2008..44-8.15). Statistical analysis of quantitative RT-PCR determinations of viral load from these 30 respiratory specimens suggests that hMPV genotype B specimens have a higher viral load than hMPV genotype A isolates (P < 0.03)...