Research TopicsGenomes and GenesSpecies | Collaborators |
Detail Information
Publications
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse modelMichael L Booker
Genzyme Corporation, Waltham, Massachusetts 02451, USA
J Biol Chem 285:33054-64. 2010..In particular, treatment with Genz-667348 at 100 mg/kg/day resulted in sterile cure. Two recent analogs of Genz-667348 are currently undergoing pilot toxicity testing to determine suitability as clinical development candidates...
