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Species | Ritu AnejaSummaryAffiliation: Georgia State University Country: USA Publications
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Publications
Non-toxic melanoma therapy by a novel tubulin-binding agentRitu Aneja
Department of Biology, Georgia State University, Atlanta, GA 30303, USA
Int J Cancer 126:256-65. 2010..Unlike currently available chemotherapeutics, EM011 is non-toxic to normal tissues and most importantly, does not cause any immunosuppression and neurotoxicity. Our data thus warrant a clinical evaluation of EM011 for melanoma therapy...- A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cellsRitu Aneja
Department of Biology, Georgia State University, Atlanta, GA 30303, USA
Eur J Cancer 46:1668-78. 2010..EM011 did not exert any detectable toxicity in normal tissues with frequently dividing cells such as the gut and bone marrow. Thus, these data warrant further evaluation of EM011 for the management of prostate cancer... - Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell deathRitu Aneja
Laboratory for Drug Discovery and Research, Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Biochem Pharmacol 72:415-26. 2006..Thus, our data indicate a great potential of these compounds for studying microtubule-mediated processes and as chemotherapeutic agents for the management of human cancers... - Rational design of the microtubule-targeting anti-breast cancer drug EM015Ritu Aneja
Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Cancer Res 66:3782-91. 2006..Thus, EM015 has a great promise in the clinic... - Treatment of hormone-refractory breast cancer: apoptosis and regression of human tumors implanted in miceRitu Aneja
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cancer Ther 5:2366-77. 2006..Thus, our data provide compelling evidence that 9-bromonoscapine can be useful for the therapy of hormone-refractory breast cancer... - EM011 activates a survivin-dependent apoptotic program in human non-small cell lung cancer cellsPrasanthi Karna
Department of Biology, Georgia State University, Atlanta, GA 30303, USA
Mol Cancer 8:93. 2009..EM011, a rationally-designed member of this class of non-toxic agents, is more potent than the lead molecule, noscapine... - Multidrug resistance-associated protein-overexpressing teniposide-resistant human lymphomas undergo apoptosis by a tubulin-binding agentRitu Aneja
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 68:1495-503. 2008..In addition, EM011 treatment caused a suppression of natural survival pathways such as the phosphatidylinositol-3'-kinase/Akt signaling. These preclinical findings suggest that EM011 is an excellent candidate for clinical evaluation... - Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphomaRitu Aneja
Department of Cell Biology, Emory University School of Medicine, Laboratory for Drug Discovery and Research, 615 Michael St, Atlanta, GA 30322, USA
Mol Pharmacol 69:1801-9. 2006..Thus, we conclude that 9-nitro-nos has great potential to be a novel therapeutic agent for ovarian and T-cell lymphoma cancers, even those that have become drug-resistant to currently available chemotherapeutic drugs... - Drug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011Ritu Aneja
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood 107:2486-92. 2006..These findings suggest that EM011 may be a safe and effective chemotherapeutic agent for oral treatment of drug-resistant human lymphomas... - Rational design, synthesis and biological evaluations of amino-noscapine: a high affinity tubulin-binding noscapinoidPradeep K Naik
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Comput Aided Mol Des 25:443-54. 2011..Our results revealed that amino-noscapine has better anti-tumor activity than noscapine... - Synthesis and biological evaluation of a cyclic ether fluorinated noscapine analogRitu Aneja
Laboratory for Drug Discovery and Research, Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Bioorg Med Chem 14:8352-8. 2006..Mechanistically, CEFNA exerts a strong antimitotic effect as revealed by cell-cycle studies that show a dose-dependent increase in G2/M population preceding a rising sub-G1 population, suggesting apoptosis... - Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluationRam Chandra Mishra
Department of Biology, Georgia State University, Atlanta, GA 30303, United States
Biochem Pharmacol 82:110-21. 2011..The varying biological activity of these analogs that differ in the nature and bulk of substituent at position-7 was rationalized utilizing predictive in silico molecular modeling... - EM012, a microtubule-interfering agent, inhibits the progression of multidrug-resistant human ovarian cancer both in cultured cells and in athymic nude miceJun Zhou
Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Cancer Chemother Pharmacol 55:461-5. 2005..Furthermore, EM012 treatment did not cause detectable toxicity to normal tissues. These findings suggest that EM012 may serve as a novel chemotherapeutic agent for the treatment of multidrug-resistant human ovarian cancer... - Benefits of whole ginger extract in prostate cancerPrasanthi Karna
Department of Biology, Georgia State University, Atlanta, GA 30303, USA
Br J Nutr 107:473-84. 2012..To the best of our knowledge, this is the first report to demonstrate the in vitro and in vivo anticancer activity of whole GE for the management of prostate cancer... - Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agentRitu Aneja
Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Cancer Chemother Pharmacol 60:831-9. 2007..Unlike currently available antimitotics such as taxanes and vincas, noscapine is water-soluble, well tolerated, and shows no detectable toxicity... - Enhancement of paclitaxel-induced microtubule stabilization, mitotic arrest, and apoptosis by the microtubule-targeting agent EM012Jun Zhou
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Biochem Pharmacol 68:2435-41. 2004..Our results therefore suggest a therapeutic potential of EM012/paclitaxel combination in the management of human cancer and provide mechanistic insights into the combined effects of these two microtubule-targeting agents... - Induction of reactive oxygen species-mediated autophagy by a novel microtubule-modulating agentPrasanthi Karna
Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
J Biol Chem 285:18737-48. 2010.... - Enhanced noscapine delivery using uPAR-targeted optical-MR imaging trackable nanoparticles for prostate cancer therapyMohamed O Abdalla
Department of Biology, Georgia State University, Atlanta, GA 30303, United States
J Control Release 149:314-22. 2011.... - p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cellsRitu Aneja
Department of Cell Biology and Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Cancer Res 67:3862-70. 2007..Interestingly, despite increased levels of p53, p21-null cells were resistant to apoptosis, suggesting a proapoptotic role of p21 and implying that p53 is a necessary but not sufficient condition for noscapine-mediated apoptosis... - Synergistic antimicrotubule therapy for prostate cancerVaishali Pannu
Department of Biology, P O Box 4010, Georgia State University, Atlanta, GA 30303, United States
Biochem Pharmacol 81:478-87. 2011..Our studies suggest the potential usefulness of EM011 in the clinic to enhance docetaxel activity. This would reduce toxicity, thus improving the quality of life of docetaxel-treated patients... - Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivoPrasanthi Karna
Department of Biology, Georgia State University, Atlanta, GA 30303, USA
Carcinogenesis 32:1872-80. 2011..This is the first report to demonstrate the in vitro and in vivo anticancer activity of sweet potato greens in prostate cancer... - Nonimmunosuppressive chemotherapy: EM011-treated mice mount normal T-cell responses to an acute lymphocytic choriomeningitis virus infectionRitu Aneja
Laboratory for Drug Discovery, Design, and Research, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cancer Ther 6:2891-9. 2007..These data provide compelling evidence to support the nonimmunosuppressive nature of EM011 therapy and provide strong impetus for combining chemotherapy with immunotherapy as a novel anticancer strategy... - In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin)Pradeep K Naik
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA
J Comput Aided Mol Des 26:233-47. 2012..Quite strikingly, ovarian cancer cells (SKOV3 and A2780), known to overexpress FR?, were much more sensitive to targetin (IC(50) in the range of 0.3-1.5 ?M)... - Drugs that target dynamic microtubules: a new molecular perspectiveRichard A Stanton
Department of Biology, Georgia State University, Atlanta, USA
Med Res Rev 31:443-81. 2011..These "biological vectors" can thus be used as a spatiotemporal context to describe molecular mechanisms by which microtubule-targeting drugs work... - Brominated derivatives of noscapine are potent microtubule-interfering agents that perturb mitosis and inhibit cell proliferationJun Zhou
Graduate Program in Biochemistry, Cell and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
Mol Pharmacol 63:799-807. 2003..Our results thus indicate a great potential for the use of 5-Br-nosc and Rd 5-Br-nosc both as biological tools for studying microtubule-mediated processes and as chemotherapeutic agents for the treatment of human cancers... - Recent patents on proteases and kinases as anti-infective agents: a reviewSurya N Vangapandu
Laboratory for Drug Discovery and Research, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Recent Pat Antiinfect Drug Discov 1:209-24. 2006..We apologize to those whose patents we could not cite. Our goal is to inform public at large of the new inventions in the pipeline and their status toward development of these technologies as drugs in the clinic... - Near infrared active heptacyanine dyes with unique cancer-imaging and cytotoxic propertiesMaged Henary
Georgia State University, Department of Chemistry, Petit Science Center, 100 Piedmont Ave, Atlanta, GA 30303, USA
Bioorg Med Chem Lett 22:1242-6. 2012..Additionally, confocal fluorescence imaging confirmed selective uptake of these dyes in cancer cells, thus suggesting tumor cell targeting... - High-performance liquid chromatography separation of enantiomers of mandelic acid and its analogs on a chiral stationary phaseRitu Aneja
Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA
Chirality 22:479-85. 2010..Chiral recognition models have been suggested to account for the observed separations. These models provide mechanistic insights into the chiral recognition process...