Research Topics
Genomes and Genes
| Sarah G HymowitzSummaryAffiliation: Genentech Inc Country: USA Publications
| Collaborators
|
Detail Information
Publications
The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificitySarah G Hymowitz
Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Structure 11:1513-20. 2003..While the backbone conformation around the splice difference is similar in both isoforms, the conformation of the following loop, the surface charge, and the shape of the expected receptor binding site differ significantly...- Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand bindingSarah G Hymowitz
Department of Protein Engineering, Molecular Oncology, Medicinal Chemistry, and Immunology, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 280:7218-27. 2005..TACI_d2 and APRIL.BCMA complexes that together reveal the mechanism by which TACI engages high affinity ligand binding through a single CRD, and we highlight sources of ligand-receptor specificity within the APRIL/BAFF system... - Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonistsBing Li
Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Mol Biol 361:522-36. 2006..These phage-derived ligands may be useful for elucidating DR5 activation at the molecular level and for creating synthetic agonists of proapoptotic death receptors... - Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cellsChingwei V Lee
Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Blood 108:3103-11. 2006.... - Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active siteHenry R Maun
Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 285:26570-80. 2010..Furthermore, to our knowledge, the ch5E1 Fab-Shh complex represents the first structure of an inhibitor antibody bound to a metalloprotease fold... - Preparation of distinct ubiquitin chain reagents of high purity and yieldKen C Dong
Department of Structural Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Structure 19:1053-63. 2011.... - Ubiquitin binding to A20 ZnF4 is required for modulation of NF-?B signalingIvan Bosanac
Department of Structural Biology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Mol Cell 40:548-57. 2010.... - Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage displayNathaniel C Gordon
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Mol Biol 396:166-77. 2010.... - Modulation of K11-linkage formation by variable loop residues within UbcH5AIvan Bosanac
Department of Structural Biology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Mol Biol 408:420-31. 2011..This study provides direct evidence that the linkage specificity of E2 enzymes may be altered through active-site mutagenesis... - Phosphorylation-dependent activity of the deubiquitinase DUBAOscar W Huang
Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, USA
Nat Struct Mol Biol 19:171-5. 2012..Phosphoactivation of DUBA represents an unprecedented mode of protease regulation and a clear link between two major cellular signal transduction systems: phosphorylation and ubiquitin modification... - The crystal structure of the costimulatory OX40-OX40L complexDeanne M Compaan
Department of Protein Engineering, Genentech, Incorporated, 1 DNA Way, South San Francisco, California 94080, USA
Structure 14:1321-30. 2006..These structures demonstrate the structural plasticity of TNFSF members and their interactions with receptors... - K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibodyMarissa L Matsumoto
Department of Antibody Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
Mol Cell 39:477-84. 2010..Our results underscore the importance of K11-linked ubiquitin chains as critical regulators of mitotic protein degradation... - The crystal structure of a proliferation-inducing ligand, APRILHeidi J A Wallweber
Department of Protein Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Mol Biol 343:283-90. 2004..0 and 8.5. Modeling of the APRIL-BCMA complex shows the resulting interface is in agreement with mutagenesis data... - Engineering and structural characterization of a linear polyubiquitin-specific antibodyMarissa L Matsumoto
Department of Antibody Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Mol Biol 418:134-44. 2012..This antibody provides an essential tool for further investigation of the function of linear chains... - BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding siteNathaniel C Gordon
Department of Protein Engineering, Genentech, Inc, One DNA Way, South San Francisco, California 94080, USA
Biochemistry 42:5977-83. 2003..Thus, BR3 binds BAFF through a highly focused interaction site, unprecedented in the TNFR family... - The mitotic regulator Survivin binds as a monomer to its functional interactor BorealinEric Bourhis
Department of Protein Engineering, Genentech, Incorporated, South San Francisco, California 94080, USA
J Biol Chem 282:35018-23. 2007..This suggests that the mutant is dominant-negative and confirms the functional importance of the interaction surface identified in the crystal structures... - Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complexDeanne M Compaan
Department of Protein Engineering, Genentech, Inc, S San Francisco, California 94080, USA
J Biol Chem 280:39553-61. 2005..Finally, BTLA adopts an immunoglobulin I-set fold. Despite structural similarities to other CD28-like members, BTLA represents a unique co-receptor... - A20: from ubiquitin editing to tumour suppressionSarah G Hymowitz
Department of Structural Biology, Genentech, Inc 1 DNA Way, M S 40, South San Francisco, CA 94080, USA
Nat Rev Cancer 10:332-41. 2010.... - Therapeutic antibody targeting of individual Notch receptorsYan Wu
Department of Antibody Engineering, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 464:1052-7. 2010..Our studies emphasize the value of paralogue-specific antagonists in dissecting the contributions of distinct Notch receptors to differentiation and disease and reveal the therapeutic promise in targeting Notch1 and Notch2 independently... - Antagonists induce a conformational change in cIAP1 that promotes autoubiquitinationErin C Dueber
Department of Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Science 334:376-80. 2011..Antagonist binding induces conformational rearrangements that enable RING dimerization and formation of the active E3 ligase... - Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signalingRobert F Kelley
Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
J Biol Chem 280:2205-12. 2005..These results suggest that DR5 may contribute more than DR4 to Apo2L/TRAIL-induced apoptosis in cancer cells that express both death receptors... - Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodiesKim Newton
Department of Physiological Chemistry, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Cell 134:668-78. 2008..Polyubiquitin editing may therefore be a general mechanism for attenuating innate immune signaling... - The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingIvan Bosanac
Department of Structural Biology, Genentech, Inc, South San Francisco, California, USA
Nat Struct Mol Biol 16:691-7. 2009.... - Molecular recognition by a binary codeFrederic A Fellouse
Department of Protein Engineering, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Mol Biol 348:1153-62. 2005..Furthermore, these results demonstrate that molecular recognition can evolve from even the simplest chemical diversity... - Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonistsChudi Ndubaku
Departments of Medicinal Chemistry and Protein Engineering, Genentech, Inc, South San Francisco, CA 94080, USA
ACS Chem Biol 4:557-66. 2009..Therefore, although compounds that specifically target c-IAP1 and c-IAP2 are capable of inducing apoptosis, antagonism of the c-IAP proteins and XIAP is required for efficient induction of cancer cell death by IAP antagonists... - Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAILKlaus W Wagner
Department of Molecular Diagnostics, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nat Med 13:1070-7. 2007..These results uncover a new link between death-receptor O-glycosylation and apoptotic signaling, providing potential predictive biomarkers for Apo2L/TRAIL-based cancer therapy... - Regulation and functions of the IL-10 family of cytokines in inflammation and diseaseWenjun Ouyang
Department of Immunology, Genentech, Inc, South San Francisco, California 94080, USA
Annu Rev Immunol 29:71-109. 2011..Finally, IL-10 itself can repress proinflammatory responses and limit unnecessary tissue disruptions caused by inflammation. Thus, IL-10 family cytokines have indispensable functions in many infectious and inflammatory diseases... - In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammationDhaya Seshasayee
Department of Immunology, Genentech Inc, South San Francisco, California 94080, USA
J Clin Invest 117:3868-78. 2007..The use of a blocking, OX40L-specific mAb thus presents a promising strategy for the treatment of allergic diseases associated with pathologic Th2 immune responses... - Toward small-molecule agonists of TNF receptorsSarah G Hymowitz
Nat Chem Biol 1:353-4. 2005