Heidi S Phillips

Summary

Affiliation: Genentech Inc
Country: USA

Publications

  1. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
  2. ncbi Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance
    Heidi S Phillips
    Genentech Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA
    Brain Res Mol Brain Res 124:1-11. 2004
  3. ncbi Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF
    Susan M W Harrison
    School of Biological Sciences, University of Kentucky, Lexington, KY 40506, USA
    Brain Res Mol Brain Res 122:116-25. 2004
  4. ncbi Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth
    Chibo Hong
    Department of Neurological Surgery and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 104:10974-9. 2007
  5. ncbi Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin
    Albert Lai
    Genentech, 1 DNA Way, South San Francisco, CA 94080
    J Clin Oncol 29:4482-90. 2011
  6. ncbi Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma
    Liliana Soroceanu
    Department of Tumor Biology and Angiogenesis, Molecular Biology, Biostatistics, and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:3466-71. 2007
  7. ncbi A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
    Ruihuan Chen
    Department of Tumor Biology and Angiogenesis, Genentech Inc, San Francisco, CA 94080, USA
    Cancer Cell 17:362-75. 2010
  8. ncbi TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma
    Kui Lin
    Genentech, South San Francisco, California, United States of America
    PLoS ONE 6:e18608. 2011

Collaborators

Detail Information

Publications8

  1. ncbi Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    Heidi S Phillips
    Department of Tumor Biology and Angiogenesis, Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Cell 9:157-73. 2006
    ..A robust two-gene prognostic model utilizing PTEN and DLL3 expression suggests that Akt and Notch signaling are hallmarks of poor prognosis versus better prognosis gliomas, respectively...
  2. ncbi Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance
    Heidi S Phillips
    Genentech Incorporated, 1 DNA Way, South San Francisco, CA 94080, USA
    Brain Res Mol Brain Res 124:1-11. 2004
    ..These results indicate that NGF is required for induction of proper innervation by BFC neurons, but that the cellular pattern of expression of this factor is not critical for specifying the distribution of axon terminals...
  3. ncbi Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF
    Susan M W Harrison
    School of Biological Sciences, University of Kentucky, Lexington, KY 40506, USA
    Brain Res Mol Brain Res 122:116-25. 2004
    ..Thus, the most vital functions of NGF are not dependent on faithful recapitulation of the normal spatiotemporal pattern of gene expression...
  4. ncbi Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth
    Chibo Hong
    Department of Neurological Surgery and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 104:10974-9. 2007
    ..Thus, our integrated genetic and epigenetic approach might be useful to identify genes that are widely relevant to cancer, even when genetic alterations of the locus are infrequent...
  5. ncbi Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin
    Albert Lai
    Genentech, 1 DNA Way, South San Francisco, CA 94080
    J Clin Oncol 29:4482-90. 2011
    ..Optimal clinical management should account for the distinction between these GBM disease subtypes...
  6. ncbi Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma
    Liliana Soroceanu
    Department of Tumor Biology and Angiogenesis, Molecular Biology, Biostatistics, and Pathology, Genentech, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 104:3466-71. 2007
    ..Further, these findings highlight the parallels between growth factors or receptors that are overexpressed in GBMs and those that support in vitro growth of tumor-derived stem-like cells...
  7. ncbi A hierarchy of self-renewing tumor-initiating cell types in glioblastoma
    Ruihuan Chen
    Department of Tumor Biology and Angiogenesis, Genentech Inc, San Francisco, CA 94080, USA
    Cancer Cell 17:362-75. 2010
    ....
  8. ncbi TMEFF2 is a PDGF-AA binding protein with methylation-associated gene silencing in multiple cancer types including glioma
    Kui Lin
    Genentech, South San Francisco, California, United States of America
    PLoS ONE 6:e18608. 2011
    ..The biological function of TMEFF2 remains unclear with conflicting reports suggesting both a positive and a negative association between TMEFF2 expression and human cancers...