Research Topics
Species | Raúl J GazmuriSummaryCountry: USA Publications
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Publications
Effects of repetitive electrical shocks on postresuscitation myocardial functionR J Gazmuri
Medical Service, Section of Critical Care Medicine, North Chicago Veterans Affairs Medical Center, Illinois 60064, USA
Crit Care Med 28:N228-32. 2000....
Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporideR J Gazmuri
Medical Service, Section of Critical Care Medicine, North Chicago VA Medical Center, Chicago, IL 60064, USA
Circulation 104:234-9. 2001..CONCLUSION: NHE-1 inhibition may represent a novel and remarkably effective intervention for resuscitation from VF...
Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1Raúl J Gazmuri
Section of Critical Care Medicine, North Chicago VA Medical Center, North Chicago, IL 60064, USA
Crit Care Med 30:S166-71. 2002..15 of 24 [63%] in control rats, p <.05). We conclude that NHE-1 inhibition may represent a novel and highly effective form of treatment for resuscitation from ventricular fibrillation...
Myocardial protection during resuscitation from cardiac arrestRaúl J Gazmuri
Department of Medicine, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois, USA
Curr Opin Crit Care 9:199-204. 2003..In this review, we examine mechanisms of such myocardial injury and discuss potential new strategies for myocardial protection during resuscitation from cardiac arrest...
Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injurySufen Wang
Department of Medicine, Division of Critical Care Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
J Appl Physiol 103:55-65. 2007..We investigated whether limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation (VF) attenuates Ca2+ m overload and lessens myocardial dysfunction in a rat model of VF and closed-chest resuscitation...
Activation of caspase-3 may not contribute to postresuscitation myocardial dysfunctionJeejabai Radhakrishnan
Medical Service 111F North Chicago VA Medical Center, 3001 Green Bay Road, North Chicago, IL 60064, USA
Am J Physiol Heart Circ Physiol 296:H1164-74. 2009..Concomitant activation of intrinsic antiapoptotic mechanisms could play a protective role downstream to caspase-3 activation...
Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activityIyad M Ayoub
Resuscitation Institute at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Resuscitation 81:106-10. 2010..We investigated in a pig model of VF whether limiting Na(+)-induced cytosolic Ca(2+) overload using the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor cariporide promotes resuscitation with stable circulation...
Targeting mitochondria for resuscitation from cardiac arrestIyad M Ayoub
Department of Medicine, Division of Critical Care Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
Crit Care Med 36:S440-6. 2008....
Zoniporide preserves left ventricular compliance during ventricular fibrillation and minimizes postresuscitation myocardial dysfunction through benefits on energy metabolismIyad M Ayoub
Department of Medicine, Rosalind Franklin University of Medicine and Science, and North Chicago VA Medical Center, North Chicago, IL, USA
Crit Care Med 35:2329-36. 2007....
AVE4454B--a novel sodium-hydrogen exchanger isoform-1 inhibitor--compared less effective than cariporide for resuscitation from cardiac arrestJeejabai Radhakrishnan
Resuscitation Institute at Rosalind Franklin University of Medicine and Science and Medical Service, Section of Critical Care Medicine, Captain James A Lovell Federal Health Care Center, North Chicago, Ill 60064, USA
Transl Res 157:71-80. 2011..We conclude that cariporide is more effective than AVE4454B for resuscitation from cardiac arrest given its more prominent effect on preserving left ventricular myocardial distensibility and promoting survival...
Circulating levels of cytochrome c after resuscitation from cardiac arrest: a marker of mitochondrial injury and predictor of survivalJeejabai Radhakrishnan
Division of Critical Care Medicine, Department of Medicine, Rosalind Franklin University of Medicine and Science, and North Chicago Veterans Affairs Medical Center, North Chicago, Illinois, USA
Am J Physiol Heart Circ Physiol 292:H767-75. 2007..5) vs. 0.1 (SD 0.1) microg.ml(-1).h(-1), P = 0.046] than in survivors. Plasma cytochrome c may represent a novel in vivo marker of mitochondrial injury after resuscitation from cardiac arrest that relates inversely with survival outcome...
[Trends in cardiopulmonary resuscitation]Raúl J Gazmuri
North Chicago VA Medical Center and Medical Service, Chicago, Illinois, USA
Med Intensiva 33:31-9. 2009....
Clinically plausible hyperventilation does not exert adverse hemodynamic effects during CPR but markedly reduces end-tidal PCO?Raúl J Gazmuri
Resuscitation Institute at Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Resuscitation 83:259-64. 2012..We examined whether ventilation at high, yet clinically plausible, tidal volumes could also be detrimental, and further examined effects on end-tidal pCO(2) (P(ET)CO(2))...
